Rosai-Dorfman disease

Common Name(s)

Rosai-Dorfman disease

Rosai-Dorfman disease was first described by Rosai and Dorfman in 1969.  It is a benign disease which is characterized by over-production and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body, most often those of the neck (cervical).  Other lymph node groups may also be involved and, in some cases, abnormal accumulation of histiocytes may occur in other areas of the body (extranodal). The cause of this condition remains unknown, although altered immune responses and infectious agents may play a role. SHML is a self-limited and seldom life-threatening disease which commonly does not require therapy.
 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

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Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

Last Updated: 30 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rosai-Dorfman disease" for support, advocacy or research.

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Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

http://www.histio.org

Last Updated: 30 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rosai-Dorfman disease" returned 93 free, full-text research articles on human participants. First 3 results:

Rosai-Dorfman disease (RDD) in the paraglottic space: report of a case and review of literature.
 

Author(s): Yu-Ling Ma, Zhuo-Ping Liang, Sheng-En Xu, Zhi-Hui Yang, Yi Peng, Xiao-Qiang Sun, Gang Qin

Journal:

 

Sinus histiocytosis with massive lymphadenopathy is also known as Rosai-Dorfman disease (RDD) and is characterized by painless bilateral cervical lymphadenopathy. In the present case report, a 67-year-old Chinese woman presented with a 3-month history of progressive voice hoarseness, ...

Last Updated: 1 Jan 2016

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Extranodal Rosai-Dorfman Disease as Isolated Lesion of the Tibia Diagnosed by Fine-Needle Aspiration Cytology: A Case Report.
 

Author(s): Jie Xu, Chun-Hua Liu, Yan-Si Wang, Chang-Xian Chen

Journal: Medicine (Baltimore). 2015 Nov;94(47):e2038.

 

Few studies have used fine-needle aspiration cytology for the purpose of isolated skeletal Rosai-Dorfman diseases (RDDs) diagnosis.Herein, we described an extremely rare case of a 56-year-old woman who presented to our hospital with an insidious onset of pain in the right proximal ...

Last Updated: 4 Dec 2015

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Combined Cutaneous Rosai-Dorfman Disease and Localized Cutaneous Langerhans Cell Histiocytosis Within a Single Subcutaneous Nodule.
 

Author(s): Brandon R Litzner, Antonio Subtil, Claudia I Vidal

Journal: Am J Dermatopathol. 2015 Dec;37(12):936-9.

 

Rosai-Dorfman disease (RDD) is a reactive multisystem histiocytosis that typically presents with cervical lymphadenopathy and systemic symptoms. Cutaneous involvement occurs in approximately 10% of cases, and 3% of cases are limited to the skin without nodal or other extranodal involvement. ...

Last Updated: 21 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rosai-Dorfman disease" returned 16 free, full-text review articles on human participants. First 3 results:

Tracheobronchial Involvement of Rosai-Dorfman Disease: Case Report and Review of the Literature.
 

Author(s): Louis Boissière, Martine Patey, Olivier Toubas, Juliette Vella-Boucaud, Jeanne-Marie Perotin-Collard, Gaëtan Deslée, Francois Lebargy, Sandra Dury

Journal: Medicine (Baltimore). 2016 Feb;95(7):e2821.

 

Rosai-Dorfman Disease (RDD) is a rare non-neoplastic entity, also known as sinus histiocytosis with massive lymphadenopathy (SHML), characterized by a benign proliferation of histiocytes in lymph nodes. Localized forms of RDD involving the tracheobronchial tree are very rare. There ...

Last Updated: 18 Feb 2016

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Co-occurrence of intracranial Rosai-Dorfman disease and Langerhans histiocytosis of the skull: case report and review of literature.
 

Author(s): Shankar Ayyappan Kutty, Sreekala Sreehari

Journal: Turk Neurosurg. 2015 ;25(3):496-9.

 

Rosai-Dorfman Disease involves histiocytic proliferation of the lymphatic system. Extranodal disease involving the central nervous system is uncommon. Furthermore, the combination of this disease entity with Langerhans cell histiocytosis is an even rarer phenomenon that has only recently ...

Last Updated: 3 Jun 2015

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Rosai-Dorfman disease with atypical intrascrotal involvement.
 

Author(s): Cristina Rodríguez Torres, Gema Riazuelo Fantova, Irene Escartín Martínez, Juan José Castillo Escudero, Celia del Agua Arias

Journal: Int. J. Urol.. 2015 Aug;22(8):794-6.

 

We describe two new cases of Rosai-Dorfman disease with intrascrotal involvement. Also known as sinus histiocytosis with massive lymphadenopathy, this is a rare entity, usually presenting with massive bilateral cervical lymphadenopathy. It is associated with extranodal involvement ...

Last Updated: 27 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

International Rare Histiocytic Disorders Registry (IRHDR)
 

Status: Recruiting

Condition Summary: Rare Histiocytic Disorders (RHDs); Juvenile Xanthogranuloma (JXG); Reticulohistiocytoma (Epithelioid Histiocytoma); Xanthoma Disseminatum (XD); Multicentric Reticulohistiocytosis (MRH); Systemic Juvenile Xanthogranuloma; Erdheim-Chester Disease (ECD); Multi-system Rosai-Dorfman Disease (RDD)

 

Last Updated: 25 Apr 2016

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