Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 1531 free, full-text research articles on human participants. First 3 results:

Serum levels of TNF- α , IL-12/23 p40, and IL-17 in psoriatic patients with and without nail psoriasis: a cross-sectional study.
 

Author(s): Aikaterini Kyriakou, Aikaterini Patsatsi, Timoleon-Achilleas Vyzantiadis, Dimitrios Sotiriadis

Journal: ScientificWorldJournal. 2014 ;2014():508178.

 

Nail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels ...

Last Updated: 23 Jan 2015

Go To URL
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
 

Author(s): Hansjörg Baurecht, Melanie Hotze, Stephan Brand, Carsten Büning, Paul Cormican, Aiden Corvin, David Ellinghaus, Eva Ellinghaus, Jorge Esparza-Gordillo, Regina Fölster-Holst, Andre Franke, Christian Gieger, Norbert Hubner, Thomas Illig, Alan D Irvine, Michael Kabesch, Young A E Lee, Wolfgang Lieb, Ingo Marenholz, W H Irwin McLean, Derek W Morris, Ulrich Mrowietz, Rajan Nair, Markus M Nöthen, Natalija Novak, Grainne M O'Regan, , Stefan Schreiber, Catherine Smith, Konstantin Strauch, Philip E Stuart, Richard Trembath, Lam C Tsoi, Michael Weichenthal, Jonathan Barker, James T Elder, Stephan Weidinger, Heather J Cordell, Sara J Brown

Journal: Am. J. Hum. Genet.. 2015 Jan;96(1):104-20.

 

Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive clinical phenotypes and opposing immune mechanisms. Despite ...

Last Updated: 10 Jan 2015

Go To URL
Psoriasis as a manifestation of HIV-related immune reconstitution inflammatory syndrome.
 

Author(s): Shivani V Tripathi, Kieron S Leslie, Toby A Maurer, Erin H Amerson

Journal: J. Am. Acad. Dermatol.. 2015 Jan;72(1):e35-6.

 

Last Updated: 16 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 244 free, full-text review articles on human participants. First 3 results:

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials.
 

Author(s): Richard Conway, Candice Low, Robert J Coughlan, Martin J O'Donnell, John J Carey

Journal:

 

To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.

Last Updated: 15 Mar 2015

Go To URL
The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis.
 

Author(s): Camille Roubille, Vincent Richer, Tara Starnino, Collette McCourt, Alexandra McFarlane, Patrick Fleming, Stephanie Siu, John Kraft, Charles Lynde, Janet Pope, Wayne Gulliver, Stephanie Keeling, Jan Dutz, Louis Bessette, Robert Bissonnette, Boulos Haraoui

Journal: Ann. Rheum. Dis.. 2015 Mar;74(3):480-9.

 

The objective of this systematic literature review was to determine the association between cardiovascular events (CVEs) and antirheumatic drugs in rheumatoid arthritis (RA) and psoriatic arthritis (PsA)/psoriasis (Pso). Systematic searches were performed of MEDLINE, EMBASE and Cochrane ...

Last Updated: 6 Feb 2015

Go To URL
Targeting VEGF/VEGFR in the treatment of psoriasis.
 

Author(s): Wei Li, Xiao-Yong Man, Jia-Qi Chen, Jiong Zhou, Sui-Qing Cai, Min Zheng

Journal: Discov Med. 2014 Sep;18(98):97-104.

 

Psoriasis is a common chronic skin disorder characterized by cutaneous inflammation and keratinocyte hyperproliferation. In the past decade, a number of novel effective biological agents have been developed to treat moderate-to-severe psoriasis. However, these drugs have potential ...

Last Updated: 17 Sep 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris
 

Status: Recruiting

Condition Summary: Psoriasis; Psoriasis Vulgaris

 

Last Updated: 1 Feb 2010

Go to URL

Last Updated: 15 Jun 2015

Go to URL

Last Updated: 15 Jun 2015

Go to URL