Psoriatic arthritis

Common Name(s)

Psoriatic arthritis

Psoriatic arthritis is joint inflammation and stiffness (arthritis) that affects people who have a condition that causes red, itchy, and scaly skin patches (psoriasis). Signs and symptoms of psoriatic arthritis are similar to other forms of arthritis and include stiff and painful joints. In addition, psoriatic arthritis can also cause finger and toe swelling, foot pain and lower back pain. Typically, psoriasis appears before joint problems. Psoriasis symptoms typically occur between the ages of 15 and 35 years and arthritis symptoms usually occur between the ages of 30 and 50. However, both conditions can occur at any age.

Psoriatic arthritis occurs when the body’s immune system attacks healthy cells and tissues. This abnormal immune response, which causes inflammation in your joints, may be due to a combination of genetic and environmental reasons. Risk factors for psoriatic arthritis include having psoriasis, being between the ages of 30 and 50, and having a family history of psoriatic arthritis. There are five types of psoriatic arthritis: distal interphalangeal (DIP), asymmetric oligoarticular, symmetric polyarthritis, spondylitis, and arthritis mutilans. The distal interphalangeal type predominantly affects the ends of fingers and toes. The symmetric polyarthritis form affects matching joints on opposite sides of the body (e.g. Right and left wrist), while the asymmetric oligoarticular type involves nonmatching joints of each side of the body. Spondylitis is inflammation in the joints between the vertebrae in the spine. Arthritis mutilans, which is the most severe and least common type of psoriatic arthritis, causes damage and loss of function of affected joints.

Your doctor may use a physical exam along with imaging and lab tests to diagnosis psoriatic arthritis. There is no cure, but treatment can help manage pain. Talk with a doctor if you have been diagnosed with psoriatic arthritis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

View Details
Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriatic arthritis" returned 634 free, full-text research articles on human participants. First 3 results:

Elevated C-Reactive Protein Level Predicts Earlier Treatment with Tumor Necrosis Factor-Alpha Inhibitors in Psoriatic Arthritis.
 

Author(s): Shachaf Ofer-Shiber, Yair Molad

Journal: Isr. Med. Assoc. J.. 2016 May;18(5):279-82.

 

Tumor necrosis factor-alpha (TNFα) inhibitors are indicated for patients with psoriatic arthritis (PsA) in whom conventional disease-modifying anti-rheumatic drugs (DMARDs) are insufficient to achieve disease remission.

Last Updated: 19 Jul 2016

Go To URL
Effect of Vitamin D on Peripheral Blood Mononuclear Cells from Patients with Psoriasis Vulgaris and Psoriatic Arthritis.
 

Author(s): Susana Cubillos, Nadine Krieg, Johannes Norgauer

Journal:

 

Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as well as regulation of immune response. We aimed ...

Last Updated: 7 Apr 2016

Go To URL
Psoriatic Arthritis with Annular Pustular Psoriasis.
 

Author(s): Hiroko Nagafuchi, Kyoko Watanabe, Hidenori Mikage, Shoichi Ozaki

Journal: Intern. Med.. 2016 ;55(5):519-21.

 

We herein present the case of a 56-year-old woman who presented with symptoms of psoriatic arthritis (PsA) with erythema that progressed to annular pustular psoriasis. The patient had a 15-year history of polyarthritis. Annular pustular psoriasis is not typically observed in cases ...

Last Updated: 3 Mar 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriatic arthritis" returned 122 free, full-text review articles on human participants. First 3 results:

Sex Differences in the Treatment of Psoriatic Arthritis: A Systematic Literature Review.
 

Author(s): Elena Generali, Carlo A Sciré, Luca Cantarini, Carlo Selmi

Journal: Isr. Med. Assoc. J.. ;18(3-4):203-8.

 

Psoriatic arthritis (PsA) is a chronic inflammatory condition associated with skin psoriasis and manifests a wide clinical phenotype, with proposed differences between sexes. Current treatments are based on traditional disease-modifying anti-rheumatic drugs (DMARD), and biologic agents ...

Last Updated: 27 May 2016

Go To URL
Do Anti-TNF Blockers Increase the Risk of Lung Involvement in Patients with Ankylosing Spondylitis or Psoriatic Arthritis? A Systematic Review.
 

Author(s): Fabiola Atzeni, Elisabetta Grillo, Ignazio F Masala, Piercarlo Sarzi-Puttini, Gareth T Jones

Journal: Isr. Med. Assoc. J.. ;18(3-4):154-5.

 

Lung involvement is a well-recognized extra-articular manifestation of ankylosing spondylitis (AS). Anecdotal reports suggest that the use of anti-TNF drugs may be related to lung disease and pulmonary fibrosis. To examine the association between anti-TNF drugs and the development ...

Last Updated: 27 May 2016

Go To URL
Emerging biomarkers in psoriatic arthritis.
 

Author(s): So Yeon Paek, Ling Han, Matthew Weiland, Chuan-Jian Lu, Kathleen McKinnon, Li Zhou, Henry W Lim, James T Elder, Qing-Sheng Mi

Journal: IUBMB Life. 2015 Dec;67(12):923-7.

 

Psoriasis is an immune-mediated skin disease which affects 2-4% of the worldwide population. Approximately 20-30% of patients with psoriasis develop psoriatic arthritis (PsA), a frequently destructive and disabling condition. As skin manifestations precede joint symptoms in nearly ...

Last Updated: 23 Dec 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 21 Oct 2016

Go to URL