Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 590 free, full-text research articles on human participants. First 3 results:

Comparing prothrombin induced by vitamin K absence-II (PIVKA-II) with the oncofetal proteins glypican-3, Alpha feto protein and carcinoembryonic antigen in diagnosing hepatocellular carcinoma among Egyptian patients.
 

Author(s): Iman A Abd El Gawad, Ghada I Mossallam, Noha H Radwan, Heba M Elzawahry, Niveen M Elhifnawy

Journal: J Egypt Natl Canc Inst. 2014 Jun;26(2):79-85.

 

Hepatocellular carcinoma (HCC) is usually asymptomatic in the early stage and does not show elevated alpha-feto protein (AFP). AFP shows 60-80% sensitivity in diagnosing HCC. Glypican3 (GPC-3) is an oncofetal protein that is only detected in HCC cells but not in benign liver tissues, ...

Last Updated: 20 May 2014

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The linker connecting the two kringles plays a key role in prothrombin activation.
 

Author(s): Nicola Pozzi, Zhiwei Chen, Leslie A Pelc, Daniel B Shropshire, Enrico Di Cera

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(21):7630-5.

 

The zymogen prothrombin is proteolytically converted by factor Xa to the active protease thrombin in a reaction that is accelerated >3,000-fold by cofactor Va. This physiologically important effect is paradigmatic of analogous cofactor-dependent reactions in the coagulation and complement ...

Last Updated: 10 Jun 2014

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Guideline-concordant administration of prothrombin complex concentrate and vitamin K is associated with decreased mortality in patients with severe bleeding under vitamin K antagonist treatment (EPAHK study).
 

Author(s): Karim Tazarourte, Bruno Riou, Benjamin Tremey, Charles-Marc Samama, Eric Vicaut, Bernard Vigué,

Journal:

 

In vitamin K antagonist (VKA)-treated patients with severe hemorrhage, guidelines recommend prompt VKA reversal with prothrombin complex concentrate (PCC) and vitamin K. The aim of this observational cohort study was to evaluate the impact of guideline concordant administration of ...

Last Updated: 17 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 17 free, full-text review articles on human participants. First 3 results:

Clinical use and the Italian demand for prothrombin complex concentrates.
 

Author(s): Massimo Franchini, Giancarlo M Liumbruno, Monica Lanzoni, Fabio Candura, Stefania Vaglio, Samantha Profili, Giuseppina Facco, Gabriele Calizzani, Giuliano Grazzini

Journal: Blood Transfus. 2013 Sep;11 Suppl 4():s94-100.

 

Last Updated: 16 Dec 2013

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Clinical use and the Italian demand for activated prothrombin complex and activated recombinant factor VII concentrates.
 

Author(s): Antonio Coppola, Annarita Tagliaferri, Gabriele Calizzani, Fabio Candura, Massimo Franchini, Carlo Ruosi, Giuliano Grazzini, Giovanni Di Minno

Journal: Blood Transfus. 2013 Sep;11 Suppl 4():s101-9.

 

Last Updated: 16 Dec 2013

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Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.
 

Author(s): A A Hanke, C Joch, K Görlinger

Journal: Br J Anaesth. 2013 May;110(5):764-72.

 

The rapid reversal of the effects of vitamin K antagonists is often required in cases of emergency surgery and life-threatening bleeding, or during bleeding associated with high morbidity and mortality such as intracranial haemorrhage. Increasingly, four-factor prothrombin complex ...

Last Updated: 19 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prognostic Value of Prothrombin Fragments 1+2 for Pulmonary Embolism Incidence
 

Status: Not yet recruiting

Condition Summary: Pulmonary Disease, Chronic Obstructive; Disease Exacerbation; Pulmonary Embolism; Prothrombin Fragments

 

Last Updated: 1 Mar 2010

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Thrombin Generation Numerical Models Validation in Haemophilic Case
 

Status: Not yet recruiting

Condition Summary: Haemophilia B; Haemophilia A

 

Last Updated: 12 Feb 2015

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Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery
 

Status: Recruiting

Condition Summary: Coronary Artery Bypass; Thrombosis

 

Last Updated: 8 May 2013

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