Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 204 free, full-text research articles on human participants. First 3 results:

Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis?
 

Author(s): Julia Krämer, Jan-Gerd Tenberge, Ingo Kleiter, Wolfgang Gaissmaier, Tobias Ruck, Christoph Heesen, Sven G Meuth

Journal:

 

Progressive multifocal leukoencephalopathy (PML) is one of the major risks of natalizumab therapy. Despite introduction of the currently employed PML risk stratification algorithm, the incidence of natalizumab-associated PML cases is not decreasing.

Last Updated: 13 Apr 2017

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Natalizumab-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: Findings from an Italian Independent Registry.
 

Author(s): Luca Prosperini, Nicola de Rossi, Cristina Scarpazza, Lucia Moiola, Mirco Cosottini, Simonetta Gerevini, Ruggero Capra,

Journal:

 

The monoclonal antibody natalizumab (NTZ) is a highly effective treatment for patients with multiple sclerosis (MS). However, this drug is associated with increased risk of developing Progressive Multifocal Leukoencephalopathy (PML), an opportunistic infection of central nervous system ...

Last Updated: 20 Dec 2016

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Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.
 

Author(s): Kenta Takahashi, Tsuyoshi Sekizuka, Hitomi Fukumoto, Kazuo Nakamichi, Tadaki Suzuki, Yuko Sato, Hideki Hasegawa, Makoto Kuroda, Harutaka Katano

Journal:

 

JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation ...

Last Updated: 31 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 39 free, full-text review articles on human participants. First 3 results:

Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature.
 

Author(s): Christa S Zerbe, Beatriz E Marciano, Rohit K Katial, Carah B Santos, Nick Adamo, Amy P Hsu, Mary E Hanks, Dirk N Darnell, Martha M Quezado, Cathleen Frein, Lisa A Barnhart, Victoria L Anderson, Gulbu Uzel, Alexandra F Freeman, Andrea Lisco, Avindra Nath, Eugene O Major, Elizabeth P Sampaio, Steven M Holland

Journal: Clin. Infect. Dis.. 2016 Apr;62(8):986-94.

 

Progressive multifocal leukoencephalopathy (PML) is a rare, severe, otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically occurs only in immunocompromised patients. One patient with dominant gain-of-function (GOF) mutation ...

Last Updated: 23 Mar 2016

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Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.
 

Author(s): Martyn K White, Ilker K Sariyer, Jennifer Gordon, Serena Delbue, Valeria Pietropaolo, Joseph R Berger, Kamel Khalili

Journal: Rev. Med. Virol.. 2016 Mar;26(2):102-14.

 

Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal demyelinating disease of the central nervous system for which effective therapies are lacking. It is caused by the replication of polyomavirus JC (JCV) in the oligodendrocytes and astrocytes leading ...

Last Updated: 3 Mar 2016

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Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group.
 

Author(s): C McGuigan, M Craner, J Guadagno, R Kapoor, G Mazibrada, P Molyneux, R Nicholas, J Palace, O R Pearson, D Rog, C A Young

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 Feb;87(2):117-25.

 

The use of natalizumab for highly active relapsing-remitting multiple sclerosis (MS) is influenced by the occurrence of progressive multifocal leukoencephalopathy (PML). Through measurement of the anti-JCV antibody index, and in combination with the presence or absence of other known ...

Last Updated: 15 Jan 2016

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Symptoms, Diagnosis, and Treatment

This information is provided by Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 30 Jun 2017

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Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 21 Feb 2017

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