Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 248 free, full-text research articles on human participants. First 3 results:

Eculizumab-related progressive multifocal leukoencephalopathy.
 

Author(s): Emilio Gómez-Cibeira, Yerko Ivanovic-Barbeito, Eduardo Gutiérrez-Martínez, Enrique Morales, Manuel Abradelo, Amaya Hilario, Ana Ramos, Juan Ruiz-Morales, Alberto Villarejo-Galende

Journal: Neurology. 2016 Jan;86(4):399-400.

 

Last Updated: 26 Jan 2016

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Expression of Signaling Molecules in Progressive Multifocal Leukoencephalopathy.
 

Author(s): Hassen S Wollebo, Bianca Cotto, Radhika Adiga, Dianne Langford, Martyn K White

Journal: Curr. HIV Res.. 2016 ;14(1):47-53.

 

Progressive multifocal leukoencephalopathy (PML) is a debilitating demyelinating disease of the CNS caused by the infection and destruction of glial cells by JC virus (JCV) and is an AIDS-defining disease. Infection with JCV is common and most people acquire antibodies early in life. ...

Last Updated: 4 Nov 2015

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Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.
 

Author(s): Ivan Jelcic, Benoit Combaluzier, Ilijas Jelcic, Wolfgang Faigle, Luzia Senn, Brenda J Reinhart, Luisa Ströh, Roger M Nitsch, Thilo Stehle, Mireia Sospedra, Jan Grimm, Roland Martin

Journal: Sci Transl Med. 2015 Sep;7(306):306ra150.

 

In immunocompromised individuals, JC polyomavirus (JCPyV) may mutate and gain access to the central nervous system resulting in progressive multifocal leukoencephalopathy (PML), an often fatal opportunistic infection for which no treatments are currently available. Despite recent ...

Last Updated: 24 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 32 free, full-text review articles on human participants. First 3 results:

Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group.
 

Author(s): C McGuigan, M Craner, J Guadagno, R Kapoor, G Mazibrada, P Molyneux, R Nicholas, J Palace, O R Pearson, D Rog, C A Young

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 Feb;87(2):117-25.

 

The use of natalizumab for highly active relapsing-remitting multiple sclerosis (MS) is influenced by the occurrence of progressive multifocal leukoencephalopathy (PML). Through measurement of the anti-JCV antibody index, and in combination with the presence or absence of other known ...

Last Updated: 15 Jan 2016

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Animal Models for Progressive Multifocal Leukoencephalopathy.
 

Author(s): Martyn K White, Jennifer Gordon, Joseph R Berger, Kamel Khalili

Journal: J. Cell. Physiol.. 2015 Dec;230(12):2869-74.

 

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the CNS caused by the human polyomavirus JC (JCV). JCV replication occurs only in human cells and investigation of PML has been severely hampered by the lack of an animal model. The common feature ...

Last Updated: 25 Aug 2015

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Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review.
 

Author(s): Hayden Schwenk, Lynn Ramirez-Avila, Shu-Hsien Sheu, Christian Wuthrich, Jeff Waugh, Adam Was, Umberto Degirolami, Sandra Burchett, Igor J Koralnik, Asim Ahmed

Journal: Pediatr. Infect. Dis. J.. 2014 Apr;33(4):e99-105.

 

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy ...

Last Updated: 17 Mar 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 31 Aug 2016

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Last Updated: 21 Sep 2015

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