Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 585 free, full-text research articles on human participants. First 3 results:

The linker connecting the two kringles plays a key role in prothrombin activation.
 

Author(s): Nicola Pozzi, Zhiwei Chen, Leslie A Pelc, Daniel B Shropshire, Enrico Di Cera

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(21):7630-5.

 

The zymogen prothrombin is proteolytically converted by factor Xa to the active protease thrombin in a reaction that is accelerated >3,000-fold by cofactor Va. This physiologically important effect is paradigmatic of analogous cofactor-dependent reactions in the coagulation and complement ...

Last Updated: 10 Jun 2014

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A deep vein thrombosis caused by 20209C>T mutation in homozygosis of the prothrombin gene in a Caucasian patient.
 

Author(s): Silvia Izquierdo Alvarez, Eva Barrio Ollero, Francisco Miguel Llinares Sanjuan, Fabiola Lorente Martínez, María Teresa Calvo Martín

Journal:

 

Additional nucleotide substitutions in the 3'-untranslated region of prothrombin gene could explain some thrombotic events and also adverse pregnancy outcomes. We describe the first case of a homozygous 20209C>T mutation as the cause of deep vein thrombosis in a Spanish patient.

Last Updated: 14 Mar 2014

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Rivaroxaban in clinical practice for atrial fibrillation with special reference to prothrombin time.
 

Author(s): Shinya Suzuki, Takayuki Otsuka, Koichi Sagara, Hiroto Kano, Shunsuke Matsuno, Yuko Kato, Hideaki Takai, Tokuhisa Uejima, Yuji Oikawa, Kazuyuki Nagashima, Hajime Kirigaya, Junji Yajima, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita

Journal: Circ. J.. 2014 ;78(3):763-6.

 

 Prothrombin time (PT) distribution in Japanese nonvalvular atrial fibrillation (NVAF) patients under rivaroxaban therapy remains to be clarified.

Last Updated: 27 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 17 free, full-text review articles on human participants. First 3 results:

Clinical use and the Italian demand for prothrombin complex concentrates.
 

Author(s): Massimo Franchini, Giancarlo M Liumbruno, Monica Lanzoni, Fabio Candura, Stefania Vaglio, Samantha Profili, Giuseppina Facco, Gabriele Calizzani, Giuliano Grazzini

Journal: Blood Transfus. 2013 Sep;11 Suppl 4():s94-100.

 

Last Updated: 16 Dec 2013

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Clinical use and the Italian demand for activated prothrombin complex and activated recombinant factor VII concentrates.
 

Author(s): Antonio Coppola, Annarita Tagliaferri, Gabriele Calizzani, Fabio Candura, Massimo Franchini, Carlo Ruosi, Giuliano Grazzini, Giovanni Di Minno

Journal: Blood Transfus. 2013 Sep;11 Suppl 4():s101-9.

 

Last Updated: 16 Dec 2013

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Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.
 

Author(s): A A Hanke, C Joch, K Görlinger

Journal: Br J Anaesth. 2013 May;110(5):764-72.

 

The rapid reversal of the effects of vitamin K antagonists is often required in cases of emergency surgery and life-threatening bleeding, or during bleeding associated with high morbidity and mortality such as intracranial haemorrhage. Increasingly, four-factor prothrombin complex ...

Last Updated: 19 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prognostic Value of Prothrombin Fragments 1+2 for Pulmonary Embolism Incidence
 

Status: Not yet recruiting

Condition Summary: Pulmonary Disease, Chronic Obstructive; Disease Exacerbation; Pulmonary Embolism; Prothrombin Fragments

 

Last Updated: 1 Mar 2010

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Thrombin Generation Numerical Models Validation in Haemophilic Case
 

Status: Not yet recruiting

Condition Summary: Haemophilia B; Haemophilia A

 

Last Updated: 21 Nov 2014

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Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery
 

Status: Recruiting

Condition Summary: Coronary Artery Bypass; Thrombosis

 

Last Updated: 8 May 2013

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