SAPHO syndrome

Common Name(s)

SAPHO syndrome, Synovitis acne pustulosis hyperostosis osteitis

SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). The cause of SAPHO syndrome is unknown and treatment is focused on managing symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

Last Updated: 16 Aug 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

http://www.nomidalliance.org

Last Updated: 16 Aug 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "SAPHO syndrome" returned 47 free, full-text research articles on human participants. First 3 results:

Challenges in diagnosis and treatment of a case of SAPHO syndrome in.
 

Author(s): Patricia Craveiro Gomes da Silva, Elisa Fontenelle de Oliveira, Andréa Valentim Goldenzon, Pâmela Craveiro Gomes da Silva, Marta Cristine Felix Rodrigues

Journal: An Bras Dermatol. ;86(4 Suppl 1):S46-9.

 

The authors report a case of SAPHO Syndrome, in pediatric age, with a dermatological focus. This entity should be considered in patients who have pain in the anterior chest wall or other musculoskeletal symptoms, accompanied by palmoplantar pustulosis and acne fulminans. The specific ...

Last Updated: 9 Nov 2011

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SAPHO syndrome associated with hidradenitis suppurativa successfully treated with infliximab and methotrexate.
 

Author(s): Aieska De Souza, Gary E Solomon, Bruce E Strober

Journal: Bull NYU Hosp Jt Dis. 2011 ;69(2):185-7.

 

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare chronic inflammatory musculoskeletal disorder of unknown etiology observed in children and young adults, which involves both osteo-articular inflammation and skin abnormalities. We review the case of ...

Last Updated: 31 Oct 2011

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[Methotrexate to treat SAPHO syndrome with keloidal scars].
 

Author(s): V F Azevedo, V I Dal Pizzol, H Lopes, S P Coelho, L E A Czeczko

Journal: Acta Reumatol Port. ;36(2):167-70.

 

SAPHO syndrome is an uncommon clinical entity, recently described in literature, which usually affects children, young adults and middle-aged people. It is defined by the association of skin lesions (severe acne, palmo-plantar pustulosis, supurative hidradenitis), synovitis, hiperosthosis ...

Last Updated: 15 Aug 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "SAPHO syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

SAPHO syndrome--a pictorial assay.
 

Author(s): Lokesh Khanna, Georges Y El-Khoury

Journal: Iowa Orthop J. 2012 ;32():189-95.

 

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a distinct clinical entity representing involvement of the musculoskeletal and dermatologic systems. It is well known to rheumatologists because of characteristic skin manifestations and polyarthropathy. However, ...

Last Updated: 11 Apr 2013

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[Crohn's disease and the SAPHO syndrome during treatment with infliximab: a case report and review of literature].
 

Author(s): Marc Van Den Eynde, Katrien Lecluyse, Cristiano Chioccioli, Marie Brouckaert, Emmanuelle Caussin, Pierre Lammens

Journal: Gastroenterol. Clin. Biol.. ;31(6-7):607-10.

 

We report the case of a 40 year-old Turkish woman with severe ileal Crohn's disease associated with palmoplantar pustulosis and aseptic spondylitis, also known as the SAPHO syndrome. However, in the present case, the syndrome developed three months after starting infliximab (Remicade) ...

Last Updated: 24 Jul 2007

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[The synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, a rare extra-digestive manifestation of Crohn's disease. Presentation of 1 case and review of the literature].
 

Author(s): S Dharancy, N Talbodec, T Asselah, E Hachulla, E Delaporte, A Cortot, J F Colombel

Journal: Gastroenterol. Clin. Biol.. 1998 Feb;22(2):240-3.

 

We report the case of a 33-year-old man with a severe Crohn's disease since the age of sixteen. He presented with acne and palmoplantar pustulosis associated with a right knee synovitis. Investigations revealed a major axial bone condensation. The association synovitis-acne-pustulosis-hyperostosis-osteitis ...

Last Updated: 22 Oct 1998

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.