Schizophrenia

Common Name(s)

Schizophrenia

Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. There is no characteristic pathology, such as neurofibrillary tangles in Alzheimer disease ({104300}). Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. This may not be a single entity. Reviews In a review of schizophrenia, {167:van Os and Kapur (2009)} noted that in Japan the term schizophrenia was abandoned and the illness is now called integration-dysregulation syndrome.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Schizophrenia" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 16 Mar 2015

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Schizophrenia" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 16 Mar 2015

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

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General Support Organizations

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General Resources

Schizophrenia

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Schizophrenia" returned 5745 free, full-text research articles on human participants. First 3 results:

The role of NMDA receptors in schizophrenia.
 

Author(s): John M Kane

Journal: J Clin Psychiatry. 2015 Jan;76(1):e1.

 

Last Updated: 5 Feb 2015

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Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
 

Author(s): Robert Maier, Gerhard Moser, Guo-Bo Chen, Stephan Ripke, , William Coryell, James B Potash, William A Scheftner, Jianxin Shi, Myrna M Weissman, Christina M Hultman, Mikael Landén, Douglas F Levinson, Kenneth S Kendler, Jordan W Smoller, Naomi R Wray, S Hong Lee

Journal: Am. J. Hum. Genet.. 2015 Feb;96(2):283-94.

 

Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the ...

Last Updated: 9 Feb 2015

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Adjunctive recombinant human interferon gamma-1b for treatment-resistant schizophrenia in 2 patients.
 

Author(s): Lena Grüber, Tilmann Bunse, Elif Weidinger, Heidi Reichard, Norbert Müller

Journal: J Clin Psychiatry. 2014 Nov;75(11):1266-7.

 

Last Updated: 4 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Schizophrenia" returned 1226 free, full-text review articles on human participants. First 3 results:

Schizophrenia: overview and dopamine dysfunction.
 

Author(s): Anissa Abi-Dargham

Journal: J Clin Psychiatry. 2014 Nov;75(11):e31.

 

Schizophrenia is a chronic, often disabling illness that affects approximately 24 million people worldwide. Unfortunately, while the majority of first-episode schizophrenia patients respond well to initial antipsychotic treatment, less than 1 in 5 will maintain recovery over 2 to ...

Last Updated: 4 Dec 2014

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Bridging the efficacy-effectiveness gap in the antipsychotic treatment of schizophrenia: back to the basics.
 

Author(s): Rajiv Tandon

Journal: J Clin Psychiatry. 2014 Nov;75(11):e1321-2.

 

Last Updated: 4 Dec 2014

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Is non-pharmacological treatment an option for certain schizophrenia patients?
 

Author(s): Valentin P Matei, Alexandra I Mihailescu, Michael Davidson

Journal: Psychiatr Danub. 2014 Dec;26(4):308-13.

 

Schizophrenia treatment has been debated at length and presently pharmacological treatment is being advocated as the most beneficial for patients. However, research has shown contradictory results regarding the suitability of pharmacological treatment for certain groups of schizophrenia patients.

Last Updated: 7 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone
 

Status: Recruiting

Condition Summary: Schizophrenia, Catatonic; Schizophrenia, Disorganized; Schizophrenia, Paranoid; Schizophrenia; Psychotic Disorders

 

Last Updated: 6 Jul 2010

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RISE (Rehabilitation Intervention for People With Schizophrenia in Ethiopia)
 

Status: Not yet recruiting

Condition Summary: Schizophrenia Spectrum Disorder; Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder

 

Last Updated: 31 Mar 2015

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Electroconvulsive Therapy (ECT) in Patients With Super Refractory Schizophrenia
 

Status: Recruiting

Condition Summary: Refractory Schizophrenia; Super Refractory Schizophrenia

 

Last Updated: 27 Jan 2014

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