Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. The skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. A problem with the immune system causes psoriasis. In a process called cell turnover, skin cells that grow deep in the skin rise to the surface. Normally, this takes a month. In psoriasis, it happens in just days because the cells rise too fast. Although symptoms may come and go, for many, psoriasis is a lifelong condition. Infections, stress, dry skin and certain medications may make symptoms worse. Psoriasis usually occurs in adults. It sometimes runs in families. Treatments include creams, medications and light therapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 1431 free, full-text research articles on human participants. First 3 results:

Erythrodermic CD8+ pseudolymphoma during infliximab treatment in a patient with psoriasis: use of cyclosporine as a rescue therapy.
 

Author(s): Gilles Safa, Karine Luce, Laure Darrieux, Laurent Tisseau, Nicolas Ortonne

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e149-50.

 

Last Updated: 15 Sep 2014

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Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.
 

Author(s): Yukinori Okada, Buhm Han, Lam C Tsoi, Philip E Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M Bowcock, Gerald G Krueger, Michael Weichenthal, John J Voorhees, Proton Rahman, Peter K Gregersen, Andre Franke, Rajan P Nair, Gonçalo R Abecasis, Dafna D Gladman, James T Elder, Paul I W de Bakker, Soumya Raychaudhuri

Journal: Am. J. Hum. Genet.. 2014 Aug;95(2):162-72.

 

Psoriasis vulgaris (PsV) risk is strongly associated with variation within the major histocompatibility complex (MHC) region, but its genetic architecture has yet to be fully elucidated. Here, we conducted a large-scale fine-mapping study of PsV risk in the MHC region in 9,247 PsV-affected ...

Last Updated: 9 Aug 2014

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[Intestinal strongyloidiasis in a psoriasis patient with diabetes].
 

Author(s): Meryem Iraz, Ulkü Karaman, Buğçe Topukçu, Mehmet Ziya Doymaz

Journal: Turkiye Parazitol Derg. 2014 Jun;38(2):127-30.

 

This case study underlined the importance of parasitological examination before starting immunosuppressive treatment since a heavy burden of strongyloidiasis could lead to fatal infections. It represents the first strongyloidiasis from a patient with psoriasis and diabetes mellitus ...

Last Updated: 13 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 232 free, full-text review articles on human participants. First 3 results:

[Psychological and biological background of the correlation between psoriasis and stress].
 

Author(s): L János Kálmán, Xénia Gonda, Lajos Kemény, Zoltán Rihmer, Zoltán Janka

Journal: Orv Hetil. 2014 Jun;155(24):939-48.

 

Stress is considered as a major contributor to the development and exacerbation of psoriasis by a significant proportion of patients and dermatologists. As both stressor and its effects are subject-dependent, thus extremely difficult to measure, our understanding of the exact role ...

Last Updated: 11 Jun 2014

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The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis.
 

Author(s): A Batycka-Baran, J Maj, R Wolf, J C Szepietowski

Journal: J Immunol Res. 2014 ;2014():628289.

 

The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules ...

Last Updated: 6 Jun 2014

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JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis.
 

Author(s): Leeyen Hsu, April W Armstrong

Journal: J Immunol Res. 2014 ;2014():283617.

 

Janus kinase (JAK) pathways are key mediators in the immunopathogenesis of psoriasis. Psoriasis treatment has evolved with the advent of targeted therapies, which inhibit specific components of the psoriasis proinflammatory cascade. JAK inhibitors have been studied in early phase ...

Last Updated: 2 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris
 

Status: Recruiting

Condition Summary: Psoriasis; Psoriasis Vulgaris

 

Last Updated: 1 Feb 2010

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A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis
 

Status: Recruiting

Condition Summary: Nail Psoriasis; Plaque Psoriasis

 

Last Updated: 8 Oct 2014

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A Study to Evaluate the Effectiveness of STELARA ™ (USTEKINUMAB) in the Treatment of Scalp Psoriasis
 

Status: Not yet recruiting

Condition Summary: Scalp Psoriasis; Plaque Psoriasis

 

Last Updated: 17 Jul 2012

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