Retinoblastoma

Common Name(s)

Retinoblastoma

Retinoblastoma (RB) is a rare type of eye cancer in the retina that typically develops before the age of 5. It usually affects only one eye, but 1/3 of children with RB develop cancer in both eyes. The first sign is typically a visible whiteness in the pupil called "cat's eye reflex" or leukocoria, which is particularly noticeable in photographs taken with a flash. Other signs and symptoms include strabismus; persistent eye pain, redness or irritation; and blindness or poor vision in the affected eye(s). Retinoblastoma is caused by mutations in the RB1 gene. In about 60% of people with retinoblastoma, mutations are not inherited and occur only in retinal cells. In the other 40% of individuals, mutations are inherited from a parent in an autosomal dominant pattern and can be found in all body cells. Retinoblastoma that is caused by an inherited mutation is called hereditary retinoblastoma. Hereditary retinoblastoma usually occurs at a younger age than retinoblastoma that is not inherited (15 months vs. 24 months). Retinoblastoma that occurs in only one eye is usually not inherited. Retinoblastoma that occurs in both eyes is thought to be inherited.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinoblastoma" for support, advocacy or research.

Childhood Eye Cancer Trust

The Childhood Eye Cancer Trust (CHECT) is dedicated to providing support to families affected by Retinoblastoma (Rb), funding research and raising awareness.

Last Updated: 1 Oct 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinoblastoma" for support, advocacy or research.

Childhood Eye Cancer Trust

The Childhood Eye Cancer Trust (CHECT) is dedicated to providing support to families affected by Retinoblastoma (Rb), funding research and raising awareness.

http://www.chect.org.uk

Last Updated: 1 Oct 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Retinoblastoma" returned 1461 free, full-text research articles on human participants. First 3 results:

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech.
 

Author(s): Soltani Leila, Hajji Ibtissam, Essafi Hafsa, Moutaouakil Abdeljalil

Journal:

 

Retinoblastoma is the most frequent childhood intraocular tumor. The aim of our study is to evaluate the clinical features and management of extra-ocular retinoblastoma in the Mohamed VI university hospital of Marrakech. Retrospective case series, the patient's records were reviewed ...

Last Updated: 15 Mar 2017

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Outcomes of Cataract Surgery Following Treatment for Retinoblastoma.
 

Author(s): Hyeong Min Kim, Byung Joo Lee, Jeong Hun Kim, Young Suk Yu

Journal: Korean J Ophthalmol. 2017 Feb;31(1):52-57.

 

To evaluate the long-term visual outcomes and complications of cataract surgery in eyes previously treated for retinoblastoma.

Last Updated: 28 Feb 2017

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Long non-coding RNA HOTAIR regulates proliferation and invasion via activating Notch signalling pathway in retinoblastoma.
 

Author(s): Changxia Dong, Shaoyi Liu, Yongbin Lv, Chunping Zhang, Heying Gao, Lixia Tan, Hong Wang

Journal: J. Biosci.. 2016 Dec;41(4):677-687.

 

Retinoblastoma is the most frequently occurring tumour in the eyes in early childhood. Novel targets that are important for the diagnosis or treatment of retinoblastoma could be valuable in increasing the survival rate of patients affected by this disease. Long non-coding RNAs (lncRNAs) ...

Last Updated: 14 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Retinoblastoma" returned 73 free, full-text review articles on human participants. First 3 results:

Update on Ophthalmic Oncology 2014: Retinoblastoma and Uveal Melanoma.
 

Author(s): Jasmine H Francis, Ariana M Levin, David H Abramson

Journal: Asia Pac J Ophthalmol (Phila). ;5(5):368-82.

 

The aim of this study was to review peer-reviewed articles on ophthalmic oncology (specifically retinoblastoma and uveal melanoma) published from January to December 2014.

Last Updated: 16 Sep 2016

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Genetics of Retinoblastoma.
 

Author(s): Ashwin Mallipatna, Meghan Marino, Arun D Singh

Journal: Asia Pac J Ophthalmol (Phila). ;5(4):260-4.

 

Retinoblastoma is a malignant retinal tumor that affects young children. Mutations in the RB1 gene cause retinoblastoma. Mutations in both RB1 alleles within the precursor retinal cell are essential, with one mutation that may be germline or somatic and the second one that is always ...

Last Updated: 4 Aug 2016

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Therapeutic Options for Retinoblastoma.
 

Author(s): Pia R Mendoza, Hans E Grossniklaus

Journal: Cancer Control. 2016 Apr;23(2):99-109.

 

Retinoblastoma is the most common primary intraocular malignancy in children. The management of retinoblastoma is complex and depends on several factors.

Last Updated: 25 May 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intra-arterial Chemotherapy for Children With Retinoblastoma
 

Status: Recruiting

Condition Summary: Retinoblastoma

 

Last Updated: 1 Oct 2016

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Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma
 

Status: Recruiting

Condition Summary: Retinoblastoma

 

Last Updated: 30 Mar 2017

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Quality of Life in Children Cured of Retinoblastoma
 

Status: Recruiting

Condition Summary: Retinoblastoma

 

Last Updated: 1 Oct 2016

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