Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 212 free, full-text research articles on human participants. First 3 results:

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease.
 

Author(s): J E Eaton, B D Juran, E J Atkinson, E M Schlicht, X Xie, M de Andrade, C S Lammert, V A Luketic, J A Odin, A A Koteish, K V Kowdley, K B Chopra, G M Hirschfield, N P Chalasani, K N Lazaridis

Journal: Aliment. Pharmacol. Ther.. 2015 May;41(10):980-90.

 

The relationships between primary sclerosing cholangitis (PSC) and the environment are largely unknown.

Last Updated: 17 Apr 2015

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Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis.
 

Author(s): John E Eaton, Emily G Barr Fritcher, Gregory J Gores, Elizabeth J Atkinson, James H Tabibian, Mark D Topazian, Andrea A Gossard, Kevin C Halling, Benjamin R Kipp, Konstantinos N Lazaridis

Journal: Am. J. Gastroenterol.. 2015 Feb;110(2):299-309.

 

Polysomy detected by fluorescence in situ hybridization (FISH) is associated with cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC). However, a subset of PSC patients with polysomy do not manifest CCA even after long-term follow-up. It is unknown if patients ...

Last Updated: 4 Feb 2015

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[Clinicobiological and morphological profiles of primary sclerosing cholangitis in Tunisia].
 

Author(s): Kchir Héla, Ouaka Kchaou Asma, Amouri Ali, Ben Mahmoud Nadia, Moussadek Azzouz Mohamed, Tahri Nabil, Ghorbel Abdeljabbar, Zouari Béchir, Ben Mami Nabyl

Journal: Tunis Med. 2014 May;92(5):323-8.

 

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease strongly associated, in the western series, to inflammatory bowel disease (IBD) and particularly to chronic ulcerative colitis. North African data are rare. aim : To study the epidemiological, clinicobiological ...

Last Updated: 16 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 48 free, full-text review articles on human participants. First 3 results:

Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: a review of the literature.
 

Author(s): Rosy Wang, Rupert W Leong

Journal: World J. Gastroenterol.. 2014 Jul;20(27):8783-9.

 

To examine and evaluate recent evidence regarding the epidemiology, pathogenesis and management of colorectal cancer (CRC) development in inflammatory bowel disease (IBD)-primary sclerosing cholangitis (PSC) patients. Using the PubMed database, a literature search was conducted for ...

Last Updated: 1 Aug 2014

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Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies.
 

Author(s): James H Tabibian, Steven P O'Hara, Keith D Lindor

Journal: Scand. J. Gastroenterol.. 2014 Aug;49(8):901-8.

 

Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, cholestatic liver disease of unknown etiopathogenesis. PSC generally progresses to liver cirrhosis, is a major risk factor for hepatobiliary and colonic neoplasia, and confers a median survival to death or liver ...

Last Updated: 18 Jul 2014

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Inflammatory bowel disease of primary sclerosing cholangitis: a distinct entity?
 

Author(s): Takahiro Nakazawa, Itaru Naitoh, Kazuki Hayashi, Hitoshi Sano, Katsuyuki Miyabe, Shuya Shimizu, Takashi Joh

Journal: World J. Gastroenterol.. 2014 Mar;20(12):3245-54.

 

This is a review of the characteristic findings of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC) and their usefulness in the diagnosis of sclerosing cholangitis. PSC is a chronic inflammatory disease characterized by idiopathic fibrous obstruction ...

Last Updated: 3 Apr 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 3 Mar 2015

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A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 7 Jul 2015

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Last Updated: 2 Jul 2015

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