Retinal degeneration

Common Name(s)

Retinal degeneration

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinal degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Retinal degeneration" returned 278 free, full-text research articles on human participants. First 3 results:

Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration.
 

Author(s): Ryan D Mohan, George Dialynas, Vikki M Weake, Jianqi Liu, Skylar Martin-Brown, Laurence Florens, Michael P Washburn, Jerry L Workman, Susan M Abmayr

Journal: Genes Dev.. 2014 Feb;28(3):259-72.

 

The Spt-Ada-Gcn5-acetyltransferase (SAGA) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex. Here we identified and characterized Drosophila Ataxin-7 ...

Last Updated: 4 Feb 2014

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Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
 

Author(s): Yu Chen, Grazyna Palczewska, Debarshi Mustafi, Marcin Golczak, Zhiqian Dong, Osamu Sawada, Tadao Maeda, Akiko Maeda, Krzysztof Palczewski

Journal: J. Clin. Invest.. 2013 Dec;123(12):5119-34.

 

A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targets for the treatment of ...

Last Updated: 2 Dec 2013

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Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions.
 

Author(s): Emilie Arnault, Coralie Barrau, Céline Nanteau, Pauline Gondouin, Karine Bigot, Françoise Viénot, Emmanuel Gutman, Valérie Fontaine, Thierry Villette, Denis Cohen-Tannoudji, José-Alain Sahel, Serge Picaud

Journal:

 

Among the identified risk factors of age-related macular degeneration, sunlight is known to induce cumulative damage to the retina. A photosensitive derivative of the visual pigment, N-retinylidene-N-retinylethanolamine (A2E), may be involved in this phototoxicity. The high energy ...

Last Updated: 23 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Retinal degeneration" returned 29 free, full-text review articles on human participants. First 3 results:

Progress on retinal image analysis for age related macular degeneration.
 

Author(s): Yogesan Kanagasingam, Alauddin Bhuiyan, Michael D Abràmoff, R Theodore Smith, Leonard Goldschmidt, Tien Y Wong

Journal: Prog Retin Eye Res. 2014 Jan;38():20-42.

 

Age-related macular degeneration (AMD) is the leading cause of vision loss in those over the age of 50 years in the developed countries. The number is expected to increase by ∼1.5 fold over the next ten years due to an increase in aging population. One of the main measures of AMD ...

Last Updated: 23 Dec 2013

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Review: retinal degeneration: focus on the unfolded protein response.
 

Author(s): Marina Gorbatyuk, Oleg Gorbatyuk

Journal:

 

Recently published literature has provided evidence that the unfolded protein response (UPR) is involved in the development of retinal degeneration. The scope of these studies encompassed diabetic retinopathy, retinopathy of prematurity, glaucoma, retinal detachment, light-induced ...

Last Updated: 26 Sep 2013

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The cell stress machinery and retinal degeneration.
 

Author(s): Dimitra Athanasiou, Monica Aguilà, Dalila Bevilacqua, Sergey S Novoselov, David A Parfitt, Michael E Cheetham

Journal: FEBS Lett.. 2013 Jun;587(13):2008-17.

 

Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeostasis in all the different retinal ...

Last Updated: 12 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Genetics of Retinal Degenerations
 

Status: Recruiting

Condition Summary: Retinal Degeneration; Retinitis Pigmentosa

 

Last Updated: 14 Mar 2014

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Color Vision as a Measure for Inherited Retinal Diseases
 

Status: Recruiting

Condition Summary: Healthy Volunteer; Retinal Disease; Inherited Retinal Degeneration

 

Last Updated: 23 Apr 2014

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Cell Collection to Study Eye Diseases
 

Status: Recruiting

Condition Summary: Retinal Disease; AMD; Retinal Degeneration

 

Last Updated: 18 Jun 2014

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