Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 2247 free, full-text research articles on human participants. First 3 results:

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis.
 

Author(s): Kenneth B Gordon, Andrew Blauvelt, Kim A Papp, Richard G Langley, Thomas Luger, Mamitaro Ohtsuki, Kristian Reich, David Amato, Susan G Ball, Daniel K Braun, Gregory S Cameron, Janelle Erickson, Robert J Konrad, Talia M Muram, Brian J Nickoloff, Olawale O Osuntokun, Roberta J Secrest, Fangyi Zhao, Lotus Mallbris, Craig L Leonardi, , ,

Journal: N. Engl. J. Med.. 2016 Jul;375(4):345-56.

 

Two phase 3 trials (UNCOVER-2 and UNCOVER-3) showed that at 12 weeks of treatment, ixekizumab, a monoclonal antibody against interleukin-17A, was superior to placebo and etanercept in the treatment of moderate-to-severe psoriasis. We report the 60-week data from the UNCOVER-2 and ...

Last Updated: 28 Jul 2016

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Psoriasis - The Life Course Approach.
 

Author(s): Michael Dennis Linder, Stefano Piaserico, Matthias Augustin, Anna Belloni Fortina, Arnon D Cohen, Uwe Gieler, Gregor B E Jemec, Alexa Boer Kimball, Andrea Peserico, Francesca Sampogna, Richard B Warren, John de Korte

Journal: Acta Derm. Venereol.. 2016 Aug;96(217):102-8.

 

Over the last decades, Life Course Research (LCR), predominantly the domain of sociology, has been increasingly applied in health research, as Life Course Epidemiology (LCE). The latter is concerned with disease patterns over time, accumulation of exposures over time, critical time ...

Last Updated: 23 Aug 2016

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Discriminating the Presence of Psychological Distress in Patients Suffering from Psoriasis: An Application of the Clinimetric Approach in Dermatology.
 

Author(s): Emanuela Offidani, Donatella Del Basso, Francesca Prignago, Elena Tomba

Journal: Acta Derm. Venereol.. 2016 Aug;96(217):69-73.

 

Psoriasis is a chronic dermatologic disease that negatively impacts physical and mental health of patients as well as their social and work life. The aim of this study is to illustrate, by a clinimetric approach the differences in psychological distress and well-being between patients ...

Last Updated: 23 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 326 free, full-text review articles on human participants. First 3 results:

Role of IL-17A signalling in psoriasis and associated bone loss.
 

Author(s): Özge Uluçkan, Erwin F Wagner

Journal: Clin. Exp. Rheumatol.. ;34(4 Suppl 98):17-20.

 

Inflammation is a physiological reaction to tissue injury, pathogen invasion and a natural response to various stress stimuli. Innate and adaptive immune cells are activated and recruited to the site of inflammation to suppress or promote inflammation. The recruitment and activation ...

Last Updated: 2 Sep 2016

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Interplay of Itch and Psyche in Psoriasis: An Update.
 

Author(s): Adam Reich, Karolina Mędrek, Jacek C Szepietowski

Journal: Acta Derm. Venereol.. 2016 Aug;96(217):55-7.

 

Itch or pruritus is defined as an unpleasant subjective sensation leading to the need or to the idea of scratching. A number of studies have shown that pruritus is often responsible for marked morbidity, quality of life impairment, and even for increased mortality. Patients suffering ...

Last Updated: 23 Aug 2016

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Safety of ustekinumab in severe psoriasis with chronic hepatitis B.
 

Author(s): Anelise Rocha Raymundo, Ana Paula Berreta Facin, Caio César Silva de Castro, Adriane Reichert Faria

Journal: Indian J Dermatol Venereol Leprol. ;82(3):326-8.

 

Last Updated: 19 Apr 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 6 Jun 2016

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Efficacy and Safety Study of NP000888 in Subjects With Plaque and Nail Psoriasis
 

Status: Not yet recruiting

Condition Summary: Psoriasis

 

Last Updated: 15 Dec 2016

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The Association Between Psoriasis and Intestinal Bacterial Population
 

Status: Not yet recruiting

Condition Summary: Psoriasis

 

Last Updated: 16 Apr 2015

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