Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 196 free, full-text research articles on human participants. First 3 results:

Progressive Multifocal Leukoencephalopathy Localized in the Cerebellum and Brainstem Associated with Idiopathic CD4(+) T Lymphocytopenia.
 

Author(s): Yuya Aotsuka, Akiyuki Uzawa, Kazutaka Nishimura, Kazuho Kojima, Mika Yamaguchi, Takahiro Makino, Kazuo Nakamichi, Masayuki Saijo, Satoshi Kuwabara

Journal: Intern. Med.. 2016 ;55(12):1645-7.

 

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease that favors the cerebrum and typically occurs in immunosuppressed patients. We herein report the case of a 66-year-old man with PML, idiopathic CD4(+) T lymphocytopenia (ICL), and chronic renal failure. Cranial ...

Last Updated: 15 Jun 2016

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Progressive Multifocal Leukoencephalopathy with Balanced CD4/CD8 T-Cell Infiltration and Good Response to Mefloquine Treatment.
 

Author(s): Nobuo Sanjo, Satoko Kina, Yukiko Shishido-Hara, Yurie Nose, Satoru Ishibashi, Tetsuya Fukuda, Taketoshi Maehara, Yoshinobu Eishi, Hidehiro Mizusawa, Takanori Yokota

Journal: Intern. Med.. 2016 ;55(12):1631-5.

 

A 53-year-old man was admitted for sub-acute progressive dementia and Gerstmann syndrome. MRI demonstrated lesions in the white matter involving the left parietal lobe, accompanied by speckled or faint linear peripheral enhancement. Brain biopsy revealed JC virus infection in oligodendrocytes ...

Last Updated: 15 Jun 2016

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Eculizumab-related progressive multifocal leukoencephalopathy.
 

Author(s): Emilio Gómez-Cibeira, Yerko Ivanovic-Barbeito, Eduardo Gutiérrez-Martínez, Enrique Morales, Manuel Abradelo, Amaya Hilario, Ana Ramos, Juan Ruiz-Morales, Alberto Villarejo-Galende

Journal: Neurology. 2016 Jan;86(4):399-400.

 

Last Updated: 26 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 35 free, full-text review articles on human participants. First 3 results:

Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.
 

Author(s): Martyn K White, Ilker K Sariyer, Jennifer Gordon, Serena Delbue, Valeria Pietropaolo, Joseph R Berger, Kamel Khalili

Journal: Rev. Med. Virol.. 2016 Mar;26(2):102-14.

 

Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal demyelinating disease of the central nervous system for which effective therapies are lacking. It is caused by the replication of polyomavirus JC (JCV) in the oligodendrocytes and astrocytes leading ...

Last Updated: 3 Mar 2016

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Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group.
 

Author(s): C McGuigan, M Craner, J Guadagno, R Kapoor, G Mazibrada, P Molyneux, R Nicholas, J Palace, O R Pearson, D Rog, C A Young

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 Feb;87(2):117-25.

 

The use of natalizumab for highly active relapsing-remitting multiple sclerosis (MS) is influenced by the occurrence of progressive multifocal leukoencephalopathy (PML). Through measurement of the anti-JCV antibody index, and in combination with the presence or absence of other known ...

Last Updated: 15 Jan 2016

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Animal Models for Progressive Multifocal Leukoencephalopathy.
 

Author(s): Martyn K White, Jennifer Gordon, Joseph R Berger, Kamel Khalili

Journal: J. Cell. Physiol.. 2015 Dec;230(12):2869-74.

 

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the CNS caused by the human polyomavirus JC (JCV). JCV replication occurs only in human cells and investigation of PML has been severely hampered by the lack of an animal model. The common feature ...

Last Updated: 25 Aug 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 21 Mar 2017

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Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 21 Feb 2017

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