Retinoblastoma

Common Name(s)

Retinoblastoma

Retinoblastoma (RB) is a rare type of eye cancer in the retina that typically develops before the age of 5. It usually affects only one eye, but 1/3 of children with RB develop cancer in both eyes. The first sign is typically a visible whiteness in the pupil called "cat's eye reflex" or leukocoria, which is particularly noticeable in photographs taken with a flash. Other signs and symptoms include strabismus; persistent eye pain, redness or irritation; and blindness or poor vision in the affected eye(s). Retinoblastoma is caused by mutations in the RB1 gene. In about 60% of people with retinoblastoma, mutations are not inherited and occur only in retinal cells. In the other 40% of individuals, mutations are inherited from a parent in an autosomal dominant pattern and can be found in all body cells. Retinoblastoma that is caused by an inherited mutation is called hereditary retinoblastoma. Hereditary retinoblastoma usually occurs at a younger age than retinoblastoma that is not inherited (15 months vs. 24 months). Retinoblastoma that occurs in only one eye is usually not inherited. Retinoblastoma that occurs in both eyes is thought to be inherited.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinoblastoma" for support, advocacy or research.

Childhood Eye Cancer Trust

The Childhood Eye Cancer Trust (CHECT) is dedicated to providing support to families affected by Retinoblastoma (Rb), funding research and raising awareness.

Last Updated: 1 Oct 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinoblastoma" for support, advocacy or research.

Childhood Eye Cancer Trust

The Childhood Eye Cancer Trust (CHECT) is dedicated to providing support to families affected by Retinoblastoma (Rb), funding research and raising awareness.

http://www.chect.org.uk

Last Updated: 1 Oct 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Retinoblastoma" returned 1480 free, full-text research articles on human participants. First 3 results:

Alteration in Methylation Pattern of Retinoblastoma 1 Gene Promotor Region in Intestinal Metaplasia with or without Helicobacter pylori and Gastric Cancer Patients.
 

Author(s): Seda Orenay Boyacioglu, Elmas Kasap, Hakan Yuceyar, Mehmet Korkmaz

Journal: Adv Clin Exp Med. ;25(3):465-70.

 

Helicobacter pylori, intestinal metaplasia (IM), and gene methylation play important roles in gastric carcinogenesis. However, the association among H. pylori infection, IM, gastric cancer (GC), and gene methylation is not fully understood. Cell cycle control involving retinoblastoma ...

Last Updated: 16 Sep 2016

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Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma.
 

Author(s): Puran Fadakar, Abolfazl Akbari, Fariba Ghassemi, Gholam Reza Mobini, Masoumeh Mohebi, Manzar Bolhassani, Hoda Abed Khojasteh, Mansour Heidari

Journal: Acta Med Iran. 2016 Jun;54(6):352-8.

 

Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including ...

Last Updated: 16 Jun 2016

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Multiple Differential Networks Strategy Reveals Carboplatin and Melphalan-Induced Dynamic Module Changes in Retinoblastoma.
 

Author(s): Cui Chen, Feng-Wei Ma, Cui-Yun Du, Ping Wang

Journal:

 

BACKGROUND Retinoblastoma (RB) is the most common malignant tumor of the eye in childhood. The objective of this paper was to investigate carboplatin (CAR)- and melphalan (MEL)-induced dynamic module changes in RB based on multiple (M) differential networks, and to generate systems-level ...

Last Updated: 5 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Retinoblastoma" returned 72 free, full-text review articles on human participants. First 3 results:

Overview of recurrent chromosomal losses in retinoblastoma detected by low coverage next generation sequencing.
 

Author(s): A J García-Chequer, A Méndez-Tenorio, G Olguín-Ruiz, C Sánchez-Vallejo, P Isa, C F Arias, J Torres, A Hernández-Angeles, M A Ramírez-Ortiz, C Lara, M L Cabrera-Muñoz, S Sadowinski-Pine, J C Bravo-Ortiz, G Ramón-García, J Diegopérez-Ramírez, G Ramírez-Reyes, R Casarrubias-Islas, J Ramírez, M A Orjuela, M V Ponce-Castañeda

Journal: Cancer Genet. 2016 Mar;209(3):57-69.

 

Genes are frequently lost or gained in malignant tumors and the analysis of these changes can be informative about the underlying tumor biology. Retinoblastoma is a pediatric intraocular malignancy, and since deletions in chromosome 13 have been described in this tumor, we performed ...

Last Updated: 29 Feb 2016

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Treatment of Retinoblastoma: The Role of External Beam Radiotherapy.
 

Author(s): Joo-Young Kim, Younghee Park

Journal: Yonsei Med. J.. 2015 Nov;56(6):1478-91.

 

The risk of radiotherapy-related secondary cancers in children with constitutional retinoblastoma 1 (RB1) mutations has led to reduced use of external beam radiotherapy (EBRT) for RB. Presently, tumor reduction with chemotherapy with or without focal surgery (chemosurgery) is most ...

Last Updated: 8 Oct 2015

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The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
 

Author(s): Marcus C de Jong, Wijnanda A Kors, Pim de Graaf, Jonas A Castelijns, Annette C Moll, Tero Kivelä

Journal: Am. J. Ophthalmol.. 2015 Dec;160(6):1116-1126.e5.

 

To estimate the incidence of trilateral retinoblastoma in patients with retinoblastoma.

Last Updated: 17 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cancer Biology of Retinoblastoma
 

Status: Recruiting

Condition Summary: Retinoblastoma

 

Last Updated: 30 Jun 2015

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Intra-arterial Chemotherapy for Children With Retinoblastoma
 

Status: Recruiting

Condition Summary: Retinoblastoma

 

Last Updated: 1 Oct 2016

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Last Updated: 30 Jun 2015

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