Abdominal aortic aneurysm

Common Name(s)

Abdominal aortic aneurysm

An abdominal aortic aneurysm (AAA) is when the lower part of the aorta becomes enlarged, like a balloon. The aorta is the largest artery in the body. It carries blood from the heart down along the backbone where it splits into many smaller arteries that bring blood to all of the organs. Aneurysm is a general term that describes an enlargement of any blood vessel in the body. Aneurysms usually develop slowly over time and may not cause problems until they become so enlarged that they can rupture.

Smaller AAAs generally do not cause symptoms. Larger AAAs can cause symptoms such as a pulsating feeling near the belly button, deep and constant abdominal pain, or back pain. Rupture of an aortic aneurysm is a medical emergency. If an aortic aneurysm ruptures, symptoms include vomiting, intense pain, excessive sweating, a drop in blood pressure, fainting, and shortness of breath.

AAAs can be caused by stiffening of the artery walls due to plaque build up (atherosclerosis), infection of the aorta, or connective tissue diseases. Risk factors for the development of AAAs are increased in individuals who smoke, are male, or have a family history of aneurysms.

A doctor can perform many tests to diagnose this condition. Possible tests include imaging by abdominal ultrasound, chest X-ray, and MRI. Treatment options will vary depending on the size of the aneurysm. For smaller aneurysms, it may be better to wait and watch before seeking surgery. For larger aneurysms that are at risk of rupturing, surgery is usually the best treatment. Talk to your doctor about which of the current treatment options is right for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Abdominal aortic aneurysm" for support, advocacy or research.

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Canadian Marfan Association

Increasing awareness, saving lives, and improving the quality of life for patients, their families, and medical professionals affected by Marfan syndrome, genetic aortic disorders, and related connective tissue disorders through national programs of education, support, and research.

Last Updated: 22 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Abdominal aortic aneurysm" for support, advocacy or research.

Logo
Canadian Marfan Association

Increasing awareness, saving lives, and improving the quality of life for patients, their families, and medical professionals affected by Marfan syndrome, genetic aortic disorders, and related connective tissue disorders through national programs of education, support, and research.

http://www.marfan.ca

Last Updated: 22 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Abdominal aortic aneurysm" returned 1552 free, full-text research articles on human participants. First 3 results:

[Change of Serum Angiopoietin-related Growth Factor in Patients with Abdominal Aortic Aneurysm and Its Clinical Significance].
 

Author(s): Hao Nie, Yue Liang, Hua-liang Ren, Yue-wei Wang, Cui Tian, Hui-hua Li, Yue-hong Zheng

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Apr;38(2):150-4.

 

To investigate the changes and value of plasma angiopoietin-related growth factor (AGF) in patients with abdominal aortic aneurysm (AAA).

Last Updated: 16 May 2016

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Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm.
 

Author(s): Yanshuo Han, Fadwa Tanios, Christian Reeps, Jian Zhang, Kristina Schwamborn, Hans-Henning Eckstein, Alma Zernecke, Jaroslav Pelisek

Journal:

 

Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone acetyltransferases (KATs) in AAA.

Last Updated: 15 Jan 2016

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Long-Term Outcomes of Abdominal Aortic Aneurysm Repair.
 

Author(s): Marc L Schermerhorn, A James O'Malley, Bruce E Landon

Journal: N. Engl. J. Med.. 2015 Nov;373(21):2088-9.

 

Last Updated: 20 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Abdominal aortic aneurysm" returned 149 free, full-text review articles on human participants. First 3 results:

An Update on the Inflammatory Response after Endovascular Repair for Abdominal Aortic Aneurysm.
 

Author(s): Eleni Arnaoutoglou, George Kouvelos, Andreas Koutsoumpelis, Nikolaos Patelis, Andreas Lazaris, Miltiadis Matsagkas

Journal: Mediators Inflamm.. 2015 ;2015():945035.

 

Postimplantation syndrome (PIS) is the clinical and biochemical expression of an inflammatory response following endovascular repair of an aortic aneurysm (EVAR). The goal of this review is to provide an update on the inflammatory response after endovascular repair of abdominal aortic ...

Last Updated: 13 Jul 2015

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Systematic Review and Meta-analysis of Long-term survival After Elective Infrarenal Abdominal Aortic Aneurysm Repair 1969-2011: 5 Year Survival Remains Poor Despite Advances in Medical Care and Treatment Strategies.
 

Author(s): S S Bahia, P J E Holt, D Jackson, B O Patterson, R J Hinchliffe, M M Thompson, A Karthikesalingam

Journal: Eur J Vasc Endovasc Surg. 2015 Sep;50(3):320-30.

 

Improved critical care, pre-operative optimization, and the advent of endovascular surgery (EVAR) have improved 30 day mortality for elective abdominal aortic aneurysm (AAA) repair. It remains unknown whether this has translated into improvements in long-term survival, particularly ...

Last Updated: 28 Aug 2015

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Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm.
 

Author(s): M J Sweeting, R Balm, P Desgranges, P Ulug, J T Powell,

Journal: Br J Surg. 2015 Sep;102(10):1229-39.

 

The benefits of endovascular repair of ruptured abdominal aortic aneurysm remain controversial, without any strong evidence about advantages in specific subgroups.

Last Updated: 13 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cyclosporine A in Patients With Small Diameter Abdominal Aortic Aneurysms
 

Status: Recruiting

Condition Summary: Abdominal Aortic Aneurysm,; Small Abdominal Aortic Aneurysm

 

Last Updated: 1 Jun 2015

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Study of the Glycocalyx in Abdominal Aortic Aneurysm
 

Status: Recruiting

Condition Summary: Abdominal Aortic Aneurism; Surgery; Ischemic Reperfusion Injury

 

Last Updated: 16 Apr 2013

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Clinical Study of the Treovance Stent-Graft for Patients With Abdominal Aortic Aneurysms
 

Status: Recruiting

Condition Summary: Abdominal Aortic Aneurysm (AAA)

 

Last Updated: 21 Aug 2015

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