Psoriatic Arthritis

Common Name(s)

Psoriatic Arthritis

Psoriatic arthritis is a type of chronic inflammatory arthritis coupled with the skin condition known as psoriasis. Psoriatic arthritis resembles general arthritis in hindering or halting physical movement through destruction of joints, bones, muscles, cartilage or other connective tissues.

Psoriasis arthritis usually appears about 10 years after the onset of psoriasis. Psoriasis can manifest at any age, affecting about 2 percent of the U.S. population, although most people diagnosed range between 15 and 35 years old.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic Arthritis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic Arthritis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriatic Arthritis" returned 442 free, full-text research articles on human participants. First 3 results:

Varicella pneumonia in a woman receiving methotrexate for psoriatic arthritis.
 

Author(s): Yigal Helviz, Moshe Hersch, David Raveh, Lev Shmulovich, Sharon Einav

Journal: Isr. Med. Assoc. J.. 2014 Mar;16(3):175-6.

 

Last Updated: 25 Apr 2014

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Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor.
 

Author(s): Arthur Kavanaugh, Philip J Mease, Juan J Gomez-Reino, Adewale O Adebajo, Jürgen Wollenhaupt, Dafna D Gladman, Eric Lespessailles, Stephen Hall, Marla Hochfeld, ChiaChi Hu, Douglas Hough, Randall M Stevens, Georg Schett

Journal: Ann. Rheum. Dis.. 2014 Jun;73(6):1020-6.

 

Apremilast, an oral phosphodiesterase 4 inhibitor, regulates inflammatory mediators. Psoriatic Arthritis Long-term Assessment of Clinical Efficacy 1 (PALACE 1) compared apremilast with placebo in patients with active psoriatic arthritis despite prior traditional disease-modifying ...

Last Updated: 5 May 2014

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Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials.
 

Author(s): Arthur Kavanaugh, Christopher Ritchlin, Proton Rahman, Lluis Puig, Alice B Gottlieb, Shu Li, Yuhua Wang, Lenore Noonan, Carrie Brodmerkel, Michael Song, Alan M Mendelsohn, Iain B McInnes,

Journal: Ann. Rheum. Dis.. 2014 Jun;73(6):1000-6.

 

Evaluate ustekinumab, an anti-interleukin (IL)-12 and IL-23 antibody, effects on radiographic progression in psoriatic arthritis (PsA).

Last Updated: 5 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriatic Arthritis" returned 83 free, full-text review articles on human participants. First 3 results:

Methotrexate in psoriatic arthritis.
 

Author(s): Philip Mease

Journal: Bull Hosp Jt Dis (2013). 2013 ;71 Suppl 1():S41-5.

 

Psoriatic arthritis (PsA) is a form of inflammatory arthritis that occurs in patients with psoriasis and is distinct from rheumatoid arthritis (RA). Methotrexate (MTX) is one of the most commonly used drugs for the treatment of PsA, yet there is scant controlled trial data to document ...

Last Updated: 13 Nov 2013

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The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis.
 

Author(s): Athanasios Mavropoulos, Eirini I Rigopoulou, Christos Liaskos, Dimitrios P Bogdanos, Lazaros I Sakkas

Journal: Clin. Dev. Immunol.. 2013 ;2013():569751.

 

The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. ...

Last Updated: 23 Oct 2013

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Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force.
 

Author(s): Josef S Smolen, Jürgen Braun, Maxime Dougados, Paul Emery, Oliver Fitzgerald, Philip Helliwell, Arthur Kavanaugh, Tore K Kvien, Robert Landewé, Thomas Luger, Philip Mease, Ignazio Olivieri, John Reveille, Christopher Ritchlin, Martin Rudwaleit, Monika Schoels, Joachim Sieper, Martinus de Wit, Xenofon Baraliakos, Neil Betteridge, Ruben Burgos-Vargas, Eduardo Collantes-Estevez, Atul Deodhar, Dirk Elewaut, Laure Gossec, Merryn Jongkees, Mara Maccarone, Kurt Redlich, Filip van den Bosch, James Cheng-Chung Wei, Kevin Winthrop, Désirée van der Heijde

Journal: Ann. Rheum. Dis.. 2014 Jan;73(1):6-16.

 

Therapeutic targets have been defined for diseases like diabetes, hypertension or rheumatoid arthritis and adhering to them has improved outcomes. Such targets are just emerging for spondyloarthritis (SpA).

Last Updated: 5 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

TIght COntrol of Psoriatic Arthritis
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 30 Sep 2010

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Exploratory Study on Quality of Life in Patient With Moderate Psoriasis and Moderate Psoriatic Arthritis
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis; Psoriasis

 

Last Updated: 6 Nov 2013

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A Study of Golimumab in Participants With Active Psoriatic Arthritis
 

Status: Not yet recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 2 Jul 2014

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