Psoriatic arthritis

Common Name(s)

Psoriatic arthritis

Psoriatic arthritis is joint inflammation and stiffness (arthritis) that affects people who have a condition that causes red, itchy, and scaly skin patches (psoriasis). Signs and symptoms of psoriatic arthritis are similar to other forms of arthritis and include stiff and painful joints. In addition, psoriatic arthritis can also cause finger and toe swelling, foot pain and lower back pain. Typically, psoriasis appears before joint problems. Psoriasis symptoms typically occur between the ages of 15 and 35 years and arthritis symptoms usually occur between the ages of 30 and 50. However, both conditions can occur at any age.

Psoriatic arthritis occurs when the body’s immune system attacks healthy cells and tissues. This abnormal immune response, which causes inflammation in your joints, may be due to a combination of genetic and environmental reasons. Risk factors for psoriatic arthritis include having psoriasis, being between the ages of 30 and 50, and having a family history of psoriatic arthritis. There are five types of psoriatic arthritis: distal interphalangeal (DIP), asymmetric oligoarticular, symmetric polyarthritis, spondylitis, and arthritis mutilans. The distal interphalangeal type predominantly affects the ends of fingers and toes. The symmetric polyarthritis form affects matching joints on opposite sides of the body (e.g. Right and left wrist), while the asymmetric oligoarticular type involves nonmatching joints of each side of the body. Spondylitis is inflammation in the joints between the vertebrae in the spine. Arthritis mutilans, which is the most severe and least common type of psoriatic arthritis, causes damage and loss of function of affected joints.

Your doctor may use a physical exam along with imaging and lab tests to diagnosis psoriatic arthritis. There is no cure, but treatment can help manage pain. Talk with a doctor if you have been diagnosed with psoriatic arthritis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriatic arthritis" returned 500 free, full-text research articles on human participants. First 3 results:

Comparative genomic profiling of synovium versus skin lesions in psoriatic arthritis.
 

Author(s): Jennifer Belasco, James S Louie, Nicholas Gulati, Nathan Wei, Kristine Nograles, Judilyn Fuentes-Duculan, Hiroshi Mitsui, Mayte Suárez-Fariñas, James G Krueger

Journal: Arthritis Rheumatol. 2015 Apr;67(4):934-44.

 

To our knowledge, there is no broad genomic analysis comparing skin and synovium in psoriatic arthritis (PsA). Also, there is little understanding of the relative levels of cytokines and chemokines in skin and synovium. The purpose of this study was to better define inflammatory pathways ...

Last Updated: 30 Mar 2015

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New biological treatments for psoriatic arthritis.
 

Author(s): Piercarlo Sarzi-Puttini, Fabiola Atzeni

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):643-5.

 

Last Updated: 2 Dec 2014

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High-resolution MRI assessment of dactylitis in psoriatic arthritis shows flexor tendon pulley and sheath-related enthesitis.
 

Author(s): Ai Lyn Tan, Eiji Fukuba, Nicola Ann Halliday, Steven F Tanner, Paul Emery, Dennis McGonagle

Journal: Ann. Rheum. Dis.. 2015 Jan;74(1):185-9.

 

Dactylitis is a hallmark of psoriatic arthritis (PsA) where flexor tenosynovitis is common. This study explored the microanatomical basis of dactylitis using high-resolution MRI (hrMRI) to visualise the small entheses around the digits.

Last Updated: 5 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriatic arthritis" returned 91 free, full-text review articles on human participants. First 3 results:

The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis.
 

Author(s): Camille Roubille, Vincent Richer, Tara Starnino, Collette McCourt, Alexandra McFarlane, Patrick Fleming, Stephanie Siu, John Kraft, Charles Lynde, Janet Pope, Wayne Gulliver, Stephanie Keeling, Jan Dutz, Louis Bessette, Robert Bissonnette, Boulos Haraoui

Journal: Ann. Rheum. Dis.. 2015 Mar;74(3):480-9.

 

The objective of this systematic literature review was to determine the association between cardiovascular events (CVEs) and antirheumatic drugs in rheumatoid arthritis (RA) and psoriatic arthritis (PsA)/psoriasis (Pso). Systematic searches were performed of MEDLINE, EMBASE and Cochrane ...

Last Updated: 6 Feb 2015

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Qualifying unmet needs and improving standards of care in psoriatic arthritis.
 

Author(s): Philip Helliwell, Laura Coates, Vinod Chandran, Dafna Gladman, Maarten de Wit, Oliver FitzGerald, Arthur Kavanaugh, Vibeke Strand, Philip J Mease, Wolf-Henning Boehncke, Richard G Langley, Ennio Lubrano, Mara Maccarone, Hendrik Schulze-Koops, Corinne Miceli-Richard, Ruben Queiro

Journal: Arthritis Care Res (Hoboken). 2014 Dec;66(12):1759-66.

 

Last Updated: 25 Nov 2014

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Anti-cyclic citrullinated peptide antibodies in psoriatic arthritis--cross-sectional study and literature review.
 

Author(s): C Popescu, S Zofotă, V Bojincă, R Ionescu

Journal: J Med Life. 2013 ;6(4):376-82.

 

Anti-CCP antibodies are detectable not only in rheumatoid arthritis (RA), but also in psoriatic arthritis (PsA). It is possible those anti-CCP antibodies are associated with features of PsA and that these auto-antibodies are useful in distinguishing PsA from RA.

Last Updated: 4 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Psoriatic Arthritis Treat to Target vs. Usual Care
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis (PsA)

 

Last Updated: 13 Nov 2013

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Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 11 May 2015

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