SAPHO syndrome

Common Name(s)

SAPHO syndrome, Synovitis acne pustulosis hyperostosis osteitis

SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). The cause of SAPHO syndrome is unknown and treatment is focused on managing symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 7 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 7 May 2015

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General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "SAPHO syndrome" returned 53 free, full-text research articles on human participants. First 3 results:

Acute venous thrombosis as complication and clue to diagnose a SAPHO syndrome case. A case report.
 

Author(s): A Rosero, R Ruano, M Martin, C Hidalgo, J Garcia-Talavera

Journal: Acta Reumatol Port. ;38(3):203-6.

 

This report concerns a male adult admitted for sternal and left arm pain, who was diagnosed and treated for acute deep venous thrombosis in the left subclavian and axillary veins. X-ray and a hybrid single photon emission tomography and computed tomography (SPECT-CT) scintigraphy ...

Last Updated: 23 Oct 2013

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Serum levels of angiogenic cytokines in psoriatic arthritis and SAPHO syndrome.
 

Author(s): Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko

Journal: Pol. Arch. Med. Wewn.. 2013 ;123(6):297-302.

 

Angiogenesis is involved in the pathogenesis of arthritis.

Last Updated: 5 Jul 2013

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Successful treatment of resistant SAPHO syndrome with anti-TNF therapy.
 

Author(s): Shayma Lamya Hampton, Hazem Youssef

Journal:

 

A 42-year-old Caucasian woman with SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) refractory to non-steroidal anti-inflammatory drugs, sulfasalzine, methotrexate, bisphosphonates and steroids was successfully treated with antitumour necrosis factor therapy ...

Last Updated: 28 Jan 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "SAPHO syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

The SAPHO syndrome.
 

Author(s): Minhchau Thi Nguyen, Andrea Borchers, Carlo Selmi, Stanley M Naguwa, Gurtej Cheema, M Eric Gershwin

Journal: Semin. Arthritis Rheum.. 2012 Dec;42(3):254-65.

 

To review the epidemiology, presentation, diagnosis, treatment, pathogenesis, and genetics of the syndrome known under the acronym of SAPHO for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis to heighten awareness of this entity.

Last Updated: 16 Nov 2012

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SAPHO syndrome--a pictorial assay.
 

Author(s): Lokesh Khanna, Georges Y El-Khoury

Journal: Iowa Orthop J. 2012 ;32():189-95.

 

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a distinct clinical entity representing involvement of the musculoskeletal and dermatologic systems. It is well known to rheumatologists because of characteristic skin manifestations and polyarthropathy. However, ...

Last Updated: 11 Apr 2013

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[Crohn's disease and the SAPHO syndrome during treatment with infliximab: a case report and review of literature].
 

Author(s): Marc Van Den Eynde, Katrien Lecluyse, Cristiano Chioccioli, Marie Brouckaert, Emmanuelle Caussin, Pierre Lammens

Journal: Gastroenterol. Clin. Biol.. ;31(6-7):607-10.

 

We report the case of a 40 year-old Turkish woman with severe ileal Crohn's disease associated with palmoplantar pustulosis and aseptic spondylitis, also known as the SAPHO syndrome. However, in the present case, the syndrome developed three months after starting infliximab (Remicade) ...

Last Updated: 24 Jul 2007

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.