Aspergillosis

Common Name(s)

Aspergillosis

Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aspergillosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aspergillosis" returned 1007 free, full-text research articles on human participants. First 3 results:

[Early serological diagnosis of invasive aspergillosis in renal transplant recipients].
 

Author(s): Xianghua Shi, Lipei Fan, Ding Liu, Liuyang Li, Min Li

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Nov;35(11):1659-61.

 

To evaluate the clinical value of serum 1,3-beta-D-glucan (BG) and galactomannan (GM) detection for early diagnosis of invasive aspergillosis (IA) in patients after renal transplantation.

Last Updated: 26 Nov 2015

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A Case of Rapid Exacerbation of Pulmonary Mycobacterium Avium Complex Infection Mimicking Pulmonary Aspergillosis.
 

Author(s): Shingo Noguchi, Kazuhiro Yatera, Kei Yamasaki, Toshinori Kawanami, Toru Takahashi, Ikuko Shimabukuro, Kentarou Akata, Hiroshi Ishimoto, Takashi Fujii, Chiharu Yoshii, Hiroshi Mukae

Journal: J. UOEH. 2015 Sep;37(3):177-83.

 

We herein report a case of pulmonary Mycobacterium avium complex (MAC) infection with pulmonary multiple nodules and the "halo sign" on chest computed tomography (CT) in which the patient showed rapid exacerbation seven years after undergoing bone marrow transplantation (BMT). A 68-year-old ...

Last Updated: 15 Sep 2015

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Invasive Primary Colonic Aspergillosis in the Immunocompetent Host without Classical Risk Factors.
 

Author(s): Seon Ah Cha, Mi Hee Kim, Tae Seok Lim, Hyun Ho Kim, Kyung Yoon Chang, Hoon Suk Park, Hyung Wook Kim, Seong Heon Wie, Dong Chan Jin

Journal: Yonsei Med. J.. 2015 Sep;56(5):1453-6.

 

Invasive aspergillosis (IA), generally considered an opportunistic infection in immunocompromised hosts, is associated with high morbidity and mortality. IA commonly occurs in the respiratory tract with isolated reports of aspergillosis infection in the nasal sinuses, central nervous ...

Last Updated: 10 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aspergillosis" returned 124 free, full-text review articles on human participants. First 3 results:

Cutaneous Invasive Aspergillosis: Retrospective Multicenter Study of the French Invasive-Aspergillosis Registry and Literature Review.
 

Author(s): Céline Bernardeschi, Francoise Foulet, Saskia Ingen-Housz-Oro, Nicolas Ortonne, Karine Sitbon, Gaëlle Quereux, Olivier Lortholary, Olivier Chosidow, Stéphane Bretagne,

Journal: Medicine (Baltimore). 2015 Jul;94(26):e1018.

 

Invasive aspergillosis (IA) has poor prognosis in immunocompromised patients. Skin manifestations, when present, should contribute to an early diagnosis. The authors aimed to provide prevalence data and a clinical and histologic description of cutaneous manifestations of primary cutaneous ...

Last Updated: 3 Jul 2015

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Nasopharyngeal carcinoma mimicking Aspergillosis rhinosinusitis: an unusual case report and review of the literature.
 

Author(s): Kexing Ren, Weiya Wang, Xuelei Ma, Fuchun Guo, Ping Li, Lei Liu

Journal:

 

Clinical symptoms and imaging features of fungal infection are confused with those of atypical nasopharyngeal carcinoma (NPC), and therefore development of a more effective diagnostic method is essential. It is a common knowledge that there is a significant association between Epstein-Barr ...

Last Updated: 12 Feb 2015

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Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature.
 

Author(s): Shuanshuan Xie, Changxing Shen, Yunfeng Zhang, Kun Lu, Feng Hu, Min Tan, Haiyan Lin, Lei Xu, Qing Yuan, Xiaolian Song, Changhui Wang

Journal:

 

Concomitant occurrence of invasive pulmonary aspergillosis (IPA) with cryptogenic organizing pneumonia (COP) is scarce. Here, we report a case where COP was a presenting feature in a patient with diagnosed IPA, and review additional 58 COP patients reported in the literature from 1988 through 2013.

Last Updated: 12 Feb 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bronchoalveolar Lavage Lateral-Flow Device Test for Invasive Pulmonary Aspergillosis: a Multicenter Study
 

Status: Recruiting

Condition Summary: Invasive Pulmonary Aspergillosis

 

Last Updated: 2 Apr 2015

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A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis
 

Status: Recruiting

Condition Summary: Allergic Bronchopulmonary Aspergillosis

 

Last Updated: 6 May 2015

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Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Invasive Pulmonary Aspergillosis; Chronic Obstructive Pulmonary Disease

 

Last Updated: 22 Jan 2014

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