Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 310 free, full-text research articles on human participants. First 3 results:

Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis.
 

Author(s): Kentaro Yamao, Mamoru Takenaka, Hajime Imai, Atsushi Nakai, Shunske Omoto, Ken Kamata, Kosuke Minaga, Takeshi Miyata, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Ippei Matsumoto, Yosihumi Takeyama, Takaaki Chikugo, Masatoshi Kudo

Journal: Oncology. 2017 ;93 Suppl 1():76-80.

 

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by multiple fibrotic strictures of the bile duct. More than 40% of deaths in PSC patients are related to malignant tumors, including cholangiocarcinoma. Primary hepatic adenosquamous carcinoma ...

Last Updated: 31 Dec 1969

Go To URL
PRIMARY SCLEROSING CHOLANGITIS IN CHILDREN AND ADOLESCENTS.
 

Author(s): Eleonora Druve Tavares Fagundes, Alexandre Rodrigues Ferreira, Caroline Caldeira Hosken, Thaís Costa Nascentes Queiroz

Journal: Arq Gastroenterol. 2017 Dec;54(4):286-291.

 

Primary sclerosing cholangitis is a rare disease, but its prevalence has been underestimated in children and adolescents due to broad variation in clinical presentation as well as diagnostic challenges in this life period.

Last Updated: 31 Dec 1969

Go To URL
Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia.
 

Author(s): Pedro Pereira, Velma Aho, Johanna Arola, Sonja Boyd, Kalle Jokelainen, Lars Paulin, Petri Auvinen, Martti Färkkilä

Journal:

 

The etiopathogenesis and risk for development of biliary neoplasia in primary sclerosing cholangitis (PSC) are largely unknown. Microbes or their metabolites have been suggested to play a role. To explore this potential microbial involvement, we evaluated the differences in biliary ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 67 free, full-text review articles on human participants. First 3 results:

Endoscopic Management of Primary Sclerosing Cholangitis.
 

Author(s): Jodie A Barkin, Cynthia Levy, Enrico O Souto

Journal: Ann Hepatol. ;16(6):842-850.

 

Primary sclerosing cholangitis (PSC) remains a rare but potentially devastating chronic, cholestatic liver disease. PSC causes obstruction of intra- and/or extra-hepatic bile ducts by inflammation and fibrosis, leading to biliary obstruction, cirrhosis and portal hypertension with ...

Last Updated: 31 Dec 1969

Go To URL
Pathogenesis and clinical spectrum of primary sclerosing cholangitis.
 

Author(s): Neelam G Gidwaney, Swati Pawa, Kiron M Das

Journal: World J. Gastroenterol.. 2017 Apr;23(14):2459-2469.

 

Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory ...

Last Updated: 31 Dec 1969

Go To URL
The evolution of natural history of primary sclerosing cholangitis.
 

Author(s): Will R Takakura, James H Tabibian, Christopher L Bowlus

Journal: Curr. Opin. Gastroenterol.. 2017 Mar;33(2):71-77.

 

Primary sclerosing cholangitis (PSC) is a rare, idiopathic biliary disease often with an insidious onset, variable disease course, and premature death related to benign and malignant PSC-related sequelae. This review aims to discuss the epidemiology, clinical variants, and natural ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 1 Mar 2018

Go to URL
A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC)
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 18 Apr 2018

Go to URL
A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 12 Jun 2017

Go to URL