Prothrombin

Common Name(s)

Prothrombin

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin" returned 581 free, full-text research articles on human participants. First 3 results:

A deep vein thrombosis caused by 20209C>T mutation in homozygosis of the prothrombin gene in a Caucasian patient.
 

Author(s): Silvia Izquierdo Alvarez, Eva Barrio Ollero, Francisco Miguel Llinares Sanjuan, Fabiola Lorente Martínez, María Teresa Calvo Martín

Journal:

 

Additional nucleotide substitutions in the 3'-untranslated region of prothrombin gene could explain some thrombotic events and also adverse pregnancy outcomes. We describe the first case of a homozygous 20209C>T mutation as the cause of deep vein thrombosis in a Spanish patient.

Last Updated: 14 Mar 2014

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Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes.
 

Author(s): Paras Karmacharya, Madan Raj Aryal, Anthony Donato

Journal: World J. Gastroenterol.. 2013 Nov;19(43):7813-5.

 

Mesenteric venous thrombosis (MVT) is a rare but life threatening form of bowel ischemia. It is implicated in 6%-9% of all cases of acute mesenteric ischemia. The proportion of patients with primary (or idiopathic) MVT varies from 0% to 49%, with a decrease in frequency secondary ...

Last Updated: 27 Nov 2013

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Detection of antiphosphatidylserine/prothrombin antibodies and their potential diagnostic value.
 

Author(s): Polona Žigon, Saša Čučnik, Aleš Ambrožič, Tanja Kveder, Snežna Sodin Šemrl, Blaž Rozman, Borut Božič

Journal: Clin. Dev. Immunol.. 2013 ;2013():724592.

 

Antiprothrombin antibodies, measured with phosphatidylserine/prothrombin complex (aPS/PT) ELISA, have been reported to be associated with antiphospholipid syndrome (APS). They are currently being evaluated as a potential classification criterion for this autoimmune disease, characterized ...

Last Updated: 4 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin" returned 15 free, full-text review articles on human participants. First 3 results:

Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.
 

Author(s): A A Hanke, C Joch, K Görlinger

Journal: Br J Anaesth. 2013 May;110(5):764-72.

 

The rapid reversal of the effects of vitamin K antagonists is often required in cases of emergency surgery and life-threatening bleeding, or during bleeding associated with high morbidity and mortality such as intracranial haemorrhage. Increasingly, four-factor prothrombin complex ...

Last Updated: 19 Apr 2013

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Perioperative use of prothrombin complex concentrates.
 

Author(s): M J Colomina, A Díez Lobo, I Garutti, A Gómez-Luque, J V Llau, E Pita

Journal: Minerva Anestesiol. 2012 Mar;78(3):358-68.

 

Prothrombin complex concentrates (PCCs) are purified drug products with hemostatic activity derived from a plasma pool. Today, PCCs contain a given and proportional amount of four non-activated vitamin K-dependent coagulation factors (II, VII, IX, and X), a variable amount of anticoagulant ...

Last Updated: 23 Feb 2012

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Clinical review: Prothrombin complex concentrates--evaluation of safety and thrombogenicity.
 

Author(s): Benny Sørensen, Donat R Spahn, Petra Innerhofer, Michael Spannagl, Rolf Rossaint

Journal: Crit Care. 2011 ;15(1):201.

 

Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications. The aims of the present review are to examine thrombotic complications reported ...

Last Updated: 27 Jul 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prognostic Value of Prothrombin Fragments 1+2 for Pulmonary Embolism Incidence
 

Status: Not yet recruiting

Condition Summary: Pulmonary Disease, Chronic Obstructive; Disease Exacerbation; Pulmonary Embolism; Prothrombin Fragments

 

Last Updated: 1 Mar 2010

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Last Updated: 26 Feb 2014

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