Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 2060 free, full-text research articles on human participants. First 3 results:

[Cost Effectiveness of Treatments of Psoriasis with a PASI 75 and one Period of 12 Weeks].
 

Author(s): Fernando Alfageme Roldán, Almudena Bermejo Hernando, José Luís Calvo González, Pilar Marqués Sánchez

Journal:

 

The objective was to evaluate the efficiency (relation between the cost and the results in health) of the treatments in psoriasis, seeking a higher quality of economic evaluations, consistency and transparency in these studies.

Last Updated: 13 Apr 2016

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Human ß-Defensin 3 and Its Mouse Ortholog Murine ß-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice.
 

Author(s): Cheryl M Sweeney, Shane E Russell, Anna Malara, Genevieve Kelly, Rosalind Hughes, Anne-Marie Tobin, Karoline Adamzik, Patrick T Walsh, Brian Kirby

Journal: J. Invest. Dermatol.. 2016 Mar;136(3):723-7.

 

Last Updated: 26 Mar 2016

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Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.
 

Author(s): Susan H Smith, Carlos E Peredo, Yukimasa Takeda, Thi Bui, Jessica Neil, David Rickard, Elizabeth Millerman, Jean-Philippe Therrien, Edwige Nicodeme, Jean-Marie Brusq, Veronique Birault, Fabrice Viviani, Hans Hofland, Anton M Jetten, Javier Cote-Sierra

Journal:

 

Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, the stratum corneum prevents penetration of ...

Last Updated: 13 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 276 free, full-text review articles on human participants. First 3 results:

Adenosine: an endogenous mediator in the pathogenesis of psoriasis.
 

Author(s): Moira Festugato

Journal: An Bras Dermatol. ;90(6):862-7.

 

It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured ...

Last Updated: 7 Jan 2016

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Association between Psoriasis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis.
 

Author(s): Xin Li, Lingjun Kong, Fulun Li, Chen Chen, Rong Xu, Hongshen Wang, Shiguang Peng, Min Zhou, Bin Li

Journal:

 

Psoriasis is considered a systemic inflammatory disorder. Previous studies have reported conflicting positive or negative correlations between psoriasis and chronic obstructive pulmonary disease. We performed a meta-analysis to determine whether there is an associated risk between ...

Last Updated: 24 Dec 2015

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An Exploration of the Role of MicroRNAs in Psoriasis: A Systematic Review of the Literature.
 

Author(s): Run-Yue Huang, Li Li, Mao-Jie Wang, Xiu-Min Chen, Qing-Chun Huang, Chuan-Jian Lu

Journal: Medicine (Baltimore). 2015 Nov;94(45):e2030.

 

Psoriasis is recently characterized by a specific microRNAs (miRNAs) expression profile, which guides the researchers' efforts to explore the therapeutic targets and objective biomarkers that reflect the diagnosis and disease activity in clinical use for psoriasis.The paper presents ...

Last Updated: 12 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

MSB11022 in Moderate to Severe Chronic Plaque Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis; Plaque Type Psoriasis; Moderate to Severe Plaque Psoriasis

 

Last Updated: 14 Jul 2016

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Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris
 

Status: Recruiting

Condition Summary: Psoriasis; Psoriasis Vulgaris

 

Last Updated: 1 Feb 2010

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Safety and Efficacy Study of Etanercept (Qiangke®) to Treat Moderate to Severe Plaque Psoriasis
 

Status: Recruiting

Condition Summary: Plaque Psoriasis; Psoriasis

 

Last Updated: 7 Mar 2016

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