Schizophrenia

Common Name(s)

Schizophrenia

Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. There is no characteristic pathology, such as neurofibrillary tangles in Alzheimer disease ({104300}). Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. This may not be a single entity. Reviews In a review of schizophrenia, {166:van Os and Kapur (2009)} noted that in Japan the term schizophrenia was abandoned and the illness is now called integration-dysregulation syndrome.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Schizophrenia" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 29 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Schizophrenia" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 29 Jan 2013

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General Support Organizations

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General Resources

Schizophrenia

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Schizophrenia" returned 5267 free, full-text research articles on human participants. First 3 results:

Can patients with schizophrenia undergo renal transplantation with success?
 

Author(s): Saoussen Bouhlel

Journal: Saudi J Kidney Dis Transpl. 2014 May;25(3):605-9.

 

We report a case of a 41-year-old man suffering from paranoid schizophrenia. The patient has been consulting in our psychiatric hospital since he was 29 years old. Eight years later, he developed kidney failure and required peritoneal dialysis. After more than two years, the nephrology ...

Last Updated: 13 May 2014

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Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.
 

Author(s): Shashwath A Meda, Gualberto Ruaño, Andreas Windemuth, Kasey O'Neil, Clifton Berwise, Sabra M Dunn, Leah E Boccaccio, Balaji Narayanan, Mohan Kocherla, Emma Sprooten, Matcheri S Keshavan, Carol A Tamminga, John A Sweeney, Brett A Clementz, Vince D Calhoun, Godfrey D Pearlson

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(19):E2066-75.

 

The brain's default mode network (DMN) is highly heritable and is compromised in a variety of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and psychotic bipolar disorder (PBP) is largely unknown. Study subjects (n = 1,305) underwent a resting-state ...

Last Updated: 14 May 2014

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Completed and attempted suicides among 18,154 subjects with schizophrenia included in a large simple trial.
 

Author(s): W Wolfgang Fleischhacker, John M Kane, Jamie Geier, Onur Karayal, Sheela Kolluri, Sybil M Eng, Robert F Reynolds, Brian L Strom

Journal: J Clin Psychiatry. 2014 Mar;75(3):e184-90.

 

To characterize subgroups of subjects with schizophrenia from the Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC) trial who either completed or attempted suicide and those who did not.

Last Updated: 10 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Schizophrenia" returned 1121 free, full-text review articles on human participants. First 3 results:

Schizophrenia: mechanism of action of current and novel treatments.
 

Author(s): Christoph U Correll, John M Kane

Journal: J Clin Psychiatry. 2014 Apr;75(4):347-8.

 

Last Updated: 12 May 2014

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Neurocognitive vulnerability: suicidal and homicidal behaviours in patients with schizophrenia.
 

Author(s): Stéphane Richard-Devantoy, Manuel Orsat, Alexandre Dumais, Gustavo Turecki, Fabrice Jollant

Journal: Can J Psychiatry. 2014 Jan;59(1):18-25.

 

Schizophrenia is associated with an increase in the risk of both homicide and suicide. The objectives of this study were to systematically review all published articles that examined the relation between neurocognitive deficits and suicidal or homicidal behaviours in schizophrenia, ...

Last Updated: 21 Jan 2014

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Cognition, function, and disability in patients with schizophrenia: a review of longitudinal studies.
 

Author(s): Tarek K Rajji, Dielle Miranda, Benoit H Mulsant

Journal: Can J Psychiatry. 2014 Jan;59(1):13-7.

 

This paper aims to review longitudinal studies assessing the impact of cognition on function in patients with schizophrenia. PubMed and Scholars Portal were searched using search terms related to schizophrenia, cognition, function, and longitudinal studies. Some functional abilities ...

Last Updated: 21 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone
 

Status: Recruiting

Condition Summary: Schizophrenia, Catatonic; Schizophrenia, Disorganized; Schizophrenia, Paranoid; Schizophrenia; Psychotic Disorders

 

Last Updated: 6 Jul 2010

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Yoga as Cognitive Remediation in Schizophrenia
 

Status: Recruiting

Condition Summary: Cognition in Schizophrenia; Independent Living Skills in Schizophrenia; Symptoms of Schizophrenia

 

Last Updated: 18 Jun 2013

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Electroconvulsive Therapy (ECT) in Patients With Super Refractory Schizophrenia
 

Status: Recruiting

Condition Summary: Refractory Schizophrenia; Super Refractory Schizophrenia

 

Last Updated: 27 Jan 2014

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