Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 153 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma Resembling Pyoderma Gangrenosum.
 

Author(s): Steffen Emmert, Michael P Schön

Journal: N. Engl. J. Med.. 2015 Jul;373(5):e5.

 

Last Updated: 30 Jul 2015

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Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.
 

Author(s): Anthony D Ormerod, Kim S Thomas, Fiona E Craig, Eleanor Mitchell, Nicola Greenlaw, John Norrie, James M Mason, Shernaz Walton, Graham A Johnston, Hywel C Williams,

Journal:

 

To determine whether ciclosporin is superior to prednisolone for the treatment of pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for management.

Last Updated: 13 Jun 2015

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Collagenase ointment and topical timolol gel for treating idiopathic pyoderma gangrenosum.
 

Author(s): Deede Y Liu, Ryan Fischer, Garth Fraga, Daniel J Aires

Journal: J. Am. Acad. Dermatol.. 2014 Nov;71(5):e225-6.

 

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 14 free, full-text review articles on human participants. First 3 results:

Acute postoperative pyoderma gangrenosum case and review of literature identifying chest wall predominance and no recurrence following skin grafts.
 

Author(s): Maryam Liaqat, Ashley N Elsensohn, C David Hansen, Julie A Maughan, Marta J Petersen

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e145-6.

 

Last Updated: 15 Sep 2014

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Recurrent pyoderma gangrenosum precipitated by breast cancer: a case report and review of the literature.
 

Author(s): Renata Duchnowska, Ewa Ziajka, Agnieszka Góralska, Bartłomiej Grala

Journal:

 

Pyoderma gangrenosum is a rare clinical entity of poorly understood pathogenesis, characterized by rapidly progressing skin necrosis. In around half of patients pyoderma gangrenosum is a manifestation of underlying systemic diseases, such as rheumatoid arthritis, inflammatory bowel ...

Last Updated: 11 Jul 2014

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Systematic review: IBD-associated pyoderma gangrenosum in the biologic era, the response to therapy.
 

Author(s): A Agarwal, J M Andrews

Journal: Aliment. Pharmacol. Ther.. 2013 Sep;38(6):563-72.

 

Pyoderma gangrenosum (PG) in inflammatory bowel disease (IBD) is uncommon and therapeutically challenging. Its treatment remains poorly characterised due to limited individual centre or practitioner experience. No large series are reported since 2003, yet IBD treatment has changed substantially.

Last Updated: 22 Aug 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 18 Aug 2015

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An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 18 Aug 2015

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RA-18C3 Therapy for Subjects With Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 16 Jul 2015

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