Psoriatic arthritis

Common Name(s)

Psoriatic arthritis

Psoriatic arthritis is joint inflammation and stiffness (arthritis) that affects people who have a condition that causes red, itchy, and scaly skin patches (psoriasis). Signs and symptoms of psoriatic arthritis are similar to other forms of arthritis and include stiff and painful joints. In addition, psoriatic arthritis can also cause finger and toe swelling, foot pain and lower back pain. Typically, psoriasis appears before joint problems. Psoriasis symptoms typically occur between the ages of 15 and 35 years and arthritis symptoms usually occur between the ages of 30 and 50. However, both conditions can occur at any age.

Psoriatic arthritis occurs when the body’s immune system attacks healthy cells and tissues. This abnormal immune response, which causes inflammation in your joints, may be due to a combination of genetic and environmental reasons. Risk factors for psoriatic arthritis include having psoriasis, being between the ages of 30 and 50, and having a family history of psoriatic arthritis. There are five types of psoriatic arthritis: distal interphalangeal (DIP), asymmetric oligoarticular, symmetric polyarthritis, spondylitis, and arthritis mutilans. The distal interphalangeal type predominantly affects the ends of fingers and toes. The symmetric polyarthritis form affects matching joints on opposite sides of the body (e.g. Right and left wrist), while the asymmetric oligoarticular type involves nonmatching joints of each side of the body. Spondylitis is inflammation in the joints between the vertebrae in the spine. Arthritis mutilans, which is the most severe and least common type of psoriatic arthritis, causes damage and loss of function of affected joints.

Your doctor may use a physical exam along with imaging and lab tests to diagnosis psoriatic arthritis. There is no cure, but treatment can help manage pain. Talk with a doctor if you have been diagnosed with psoriatic arthritis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriatic arthritis" returned 552 free, full-text research articles on human participants. First 3 results:

The pharmacodynamic impact of apremilast, an oral phosphodiesterase 4 inhibitor, on circulating levels of inflammatory biomarkers in patients with psoriatic arthritis: substudy results from a phase III, randomized, placebo-controlled trial (PALACE 1).
 

Author(s): Peter H Schafer, Peng Chen, Lorraine Fang, Andrew Wang, Rajesh Chopra

Journal: J Immunol Res. 2015 ;2015():906349.

 

Apremilast, an oral phosphodiesterase 4 inhibitor, demonstrated effectiveness (versus placebo) for treatment of active psoriatic arthritis in the psoriatic arthritis long-term assessment of clinical efficacy (PALACE) phase III clinical trial program. Pharmacodynamic effects of apremilast ...

Last Updated: 14 May 2015

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IgA nephropathy and psoriatic arthritis that improved with steroid pulse therapy and mizoribine in combination with treatment for chronic tonsillitis and epipharyngitis.
 

Author(s): Tomohiro Kaneko, Akiko Mii, Megumi Fukui, Kiyotaka Nagahama, Akira Shimizu, Shuichi Tsuruoka

Journal: Intern. Med.. 2015 ;54(9):1085-90.

 

A 65-year-old man was admitted to our hospital with edema and renal dysfunction. He had received a diagnosis of psoriatic arthritis at 50 years of age. As a renal biopsy showed IgA nephropathy (IgAN), bilateral tonsillectomy was performed, and one course of steroid pulse therapy with ...

Last Updated: 7 May 2015

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PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.
 

Author(s): John Bowes, Sabine Loehr, Ashley Budu-Aggrey, Steffen Uebe, Ian N Bruce, Marie Feletar, Helena Marzo-Ortega, Philip Helliwell, Anthony W Ryan, David Kane, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Matthew A Brown, Frank Behrens, Harald Burkhardt, Neil McHugh, Ulrike Huffmeier, Pauline Ho, Andre Reis, Anne Barton

Journal: Ann. Rheum. Dis.. 2015 Oct;74(10):1882-5.

 

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate ...

Last Updated: 11 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriatic arthritis" returned 101 free, full-text review articles on human participants. First 3 results:

Pharmacogenetics of treatment response in psoriatic arthritis.
 

Author(s): Meghna Jani, Anne Barton, Pauline Ho

Journal: Curr Rheumatol Rep. 2015 Jul;17(7):44.

 

TNF-blocking agents, non-biological disease-modifying anti-rheumatic drugs (nbDMARDs) and non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed treatments in psoriatic arthritis. A large proportion of patients do not respond to these medications, although unfortunately ...

Last Updated: 18 May 2015

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Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype.
 

Author(s): Oliver FitzGerald, Muhammad Haroon, Jon T Giles, Robert Winchester

Journal:

 

This review focuses on the genetic features of psoriatic arthritis (PsA) and their relationship to phenotypic heterogeneity in the disease, and addresses three questions: what do the recent studies on human leukocyte antigen (HLA) tell us about the genetic relationship between cutaneous ...

Last Updated: 7 May 2015

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Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials.
 

Author(s): Richard Conway, Candice Low, Robert J Coughlan, Martin J O'Donnell, John J Carey

Journal:

 

To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.

Last Updated: 15 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 8 Jan 2016

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Psoriatic Arthritis Treat to Target vs. Usual Care
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis (PsA)

 

Last Updated: 13 Nov 2013

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