Restless Leg Syndrome

Common Name(s)

Restless Leg Syndrome

People that are affected by restless leg syndrome (RLS) experience uncomfortable sensations in their legs and feel the urge to move them to feel better temporarily. These feelings most often occur in the legs but can also affect the arms or other parts of the body. The discomfort is usually worst in the evening and when the legs are at rest and you are sitting or lying down. Restless leg syndrome may begin at any age, affects about 10% of the population, and although it occurs in both men and women it is more common in women. The cause of RLS is unknown, although about half of people affected also have at least one family member that is also affected. The development or worsening of RLS may be affected by chronic diseases (such as Parkinson’s disease, kidney failure, or diabetes), medications (antinausea drugs or antidepressants among others), and pregnancy. This condition is diagnosed by your symptoms since there is no medical test for it. However, blood tests and other exams can be used to rule out other disorders. RLS can be alleviated by hot baths, massages, or lifestyle changes including: implementing a regular exercise program, maintaining regular sleep patterns, and limiting use of tobacco, alcohol, and caffeine. Drugs such as dopaminergic drugs, benzodiazepines, narcotic pain relievers, and antiseizure drugs can also be used to treat RLS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Restless Leg Syndrome" returned 36 free, full-text research articles on human participants. First 3 results:

Restless leg syndrome and its treatment.
 

Author(s): Khichar Shubhakaran

Journal: Saudi J Kidney Dis Transpl. 2016 May;27(3):621.

 

Last Updated: 24 May 2016

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Restless leg syndrome and slow coronary flow. Is it inflammation or autonomic nervous system?
 

Author(s): Göknur Tekin

Journal: Anatol J Cardiol. 2015 Jun;15(6):511.

 

Last Updated: 9 Jun 2015

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Relationship between restless leg syndrome and quality of life in uremic patients.
 

Author(s): Demet Tekdöş Demircioğlu, Gülis Kavadar, Özgül Esen Öre, Tuluhan Yunus Emre, Umut Yaka

Journal: Agri. 2015 ;27(2):73-8.

 

Patients with RLS suffer nonrestorative sleep, daytime sleepiness, fatigue, and concentration problems. In addition, dialysis itself effects the psychological and social life of the patient negatively. The aim of this study was to determine the prevalence of RLS in patients on regular ...

Last Updated: 6 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Restless Leg Syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
 

Author(s): Richard P Allen

Journal: Sleep Med Clin. 2015 Sep;10(3):207-14, xi.

 

Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation ...

Last Updated: 2 Sep 2015

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Review of periodic limb movement and restless leg syndrome.
 

Author(s): R Natarajan

Journal: J Postgrad Med. ;56(2):157-62.

 

Periodic limb movement (PLM) and Restless leg syndrome (RLS) are types of sleep disorders that are not very well recognized in clinical practice. While RLS is a clinical diagnosis, the diagnosis of PLM is made by polysomnography. They share the same pathophysiology and often respond ...

Last Updated: 12 Jul 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome
 

Status: Recruiting

Condition Summary: Restless Legs Syndrome

 

Last Updated: 26 Sep 2016

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A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome
 

Status: Recruiting

Condition Summary: Restless Legs Syndrome

 

Last Updated: 26 Sep 2016

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Vitamin D in the Treatment of Primary Restless Legs Syndrome
 

Status: Not yet recruiting

Condition Summary: Restless Legs Syndrome

 

Last Updated: 3 Apr 2015

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