Richter syndrome

Common Name(s)

Richter syndrome

Richter syndrome is a rare condition in which chronic lymphocytic leukemia (CLL) changes into a fast-growing type of lymphoma. Symptoms of Richter syndrome can include fever, loss of weight and muscle mass, abdominal pain, and enlargement of the lymph nodes, liver, and spleen. Laboratory results may show anemia and low platelet counts (which can lead to easy bleeding and bruising).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Richter syndrome" returned 23 free, full-text research articles on human participants. First 3 results:

Ibrutinib treatment of a patient with relapsing chronic lymphocytic leukemia and sustained remission of Richter syndrome.
 

Author(s): Elisa Albi, Stefano Baldoni, Patrizia Aureli, Erica Dorillo, Beatrice Del Papa, Stefano Ascani, Mauro Di Ianni, Franca Falzetti, Paolo Sportoletti

Journal:

 

Richter syndrome (RS) is a rare event in chronic lymphocytic leukemia (CLL) that is influenced by biological factors and prior CLL treatments. Ibrutinib is a Bruton tyrosine kinase inhibitor that has shown remarkable efficacy in CLL; however, little is known about its relationship ...

Last Updated: 31 Dec 1969

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Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years.
 

Author(s): Pavel Klener, Eva Fronkova, Adela Berkova, Radek Jaksa, Halka Lhotska, Kristina Forsterova, Jan Soukup, Vojtech Kulvait, Jarmila Vargova, Karel Fiser, Dana Prukova, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Kyra Michalova, Zuzana Zemanova, Tereza Jancuskova, Sona Pekova, Marek Trneny

Journal: Int. J. Cancer. 2016 Nov;139(10):2252-60.

 

Richter syndrome represents the transformation of the chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most frequently the diffuse large B-cell lymphoma (DLBCL). In this report we describe a patient with CLL, who developed a clonally-related pleomorphic highly-aggressive ...

Last Updated: 31 Dec 1969

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The efficacy of ibrutinib in the treatment of Richter syndrome.
 

Author(s): Mazie Tsang, Tait D Shanafelt, Timothy G Call, Wei Ding, Asher Chanan-Khan, Jose F Leis, Grzegorz S Nowakowski, Deborah Bowen, Michael Conte, Susan M Schwager, Susan L Slager, Neil E Kay, Curtis A Hanson, Sameer A Parikh

Journal: Blood. 2015 Mar;125(10):1676-8.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Richter syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Richter syndrome: biology, incidence, and therapeutic strategies.
 

Author(s): Apostolia-Maria Tsimberidou, Michael J Keating

Journal: Cancer. 2005 Jan;103(2):216-28.

 

Richter's transformation denotes the development of high-grade non-Hodgkin lymphoma, prolymphocytic leukemia, Hodgkin disease, or acute leukemia in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma. A search of published articles in Medline (PubMed) and abstracts ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 15 Mar 2017

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Last Updated: 28 Aug 2017

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Last Updated: 24 Oct 2017

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