Protein S deficiency

Common Name(s)

Protein S deficiency

Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding.  Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis.  People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins.  Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein S deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Protein S deficiency" returned 97 free, full-text research articles on human participants. First 3 results:

Thyroid storm presenting as congestive heart failure and protein-S deficiency-induced biventricular and internal jugular venous thrombii.
 

Author(s): S Kumar, N Moorthy, S Yadav, A Kapoor, D C Dale

Journal: J Postgrad Med. ;59(3):229-31.

 

The thyroid storm is a medical emergency characterized by decompensation of one or more organ systems. Associated cardiac involvement carries poor prognosis. Early recognition and appropriate management of life-threatening thyrotoxicosis is vital to prevent the high morbidity and ...

Last Updated: 13 Sep 2013

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Protein C and protein S deficiency - practical diagnostic issues.
 

Author(s): Ewa Wypasek, Anetta Undas

Journal: Adv Clin Exp Med. ;22(4):459-67.

 

Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins, that act as natural anticoagulants. The proteolytic activation of PC by thrombin occurs on the surface of endothelial cells and involves thrombomodulin and endothelial PC receptor. In the presence of PS, phospholipids ...

Last Updated: 29 Aug 2013

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[Recurring arterial reocclusion following endovascular recanalisation in a patient with protein S deficiency].
 

Author(s): Alejaandro Bustamante, Francisco Moniche-Alvarez, José Ramón Gonzalez-Marcos, Isabel Gutierrez, Antonio Mayol, Alejandro Gonzalez-Garcia

Journal: Rev Neurol. 2013 Jul;57(1):44-5.

 

Last Updated: 26 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Protein S deficiency" returned 3 free, full-text review articles on human participants. First 3 results:

Mesenteric venous thrombosis in protein S deficiency: case report and literature review.
 

Author(s): L L Lau, A H McMurray

Journal: Ulster Med J. 1999 May;68(1):33-5.

 

Last Updated: 4 Oct 1999

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Progressive intracranial occlusive disease associated with deficiency of protein S. Report of two cases.
 

Author(s): F Barinagarrementeria, C Cantú Brito, R Izaguirre, A de la Peña

Journal: Stroke. 1993 Nov;24(11):1752-6.

 

Deficiency of the free fraction of protein S has been associated with arterial or venous stroke. The pathogenesis of vascular occlusion in patients with protein S deficiency is not known. We present two cases of cerebral infarction and deficiency of protein S in which the subjects ...

Last Updated: 29 Nov 1993

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Superior sagittal sinus thrombosis in a patient with protein S deficiency.
 

Author(s): D Cros, P C Comp, G Beltran, G Gum

Journal: Stroke. 1990 Apr;21(4):633-6.

 

A 30-year-old man presented with sagittal sinus thrombosis. He had a history of multiple thrombotic events since adolescence, and his father had had a similar history. Laboratory studies revealed the complete absence of free protein S in his plasma. Protein S deficiency, an autosomal ...

Last Updated: 17 May 1990

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
 

Status: Recruiting

Condition Summary: SCID; Omenn's Syndrome; Reticular Dysgenesis; Wiskott-Aldrich Syndrome; Bare Lymphocyte Syndrome; Common Variable Immunodeficiency; Chronic Granulomatous Disease; CD40 Ligand Deficiency; Hyper IgM Syndrome; X-linked Lymphoproliferative Disease; Hemophagocytic Lymphohistiocytosis; Griscelli Syndrome; Chediak-Higashi Syndrome; Langerhan's Cell Histiocytosis

 

Last Updated: 15 May 2014

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A Study to Investigate BPL's Factor X in the Prophylaxis of Bleeding in Children <12 Years
 

Status: Not yet recruiting

Condition Summary: Factor X Deficiency

 

Last Updated: 13 Nov 2012

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Lentiviral Gene Therapy for Adenosine Deaminase (ADA) Deficiency
 

Status: Not yet recruiting

Condition Summary: Adenosine Deaminase Deficiency; Severe Combined Immunodeficiencies (SCID)

 

Last Updated: 2 Apr 2012

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