SARS

Common Name(s)

SARS

Severe Acute Respiratory Syndrome (SARS) is a respiratory illness belonging to a common class of viruses called coronaviruses. SARS was first reported in Asia in February 2003 and spread quickly to two dozen countries before being contained successfully. There have been no outbreaks since 2004. Symptoms usually begin with a high fever, and may include a headache, an overall feeling of discomfort, and body aches. Some people have mild respiratory symptoms at the outset, and 10-20% experience diarrhea. After 2-7 days, SARS patients may develop a dry cough. Most will develop pneumonia as a secondary infection. SARS is most easily spread by respiratory droplets released when an infected individual coughs or sneezes.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SARS" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "SARS" returned 778 free, full-text research articles on human participants. First 3 results:

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity.
 

Author(s): Krystal Matthews, Alexandra Schäfer, Alissa Pham, Matthew Frieman

Journal:

 

The outcome of a viral infection is regulated by complex interactions of viral and host factors. SARS coronavirus (SARS-CoV) engages and regulates several innate immune response pathways during infection. We have previously shown that the SARS-CoV Papain-like Protease (PLpro) inhibits ...

Last Updated: 27 Apr 2015

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NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion.
 

Author(s): Mukesh Mahajan, Surajit Bhattacharjya

Journal: Biochim. Biophys. Acta. 2015 Feb;1848(2):721-30.

 

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) poses a serious public health hazard. The S2 subunit of the S glycoprotein of SARS-CoV carries out fusion between the virus and the host cells. However, the exact mechanism of the cell fusion process is not well understood. ...

Last Updated: 31 Dec 2014

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Network-based analysis of comorbidities risk during an infection: SARS and HIV case studies.
 

Author(s): Mohammad Ali Moni, Pietro Liò

Journal:

 

Infections are often associated to comorbidity that increases the risk of medical conditions which can lead to further morbidity and mortality. SARS is a threat which is similar to MERS virus, but the comorbidity is the key aspect to underline their different impacts. One UK doctor ...

Last Updated: 13 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "SARS" returned 75 free, full-text review articles on human participants. First 3 results:

Coronavirus virulence genes with main focus on SARS-CoV envelope gene.
 

Author(s): Marta L DeDiego, Jose L Nieto-Torres, Jose M Jimenez-Guardeño, Jose A Regla-Nava, Carlos Castaño-Rodriguez, Raul Fernandez-Delgado, Fernando Usera, Luis Enjuanes

Journal: Virus Res.. 2014 Dec;194():124-37.

 

Coronavirus (CoV) infection is usually detected by cellular sensors, which trigger the activation of the innate immune system. Nevertheless, CoVs have evolved viral proteins that target different signaling pathways to counteract innate immune responses. Some CoV proteins act as antagonists ...

Last Updated: 8 Dec 2014

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From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design.
 

Author(s): Rolf Hilgenfeld

Journal: FEBS J.. 2014 Sep;281(18):4085-96.

 

This review focuses on the important contributions that macromolecular crystallography has made over the past 12 years to elucidating structures and mechanisms of the essential proteases of coronaviruses, the main protease (M(pro) ) and the papain-like protease (PL(pro) ). The role ...

Last Updated: 18 Sep 2014

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Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.
 

Author(s): Graham Simmons, Pawel Zmora, Stefanie Gierer, Adeline Heurich, Stefan Pöhlmann

Journal: Antiviral Res.. 2013 Dec;100(3):605-14.

 

The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic transmission of animal coronaviruses (CoV) to humans poses a significant threat to public health and warrants surveillance and the development of countermeasures. The activity of host cell proteases, which ...

Last Updated: 25 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Respiratory Virus Hospitalization Study (FLU 003 Plus)
 

Status: Recruiting

Condition Summary: Influenza; Novel Respiratory Virus-1 Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV); Novel Respiratory Virus-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

 

Last Updated: 30 Nov 2015

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SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients
 

Status: Recruiting

Condition Summary: Haematological Malignancy

 

Last Updated: 2 Feb 2016

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