Progressive supranuclear palsy

Common Name(s)

Progressive supranuclear palsy, PSP

Progressive supranuclear palsy (PSP) is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected people walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes; and speech, vision or swallowing problems. Doctors sometimes confuse PSP with Parkinson's disease or Alzheimer's disease. In most cases, the genetic cause of PSP is unknown. Rarely, the disease is known to result from mutations in the MAPT gene. PSP has no effective treatments, but some symptoms may be managed with medication.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

Last Updated: 5 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

http://www.pspassociation.org.uk/

Last Updated: 5 Jun 2015

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive supranuclear palsy" returned 232 free, full-text research articles on human participants. First 3 results:

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
 

Author(s): Antonio Piras, Ludovic Collin, Fiona Grüninger, Caroline Graff, Annica Rönnbäck

Journal:

 

The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the microtubule-associated protein tau characterizes the neuropathology of tauopathies, such as Alzheimer disease (AD), corticobasal ...

Last Updated: 3 Mar 2016

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Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders.
 

Author(s): Tatsuya Yamamoto, Fuyuki Tateno, Ryuji Sakakibara, Shogo Furukawa, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Yoshitaka Yamanaka, Miki Fuse, Yasuko Koga, Mitsuru Yanagisawa, Satoshi Kuwabara

Journal:

 

Autonomic urinary dysfunction affects patients with progressive supranuclear palsy (PSP); however, the severity and prevalence of urinary dysfunctions in these patients compared with those observed in patients with Parkinson's disease (PD) and multiple system atrophy (MSA) are unknown.

Last Updated: 18 Feb 2016

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Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases.
 

Author(s): Akane Nogami, Mineo Yamazaki, Yuko Saito, Hiroyuki Hatsuta, Yoshio Sakiyama, Masaki Takao, Kazumi Kimura, Shigeo Murayama

Journal: J Nippon Med Sch. 2015 ;82(6):266-73.

 

Diagnosing clinical progressive supranuclear palsy (PSP) is challenging. We hypothesize that there are more cases of pathological PSP than have been clinically identified, but its diagnosis is challenging because the initial lesions and progression of PSP have not yet been clarified. ...

Last Updated: 29 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive supranuclear palsy" returned 10 free, full-text review articles on human participants. First 3 results:

Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Keith A Josephs

Journal: J. Neurol.. 2015 Mar;262(3):783-8.

 

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative ...

Last Updated: 18 Mar 2015

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Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients.
 

Author(s): Elan D Louis, Rachel Babij, Karen Ma, Etty Cortés, Jean-Paul G Vonsattel

Journal: J. Neuropathol. Exp. Neurol.. 2013 Jan;72(1):8-17.

 

For many years, clinicians have commented on the development of signs of parkinsonism among their essential tremor (ET) patients, but the links between ET and parkinsonism are not well understood. We report 11 (12.4%) of 89 ET patients who were prospectively collected at the Essential ...

Last Updated: 24 Dec 2012

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Progressive supranuclear palsy: new concepts.
 

Author(s): Orlando Graziani Povoas Barsottini, André Carvalho Felício, Camila Catherine Henriques de Aquino, José Luiz Pedroso

Journal: Arq Neuropsiquiatr. 2010 Dec;68(6):938-46.

 

Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary ...

Last Updated: 18 Jan 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Progressive Supranuclear Palsy
 

Status: Not yet recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 5 Dec 2016

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Young Plasma Transfusions for Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 2 Dec 2016

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A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 23 May 2016

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