Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 1491 free, full-text research articles on human participants. First 3 results:

A case of secondary syphilis mimicking palmoplantar psoriasis in HIV infected patient.
 

Author(s): Maraya de Jesus Semblano Bittencourt, Arival Cardoso de Brito, Bianca Angelina Macêdo do Nascimento, Alessandra Haber Carvalho, Manoel Dias do Nascimento

Journal: An Bras Dermatol. ;90(3 Suppl 1):216-9.

 

Due to diverse clinical and histopathological presentations, diagnosis of secondary syphilis can occasionally prove challenging. Variable clinical presentations of secondary syphilis in HIV disease may result in an incorrect diagnosis and an inappropriate treatment regimen. Similarly, ...

Last Updated: 28 Aug 2015

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A case of generalized ostraceous psoriasis mimicking dermatitis neglecta.
 

Author(s): Bianca Angelina Macêdo do Nascimento, Alessandra Haber Carvalho, Carolina Moraes Dias, Thaiane Lima Lage, Clívia Maria Oliveira Carneiro, Maraya de Jesus Semblano Bittencourt

Journal: An Bras Dermatol. ;90(3 Suppl 1):197-9.

 

Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis ...

Last Updated: 28 Aug 2015

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Linear psoriasis: case report on three year old child.
 

Author(s): Daniela de Almeida Figueiras, Renata Cavalcanti Cauas, Daniela Mayumi Takano, Ticiana Batista Ramos, Ayana Karla de Oliveira Ferreira Marinho, Milena Sonely Mendonça Bezerra

Journal: An Bras Dermatol. ;90(3 Suppl 1):194-6.

 

Atypical and unusual locations of psoriasis are very frequent. However, localized linear psoriasis is rare, with few cases described in the literature. It is characterized by a linear distribution of psoriasis lesions along Blaschko lines. We report the case of a three years old child, ...

Last Updated: 28 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 229 free, full-text review articles on human participants. First 3 results:

Sarcoidosis at onset of Psoriasis: a common immunopathogenesis. Review and case report.
 

Author(s): A Petroianni, I Halili, M Lagalla, E Mougkaraki, C Terzano

Journal: Eur Rev Med Pharmacol Sci. 2015 May;19(10):1773-8.

 

Sarcoidosis is an inflammatory systemic disease that may present in many different ways. The pathophysiological mechanisms are not still well known, although sarcoidosis results from an exaggerated Th1 immune response. About 30% of sarcoidosis patients may suffer from skin lesions ...

Last Updated: 5 Jun 2015

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Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials.
 

Author(s): Richard Conway, Candice Low, Robert J Coughlan, Martin J O'Donnell, John J Carey

Journal:

 

To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.

Last Updated: 15 Mar 2015

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Nilotinib-induced psoriasis in a patient of chronic myeloid leukemia responding to methotrexate.
 

Author(s): Sukhjot Kaur, Amanjot Kaur Arora, Jagdev S Sekhon, Neena Sood

Journal: Indian J Dermatol Venereol Leprol. ;81(2):216-8.

 

Last Updated: 10 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

MSB11022 in Moderate to Severe Chronic Plaque Psoriasis
 

Status: Not yet recruiting

Condition Summary: Psoriasis; Plaque Type Psoriasis; Moderate to Severe Plaque Psoriasis

 

Last Updated: 5 Feb 2016

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Phase 3 Study of M923 and Humira® in Subjects With Chronic Plaque-type Psoriasis
 

Status: Recruiting

Condition Summary: Chronic Plaque Psoriasis; Psoriasis

 

Last Updated: 19 Oct 2015

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Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris
 

Status: Recruiting

Condition Summary: Psoriasis; Psoriasis Vulgaris

 

Last Updated: 1 Feb 2010

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