Restless Leg Syndrome

Common Name(s)

Restless Leg Syndrome

People that are affected by restless leg syndrome (RLS) experience uncomfortable sensations in their legs and feel the urge to move them to feel better temporarily. These feelings most often occur in the legs but can also affect the arms or other parts of the body. The discomfort is usually worst in the evening and when the legs are at rest and you are sitting or lying down. Restless leg syndrome may begin at any age, affects about 10% of the population, and although it occurs in both men and women it is more common in women. The cause of RLS is unknown, although about half of people affected also have at least one family member that is also affected. The development or worsening of RLS may be affected by chronic diseases (such as Parkinson’s disease, kidney failure, or diabetes), medications (antinausea drugs or antidepressants among others), and pregnancy. This condition is diagnosed by your symptoms since there is no medical test for it. However, blood tests and other exams can be used to rule out other disorders. RLS can be alleviated by hot baths, massages, or lifestyle changes including: implementing a regular exercise program, maintaining regular sleep patterns, and limiting use of tobacco, alcohol, and caffeine. Drugs such as dopaminergic drugs, benzodiazepines, narcotic pain relievers, and antiseizure drugs can also be used to treat RLS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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Willis-Ekbom Disease Foundation

The Willis-Ekbom Disease (WED) Foundation, also know as the Restless Legs Syndrome Foundation, is a non-profit organization which provides the latest information about WED. The three goals of the WED Foundation are to increase awareness, improve treatments, and through research, find a cure.

Last Updated: 6 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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Willis-Ekbom Disease Foundation

The Willis-Ekbom Disease (WED) Foundation, also know as the Restless Legs Syndrome Foundation, is a non-profit organization which provides the latest information about WED. The three goals of the WED Foundation are to increase awareness, improve treatments, and through research, find a cure.

http://www.willis-ekbom.org

Last Updated: 6 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Restless Leg Syndrome" returned 22 free, full-text research articles on human participants. First 3 results:

Aerobic exercise improves signs of restless leg syndrome in end stage renal disease patients suffering chronic hemodialysis.
 

Author(s): Mojgan Mortazavi, Babak Vahdatpour, Aida Ghasempour, Diana Taheri, Shahrzad Shahidi, Firouzeh Moeinzadeh, Bahareh Dolatkhah, Shahaboddin Dolatkhah

Journal:

 

Restless leg syndrome (RLS) is one of the prevalent complaints of patients with end stage renal diseases suffering chronic hemodialysis. Although there are some known pharmacological managements for this syndrome, the adverse effect of drugs causes a limitation for using them. In ...

Last Updated: 5 Dec 2013

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Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study.
 

Author(s): Marco Luigetti, Alessandra Del Grande, Elisa Testani, Giulia Bisogni, Anna Losurdo, Nadia Mariagrazia Giannantoni, Salvatore Mazza, Mario Sabatelli, Giacomo Della Marca

Journal: J Clin Sleep Med. 2013 Sep;9(9):945-9.

 

to determine the prevalence of restless legs syndrome (RLS) in a cohort of patients with demyelinating neuropathies.

Last Updated: 2 Sep 2013

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Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.
 

Author(s): Anna Cozzi, Paolo Santambrogio, Daniela Privitera, Vania Broccoli, Luisa Ida Rotundo, Barbara Garavaglia, Rudolf Benz, Sandro Altamura, Jeroen S Goede, Martina U Muckenthaler, Sonia Levi

Journal: J. Exp. Med.. 2013 Aug;210(9):1779-91.

 

The ubiquitously expressed iron storage protein ferritin plays a central role in maintaining cellular iron homeostasis. Cytosolic ferritins are composed of heavy (H) and light (L) subunits that co-assemble into a hollow spherical shell with an internal cavity where iron is stored. ...

Last Updated: 27 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Restless Leg Syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Review of periodic limb movement and restless leg syndrome.
 

Author(s): R Natarajan

Journal: J Postgrad Med. ;56(2):157-62.

 

Periodic limb movement (PLM) and Restless leg syndrome (RLS) are types of sleep disorders that are not very well recognized in clinical practice. While RLS is a clinical diagnosis, the diagnosis of PLM is made by polysomnography. They share the same pathophysiology and often respond ...

Last Updated: 12 Jul 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vasculaire Leg Compression Device for the Treatment of Restless Legs Syndrome - A Prospective Clinical Study
 

Status: Not yet recruiting

Condition Summary: Restless Legs Syndrome,; Restless Legs,; Ekbom Syndrome

 

Last Updated: 22 May 2013

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Last Updated: 6 Nov 2013

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Switching From Oral Dopamine Agonists to Rotigotine
 

Status: Recruiting

Condition Summary: Restless Legs Syndrome; Ekbom Syndrome; Willis-Ekbom Disease

 

Last Updated: 9 Sep 2014

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