Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 2220 free, full-text research articles on human participants. First 3 results:

Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis.
 

Author(s): Juan Luis Sanz-Cabanillas, Juan Ruano, Francisco Gomez-Garcia, Patricia Alcalde-Mellado, Jesus Gay-Mimbrera, Macarena Aguilar-Luque, Beatriz Maestre-Lopez, Marcelino Gonzalez-Padilla, Pedro J Carmona-Fernandez, Antonio Velez Garcia-Nieto, Beatriz Isla-Tejera

Journal:

 

Moderate-to-severe psoriasis is associated with significant comorbidity, an impaired quality of life, and increased medical costs, including those associated with treatments. Systematic reviews (SRs) and meta-analyses (MAs) of randomized clinical trials are considered two of the best ...

Last Updated: 13 Apr 2017

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Pityriasis Lichenoides et Varioliformis Acuta and Psoriasis Vulgaris: Mere Coincidence or a Rare Association?
 

Author(s): Yi-Di Liu, Yue-Ping Zeng, Ya-Nan Wang, Wen-Ling Zhao, Yue-Hua Liu, Li Li

Journal: Chin. Med. J.. 2017 02;130(4):501-502.

 

Last Updated: 20 Feb 2017

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Whole Exome Sequencing in Psoriasis Patients Contributes to Studies of Acitretin Treatment Difference.
 

Author(s): Xingchen Zhou, Yijing He, Yehong Kuang, Jie Li, Jianglin Zhang, Mingliang Chen, Wangqing Chen, Juan Su, Shuang Zhao, Panpan Liu, Menglin Chen, Minxue Shen, Xiaoping Chen, Wu Zhu, Xiang Chen

Journal:

 

Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery ...

Last Updated: 1 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 346 free, full-text review articles on human participants. First 3 results:

From the Medical Board of the National Psoriasis Foundation: Treatment targets for plaque psoriasis.
 

Author(s): April W Armstrong, Michael P Siegel, Jerry Bagel, Erin E Boh, Megan Buell, Kevin D Cooper, Kristina Callis Duffin, Lawrence F Eichenfield, Amit Garg, Joel M Gelfand, Alice B Gottlieb, John Y M Koo, Neil J Korman, Gerald G Krueger, Mark G Lebwohl, Craig L Leonardi, Arthur M Mandelin, M Alan Menter, Joseph F Merola, David M Pariser, Ronald B Prussick, Caitriona Ryan, Kara N Shah, Jeffrey M Weinberg, MaryJane O U Williams, Jashin J Wu, Paul S Yamauchi, Abby S Van Voorhees

Journal: J. Am. Acad. Dermatol.. 2017 Feb;76(2):290-298.

 

An urgent need exists in the United States to establish treatment goals in psoriasis.

Last Updated: 2 Dec 2016

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Efficacy of Immunobiologic and Small Molecule Inhibitor Drugs for Psoriasis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
 

Author(s): André Vicente Esteves de Carvalho, Rodrigo Pereira Duquia, Bernardo Lessa Horta, Renan Rangel Bonamigo

Journal: Drugs R D. 2017 Mar;17(1):29-51.

 

Psoriasis is an immune-mediated inflammatory disease for which treatment has evolved over the past few years due to the introduction of immunobiologic and small molecule inhibitor medications. A better understanding of the comparative efficacies of drugs may help doctors to choose ...

Last Updated: 13 Nov 2016

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A Review of Ixekizumab, an Anti-Interleukin-17A Monoclonal Antibody, for Moderate-to-Severe Plaque Psoriasis.
 

Author(s): A J Peranteau, A E Turkeltaub, Y Tong, Z Nawas, S K Tyring

Journal: Skin Therapy Lett.. 2016 Nov;21(6):1-6.

 

Psoriasis is a multifactorial chronic skin disease that can have significant detrimental effects on patients' physical, mental, antibodypsychosocial wellbeing. Patients often suffer from a decreased quality of life along with numerous comorbidities. Recent advances in our understanding ...

Last Updated: 8 Nov 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 24 Jan 2017

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Efficacy and Safety Study of NP000888 in Subjects With Plaque and Nail Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 18 Apr 2017

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Videocapillaroscopy Assessment During Systemic Agent Therapy in Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 22 Sep 2016

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