Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 827 free, full-text research articles on human participants. First 3 results:

The effects of hemolysis on plasma prothrombin time and activated partial thromboplastin time tests using photo-optical method.
 

Author(s): Yetti Hernaningsih, Jeine Stela Akualing

Journal: Medicine (Baltimore). 2017 Sep;96(38):e7976.

 

Hemolysis is the most common reason why coagulation test samples are rejected. However, the effects of hemolysis on plasma prothrombin time (PPT) and activated partial thromboplastin time (APTT) are rarely investigated and the results are controversial. This research aims to analyze ...

Last Updated: 20 Sep 2017

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Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate.
 

Author(s): Herbert Schöchl, Oliver Grottke, Ken Sutor, Kieron Dony, Martin Schreiber, Marco Ranucci, Peter W Collins

Journal: Anesth. Analg.. 2017 Nov;125(5):1471-1474.

 

Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship ...

Last Updated: 31 Aug 2017

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Effects of Tramadol Coadministration on Prothrombin Time-International Normalized Ratio in Patients Receiving Warfarin.
 

Author(s): Tomomi Hosono, Aiko Kondo, Yasuyuki Kambayashi, Masato Homma

Journal: Yakugaku Zasshi. 2017 ;137(8):999-1003.

 

Several case studies have reported a possible drug interaction between warfarin and tramadol where tramadol coadministration enhanced the antithrombotic effects of warfarin. To assess this drug interaction, changes in prothrombin time-international normalized ratio (PT-INR) before ...

Last Updated: 3 Aug 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 38 free, full-text review articles on human participants. First 3 results:

Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation.
 

Author(s): Oliver Grottke, James Aisenberg, Richard Bernstein, Patrick Goldstein, Menno V Huisman, Dara G Jamieson, Jerrold H Levy, Charles V Pollack, Alex C Spyropoulos, Thorsten Steiner, Gregory J Del Zoppo, John Eikelboom

Journal:

 

Dabigatran is effective in decreasing the risk of ischaemic stroke in patients with atrial fibrillation. However, like all anticoagulants, it is associated with a risk of bleeding. In cases of trauma or emergency surgery, emergency reversal of dabigatran-induced anticoagulation may ...

Last Updated: 29 Apr 2016

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A Systematic Review of Des-γ-Carboxy Prothrombin for the Diagnosis of Primary Hepatocellular Carcinoma.
 

Author(s): Ji De, Yi Shen, Jinyu Qin, Li Feng, Yiping Wang, Li Yang

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3448.

 

Determining the serum des-γ-carboxy-prothrombin (DCP) level is of great importance for the diagnosis of primary hepatocellular carcinoma (PHC). Although several studies have investigated the accuracy of diagnostic DCP tests for PHC, the results have been inconsistent.The aim of this ...

Last Updated: 29 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal
 

Status: Recruiting

Condition Summary: Acute Bleeding on Long-Term Anticoagulation Therapy; Hemorrhage; Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time); Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

 

Last Updated: 24 Apr 2017

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Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
 

Status: Not yet recruiting

Condition Summary: Platelet Function Tests; Thrombin Generation Tests; Perioperative Coagulopathy

 

Last Updated: 11 Jul 2016

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Reversal of Dabigatran With Prothrombin Complex Concentrate
 

Status: Recruiting

Condition Summary: Drug Action Reversal

 

Last Updated: 10 May 2016

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