Rhabdomyosarcoma alveolar

Common Name(s)

Rhabdomyosarcoma alveolar

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyosarcoma alveolar" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyosarcoma alveolar" returned 105 free, full-text research articles on human participants. First 3 results:

Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease.
 

Author(s): Irina V Lagutina, Virginia Valentine, Fabrizio Picchione, Frank Harwood, Marcus B Valentine, Barbara Villarejo-Balcells, Jaime J Carvajal, Gerard C Grosveld

Journal:

 

Many recurrent chromosome translocations in cancer result in the generation of fusion genes that are directly implicated in the tumorigenic process. Precise modeling of the effects of cancer fusion genes in mice has been inaccurate, as constructs of fusion genes often completely or ...

Last Updated: 9 Feb 2015

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Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.
 

Author(s): Elisa Bergantin, Carmelo Quarta, Cristina Nanni, Stefano Fanti, Andrea Pession, Giorgio Cantelli-Forti, Roberto Tonelli, Patrizia Hrelia

Journal: Cancer Biol. Ther.. 2014 Sep;15(9):1219-25.

 

Rhadbomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and is subdivided in the embryonal (ERMS) and alveolar (ARMS) subtypes, the latter being associated with the worst prognosis. We report that sulforaphane (SFN), a broccoli-derived anticancer isothiocyanate, ...

Last Updated: 9 Aug 2014

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FANCD2 is a potential therapeutic target and biomarker in alveolar rhabdomyosarcoma harboring the PAX3-FOXO1 fusion gene.
 

Author(s): Mamata Singh, Justin M Leasure, Christopher Chronowski, Brian Geier, Kathryn Bondra, Wenrui Duan, Lauren A Hensley, Miguel Villalona-Calero, Ning Li, Anthony M Vergis, Raushan T Kurmasheva, Changxian Shen, Gary Woods, Nikhil Sebastian, Denise Fabian, Rita Kaplon, Sue Hammond, Kamalakannan Palanichamy, Arnab Chakravarti, Peter J Houghton

Journal: Clin. Cancer Res.. 2014 Jul;20(14):3884-95.

 

Alveolar rhabdomyosarcoma that harbors the PAX3-FOXO1 fusion gene (t-ARMS) is a common and lethal subtype of this childhood malignancy. Improvement in clinical outcomes in this disease is predicated upon the identification of novel therapeutic targets.

Last Updated: 16 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyosarcoma alveolar" returned 4 free, full-text review articles on human participants. First 3 results:

Alveolar rhabdomyosarcoma with multiple distal metastases. A case report and review of literature.
 

Author(s): Debojyoti Sarkar, Sayantan Ray, Manjari Saha, Prantar Chakrabarti, Prantari Chakrabarti

Journal:

 

An 18-year-old boy, presented with a history of right hip pain with movement restriction and proptosis of right eye. There was severe anaemia, febrile neutropaenia and bleeding manifestations. CT scan of right orbit documented a retro orbital mass. MRI revealed a mass on right side ...

Last Updated: 5 Sep 2012

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New genetic tactics to model alveolar rhabdomyosarcoma in the mouse.
 

Author(s): Charles Keller, Mario R Capecchi

Journal: Cancer Res.. 2005 Sep;65(17):7530-2.

 

Using conditional knock-in and knock-out techniques, we designed a mouse model of the childhood muscle cancer alveolar rhabdomyosarcoma (ARMS) that is driven by the chromosomal translocation product, Pax3:Fkhr. Tumors that closely recapitulate the spectrum of molecular markers and ...

Last Updated: 5 Sep 2005

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Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma.
 

Author(s): F G Barr

Journal: Oncogene. 2001 Sep;20(40):5736-46.

 

The chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are characteristic of alveolar rhabdomyosarcoma, a pediatric soft tissue cancer related to the striated muscle lineage. These translocations rearrange PAX3 and PAX7, members of the paired box transcription factor ...

Last Updated: 18 Oct 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CREATE: Cross-tumoral Phase 2 With Crizotinib
 

Status: Recruiting

Condition Summary: Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma; Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor; Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1; Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma; Locally Advanced and/or Metastatic Clear Cell Sarcoma; Locally Advanced and/or Metastatic Alveolar Rhabdomyosarcoma

 

Last Updated: 16 Jul 2015

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Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma
 

Status: Recruiting

Condition Summary: Alveolar Childhood Rhabdomyosarcoma; Embryonal Childhood Rhabdomyosarcoma; Previously Treated Childhood Rhabdomyosarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Recurrent Childhood Rhabdomyosarcoma

 

Last Updated: 12 May 2015

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Studying Mechanisms of Radiation Therapy Resistance in Samples From Younger Patients With Rhabdomyosarcoma
 

Status: Recruiting

Condition Summary: Alveolar Childhood Rhabdomyosarcoma; Embryonal Childhood Rhabdomyosarcoma; Previously Treated Childhood Rhabdomyosarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Recurrent Childhood Rhabdomyosarcoma

 

Last Updated: 6 May 2015

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