Rickets

Common Name(s)

Rickets

Rickets is a condition that causes children to have soft, weak bones. It usually occurs when children do not get enough vitamin D, which helps growing bones absorb important nutrients. Vitamin D comes from sunlight and food. Skin produces vitamin D in response to the sun's rays. Some foods also contain vitamin D, including fortified dairy products and cereals, and some kinds of fish.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rickets" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rickets" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rickets" returned 405 free, full-text research articles on human participants. First 3 results:

Seven novel and six de novo PHEX gene mutations in patients with hypophosphatemic rickets.
 

Author(s): Shan-Shan Li, Jie-Mei Gu, Wei-Jia Yu, Jin-Wei He, Wen-Zhen Fu, Zhen-Lin Zhang

Journal: Int. J. Mol. Med.. 2016 Dec;38(6):1703-1714.

 

Inactivating mutations in phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) have been identified as a cause of X-linked hypophosphatemic rickets (XLH; OMIM 307800). In the present study, we enrolled 43 patients from 18 unrelated families clinically ...

Last Updated: 14 Nov 2016

Go To URL
A Case of Vitamin D-Dependent Rickets Type 1A with a Novel Mutation in the Uzbek Population.
 

Author(s): Bahar Özcabı, Feride Tahmiscioğlu Bucak, Sevinç Jaferova, Çiğdem Oruç, Amra Adrovic, Serdar Ceylaner, Oya Ercan, Olcay Evliyaoğlu

Journal: J Clin Res Pediatr Endocrinol. 2016 12;8(4):484-489.

 

Vitamin D-dependent rickets type 1A (VDDR-1A) (Online Mendelian Inheritance in Man #264700) is a rare, autosomal recessively inherited disorder due to inactivating mutations in CYP27B1. It is characterized by early onset of rickets with hypocalcemia. We aimed to describe the clinical ...

Last Updated: 29 Jun 2016

Go To URL
Case report of an infant with severe vitamin D deficiency rickets manifested as hypocalcemic seizures.
 

Author(s): Biljana Vuletić, Slavica Marković, Zoran Igrutinović, Radlović Vladimir, Zorica Rasković, Aleksandra Simović

Journal: Srp Arh Celok Lek. ;144(1-2):90-3.

 

Hypocalcemic seizures are uncommon in the post-neonatal period. We report an infant with hypocalcemic seizures caused by severe deficiency of vitamin D.

Last Updated: 9 Jun 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rickets" returned 26 free, full-text review articles on human participants. First 3 results:

"English Disease": Historical Notes on Rickets, the Bone-Lung Link and Child Neglect Issues.
 

Author(s): Mingyong Zhang, Fan Shen, Anna Petryk, Jingfeng Tang, Xingzhen Chen, Consolato Sergi

Journal:

 

Nutritional or classical rickets (here labeled as "rickets") is a worldwide disease involving mostly infants and young children having inadequate sunlight exposure, often associated with a low dietary intake of Vitamin D. Rickets targets all layers of society independently of economic ...

Last Updated: 17 Nov 2016

Go To URL
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
 

Author(s): Craig F Munns, Nick Shaw, Mairead Kiely, Bonny L Specker, Tom D Thacher, Keiichi Ozono, Toshimi Michigami, Dov Tiosano, M Zulf Mughal, Outi Mäkitie, Lorna Ramos-Abad, Leanne Ward, Linda A DiMeglio, Navoda Atapattu, Hamilton Cassinelli, Christian Braegger, John M Pettifor, Anju Seth, Hafsatu Wasagu Idris, Vijayalakshmi Bhatia, Junfen Fu, Gail Goldberg, Lars Sävendahl, Rajesh Khadgawat, Pawel Pludowski, Jane Maddock, Elina Hyppönen, Abiola Oduwole, Emma Frew, Magda Aguiar, Ted Tulchinsky, Gary Butler, Wolfgang Högler

Journal: J. Clin. Endocrinol. Metab.. 2016 Feb;101(2):394-415.

 

Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, and development of infants, children, and adolescents; the consequences can be lethal or can last into adulthood. The goals of this evidence-based ...

Last Updated: 4 Feb 2016

Go To URL
Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.
 

Author(s): Kenneth E White, Julia M Hum, Michael J Econs

Journal: Curr Osteoporos Rep. 2014 Sep;12(3):252-62.

 

Rapid and somewhat surprising advances have recently been made toward understanding the molecular mechanisms causing heritable disorders of hypophosphatemia. The results of clinical, genetic, and translational studies have interwoven novel concepts underlying the endocrine control ...

Last Updated: 13 Aug 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Rickets Device - Feasibility Study
 

Status: Not yet recruiting

Condition Summary: Rickets

 

Last Updated: 3 Apr 2017

Go to URL
Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project.
 

Status: Recruiting

Condition Summary: Autosomal Dominant Hypophosphatemic Rickets

 

Last Updated: 12 Apr 2016

Go to URL