Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 177 free, full-text research articles on human participants. First 3 results:

Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions.
 

Author(s): Shintaro Sagami, Yoshitaka Ueno, Shinji Tanaka, Kenta Nagai, Ryohei Hayashi, Kazuaki Chayama

Journal: Intern. Med.. 2015 ;54(17):2167-72.

 

A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea ...

Last Updated: 2 Sep 2015

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IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma Resembling Pyoderma Gangrenosum.
 

Author(s): Steffen Emmert, Michael P Schön

Journal: N. Engl. J. Med.. 2015 Jul;373(5):e5.

 

Last Updated: 30 Jul 2015

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Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.
 

Author(s): Anthony D Ormerod, Kim S Thomas, Fiona E Craig, Eleanor Mitchell, Nicola Greenlaw, John Norrie, James M Mason, Shernaz Walton, Graham A Johnston, Hywel C Williams,

Journal:

 

To determine whether ciclosporin is superior to prednisolone for the treatment of pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for management.

Last Updated: 13 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 17 free, full-text review articles on human participants. First 3 results:

Effective strategies for the management of pyoderma gangrenosum: a comprehensive review.
 

Author(s): Forum Patel, Sarah Fitzmaurice, Christopher Duong, Young He, Jonathan Fergus, Siba P Raychaudhuri, Miki Shirakawa Garcia, Emanual Maverakis

Journal: Acta Derm. Venereol.. 2015 May;95(5):525-31.

 

Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc ...

Last Updated: 29 Apr 2015

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Acute postoperative pyoderma gangrenosum case and review of literature identifying chest wall predominance and no recurrence following skin grafts.
 

Author(s): Maryam Liaqat, Ashley N Elsensohn, C David Hansen, Julie A Maughan, Marta J Petersen

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e145-6.

 

Last Updated: 15 Sep 2014

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Recurrent pyoderma gangrenosum precipitated by breast cancer: a case report and review of the literature.
 

Author(s): Renata Duchnowska, Ewa Ziajka, Agnieszka Góralska, Bartłomiej Grala

Journal:

 

Pyoderma gangrenosum is a rare clinical entity of poorly understood pathogenesis, characterized by rapidly progressing skin necrosis. In around half of patients pyoderma gangrenosum is a manifestation of underlying systemic diseases, such as rheumatoid arthritis, inflammatory bowel ...

Last Updated: 11 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

RA-18C3 Therapy for Subjects With Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 4 Jan 2016

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Canakinumab for Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 22 Jun 2012

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Last Updated: 4 Apr 2016

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