Progressive Aphasia

Common Name(s)

Progressive Aphasia

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive Aphasia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Dementias (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 25 Oct 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive Aphasia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Dementias (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.ftd-picks.org

Last Updated: 25 Oct 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive Aphasia" returned 110 free, full-text research articles on human participants. First 3 results:

Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis.
 

Author(s): Dirk Bäumer, Richard Butterworth, Ricarda A L Menke, Kevin Talbot, Monika Hofer, Martin R Turner

Journal: Neurology. 2014 Feb;82(5):457-8.

 

The onset of motor symptoms in amyotrophic lateral sclerosis (ALS) is strikingly focal. In three-quarters of cases, weakness emerges unilaterally in one limb, typically spreading contiguously over months to become bilateral.(1) An extremely rare clinical syndrome of upper motor neuron-predominant, ...

Last Updated: 4 Feb 2014

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Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.
 

Author(s): Dorothy Charles, Christopher Olm, John Powers, Sharon Ash, David J Irwin, Corey T McMillan, Katya Rascovsky, Murray Grossman

Journal: J. Neurol. Neurosurg. Psychiatr.. 2014 Mar;85(3):249-56.

 

Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable.

Last Updated: 7 Feb 2014

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Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia.
 

Author(s): Jennifer L Whitwell, Val J Lowe, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Kejal Kantarci, Samantha M Wille, Matthew L Senjem, Matthew C Murphy, Jeffrey L Gunter, Clifford R Jack, Keith A Josephs

Journal: J. Neurol. Neurosurg. Psychiatr.. 2013 Dec;84(12):1357-64.

 

Most subjects with logopenic variant of primary progressive aphasia (lvPPA) have β-amyloid (Aβ) deposition on Pittsburgh Compound B positron emission tomography (PiB-PET), usually affecting prefrontal and temporoparietal cortices, with less occipital involvement.

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive Aphasia" returned 12 free, full-text review articles on human participants. First 3 results:

Behavioural interventions for enhancing life participation in behavioural variant frontotemporal dementia and primary progressive aphasia.
 

Author(s): Kathleen B Kortte, Emily J Rogalski

Journal: Int Rev Psychiatry. 2013 Apr;25(2):237-45.

 

Primary progressive aphasia (PPA) and behavioural-variant frontotemporal dementia (bvFTD) are clinical syndromes under the umbrella term 'frontotemporal dementia' (FTD) and are caused by a neurodegenerative disease with an onset most typically in the productive years of adulthood. ...

Last Updated: 24 Apr 2013

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Primary progressive aphasia: from syndrome to disease.
 

Author(s): J A Matías-Guiu, R García-Ramos

Journal: Neurologia. ;28(6):366-74.

 

Primary progressive aphasia (PPA) is a clinical syndrome characterised by a progressive decline in language and speech of neurodegenerative origin. Major breakthroughs made in recent years have lent us a better understanding of this syndrome, which may be the first manifestation of ...

Last Updated: 15 Jul 2013

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The non-fluent/agrammatic variant of primary progressive aphasia.
 

Author(s): Murray Grossman

Journal: Lancet Neurol. 2012 Jun;11(6):545-55.

 

The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by poor grammatical comprehension and expression and a disorder of speech sound production. In an era of disease-modifying treatments, the identification ...

Last Updated: 21 May 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Language in Primary Progressive Aphasia
 

Status: Recruiting

Condition Summary: Primary Progressive Aphasia

 

Last Updated: 22 Jul 2014

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PiB PET Scanning in Speech and Language Based Dementias
 

Status: Recruiting

Condition Summary: PPA; Primary Progressive Aphasia; Aphasia; Non-fluent Aphasia; Semantic Dementia; Apraxia of Speech; Primary Progressive Nonfluent Aphasia; Progressive Aphasia

 

Last Updated: 12 Jun 2014

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Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
 

Status: Recruiting

Condition Summary: Atypical Alzheimers Disease; Logopenic Variant of Primary Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 25 Jun 2014

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