Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 181 free, full-text research articles on human participants. First 3 results:

Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions.
 

Author(s): Shintaro Sagami, Yoshitaka Ueno, Shinji Tanaka, Kenta Nagai, Ryohei Hayashi, Kazuaki Chayama

Journal: Intern. Med.. 2015 ;54(17):2167-72.

 

A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea ...

Last Updated: 2 Sep 2015

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Coexistence of pyoderma gangrenosum and sweet's syndrome in a patient with ulcerative colitis.
 

Author(s): Faida Ajili, Asmahan Souissi, Fathi Bougrine, Najah Boussetta, Nadia Ben Abdelhafidh, Sameh Sayhi, Bassem Louzir, Nejib Doss, Janet Laabidi, Salah Othmani

Journal:

 

Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs. These neutrophilic dermatosis (NDs) are distinguished by the existence of forms of transition or overlap. They ...

Last Updated: 2 Sep 2015

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IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma Resembling Pyoderma Gangrenosum.
 

Author(s): Steffen Emmert, Michael P Schön

Journal: N. Engl. J. Med.. 2015 Jul;373(5):e5.

 

Last Updated: 30 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 18 free, full-text review articles on human participants. First 3 results:

Wegener's granulomatosis and pyoderma gangrenosum--rare causes of facial ulcerations.
 

Author(s): Karolina Kędzierska, Krzysztof Sindrewicz, Tomasz Smektała, Magda Wiśniewska, Marek Masiuk, Ewelina Staniszewska, Katarzyna Sporniak-Tutak, Edyta Gołembiewska, Kazimierz Ciechanowski

Journal:

 

Pyoderma gangrenosum (PG) is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG). The purpose of this article was to compare ...

Last Updated: 27 Apr 2016

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Effective strategies for the management of pyoderma gangrenosum: a comprehensive review.
 

Author(s): Forum Patel, Sarah Fitzmaurice, Christopher Duong, Young He, Jonathan Fergus, Siba P Raychaudhuri, Miki Shirakawa Garcia, Emanual Maverakis

Journal: Acta Derm. Venereol.. 2015 May;95(5):525-31.

 

Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc ...

Last Updated: 29 Apr 2015

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Acute postoperative pyoderma gangrenosum case and review of literature identifying chest wall predominance and no recurrence following skin grafts.
 

Author(s): Maryam Liaqat, Ashley N Elsensohn, C David Hansen, Julie A Maughan, Marta J Petersen

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e145-6.

 

Last Updated: 15 Sep 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

RA-18C3 Therapy for Subjects With Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 4 Jan 2016

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Canakinumab for Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 22 Jun 2012

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Last Updated: 4 Apr 2016

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