Progressive supranuclear palsy

Common Name(s)

Progressive supranuclear palsy

Progressive supranuclear palsy is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected individuals walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes, speech, vision and swallowing problems. Doctors sometimes confuse progressive supranuclear palsy with Parkinson's disease or Alzheimer's disease. Progressive supranuclear palsy has no cure and no effective treatments.  In most cases, the genetic cause of this condition is unknown. Rarely, the disease results from mutations in the MAPT gene.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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The PSP Association

The mission of the PSP Association is the conquest of PSP, through effective research, education, welfare and communication.

Last Updated: 24 Nov 2009

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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The PSP Association

The mission of the PSP Association is the conquest of PSP, through effective research, education, welfare and communication.

http://www.pspeur.org

Last Updated: 24 Nov 2009

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive supranuclear palsy" returned 167 free, full-text research articles on human participants. First 3 results:

Characterization of tau oligomeric seeds in progressive supranuclear palsy.
 

Author(s): Julia E Gerson, Urmi Sengupta, Cristian A Lasagna-Reeves, Marcos J Guerrero-Muñoz, Juan Troncoso, Rakez Kayed

Journal:

 

Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy which is primarily defined by the deposition of tau into globose-type neurofibrillary tangles (NFT). Tau in its native form has important functions for microtubule dynamics. Tau undergoes alternative splicing in ...

Last Updated: 25 Jun 2014

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Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer.
 

Author(s): Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino, Henry Houlden, John Hardy, Janice L Holton

Journal:

 

We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy ...

Last Updated: 1 Apr 2014

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Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.
 

Author(s): Raffaele Ferrari, Mina Ryten, Roberto Simone, Daniah Trabzuni, Naiya Nicolaou, Geshanthi Hondhamuni, Adaikalavan Ramasamy, Jana Vandrovcova, , Michael E Weale, Andrew J Lees, Parastoo Momeni, John Hardy, Rohan de Silva

Journal: Neurobiol. Aging. 2014 Jun;35(6):1514.e1-12.

 

Progressive supranuclear palsy is a rare parkinsonian disorder with characteristic neurofibrillary pathology consisting of hyperphosphorylated tau protein. Common variation defining the microtubule associated protein tau gene (MAPT) H1 haplotype strongly contributes to disease risk. ...

Last Updated: 19 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive supranuclear palsy" returned 8 free, full-text review articles on human participants. First 3 results:

Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients.
 

Author(s): Elan D Louis, Rachel Babij, Karen Ma, Etty Cortés, Jean-Paul G Vonsattel

Journal: J. Neuropathol. Exp. Neurol.. 2013 Jan;72(1):8-17.

 

For many years, clinicians have commented on the development of signs of parkinsonism among their essential tremor (ET) patients, but the links between ET and parkinsonism are not well understood. We report 11 (12.4%) of 89 ET patients who were prospectively collected at the Essential ...

Last Updated: 24 Dec 2012

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Progressive supranuclear palsy: new concepts.
 

Author(s): Orlando Graziani Povoas Barsottini, André Carvalho Felício, Camila Catherine Henriques de Aquino, José Luiz Pedroso

Journal: Arq Neuropsiquiatr. 2010 Dec;68(6):938-46.

 

Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary ...

Last Updated: 18 Jan 2011

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Rational therapeutic approaches to progressive supranuclear palsy.
 

Author(s): Maria Stamelou, Rohan de Silva, Oscar Arias-Carrión, Evangelia Boura, Matthias Höllerhage, Wolfgang H Oertel, Ulrich Müller, Günter U Höglinger

Journal: Brain. 2010 Jun;133(Pt 6):1578-90.

 

Progressive supranuclear palsy is a sporadic and progressive neurodegenerative disease, most often presenting as a symmetric, akinetic-rigid syndrome with postural instability, vertical supranuclear gaze palsy and frontal lobe deficits. It belongs to the family of tauopathies and ...

Last Updated: 31 May 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Postural Instability in Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Parkinson's Disease

 

Last Updated: 23 Mar 2012

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Use of Lokomat in Patients With Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 4 Apr 2014

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Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 3 Sep 2014

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