Rosai-Dorfman disease

Common Name(s)

Rosai-Dorfman disease

Rosai-Dorfman disease was first described by Rosai and Dorfman in 1969.  It is a benign disease which is characterized by over-production and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body, most often those of the neck (cervical).  Other lymph node groups may also be involved and, in some cases, abnormal accumulation of histiocytes may occur in other areas of the body (extranodal). The cause of this condition remains unknown, although altered immune responses and infectious agents may play a role. SHML is a self-limited and seldom life-threatening disease which commonly does not require therapy.
 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

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Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

Last Updated: 30 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

Logo
Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

http://www.histio.org

Last Updated: 30 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rosai-Dorfman disease" returned 90 free, full-text research articles on human participants. First 3 results:

Isolated intracranial rosai-dorfman disease involving the meninges: report of a rare case.
 

Author(s): Amoolya Bhat, Shivakumar S Kupanur, V Geethamani

Journal: Turk Neurosurg. 2015 ;25(1):186-9.

 

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a reactive condition of unknown etiology, characterised by a proliferation of histiocytes exhibiting emperipolesis of lymphocytes and plasma cells. It usually presents as bilateral painless cervical ...

Last Updated: 2 Feb 2015

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Hypercalcemia induced by Rosai-Dorfman disease in a hemodialysis patient: histological evidence of extrarenal calcitriol overproduction.
 

Author(s): Shunsuke Yamada, Mai Uemura, Masanori Tokumoto, Tadashi Nagara, Hideko Noguchi, Minako Hirahashi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

Journal: Intern. Med.. 2014 ;53(24):2783-7.

 

Rosai-Dorfman disease (RDD) is a rare disorder characterized by the proliferation of histiocytes in the sinus of the affected lymph nodes, which leads to massive lymphadenopathy. RDD usually presents as an increased inflammatory response and lymph node swelling. We herein report the ...

Last Updated: 16 Dec 2014

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Cutaneous Rosai-Dorfman disease accompanied by Langerhans cell hyperplasia responsive to combined treatment.
 

Author(s): Jin Wei, Yu Zhang, Jiang Jin, Jianzhong Zhang

Journal: Chin. Med. J.. 2014 ;127(17):3200.

 

Last Updated: 5 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rosai-Dorfman disease" returned 14 free, full-text review articles on human participants. First 3 results:

Co-occurrence of intracranial Rosai-Dorfman disease and Langerhans histiocytosis of the skull: case report and review of literature.
 

Author(s): Shankar Ayyappan Kutty, Sreekala Sreehari

Journal: Turk Neurosurg. 2015 ;25(3):496-9.

 

Rosai-Dorfman Disease involves histiocytic proliferation of the lymphatic system. Extranodal disease involving the central nervous system is uncommon. Furthermore, the combination of this disease entity with Langerhans cell histiocytosis is an even rarer phenomenon that has only recently ...

Last Updated: 3 Jun 2015

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Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment.
 

Author(s): Samir Dalia, Elizabeth Sagatys, Lubomir Sokol, Timothy Kubal

Journal: Cancer Control. 2014 Oct;21(4):322-7.

 

Rosai-Dorfman disease (RDD) is a rare, nonmalignant clinical entity characterized by a group of clinical symptoms and characteristic pathological features.

Last Updated: 14 Oct 2014

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Rosai-Dorfman disease of the pericardium: a case report and review of literature.
 

Author(s): I-Weng Lao, Yun Dong, Jian Wang

Journal:

 

Rosai-Dorfman disease (RDD) is an uncommon histiocytic disease of unknown etiology. It typically presents as massive lymphadenopathy with a predilection for the cervical lymph nodes of children and young adults. However, extranodal involvement is not uncommon and may cause confusion ...

Last Updated: 17 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

International Rare Histiocytic Disorders Registry (IRHDR)
 

Status: Recruiting

Condition Summary: Rare Histiocytic Disorders (RHDs); Juvenile Xanthogranuloma (JXG); Reticulohistiocytoma (Epithelioid Histiocytoma); Xanthoma Disseminatum (XD); Multicentric Reticulohistiocytosis (MRH); Systemic Juvenile Xanthogranuloma; Erdheim-Chester Disease (ECD); Multi-system Rosai-Dorfman Disease (RDD)

 

Last Updated: 26 May 2015

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