Richter syndrome

Common Name(s)

Richter syndrome

Richter syndrome is a rare condition in which chronic lymphocytic leukemia (CLL) changes into a fast-growing type of lymphoma. Symptoms of Richter syndrome can include fever, loss of weight and muscle mass, abdominal pain, and enlargement of the lymph nodes, liver, and spleen. Laboratory results may show anemia and low platelet counts (which can lead to easy bleeding and bruising).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Richter syndrome" returned 22 free, full-text research articles on human participants. First 3 results:

The efficacy of ibrutinib in the treatment of Richter syndrome.
 

Author(s): Mazie Tsang, Tait D Shanafelt, Timothy G Call, Wei Ding, Asher Chanan-Khan, Jose F Leis, Grzegorz S Nowakowski, Deborah Bowen, Michael Conte, Susan M Schwager, Susan L Slager, Neil E Kay, Curtis A Hanson, Sameer A Parikh

Journal: Blood. 2015 Mar;125(10):1676-8.

 

Last Updated: 6 Mar 2015

Go To URL
Cytogenetic and flow cytometry evaluation of Richter syndrome reveals MYC, CDKN2A, IGH alterations with loss of CD52, CD62L and increase of CD71 antigen expression as the most frequent recurrent abnormalities.
 

Author(s): Renata Woroniecka, Grzegorz Rymkiewicz, Beata Grygalewicz, Katarzyna Błachnio, Jolanta Rygier, Małgorzata Jarmuż-Szymczak, Błażej Ratajczak, Barbara Pieńkowska-Grela

Journal: Am. J. Clin. Pathol.. 2015 Jan;143(1):25-35.

 

Richter syndrome (RS) is a transformation of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into high-grade lymphoma. There are only limited data on flow cytometry (FCM) and cytogenetics in RS.

Last Updated: 16 Dec 2014

Go To URL
Bing-Neel syndrome: a cerebral Richter syndrome?
 

Author(s): Emeline Tabouret, Diane Coso, Mona Matta, Maryline Barrié, Reda Bouabdallah, Olivier Chinot

Journal: Neurol India. ;62(2):229-30.

 

Last Updated: 14 May 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Richter syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Richter syndrome: biology, incidence, and therapeutic strategies.
 

Author(s): Apostolia-Maria Tsimberidou, Michael J Keating

Journal: Cancer. 2005 Jan;103(2):216-28.

 

Richter's transformation denotes the development of high-grade non-Hodgkin lymphoma, prolymphocytic leukemia, Hodgkin disease, or acute leukemia in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma. A search of published articles in Medline (PubMed) and abstracts ...

Last Updated: 17 Jan 2005

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Selinexor in Initial or Relapsed/Refractory Richter's Transformation
 

Status: Recruiting

Condition Summary: Richter's Transformation

 

Last Updated: 4 Apr 2016

Go to URL
PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)
 

Status: Recruiting

Condition Summary: Richter's Transformation

 

Last Updated: 11 Apr 2016

Go to URL
ACP-196, a Novel Bruton Tyrosine Kinase (Btk) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia
 

Status: Recruiting

Condition Summary: Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Richter's Syndrome; Prolymphocytic Leukemia

 

Last Updated: 27 Jan 2016

Go to URL