Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 194 free, full-text research articles on human participants. First 3 results:

Eculizumab-related progressive multifocal leukoencephalopathy.
 

Author(s): Emilio Gómez-Cibeira, Yerko Ivanovic-Barbeito, Eduardo Gutiérrez-Martínez, Enrique Morales, Manuel Abradelo, Amaya Hilario, Ana Ramos, Juan Ruiz-Morales, Alberto Villarejo-Galende

Journal: Neurology. 2016 Jan;86(4):399-400.

 

Last Updated: 26 Jan 2016

Go To URL
Expression of Signaling Molecules in Progressive Multifocal Leukoencephalopathy.
 

Author(s): Hassen S Wollebo, Bianca Cotto, Radhika Adiga, Dianne Langford, Martyn K White

Journal: Curr. HIV Res.. 2016 ;14(1):47-53.

 

Progressive multifocal leukoencephalopathy (PML) is a debilitating demyelinating disease of the CNS caused by the infection and destruction of glial cells by JC virus (JCV) and is an AIDS-defining disease. Infection with JCV is common and most people acquire antibodies early in life. ...

Last Updated: 4 Nov 2015

Go To URL
Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy.
 

Author(s): C Carra-Dalliere, N Menjot de Champfleur, J Deverdun, X Ayrignac, E Nerrant, A Makinson, M L Casanova, P Labauge

Journal: J Neuroradiol. 2016 Feb;43(1):6-10.

 

Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating encephalopathy related to JC virus. Its characteristics on conventional brain MRI are well known and are important for the diagnosis.

Last Updated: 6 Feb 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 34 free, full-text review articles on human participants. First 3 results:

Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.
 

Author(s): Martyn K White, Ilker K Sariyer, Jennifer Gordon, Serena Delbue, Valeria Pietropaolo, Joseph R Berger, Kamel Khalili

Journal: Rev. Med. Virol.. 2016 Mar;26(2):102-14.

 

Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal demyelinating disease of the central nervous system for which effective therapies are lacking. It is caused by the replication of polyomavirus JC (JCV) in the oligodendrocytes and astrocytes leading ...

Last Updated: 3 Mar 2016

Go To URL
Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group.
 

Author(s): C McGuigan, M Craner, J Guadagno, R Kapoor, G Mazibrada, P Molyneux, R Nicholas, J Palace, O R Pearson, D Rog, C A Young

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 Feb;87(2):117-25.

 

The use of natalizumab for highly active relapsing-remitting multiple sclerosis (MS) is influenced by the occurrence of progressive multifocal leukoencephalopathy (PML). Through measurement of the anti-JCV antibody index, and in combination with the presence or absence of other known ...

Last Updated: 15 Jan 2016

Go To URL
Animal Models for Progressive Multifocal Leukoencephalopathy.
 

Author(s): Martyn K White, Jennifer Gordon, Joseph R Berger, Kamel Khalili

Journal: J. Cell. Physiol.. 2015 Dec;230(12):2869-74.

 

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the CNS caused by the human polyomavirus JC (JCV). JCV replication occurs only in human cells and investigation of PML has been severely hampered by the lack of an animal model. The common feature ...

Last Updated: 25 Aug 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 24 Jan 2017

Go to URL
Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 6 May 2016

Go to URL