Restless Leg Syndrome

Common Name(s)

Restless Leg Syndrome

People that are affected by restless leg syndrome (RLS) experience uncomfortable sensations in their legs and feel the urge to move them to feel better temporarily. These feelings most often occur in the legs but can also affect the arms or other parts of the body. The discomfort is usually worst in the evening and when the legs are at rest and you are sitting or lying down. Restless leg syndrome may begin at any age, affects about 10% of the population, and although it occurs in both men and women it is more common in women. The cause of RLS is unknown, although about half of people affected also have at least one family member that is also affected. The development or worsening of RLS may be affected by chronic diseases (such as Parkinson’s disease, kidney failure, or diabetes), medications (antinausea drugs or antidepressants among others), and pregnancy. This condition is diagnosed by your symptoms since there is no medical test for it. However, blood tests and other exams can be used to rule out other disorders. RLS can be alleviated by hot baths, massages, or lifestyle changes including: implementing a regular exercise program, maintaining regular sleep patterns, and limiting use of tobacco, alcohol, and caffeine. Drugs such as dopaminergic drugs, benzodiazepines, narcotic pain relievers, and antiseizure drugs can also be used to treat RLS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Restless Leg Syndrome" returned 40 free, full-text research articles on human participants. First 3 results:

[Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome].
 

Author(s): Şehnaz Başaran

Journal: Turk Kardiyol Dern Ars. 2018 07;46(5):426.

 

Last Updated: 31 Dec 1969

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Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic Leg Movements of Sleep in Older Men, for the Outcomes of Sleep Disorders in Older Men Study (MrOS Sleep Study).
 

Author(s): John W Winkelman, Terri Blackwell, Katie Stone, Sonia Ancoli-Israel, Susan Redline

Journal: Sleep. 2017 04;40(4):.

 

Both restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS) may be associated with incident cardiovascular disease (CVD). However, the individual contributions of these factors to adverse CVD outcomes are unknown.

Last Updated: 31 Dec 1969

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Sequence analysis of leg movements during sleep with different intervals (<10, 10-90 and >90 s) in restless legs syndrome.
 

Author(s): Raffaele Ferri, Francesco Rundo, Alessandro Silvani, Marco Zucconi, Debora Aricò, Oliviero Bruni, Filomena I I Cosentino, Luigi Ferini-Strambi, Mauro Manconi

Journal: J Sleep Res. 2017 08;26(4):436-443.

 

The aim of this study was to define the time structure of leg movements during sleep occurring with an intermovement interval (onset-to-onset) shorter than 10 s in patients with restless legs syndrome and controls, and to compare it to the structure of movements with intervals of ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Restless Leg Syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Efficacy of Pramipexole for the Treatment of Primary Restless Leg Syndrome: A Systematic Review and Meta-analysis of Randomized Clinical Trials.
 

Author(s): Guang Jian Liu, Lang Wu, Song Lin Wang, Li Li Xu, Li Ying Chang, Yun Fu Wang

Journal: Clin Ther. 2016 Jan;38(1):162-179.e6.

 

The objective of this meta-analysis was to systematically evaluate the efficacy of pramipexole for the treatment of primary moderate-to-severe restless leg syndrome (RLS).

Last Updated: 31 Dec 1969

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Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
 

Author(s): Richard P Allen

Journal: Sleep Med Clin. 2015 Sep;10(3):207-14, xi.

 

Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation ...

Last Updated: 31 Dec 1969

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Review of periodic limb movement and restless leg syndrome.
 

Author(s): R Natarajan

Journal: J Postgrad Med. ;56(2):157-62.

 

Periodic limb movement (PLM) and Restless leg syndrome (RLS) are types of sleep disorders that are not very well recognized in clinical practice. While RLS is a clinical diagnosis, the diagnosis of PLM is made by polysomnography. They share the same pathophysiology and often respond ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome
 

Status: Recruiting

Condition Summary: Restless Legs Syndrome

 

Last Updated: 20 Aug 2018

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Last Updated: 30 Mar 2018

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Yoga vs. Education for Restless Legs Syndrome: a Feasibility Study
 

Status: Recruiting

Condition Summary: Restless Legs Syndrome

 

Last Updated: 15 Jun 2018

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