Pure autonomic failure

Common Name(s)

Pure autonomic failure

Pure autonomic failure is characterized by generalized autonomic failure without involving the brain or spinal cord (central nervous system). The autonomic nervous system is the part of our bodies that controls involuntary actions, such as the widening or narrowing of our blood vessels. Failure of this system can cause a variety of symptoms. The most common symptom of pure autonomic failure is orthostatic hypotension. Other symptoms may include decreased sweating, heat intolerance, in ability to empty the bladder, erectile dysfunction, incontinence or constipation, and pupil changes. The cause of this condition is unknown.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pure autonomic failure" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pure autonomic failure" returned 19 free, full-text research articles on human participants. First 3 results:

α-Synuclein in the skin nerve of pure autonomic failure.
 

Author(s): Ryosuke Igari, Manabu Wada, Koichi Wakabayashi, Takeo Kato

Journal: Intern. Med.. 2011 ;50(24):3049-50.

 

Last Updated: 21 Dec 2011

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[REM sleep behaviour disorder and "pure" autonomic failure. Presentation of two cases].
 

Author(s): B Tijero, J C Gómez-Esteban, K Berganzo, J J Zarranz

Journal: Neurologia. 2012 Jan;27(1):55-7.

 

Last Updated: 5 Mar 2012

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Renal impairment of pure autonomic failure.
 

Author(s): Emily M Garland, Alfredo Gamboa, Luis Okamoto, Satish R Raj, Bonnie K Black, Thomas L Davis, Italo Biaggioni, David Robertson

Journal: Hypertension. 2009 Nov;54(5):1057-61.

 

Supine hypertension is difficult to manage in patients with pure autonomic failure (PAF), because treatment can worsen orthostatic hypotension. Supine hypertension in PAF has been associated with left ventricular hypertrophy, but end organ damage in the kidney has not been assessed. ...

Last Updated: 22 Oct 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pure autonomic failure" returned 2 free, full-text review articles on human participants. First 3 results:

[Pure autonomic failure].
 

Author(s): J L Ducla-Soares, A S Guerreiro, P Póvoa, E Alvares, L Guerreiro, F Carrilho, M Santos, J Figueirinhas, M Carvalho

Journal: Acta Med Port. 1993 Nov;6(11):533-7.

 

We present the case of a 64-year-old woman who, in the past 5 years, complained of constipation/diarrhea, hyposudoresis, xerostomia and xerophthalmia, dysuria and orthostatic hypotension. Cardiovascular reflexes analysis revealed sympathetic and parasympathetic failure. Norepinephrine ...

Last Updated: 28 Apr 1994

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[A case of "pure" progressive autonomic failure in an elderly male].
 

Author(s): T Kuwahara, T Okura, S Matsumoto, Y Dazai, T Iwata, K Hiwada

Journal: Nihon Ronen Igakkai Zasshi. 1992 Oct;29(10):790-3.

 

A 68-year-old man was admitted to our hospital because of postural hypotension in July 1991. He was also suffering from anhydrosis, urinary disturbances, constipation and impotence. He had not developed signs of Parkinsonism, cerebellar or peripheral neuropathy four years from the ...

Last Updated: 8 Jan 1993

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Magnetic Resonance Spectroscopy in Autonomic Failure
 

Status: Recruiting

Condition Summary: Pure Autonomic Failure; Multiple System Atrophy

 

Last Updated: 27 May 2014

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The Role of Endothelin in the Supine Hypertension of Autonomic Failure
 

Status: Recruiting

Condition Summary: Hypertension; Pure Autonomic Failure; Multiple System Atrophy

 

Last Updated: 20 Nov 2014

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Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure
 

Status: Recruiting

Condition Summary: Hypertension; Pure Autonomic Failure; Multiple System Atrophy

 

Last Updated: 27 May 2014

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