Restless Leg Syndrome
Common Name(s)
Restless Leg Syndrome
Advocacy and Support Organizations
Condition Specific Organizations
Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.
The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.
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Advocacy and Support Organizations
Condition Specific Organizations
Following organizations serve the condition "Restless Leg Syndrome" for support, advocacy or research.
The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.
http://www.movementdisorders.org/MDS.htmRecommended Apps
Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.
Finding the right clinical trial for Restless Leg Syndrome can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.
Scientific Literature
Articles from the PubMed Database
Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Restless Leg Syndrome" returned 38 free, full-text research articles on human participants.
First 3 results:
Journal: Sleep. 2017 04;40(4):.
Both restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS) may be associated with incident cardiovascular disease (CVD). However, the individual contributions of these factors to adverse CVD outcomes are unknown.
Journal: Agri. 2016 Oct;28(4):203-204.
To view other free, full-text articles on human participants, please click on the link below.
Reviews from the PubMed Database
Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Restless Leg Syndrome" returned 3 free, full-text review articles on human participants.
First 3 results:
Journal: Clin Ther. 2016 Jan;38(1):162-179.e6.
The objective of this meta-analysis was to systematically evaluate the efficacy of pramipexole for the treatment of primary moderate-to-severe restless leg syndrome (RLS).
Journal: Sleep Med Clin. 2015 Sep;10(3):207-14, xi.
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation ...
Journal: J Postgrad Med. ;56(2):157-62.
Periodic limb movement (PLM) and Restless leg syndrome (RLS) are types of sleep disorders that are not very well recognized in clinical practice. While RLS is a clinical diagnosis, the diagnosis of PLM is made by polysomnography. They share the same pathophysiology and often respond ...
To view other free, full-text review articles on human participants, please click on the link below.
Symptoms, Diagnosis, and Treatment
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There are currently no related results available in GeneReviews.
There are currently no related results available in Genetic Testing Registry.
Clinical Trial Information This information is provided by ClinicalTrials.gov
Condition Summary: Restless Legs Syndrome
Condition Summary: Restless Legs Syndrome

Finding the right clinical trial for Restless Leg Syndrome can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.