Rosai-Dorfman disease

Common Name(s)

Rosai-Dorfman disease

Rosai-Dorfman disease was first described by Rosai and Dorfman in 1969.  It is a benign disease which is characterized by over-production and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body, most often those of the neck (cervical).  Other lymph node groups may also be involved and, in some cases, abnormal accumulation of histiocytes may occur in other areas of the body (extranodal). The cause of this condition remains unknown, although altered immune responses and infectious agents may play a role. SHML is a self-limited and seldom life-threatening disease which commonly does not require therapy.
 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

Logo
Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

Last Updated: 30 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

Logo
Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

http://www.histio.org

Last Updated: 30 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rosai-Dorfman disease" returned 108 free, full-text research articles on human participants. First 3 results:

Multimodality imaging-based evaluation of Rosai-Dorfman disease in the head and neck: A retrospective observational study.
 

Author(s): Qinggang Xu, Liping Fu, Chengyao Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9372.

 

Rosai-Dorfman disease (RDD) is an uncommon benign entity characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. This study was performed to delineate its imaging features, reviewed retrospectively in 12 patients (8 women and 4 men, mean age 58.2 ...

Last Updated: 31 Dec 1969

Go To URL
Rosai-Dorfman Disease with Activating KRAS Mutation - Response to Cobimetinib.
 

Author(s): Eric Jacobsen, Vignesh Shanmugam, Jyothi Jagannathan

Journal: N. Engl. J. Med.. 2017 12;377(24):2398-2399.

 

Last Updated: 31 Dec 1969

Go To URL
Cystoid macular oedema associated with Rosai-Dorfman disease: a case report.
 

Author(s): Rubens Camargo Siqueira, Antonio Augusto Velasco E Cruz

Journal:

 

The aim of this study is to report a case of cystoid macular oedema (CME) associated with Rosai-Dorfman Disease (RDD).

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rosai-Dorfman disease" returned 22 free, full-text review articles on human participants. First 3 results:

Isolated intracranial Rosai-Dorfman disease mimicking petroclival meningioma in a child: Case report and review of the literature.
 

Author(s): Xiang Yang, Jiagang Liu, Yanming Ren, Seidu A Richard, Yuekang Zhang

Journal: Medicine (Baltimore). 2017 Nov;96(47):e8754.

 

Rosai -Dorfman disease (RDD) is a rare, idiopathic, and non-neoplastic histioproliferative disease with distinctive entity of unknown etiology. Central nervous system (CNS) RDD is uncommon, hence, isolated intracranial RDD is extremely rare. So far only 6 cases of CNS RDD with the ...

Last Updated: 31 Dec 1969

Go To URL
Bone Involvement in Rosai-Dorfman Disease (RDD): a Case Report and Systematic Literature Review.
 

Author(s): Birgit A Mosheimer, Bastian Oppl, Shahin Zandieh, Michael Fillitz, Felix Keil, Klaus Klaushofer, G√ľnter Weiss, Jochen Zwerina

Journal: Curr Rheumatol Rep. 2017 May;19(5):29.

 

Rosai-Dorfman disease (RDD) is a rare histiocytic disorder typically presenting as painless cervical lymphadenopathy. Extranodal involvement is common and may also affect bones. Here, we present a patient with typical nodal disease and multifocal bone manifestations. Further, a systematic ...

Last Updated: 31 Dec 1969

Go To URL
Isolated localization of Rosai Dorfman disease as renal mass: a case report and review of literature.
 

Author(s): Aziz El Majdoub, Aziza El Houari, Laila Chbani, Hinde El Fatemi, Abdelhak Khallouk, Moulay Hassan Farih

Journal:

 

We report a rare case of an elderly woman presented with right renal mass with invasion of renal vein and several small lymphadenopathy in the hilar area. The diagnosis of kidney cancer is suspected and the patient underwent open radical nephrectomy, surrenalectomy and lymphadenectomy ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis
 

Status: Recruiting

Condition Summary: Histiocytosis

 

Last Updated: 8 Dec 2017

Go to URL
International Rare Histiocytic Disorders Registry (IRHDR)
 

Status: Recruiting

Condition Summary: Rare Histiocytic Disorders (RHDs); Juvenile Xanthogranuloma (JXG); Reticulohistiocytoma (Epithelioid Histiocytoma); Xanthoma Disseminatum (XD); Multicentric Reticulohistiocytosis (MRH); Systemic Juvenile Xanthogranuloma; Erdheim-Chester Disease (ECD); Multi-system Rosai-Dorfman Disease (RDD)

 

Last Updated: 18 Apr 2018

Go to URL