Richter syndrome

Common Name(s)

Richter syndrome

Richter syndrome is a rare condition in which chronic lymphocytic leukemia (CLL) changes into a fast-growing type of lymphoma. Symptoms of Richter syndrome can include fever, loss of weight and muscle mass, abdominal pain, and enlargement of the lymph nodes, liver, and spleen. Laboratory results may show anemia and low platelet counts (which can lead to easy bleeding and bruising).
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Richter syndrome" returned 22 free, full-text research articles on human participants. First 3 results:

The efficacy of ibrutinib in the treatment of Richter syndrome.
 

Author(s): Mazie Tsang, Tait D Shanafelt, Timothy G Call, Wei Ding, Asher Chanan-Khan, Jose F Leis, Grzegorz S Nowakowski, Deborah Bowen, Michael Conte, Susan M Schwager, Susan L Slager, Neil E Kay, Curtis A Hanson, Sameer A Parikh

Journal: Blood. 2015 Mar;125(10):1676-8.

 

Last Updated: 6 Mar 2015

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Cytogenetic and flow cytometry evaluation of Richter syndrome reveals MYC, CDKN2A, IGH alterations with loss of CD52, CD62L and increase of CD71 antigen expression as the most frequent recurrent abnormalities.
 

Author(s): Renata Woroniecka, Grzegorz Rymkiewicz, Beata Grygalewicz, Katarzyna Błachnio, Jolanta Rygier, Małgorzata Jarmuż-Szymczak, Błażej Ratajczak, Barbara Pieńkowska-Grela

Journal: Am. J. Clin. Pathol.. 2015 Jan;143(1):25-35.

 

Richter syndrome (RS) is a transformation of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into high-grade lymphoma. There are only limited data on flow cytometry (FCM) and cytogenetics in RS.

Last Updated: 16 Dec 2014

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Bing-Neel syndrome: a cerebral Richter syndrome?
 

Author(s): Emeline Tabouret, Diane Coso, Mona Matta, Maryline Barrié, Reda Bouabdallah, Olivier Chinot

Journal: Neurol India. ;62(2):229-30.

 

Last Updated: 14 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Richter syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Richter syndrome: biology, incidence, and therapeutic strategies.
 

Author(s): Apostolia-Maria Tsimberidou, Michael J Keating

Journal: Cancer. 2005 Jan;103(2):216-28.

 

Richter's transformation denotes the development of high-grade non-Hodgkin lymphoma, prolymphocytic leukemia, Hodgkin disease, or acute leukemia in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma. A search of published articles in Medline (PubMed) and abstracts ...

Last Updated: 17 Jan 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Registry of the German CLL Study Group
 

Status: Recruiting

Condition Summary: CLL; SLL; HCL; Richter´s Transformation; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; T-LGL Leukemia; NK-LGL Leukemia

 

Last Updated: 15 Sep 2016

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Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas
 

Status: Recruiting

Condition Summary: Recurrent Chronic Lymphocytic Leukemia; Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Lymphoplasmacytic Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Nodal Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Splenic Marginal Zone Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Refractory Follicular Lymphoma; Refractory Lymphoplasmacytic Lymphoma; Refractory Nodal Marginal Zone Lymphoma; Refractory Small Lymphocytic Lymphoma; Refractory Splenic Marginal Zone Lymphoma; Richter Syndrome; Waldenstrom Macroglobulinemia

 

Last Updated: 2 Jun 2016

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