Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 200 free, full-text research articles on human participants. First 3 results:

JC virus inclusions in progressive multifocal leukoencephalopathy: scaffolding promyelocytic leukemia nuclear bodies grow with cell cycle transition through an S-to-G2-like state in enlarging oligodendrocyte nuclei.
 

Author(s): Yukiko Shishido-Hara, Takuya Yazawa, Motoo Nagane, Kayoko Higuchi, Shiho Abe-Suzuki, Morito Kurata, Masanobu Kitagawa, Hiroshi Kamma, Toshiki Uchihara

Journal: J. Neuropathol. Exp. Neurol.. 2014 May;73(5):442-53.

 

In progressive multifocal leukoencephalopathy, JC virus-infected oligodendroglia display 2 distinct patterns of intranuclear viral inclusions: full inclusions in which progeny virions are present throughout enlarged nuclei and dot-shaped inclusions in which virions are clustered in ...

Last Updated: 17 Apr 2014

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Detection of human herpesviruses in the cerebrospinal fluid from patients diagnosed with or suspected of having progressive multifocal leukoencephalopathy.
 

Author(s): Kazuo Nakamichi, Naoki Inoue, Toshio Shimokawa, Ichiro Kurane, Chang-Kweng Lim, Masayuki Saijo

Journal:

 

Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. While JCV DNA is detected in the cerebrospinal fluid (CSF) from a certain proportion of patients suspected of having PML, JCV-negative ...

Last Updated: 19 Dec 2013

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Progressive multifocal leukoencephalopathy, a rare but devastating disease in AIDS patients.
 

Author(s): Vicenç Falcó

Journal: Indian J. Med. Res.. 2013 ;138():13-5.

 

Last Updated: 23 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 24 free, full-text review articles on human participants. First 3 results:

Progressive multifocal leukoencephalopathy: new concepts.
 

Author(s): Marco A Lima

Journal: Arq Neuropsiquiatr. 2013 Sep;71(9B):699-702.

 

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant ...

Last Updated: 21 Oct 2013

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New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy.
 

Author(s): Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Anna Teresa Palamara, Lucia Nencioni, Valeria Pietropaolo

Journal: Clin. Dev. Immunol.. 2013 ;2013():839719.

 

John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered. Until the human immunodeficiency ...

Last Updated: 21 May 2013

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Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy.
 

Author(s): Edward M Johnson, Margaret J Wortman, Ayuna V Dagdanova, Patric S Lundberg, Dianne C Daniel

Journal: Clin. Dev. Immunol.. 2013 ;2013():197807.

 

Polyomavirus JC (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a demyelinating infection of oligodendrocytes in the brain. PML, a frequently fatal opportunistic infection in AIDS, has also emerged as a consequence of treatment with several new ...

Last Updated: 21 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 3 Jul 2014

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Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 11 Jun 2014

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Last Updated: 4 Nov 2013

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