Progressive supranuclear palsy

Common Name(s)

Progressive supranuclear palsy, PSP

Progressive supranuclear palsy (PSP) is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected people walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes; and speech, vision or swallowing problems. Doctors sometimes confuse PSP with Parkinson's disease or Alzheimer's disease. In most cases, the genetic cause of PSP is unknown. Rarely, the disease is known to result from mutations in the MAPT gene. PSP has no effective treatments, but some symptoms may be managed with medication.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

Last Updated: 5 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear palsy" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

http://www.pspassociation.org.uk/

Last Updated: 5 Jun 2015

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive supranuclear palsy" returned 191 free, full-text research articles on human participants. First 3 results:

The pattern of verbal, visuospatial and procedural learning in Richardson variant of progressive supranuclear palsy in comparison to Parkinson's disease.
 

Author(s): Emilia J Sitek, Dariusz Wieczorek, Agnieszka Konkel, Magda Dąbrowska, Jarosław Sławek

Journal: Psychiatr. Pol.. 2017 Aug;51(4):647-659.

 

Progressive supranuclear palsy (PSP) is regarded either within spectrum of atypical parkinsonian syndromes or frontotemporal lobar degeneration. We compared the verbal, visuospatial and procedural learning profiles in patients with PSP and Parkinson's disease (PD). Furthermore, the ...

Last Updated: 7 Oct 2017

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Multireceptor fingerprints in progressive supranuclear palsy.
 

Author(s): Wang Zheng Chiu, Laura Donker Kaat, Agnita J W Boon, Wouter Kamphorst, Axel Schleicher, Karl Zilles, John C van Swieten, Nicola Palomero-Gallagher

Journal:

 

Progressive supranuclear palsy (PSP) with a frontal presentation, characterized by cognitive deficits and behavioral changes, has been recognized as an early clinical picture, distinct from the classical so-called Richardson and parkinsonism presentations. The midcingulate cortex ...

Last Updated: 17 Apr 2017

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Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
 

Author(s): Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, Günter U Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, , Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desikan

Journal: Acta Neuropathol.. 2017 May;133(5):825-837.

 

Corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and a subset of frontotemporal dementia (FTD) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). Although clinical, pathological and genetic evidence suggests overlapping ...

Last Updated: 8 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive supranuclear palsy" returned 8 free, full-text review articles on human participants. First 3 results:

Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Keith A Josephs

Journal: J. Neurol.. 2015 Mar;262(3):783-8.

 

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative ...

Last Updated: 18 Mar 2015

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Familial progressive supranuclear palsy: a literature review.
 

Author(s): Shinsuke Fujioka, Jay A Van Gerpen, Ryan J Uitti, Dennis W Dickson, Zbigniew K Wszolek

Journal: Neurodegener Dis. 2014 ;13(2-3):180-2.

 

Many genes/loci associated with Parkinsonian disorders have been identified. However, the genetic causes for a number of familial forms of Parkinsonian disorders remain to be elucidated.

Last Updated: 7 Feb 2014

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Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients.
 

Author(s): Elan D Louis, Rachel Babij, Karen Ma, Etty Cortés, Jean-Paul G Vonsattel

Journal: J. Neuropathol. Exp. Neurol.. 2013 Jan;72(1):8-17.

 

For many years, clinicians have commented on the development of signs of parkinsonism among their essential tremor (ET) patients, but the links between ET and parkinsonism are not well understood. We report 11 (12.4%) of 89 ET patients who were prospectively collected at the Essential ...

Last Updated: 24 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Oct 2017

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Young Plasma Transfusions for Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 24 Oct 2017

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A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 11 Oct 2017

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