Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 147 free, full-text research articles on human participants. First 3 results:

Pyoderma gangrenosum triggered by red tattoo dye.
 

Author(s): Ivan V Litvinov, Denis Sasseville

Journal: CMAJ. 2014 Sep;186(12):935.

 

Last Updated: 3 Sep 2014

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Concomitant occurrence of pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease.
 

Author(s): Ilan Goldberg, Oksana Finkel, Andrea Gat, Eli Sprecher, Helena Martinez de Morentin

Journal: Isr. Med. Assoc. J.. 2014 Mar;16(3):168-70.

 

Erythema nodosum and pyoderma gangrenosum are common skin manifestations in inflammatory bowel diseases. Curiously, these two cutaneous features have seldom been reported to occur simultaneously. We present three patients affected with inflammatory bowel disease with concomitant erythema ...

Last Updated: 25 Apr 2014

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Pyoderma gangrenosum, rare parietal complication after colorectal surgery.
 

Author(s): A Miron, C Giulea, I Tudose, D Petrache, C Giurcaneanu

Journal: Chirurgia (Bucur). ;109(2):248-53.

 

Pyoderma gangrenosum (PG) is a rare chronic destructive inflammatory skin disease characterized by the presence of nodules and pustules with progressively enlarging ulcers and orcutaneous necrosis. In most cases PG is idiopathic, but sometimes it is associated with conditions that ...

Last Updated: 18 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 13 free, full-text review articles on human participants. First 3 results:

Acute postoperative pyoderma gangrenosum case and review of literature identifying chest wall predominance and no recurrence following skin grafts.
 

Author(s): Maryam Liaqat, Ashley N Elsensohn, C David Hansen, Julie A Maughan, Marta J Petersen

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e145-6.

 

Last Updated: 15 Sep 2014

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Pyoderma gangrenosum with oral involvement - case report and review of the literature.
 

Author(s): Geetha Paramkusam, Venkateswarlu Meduri, Naresh Gangeshetty

Journal: Int J Oral Sci. 2010 Jun;2(2):111-6.

 

Pyoderma gangrenosum (PG) is a rare, noninfectious neutrophilic dermatosis. Clinically, it begins with sterile pustules that rapidly progress into painful ulcers of variable depth and size with undermined violaceous borders. The diagnosis of PG is based on the history of an underlying ...

Last Updated: 26 Aug 2010

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[Pyoderma gangrenosum--clinical, laboratory and therapeutic approaches. Review of 28 cases].
 

Author(s): Ana F Duarte, Ana Nogueira, Carmen Lisboa, Filomena Azevedo

Journal:

 

Pyoderma gangrenosum is an uncommon neutrophilic dermatosis, idiopatic in 25-50 percent of cases. We present a retrospective study of 28 patients, admitted to Hospital de São João, EPE, between January of 1990 and June of 2008. Pyoderma gangrenosum was observed more frequently in ...

Last Updated: 11 Nov 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

RA-18C3 Therapy for Subjects With Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 12 May 2014

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Canakinumab for Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 22 Jun 2012

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Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
 

Status: Recruiting

Condition Summary: Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue; Pyoderma Gangrenosum; Erosive Pustular Dermatosis of the Scalp; Sweet's Syndrome; Behcet's Disease; Bowel-associated Dermatosis-arthritis Syndrome; Pustular Psoriasis; Acute Generalized Exanthematous Pustulosis; Keratoderma Blenorrhagicum; Sneddon-Wilkinson Disease; IgA Pemphigus; Amicrobial Pustulosis of the Folds; Infantile Acropustulosis; Transient Neonatal Pustulosis; Neutrophilic Eccrine Hidradenitis; Rheumatoid Neutrophilic Dermatitis; Neutrophilic Urticaria; Still's Disease; Erythema Marginatum; Unclassified Periodic Fever Syndromes / Autoinflammatory Syndromes; Dermatitis Herpetiformis; Linear IgA Bullous Dermatosis; Bullous Systemic Lupus Erythematosus; Inflammatory Epidermolysis Bullosa Aquisita; Neutrophilic Dermatosis of the Dorsal Hands (Pustular Vasculitis); Small Vessel Vasculitis Including Urticarial Vasculitis; Erythema Elevatum Diutinum; Medium Vessel Vasculitis

 

Last Updated: 11 Jun 2014

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