Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 209 free, full-text research articles on human participants. First 3 results:

Bullous pyoderma gangrenosum as a predictor of hematological malignancies.
 

Author(s): Aldana Soledad Vacas, María Luz Bollea-Garlatti, Ana Clara Torre, Ricardo Luis Galimberti

Journal: An Bras Dermatol. ;93(1):133-134.

 

Pyoderma gangrenosum may precede, coexist or follow diverse systemic diseases. The bullous variety is usually associated with hematologic disorders. From 31 patients with pyoderma gangrenosum diagnosed in our hospital during 10 years, only 2 presented with the bullous type. One patient ...

Last Updated: 31 Dec 1969

Go To URL
Pyoderma gangrenosum associated with left iliac vein compression syndrome: presentation of difficult diagnosis.
 

Author(s): Verena Mony Paes de Freitas, Silvia Marcondes Pereira, Mílvia Maria Simões E Silva Enokihara, Silmara da Costa Pereira Cestari

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):129-131.

 

Pyoderma gangrenosum is a rare neutrophilic dermatosis of unknown etiology, of which the most frequent clinical manifestations are ulcers. The diagnosis difficulty is, among other things, to rule out other causes of ulcers, since it is considered a diagnosis of exclusion. Skin ulcerations ...

Last Updated: 31 Dec 1969

Go To URL
Pyoderma Gangrenosum after Breast Mastectomy and Primary Rectus Abdominis Flap Reconstruction.
 

Author(s): Yasuhiro Suzuki, Kozue Yokoyama, Mayako Terao, Toru Morioka, Banri Tsuda, Naoki Niikura, Takuho Okamura, Eri Yamada, Kotaro Imagawa, Tadashi Akamatsu, Yutaka Tokuda, Nobue Kumaki

Journal:

 

Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions. Here, we report a rare case of pyoderma gangrenosum ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 20 free, full-text review articles on human participants. First 3 results:

Wegener's granulomatosis and pyoderma gangrenosum--rare causes of facial ulcerations.
 

Author(s): Karolina Kędzierska, Krzysztof Sindrewicz, Tomasz Smektała, Magda Wiśniewska, Marek Masiuk, Ewelina Staniszewska, Katarzyna Sporniak-Tutak, Edyta Gołembiewska, Kazimierz Ciechanowski

Journal:

 

Pyoderma gangrenosum (PG) is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG). The purpose of this article was to compare ...

Last Updated: 31 Dec 1969

Go To URL
A case report of successful treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis, and review of the literature.
 

Author(s): Theodoros Androutsakos, Paraskevas Stamopoulos, Kiriaki Aroni, Gregorios Hatzis

Journal:

 

Pyoderma Gangrenosum (PG) is a cutaneous condition, its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression. Pyoderma gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including inflammatory bowel disease (IBD), ...

Last Updated: 31 Dec 1969

Go To URL
The diagnostic tangle of pyoderma gangrenosum: a case report and review of the literature.
 

Author(s): E Bakelants, J van der Hilst, L Corluy, R Achten, I Gyssens, P Messiaen

Journal: Neth J Med. 2014 Dec;72(10):541-4.

 

This report describes a 55-year-old patient with the rare inflammatory dermatosis pyoderma gangrenosum. It is an often misdiagnosed condition of unclear origin and pathogenesis. There is an association with underlying systemic disorders such as inflammatory bowel disease, haematological ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Apr 2018

Go to URL
An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 3 Apr 2018

Go to URL
Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 31 Jul 2017

Go to URL