Protein S deficiency

Common Name(s)

Protein S deficiency

Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding.  Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis.  People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins.  Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein S deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Protein S deficiency" returned 127 free, full-text research articles on human participants. First 3 results:

Hereditary protein S deficiency leads to ischemic stroke.
 

Author(s): Zhao-Hui Wang, Zhi-Jun Zhao, Kang Xu, Guo-Bing Sun, Lin Song, Hong-Xiang Yin, Xiao-Qi Chen

Journal: Mol Med Rep. 2015 Sep;12(3):3279-84.

 

Hereditary protein S (PS) deficiency is an independent risk factor for venous thromboembolism. However, the correlation between PS and arterial thrombotic disease, such as cerebral thrombosis, is not clear. The present study focused on the molecular mechanisms underlying ischemic ...

Last Updated: 16 Jul 2015

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Skin necrosis complicated by warfarin-induced protein S deficiency.
 

Author(s): Tse-Yuan Liaw, Chung-Hsing Chang

Journal: J. Formos. Med. Assoc.. 2014 Oct;113(10):758-9.

 

Last Updated: 22 Sep 2014

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[Portal-splenic-mesenteric venous thrombosis in a patients with protein S deficiency due to novel PROS1 gene mutation].
 

Author(s): Eui Tae Hwang, Won Sik Kang, Jin Woo Park, Ji Hyun Lee, Hyun Jeong Han, Sang Yong Shin, Hee Jin Kim, Ja Sung Choi

Journal: Korean J Gastroenterol. 2014 Aug;64(2):110-4.

 

Protein S (PS), a vitamin K-dependent glycoprotein, performs an important role in the anticoagulation cascade as a cofactor of protein C. Because of the presence of a pseudogene and two different forms of PS in the plasma, protein S deficiency (PSD) is one of the most difficult thrombophilias ...

Last Updated: 29 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Protein S deficiency" returned 5 free, full-text review articles on human participants. First 3 results:

Acquired pial and dural arteriovenous fistulae following superior sagittal sinus thrombosis in patients with protein S deficiency: a report of two cases.
 

Author(s): Shunji Matsubara, Koichi Satoh, Junichiro Satomi, Toshio Shigekiyo, Tomoya Kinouchi, Hajimu Miyake, Shinji Nagahiro

Journal: Neurol. Med. Chir. (Tokyo). 2014 ;54(3):245-52.

 

Two patients with protein S deficiency with acquired multiple pial and dural arteriovenous fistulae (AVFs) following superior sagittal sinus (SSS) thrombosis are reported. Case 1 is a 38-year-old male with protein S deficiency who developed generalized seizure due to SSS thrombosis. ...

Last Updated: 17 Mar 2014

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[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
 

Author(s): Fang Liu, Lanyan Zhu, Ping Chen, Zhihui Shi, Shaokun Liu

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;38(9):971-6.

 

To explore the clinical manifestations, diagnosis and treatment of pulmonary thromboembolism associated with protein C (PC)/protein S (PS) deficiency. Two male patients 29 and 26 years old diagnosed with PC deficiency and/or PS deficiency were retrospectively analyzed and related ...

Last Updated: 27 Sep 2013

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Mesenteric venous thrombosis in protein S deficiency: case report and literature review.
 

Author(s): L L Lau, A H McMurray

Journal: Ulster Med J. 1999 May;68(1):33-5.

 

Last Updated: 4 Oct 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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