Rickets

Common Name(s)

Rickets

Rickets is a condition that causes children to have soft, weak bones. It usually occurs when children do not get enough vitamin D, which helps growing bones absorb important nutrients. Vitamin D comes from sunlight and food. Skin produces vitamin D in response to the sun's rays. Some foods also contain vitamin D, including fortified dairy products and cereals, and some kinds of fish.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rickets" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rickets" returned 409 free, full-text research articles on human participants. First 3 results:

Novel Vitamin D Receptor Mutations in Hereditary Vitamin D Resistant Rickets in Chinese.
 

Author(s): Lee-Moay Lim, Xuan Zhao, Mei-Chyn Chao, Jer-Ming Chang, Wei-Chiao Chang, Hung-Ying Kao, Daw-Yang Hwang, Hung-Chun Chen

Journal:

 

Hereditary 1, 25-dihydroxyvitamin D-resistant rickets (HVDRR), a rare recessive disease, is caused by mutation in the VDR gene encoding the vitamin D receptor leading to the resistance to vitamin D. We described a female toddler with initial presentation of leg tenderness and clinical ...

Last Updated: 1 Oct 2015

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Detection of Hereditary 1,25-Hydroxyvitamin D-Resistant Rickets Caused by Uniparental Disomy of Chromosome 12 Using Genome-Wide Single Nucleotide Polymorphism Array.
 

Author(s): Mayuko Tamura, Tsuyoshi Isojima, Minae Kawashima, Hideki Yoshida, Keiko Yamamoto, Taichi Kitaoka, Noriyuki Namba, Akira Oka, Keiichi Ozono, Katsushi Tokunaga, Sachiko Kitanaka

Journal:

 

Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by biallelic mutations in the vitamin D receptor (VDR) gene. No patients have been reported with uniparental disomy (UPD).

Last Updated: 9 Jul 2015

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Novel CYP27B1 Gene Mutations in Patients with Vitamin D-Dependent Rickets Type 1A.
 

Author(s): Korcan Demir, Walaa E Kattan, Minjing Zou, Erdem Durmaz, Huda BinEssa, Özlem Nalbantoğlu, Roua A Al-Rijjal, Brian Meyer, Behzat Özkan, Yufei Shi

Journal:

 

The CYP27B1 gene encodes 25-hydroxyvitamin D-1α-hydroxylase. Mutations of this gene cause vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700), which is a rare autosomal recessive disorder. To investigate CYP27B1 mutations, we studied 8 patients from 7 unrelated families. All ...

Last Updated: 3 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rickets" returned 25 free, full-text review articles on human participants. First 3 results:

Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.
 

Author(s): Kenneth E White, Julia M Hum, Michael J Econs

Journal: Curr Osteoporos Rep. 2014 Sep;12(3):252-62.

 

Rapid and somewhat surprising advances have recently been made toward understanding the molecular mechanisms causing heritable disorders of hypophosphatemia. The results of clinical, genetic, and translational studies have interwoven novel concepts underlying the endocrine control ...

Last Updated: 13 Aug 2014

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Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease.
 

Author(s): Myles Wolf, Kenneth E White

Journal: Curr. Opin. Nephrol. Hypertens.. 2014 Jul;23(4):411-9.

 

High levels of fibroblast growth factor 23 (FGF23) cause the rare disorders of hypophosphatemic rickets and are a risk factor for cardiovascular disease and death in patients with chronic kidney disease (CKD). Despite major advances in understanding FGF23 biology, fundamental aspects ...

Last Updated: 6 Jun 2014

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[Rickets-like genetic diseases].
 

Author(s): Hong-Wei Ma

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):923-7.

 

This paper summarizes the clinical features, causative genes and treatment progress of patients with rickets-like genetic diseases, including X-linked hypophosphatemic rickets (XLH), hypophosphatasia, achondroplasia, vitamin D-dependent rickets, pycnodysostosis and ectodermal dysplasia, ...

Last Updated: 15 Nov 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project.
 

Status: Recruiting

Condition Summary: Autosomal Dominant Hypophosphatemic Rickets

 

Last Updated: 12 Apr 2016

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Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets
 

Status: Recruiting

Condition Summary: Hypophosphatemic Rickets, X-Linked Dominant

 

Last Updated: 22 Oct 2007

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Pilot Study: Hypovitaminosis D, Hyperparathyroidism and Hypomagnesemia in Patients With Congestive Heart Failure
 

Status: Recruiting

Condition Summary: Congestive Heart Failure; Hypovitaminosis D; Hypomagnesemia; Hyperparathyroidism

 

Last Updated: 23 Apr 2009

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