Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 2231 free, full-text research articles on human participants. First 3 results:

Regional Differences in the Prescription of Biologics for Psoriasis in Sweden: A Register-Based Study of 4168 Patients.
 

Author(s): Paul S Calara, Rikard Althin, Katarina Steen Carlsson, Marcus Schmitt-Egenolf

Journal: BioDrugs. 2017 Feb;31(1):75-82.

 

Observational studies suggest an inequitable prescription of biologics in psoriasis care, which may be attributed to geographical differences in treatment access. Sweden regularly ranks high in international comparisons of equitable healthcare, and is, in connection with established ...

Last Updated: 18 Jan 2017

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Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine.
 

Author(s): Ramzi Shawahna, Nidal Amin Jaradat

Journal:

 

Psoriasis is a frequent skin inflammatory disorder that inflicts millions of patients around the globe. To meet their healthcare needs, patients with psoriasis often seek treatment outside the allopathic paradigm. Use of medicinal plants has emerged as one of the most common and preferred ...

Last Updated: 4 Jan 2017

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Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort.
 

Author(s): Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez,

Journal: Medicine (Baltimore). 2016 Dec;95(51):e5652.

 

The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section ...

Last Updated: 21 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 333 free, full-text review articles on human participants. First 3 results:

Role of IL-17A signalling in psoriasis and associated bone loss.
 

Author(s): Özge Uluçkan, Erwin F Wagner

Journal: Clin. Exp. Rheumatol.. ;34(4 Suppl 98):17-20.

 

Inflammation is a physiological reaction to tissue injury, pathogen invasion and a natural response to various stress stimuli. Innate and adaptive immune cells are activated and recruited to the site of inflammation to suppress or promote inflammation. The recruitment and activation ...

Last Updated: 2 Sep 2016

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A Clinician's Guide to the Diagnosis and Treatment of Candidiasis in Patients with Psoriasis.
 

Author(s): April W Armstrong, Michael Bukhalo, Andrew Blauvelt

Journal: Am J Clin Dermatol. 2016 Aug;17(4):329-36.

 

Many of the molecular pathways associated with psoriasis pathogenesis are also involved in host defense mechanisms that protect against common pathogens. Candida can stimulate the production of cytokines that trigger or exacerbate psoriasis, and many systemic psoriasis treatments ...

Last Updated: 28 Jul 2016

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Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis.
 

Author(s): Ilaria Peluso, Arturo Cavaliere, Maura Palmery

Journal:

 

Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities. In this review we aimed to evaluate the relationship between plasma total antioxidant capacity (TAC) and ...

Last Updated: 5 Jul 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 24 Jan 2017

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Efficacy and Safety Study of NP000888 in Subjects With Plaque and Nail Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 14 Feb 2017

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The Association Between Psoriasis and Intestinal Bacterial Population
 

Status: Not yet recruiting

Condition Summary: Psoriasis

 

Last Updated: 16 Apr 2015

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