Rickets

Common Name(s)

Rickets

Rickets is a condition that causes children to have soft, weak bones. It usually occurs when children do not get enough vitamin D, which helps growing bones absorb important nutrients. Vitamin D comes from sunlight and food. Skin produces vitamin D in response to the sun's rays. Some foods also contain vitamin D, including fortified dairy products and cereals, and some kinds of fish.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rickets" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rickets" returned 330 free, full-text research articles on human participants. First 3 results:

[Three PHEX gene mutations in Chinese subjects with hypophosphatemic rickets and literature review].
 

Author(s): Shuang Liu, Min Wei, Juan Xiao, Chang-Yan Wang, Zheng-Qing Qiu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):518-23.

 

The clinical data of three Chinese children who had been definitely diagnosed with X-link dominate hypophosphatemic rickets (XLH) by gene mutation analysis of phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) were retrospectively studied and the ...

Last Updated: 26 May 2014

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Vitamin D treatment in calcium-deficiency rickets: a randomised controlled trial.
 

Author(s): Tom D Thacher, Philip R Fischer, John M Pettifor

Journal: Arch. Dis. Child.. 2014 Sep;99(9):807-11.

 

To determine whether children with calcium-deficiency rickets have a better response to treatment with vitamin D and calcium than with calcium alone.

Last Updated: 19 Aug 2014

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Dental manifestations of patient with vitamin D-resistant rickets.
 

Author(s): Andréia Pereira Souza, Tatiana Yuriko Kobayashi, Natalino Lourenço Neto, Salete Moura Bonifácio Silva, Maria Aparecida Andrade Moreira Machado, Thais Marchini Oliveira

Journal: J Appl Oral Sci. ;21(6):601-6.

 

Patients with Vitamin D-resistant rickets have abnormal tooth morphology such as thin globular dentin and enlarged pulp horns that extend into the dentino-enamel junction. Invasion of the pulp by microorganisms and toxins is inevitable. The increased fibrotic content of the pulp, ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rickets" returned 22 free, full-text review articles on human participants. First 3 results:

[Rickets-like genetic diseases].
 

Author(s): Hong-Wei Ma

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):923-7.

 

This paper summarizes the clinical features, causative genes and treatment progress of patients with rickets-like genetic diseases, including X-linked hypophosphatemic rickets (XLH), hypophosphatasia, achondroplasia, vitamin D-dependent rickets, pycnodysostosis and ectodermal dysplasia, ...

Last Updated: 15 Nov 2013

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Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.
 

Author(s): Jian Q Feng, Erica L Clinkenbeard, Baozhi Yuan, Kenneth E White, Marc K Drezner

Journal: Bone. 2013 Jun;54(2):213-21.

 

Although recent studies have established that osteocytes function as secretory cells that regulate phosphate metabolism, the biomolecular mechanism(s) underlying these effects remain incompletely defined. However, investigations focusing on the pathogenesis of X-linked hypophosphatemia ...

Last Updated: 10 Apr 2013

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Nutritional rickets.
 

Author(s): Behzat Ozkan

Journal: J Clin Res Pediatr Endocrinol. 2010 ;2(4):137-43.

 

Nutritional rickets (NR) is still the most common form of growing bone disease despite the efforts of health care providers to reduce the incidence of the disease. Today, it is well known that the etiology of NR ranges from isolated vitamin D deficiency (VDD) to isolated calcium deficiency. ...

Last Updated: 28 Jan 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project.
 

Status: Recruiting

Condition Summary: Autosomal Dominant Hypophosphatemic Rickets

 

Last Updated: 2 Sep 2014

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Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets
 

Status: Recruiting

Condition Summary: Hypophosphatemic Rickets, X-Linked Dominant

 

Last Updated: 22 Oct 2007

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A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia
 

Status: Recruiting

Condition Summary: X-linked Hypophosphatemic Rickets/Osteomalacia

 

Last Updated: 2 Jul 2014

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