Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 266 free, full-text research articles on human participants. First 3 results:

Clinical course of primary sclerosing cholangitis and concomitant ulcerative colitis - a preliminary report of retrospective study among patients from Southern Poland.
 

Author(s): Mikołaj K Głowacki, Małgorzata Zwolińska-Wcisło, Paulina Frączek, Martyna Gomulska, Danuta Owczarek, Dorota Cibor, Andrzej Cieśla, Tomasz Mach

Journal: Folia Med Cracov. 2015 ;55(2):61-8.

 

Both ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) are chronic and progressive diseases of uncertain etiology, that may affect one patient. Approximately 70% of PSC cases are also diagnosed with UC, whereas in the group of UC the prevalence of PSC is about 2-5%. ...

Last Updated: 3 Feb 2016

Go To URL
Malignancies in Primary Sclerosing Cholangitis--A Continuing Threat.
 

Author(s): Giulia Bonato, Laura Cristoferi, Mario Strazzabosco, Luca Fabris

Journal: Dig Dis. 2015 ;33 Suppl 2():140-8.

 

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease of unknown etiology, primarily targeting cholangiocytes at any portion of the biliary tree. No effective medical treatments are currently available. A unique feature of PSC is its close association (about ...

Last Updated: 9 Dec 2015

Go To URL
Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.
 

Author(s): Ewa Wunsch, Marta Klak, Urszula Wasik, Malgorzata Milkiewicz, Malgorzata Blatkiewicz, Elzbieta Urasinska, Olivier Barbier, Dariusz Bielicki, Dimitrios P Bogdanos, Elwyn Elias, Piotr Milkiewicz

Journal: J Immunol Res. 2015 ;2015():571353.

 

Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and primary ...

Last Updated: 27 Oct 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 57 free, full-text review articles on human participants. First 3 results:

Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis.
 

Author(s): A Boudewijn de Vries, Marcel Janse, Hans Blokzijl, Rinse K Weersma

Journal: World J. Gastroenterol.. 2015 Feb;21(6):1956-71.

 

To review the current literature for the specific clinical characteristics of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC).

Last Updated: 16 Feb 2015

Go To URL
Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: a review of the literature.
 

Author(s): Rosy Wang, Rupert W Leong

Journal: World J. Gastroenterol.. 2014 Jul;20(27):8783-9.

 

To examine and evaluate recent evidence regarding the epidemiology, pathogenesis and management of colorectal cancer (CRC) development in inflammatory bowel disease (IBD)-primary sclerosing cholangitis (PSC) patients. Using the PubMed database, a literature search was conducted for ...

Last Updated: 1 Aug 2014

Go To URL
Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies.
 

Author(s): James H Tabibian, Steven P O'Hara, Keith D Lindor

Journal: Scand. J. Gastroenterol.. 2014 Aug;49(8):901-8.

 

Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, cholestatic liver disease of unknown etiopathogenesis. PSC generally progresses to liver cirrhosis, is a major risk factor for hepatobiliary and colonic neoplasia, and confers a median survival to death or liver ...

Last Updated: 18 Jul 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 20 Jul 2016

Go to URL
Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Not yet recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 30 Mar 2016

Go to URL
A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 1 Jul 2016

Go to URL