Aspergillosis

Common Name(s)

Aspergillosis

Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aspergillosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aspergillosis" returned 1070 free, full-text research articles on human participants. First 3 results:

Magnetic Resonance Imaging of Cerebral Aspergillosis: Imaging and Pathological Correlations.
 

Author(s): Guillaume Marzolf, Marcela Sabou, Béatrice Lannes, François Cotton, David Meyronet, Damien Galanaud, Jean-Philippe Cottier, Sylvie Grand, Hubert Desal, Julie Kreutz, Maleka Schenck, Nicolas Meyer, Francis Schneider, Jean-Louis Dietemann, Meriam Koob, Raoul Herbrecht, Stéphane Kremer

Journal:

 

Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis ...

Last Updated: 21 Apr 2016

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Combined Allergic Bronchopulmonary Aspergillosis and Eosinophilic Granulomatosis with Polyangiitis: Three Cases and a Review of the Literature.
 

Author(s): Takashi Ishiguro, Noboru Takayanagi, Yotaro Takaku, Naho Kagiyama, Kazuyoshi Kurashima, Yutaka Sugita

Journal: Intern. Med.. 2016 ;55(7):793-7.

 

Previous reports of combined allergic bronchopulmonary mycosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA) are limited; however, among 41 cases of ABPM and 18 cases of EGPA treated at our hospital, we experienced three cases of combined ABPM and EGPA. In two of ...

Last Updated: 4 Apr 2016

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Detection of a Serum Siderophore by LC-MS/MS as a Potential Biomarker of Invasive Aspergillosis.
 

Author(s): Cassandra S Carroll, Lawrence N Amankwa, Linda J Pinto, Jeffrey D Fuller, Margo M Moore

Journal:

 

Invasive aspergillosis (IA) is a life-threatening systemic mycosis caused primarily by Aspergillus fumigatus. Early diagnosis of IA is based, in part, on an immunoassay for circulating fungal cell wall carbohydrate, galactomannan (GM). However, a wide range of sensitivity and specificity ...

Last Updated: 15 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aspergillosis" returned 127 free, full-text review articles on human participants. First 3 results:

Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
 

Author(s): Yvonne Schmiedel, Stephan Zimmerli

Journal:

 

Every year, Candida, Aspergillus, Cryptococcus and Pneumocystis infect an estimated two million individuals worldwide. Most are immunocompromised or critically ill. Candida is the most common fungal pathogen of the critically ill and of recipients of transplanted abdominal organs. ...

Last Updated: 23 Feb 2016

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Cutaneous Invasive Aspergillosis: Retrospective Multicenter Study of the French Invasive-Aspergillosis Registry and Literature Review.
 

Author(s): Céline Bernardeschi, Francoise Foulet, Saskia Ingen-Housz-Oro, Nicolas Ortonne, Karine Sitbon, Gaëlle Quereux, Olivier Lortholary, Olivier Chosidow, Stéphane Bretagne,

Journal: Medicine (Baltimore). 2015 Jul;94(26):e1018.

 

Invasive aspergillosis (IA) has poor prognosis in immunocompromised patients. Skin manifestations, when present, should contribute to an early diagnosis. The authors aimed to provide prevalence data and a clinical and histologic description of cutaneous manifestations of primary cutaneous ...

Last Updated: 3 Jul 2015

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[Pathogenesis of chronic necrotizing pulmonary aspergillosis].
 

Author(s): Takayoshi Tashiro

Journal: Med Mycol J. 2015 ;56(1):J3-J13.

 

Chronic necrotizing pulmonary aspergillosis (CNPA) is a slowly progressive inflammatory destruction of lung tissue due to Aspergillus infection. The main radiographic features are chronic pulmonary infiltrates, progressive cavitation, and subsequent aspergilloma formation. Although ...

Last Updated: 9 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exhaled Breath Analysis in the Early Detection of Aspergillosis
 

Status: Recruiting

Condition Summary: Invasive Aspergillosis

 

Last Updated: 1 Apr 2015

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Bronchoalveolar Lavage Lateral-Flow Device Test for Invasive Pulmonary Aspergillosis: a Multicenter Study
 

Status: Recruiting

Condition Summary: Invasive Pulmonary Aspergillosis

 

Last Updated: 19 Sep 2016

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A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis
 

Status: Recruiting

Condition Summary: Allergic Bronchopulmonary Aspergillosis

 

Last Updated: 6 May 2015

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