Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 811 free, full-text research articles on human participants. First 3 results:

Relationship Between Infarct Volume and Prothrombin Time-International Normalized Ratio in Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation.
 

Author(s): Mari Matsumoto, Manabu Sakaguchi, Shuhei Okazaki, Kazuo Hashikawa, Tsutomu Takahashi, Masayasu Matsumoto, Toshiho Ohtsuki, Takeshi Shimazu, Toshiki Yoshimine, Hideki Mochizuki, Kazuo Kitagawa

Journal: Circ. J.. 2017 Feb;81(3):391-396.

 

In Japan, warfarin treatment at prothrombin time-international normalized ratio (PT-INR) of 1.60-2.60 is recommended for elderly patients with nonvalvular atrial fibrillation (NVAF). But it remains unknown whether PT-INR 1.60-1.99 has a similar effect on stroke severity as a value ...

Last Updated: 3 Feb 2017

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4-Factor Prothrombin Complex Concentrate (PCC4, Kcentra®) Protocol Reduces Blood Requirements for Heart Transplantation: A Novel Protocol.
 

Author(s): Jacqueline Pratt Cleary, Laura Hodge, Brittany Palmer, Christopher J Barreiro, Amanda Ingemi

Journal:

 

BACKGROUND All patients with a ventricular assist device (VAD) awaiting heart transplantation are anticoagulated with warfarin to prevent thromboembolism. The use of 4 factor prothrombin complex concentrate (PCC4, Kcentra®) for anticoagulation reversal prior to surgery may include ...

Last Updated: 25 Aug 2016

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Early Decreases in α-Fetoprotein and Des-γ-carboxy Prothrombin Predict the Antitumor Effects of Hepatic Transarterial Infusion Chemotherapy with Cisplatin (CDDP) Powder in Patients with Advanced Hepatocellular Carcinoma.
 

Author(s): Takeshi Hatanaka, Satoru Kakizaki, Yasushi Shimada, Daichi Takizawa, Kenji Katakai, Yuichi Yamazaki, Ken Sato, Motoyasu Kusano, Masanobu Yamada

Journal: Intern. Med.. 2016 ;55(16):2163-71.

 

Objective We retrospectively investigated the relationship between the tumor response and serial changes in α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) during hepatic arterial infusion of a cisplatin powder formulation (CDDP powder) in patients with advanced hepatocellular ...

Last Updated: 15 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 37 free, full-text review articles on human participants. First 3 results:

Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation.
 

Author(s): Oliver Grottke, James Aisenberg, Richard Bernstein, Patrick Goldstein, Menno V Huisman, Dara G Jamieson, Jerrold H Levy, Charles V Pollack, Alex C Spyropoulos, Thorsten Steiner, Gregory J Del Zoppo, John Eikelboom

Journal:

 

Dabigatran is effective in decreasing the risk of ischaemic stroke in patients with atrial fibrillation. However, like all anticoagulants, it is associated with a risk of bleeding. In cases of trauma or emergency surgery, emergency reversal of dabigatran-induced anticoagulation may ...

Last Updated: 29 Apr 2016

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A Systematic Review of Des-γ-Carboxy Prothrombin for the Diagnosis of Primary Hepatocellular Carcinoma.
 

Author(s): Ji De, Yi Shen, Jinyu Qin, Li Feng, Yiping Wang, Li Yang

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3448.

 

Determining the serum des-γ-carboxy-prothrombin (DCP) level is of great importance for the diagnosis of primary hepatocellular carcinoma (PHC). Although several studies have investigated the accuracy of diagnostic DCP tests for PHC, the results have been inconsistent.The aim of this ...

Last Updated: 29 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal
 

Status: Recruiting

Condition Summary: Acute Bleeding on Long-Term Anticoagulation Therapy; Hemorrhage; Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time); Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

 

Last Updated: 24 Apr 2017

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Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
 

Status: Not yet recruiting

Condition Summary: Platelet Function Tests; Thrombin Generation Tests; Perioperative Coagulopathy

 

Last Updated: 11 Jul 2016

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Reversal of Dabigatran With Prothrombin Complex Concentrate
 

Status: Recruiting

Condition Summary: Drug Action Reversal

 

Last Updated: 10 May 2016

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