Retinal degeneration

Common Name(s)

Retinal degeneration

Description for this condition is not yet available.
 

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Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinal degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Retinal degeneration" returned 297 free, full-text research articles on human participants. First 3 results:

Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism.
 

Author(s): Mei Du, Laura Otalora, Ashley A Martin, Gennadiy Moiseyev, Phillip Vanlandingham, Qilong Wang, Rafal Farjo, Alexander Yeganeh, Alexander Quiambao, Krysten M Farjo

Journal: Mol. Cell. Biol.. 2015 Aug;35(16):2771-89.

 

Serum retinol-binding protein 4 (RBP4) is the sole specific transport protein for retinol in the blood, but it is also an adipokine with retinol-independent, proinflammatory activity associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. Moreover, ...

Last Updated: 21 Jul 2015

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Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium.
 

Author(s): Emma C Zanzottera, Jeffrey D Messinger, Thomas Ach, R Theodore Smith, Christine A Curcio

Journal: Invest. Ophthalmol. Vis. Sci.. 2015 May;56(5):3269-78.

 

To describe, illustrate, and account for two cell types plausibly derived from RPE in geographic atrophy (GA) and choroidal neovascularization (CNV) of AMD, using melanosomes, lipofuscin, and basal laminar deposit (BLamD) as anatomical markers.

Last Updated: 30 May 2015

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Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model.
 

Author(s): Bhubanananda Sahu, Venkata R M Chavali, Akhila Alapati, John Suk, Dirk-Uwe Bartsch, Monica M Jablonski, Radha Ayyagari

Journal:

 

A spontaneous frameshift mutation, c.3481delC, in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice. The rd8 mutation is found in C57BL/6N but not in C57BL/6J mouse sub-strains. The development of ocular pathology in single knockout Ccl2-/-, Cx3cr1-/- ...

Last Updated: 27 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Retinal degeneration" returned 37 free, full-text review articles on human participants. First 3 results:

Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium.
 

Author(s): Debra A Thompson, Robin R Ali, Eyal Banin, Kari E Branham, John G Flannery, David M Gamm, William W Hauswirth, John R Heckenlively, Alessandro Iannaccone, K Thiran Jayasundera, Naheed W Khan, Robert S Molday, Mark E Pennesi, Thomas A Reh, Richard G Weleber, David N Zacks,

Journal:

 

Although rare in the general population, retinal dystrophies occupy a central position in current efforts to develop innovative therapies for blinding diseases. This status derives, in part, from the unique biology, accessibility, and function of the retina, as well as from the synergy ...

Last Updated: 10 Feb 2015

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Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.
 

Author(s): Milosz P Kawa, Anna Machalinska, Dorota Roginska, Boguslaw Machalinski

Journal: J Immunol Res. 2014 ;2014():483960.

 

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly, especially in Western countries. Although the prevalence, risk factors, and clinical course of the disease are well described, its pathogenesis is not entirely elucidated. AMD is associated ...

Last Updated: 3 Oct 2014

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Interventions for asymptomatic retinal breaks and lattice degeneration for preventing retinal detachment.
 

Author(s): Charles P Wilkinson

Journal:

 

Asymptomatic retinal breaks and lattice degeneration are visible lesions that are risk factors for later retinal detachment. Retinal detachments occur when fluid in the vitreous cavity passes through tears or holes in the retina and separates the retina from the underlying retinal ...

Last Updated: 6 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Genetics of Retinal Degenerations
 

Status: Recruiting

Condition Summary: Retinal Degeneration; Retinitis Pigmentosa

 

Last Updated: 2 Dec 2015

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Treatment of Cystoid Macular Edema in Patients With Retinal Degeneration
 

Status: Recruiting

Condition Summary: Retinal Degenerations

 

Last Updated: 12 Dec 2014

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Color Vision as a Measure for Inherited Retinal Diseases
 

Status: Recruiting

Condition Summary: Healthy Volunteer; Retinal Disease; Inherited Retinal Degeneration

 

Last Updated: 11 Apr 2015

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