Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 814 free, full-text research articles on human participants. First 3 results:

Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series.
 

Author(s): Nina Haagenrud Schultz, Runar Lundblad, Pål Andre Holme

Journal:

 

The lack of an antidote against factor Xa inhibitors in case of major bleeding or need for urgent surgery is a concern to clinicians. Guidelines on managing major bleeding in patients under anticoagulation with a factor Xa inhibitor suggest several hemostatic agents to reverse the ...

Last Updated: 31 Dec 1969

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Randomised controlled trial protocol to evaluate a fixed dose prothrombin complex concentrate against the variable dose in vitamin K antagonist related bleeding (PROPER3).
 

Author(s): Rahat A Abdoellakhan, Nakisa Khorsand, Reinier M Van Hest, Nic Veeger, Ewoud Ter Avest, Paula F Ypma, Laura M Faber, Karina Meijer

Journal:

 

There is currently little evidence for the optimal dosing strategy of four-factor prothrombin complex concentrates (PCC) in vitamin K antagonist (VKA)-related bleeds. The generally accepted dosing strategy is the use of a variable dose calculated using patient-specific characteristics ...

Last Updated: 31 Dec 1969

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Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification.
 

Author(s): Hideki Hashimoto, Makoto Saito, Naoki Kanda, Takehito Yamamoto, Makiko Mieno, Shuji Hatakeyama

Journal:

 

Several studies have reported that daptomycin induced artificial prolongation of prothrombin time (PT) in some test reagents, particularly in warfarin users. However, it remains unknown whether the artificial prolongation can be affected by coagulation abnormalities other than the ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 44 free, full-text review articles on human participants. First 3 results:

Prothrombin Complex Concentrate for Vitamin K Antagonist-Associated Intracranial Hemorrhage - Global Evidence and the Japanese Perspective.
 

Author(s): Masahiro Yasaka, Andres Brainsky, Kazunori Toyoda

Journal: Circ. J.. 2017 Oct;81(11):1564-1573.

 

Patients receiving vitamin K antagonists (VKAs) are at increased risk of bleeding. Intracranial hemorrhage (ICH) is a major cause of morbidity and mortality in this population, and is a particular concern among Japanese clinicians, given reports of an elevated risk of this bleeding ...

Last Updated: 31 Dec 1969

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Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis.
 

Author(s): Marjolein P A Brekelmans, Kim van Ginkel, Joost G Daams, Barbara A Hutten, Saskia Middeldorp, Michiel Coppens

Journal: J. Thromb. Thrombolysis. 2017 Jul;44(1):118-129.

 

Prothrombin complex concentrate (PCC) is used for reversal of vitamin K antagonists (VKA) in patients with bleeding complications. This study aims to assess benefits and harms of 4-factor PCC compared to fresh frozen plasma (FFP) or no treatment in VKA associated bleeding. PubMed, ...

Last Updated: 31 Dec 1969

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Why is it so difficult to show that prothrombin complex concentrates are superior to fresh-frozen plasma for warfarin reversal?
 

Author(s): Giorgia Saccullo, Alexandra M Bucko, Joost J Van Veen, Michael Makris

Journal: Blood Transfus. 2017 05;15(3):277-278.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal
 

Status: Recruiting

Condition Summary: Acute Bleeding on Long-Term Anticoagulation Therapy; Hemorrhage; Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time); Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

 

Last Updated: 5 Jun 2018

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Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
 

Status: Not yet recruiting

Condition Summary: Platelet Function Tests; Thrombin Generation Tests; Perioperative Coagulopathy

 

Last Updated: 8 May 2018

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The Role of Prothrombin Gene Polymorphism as a Risk Factor for Recurrent Pregnancy Loss
 

Status: Not yet recruiting

Condition Summary: Recurrent Pregnancy Loss

 

Last Updated: 3 Jul 2017

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