Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 1492 free, full-text research articles on human participants. First 3 results:

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
 

Author(s): Hansjörg Baurecht, Melanie Hotze, Stephan Brand, Carsten Büning, Paul Cormican, Aiden Corvin, David Ellinghaus, Eva Ellinghaus, Jorge Esparza-Gordillo, Regina Fölster-Holst, Andre Franke, Christian Gieger, Norbert Hubner, Thomas Illig, Alan D Irvine, Michael Kabesch, Young A E Lee, Wolfgang Lieb, Ingo Marenholz, W H Irwin McLean, Derek W Morris, Ulrich Mrowietz, Rajan Nair, Markus M Nöthen, Natalija Novak, Grainne M O'Regan, , Stefan Schreiber, Catherine Smith, Konstantin Strauch, Philip E Stuart, Richard Trembath, Lam C Tsoi, Michael Weichenthal, Jonathan Barker, James T Elder, Stephan Weidinger, Heather J Cordell, Sara J Brown

Journal: Am. J. Hum. Genet.. 2015 Jan;96(1):104-20.

 

Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive clinical phenotypes and opposing immune mechanisms. Despite ...

Last Updated: 10 Jan 2015

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Psoriasis as a manifestation of HIV-related immune reconstitution inflammatory syndrome.
 

Author(s): Shivani V Tripathi, Kieron S Leslie, Toby A Maurer, Erin H Amerson

Journal: J. Am. Acad. Dermatol.. 2015 Jan;72(1):e35-6.

 

Last Updated: 16 Dec 2014

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Varicella zoster virus-associated generalized pustular psoriasis in a baby with heterozygous IL36RN mutation.
 

Author(s): Kazumitsu Sugiura, Ryuhei Uchiyama, Ryuhei Okuyama, Masashi Akiyama

Journal: J. Am. Acad. Dermatol.. 2014 Nov;71(5):e216-8.

 

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 238 free, full-text review articles on human participants. First 3 results:

The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis.
 

Author(s): A Batycka-Baran, J Maj, R Wolf, J C Szepietowski

Journal: J Immunol Res. 2014 ;2014():628289.

 

The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules ...

Last Updated: 6 Jun 2014

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JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis.
 

Author(s): Leeyen Hsu, April W Armstrong

Journal: J Immunol Res. 2014 ;2014():283617.

 

Janus kinase (JAK) pathways are key mediators in the immunopathogenesis of psoriasis. Psoriasis treatment has evolved with the advent of targeted therapies, which inhibit specific components of the psoriasis proinflammatory cascade. JAK inhibitors have been studied in early phase ...

Last Updated: 2 Jun 2014

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Nail psoriasis: a review of the literature.
 

Author(s): Karen Regina Rosso Schons, Cristiane Faccin Knob, Nádia Murussi, André Avelino Costa Beber, Walter Neumaier, Odirlei André Monticielo

Journal: An Bras Dermatol. ;89(2):312-7.

 

Nails are considered epidermal appendages, and as such, are commonly affected in patients with psoriasis, 80% of whom are likely to develop nail psoriasis as a result of their condition. Two patterns of nail disorders have been shown to be caused by psoriasis. Nail matrix involvement ...

Last Updated: 28 Apr 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis
 

Status: Recruiting

Condition Summary: Nail Psoriasis; Plaque Psoriasis

 

Last Updated: 21 Apr 2015

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Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris
 

Status: Recruiting

Condition Summary: Psoriasis; Psoriasis Vulgaris

 

Last Updated: 1 Feb 2010

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Last Updated: 18 Apr 2015

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