Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 215 free, full-text research articles on human participants. First 3 results:

Atypical progressive multifocal leukoencephalopathy in a patient with antisynthetase syndrome.
 

Author(s): Moncef Belhassen-Garcia, Alberto Rábano-Gutiérrez, Virginia Velasco-Tirado, Angela Romero-Alegria, Maria-Luisa Pérez-Garcia, Jose Angel Martin-Oterino

Journal: Intern. Med.. 2015 ;54(5):519-24.

 

Antisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, ...

Last Updated: 11 Mar 2015

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Mirtazapine and mefloquine therapy for non-AIDS-related progressive multifocal leukoencephalopathy.
 

Author(s): Narendranath Epperla, Rafael Medina-Flores, Joseph J Mazza, Steven H Yale

Journal: WMJ. 2014 Dec;113(6):242-5.

 

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the human nervous system caused by the JC virus. We report what is, to the best of our knowledge, the second reported case using a combination of mefloquine and mirtazapine in a patient with non-AIDS-related ...

Last Updated: 9 Mar 2015

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JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.
 

Author(s): Tom Van Loy, Kim Thys, Caroline Ryschkewitsch, Ole Lagatie, Maria C Monaco, Eugene O Major, Luc Tritsmans, Lieven J Stuyver

Journal: J. Virol.. 2015 Jan;89(2):1340-7.

 

Opportunistic infection of oligodendrocytes by human JC polyomavirus may result in the development of progressive multifocal encephalopathy in immunocompromised individuals. Neurotropic JC virus generally harbors reorganized noncoding control region (NCCR) DNA interspersed on the ...

Last Updated: 5 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 26 free, full-text review articles on human participants. First 3 results:

Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review.
 

Author(s): Hayden Schwenk, Lynn Ramirez-Avila, Shu-Hsien Sheu, Christian Wuthrich, Jeff Waugh, Adam Was, Umberto Degirolami, Sandra Burchett, Igor J Koralnik, Asim Ahmed

Journal: Pediatr. Infect. Dis. J.. 2014 Apr;33(4):e99-105.

 

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy ...

Last Updated: 17 Mar 2014

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Progressive multifocal leukoencephalopathy: new concepts.
 

Author(s): Marco A Lima

Journal: Arq Neuropsiquiatr. 2013 Sep;71(9B):699-702.

 

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant ...

Last Updated: 21 Oct 2013

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New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy.
 

Author(s): Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Anna Teresa Palamara, Lucia Nencioni, Valeria Pietropaolo

Journal: Clin. Dev. Immunol.. 2013 ;2013():839719.

 

John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered. Until the human immunodeficiency ...

Last Updated: 21 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 8 May 2015

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Last Updated: 4 Nov 2013

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Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 24 Apr 2015

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