Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 283 free, full-text research articles on human participants. First 3 results:

Incidence, prevalence, and natural history of primary sclerosing cholangitis in the United Kingdom.
 

Author(s): Huifang Liang, Sudhakar Manne, Jesse Shick, Trevor Lissoos, Paul Dolin

Journal: Medicine (Baltimore). 2017 Jun;96(24):e7116.

 

Primary sclerosing cholangitis (PSC) is a rare obliterative fibrotic condition of the bile ducts. We assessed PSC epidemiology and natural history within the UK Clinical Practice Research Datalink (CPRD).Incidence and natural history of PSC were evaluated in a retrospective cohort ...

Last Updated: 14 Jun 2017

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Two Cases of Primary Sclerosing Cholangitis Overlapping with Autoimmune Hepatitis in Adults.
 

Author(s): Go Igarashi, Tetsu Endo, Kenichiro Mikami, Naoya Sawada, Ryu Satake, Rie Ohta, Juichi Sakamoto, Tetsuro Yoshimura, Akira Kurose, Hiroshi Kijima, Shinsaku Fukuda

Journal: Intern. Med.. 2017 ;56(5):509-515.

 

Overlap syndrome between primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) is extremely rare in Japan. We herein report two adult patients with PSC-AIH overlap syndrome. They were diagnosed with PSC-AIH overlap syndrome based on the findings of endoscopic retrograde ...

Last Updated: 2 Mar 2017

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Innumerable Liver Masses in a Patient with Autoimmune Hepatitis and Primary Sclerosing Cholangitis Overlap Syndrome.
 

Author(s): Alireza Gharibpoor, Fariborz Mansour-Ghanaei, Mahbobe Sadeghi, Faeze Gharibpoor, Farahnaz Joukar, Sara Mavaddati

Journal:

 

BACKGROUND In patients with the diagnosis of autoimmune hepatitis (AIH), the presence of cholestatic features raise the possibility of an overlap syndrome with primary sclerosing cholangitis (PSC). Here, we present a unique case with AIH-PSC overlap syndrome and innumerable liver ...

Last Updated: 7 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 60 free, full-text review articles on human participants. First 3 results:

Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC).
 

Author(s): Jochen Mattner

Journal:

 

Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) represent the major clinical entities of chronic cholestatic liver diseases. Both disorders are characterized by portal inflammation and slowly progress to obliterative fibrosis and eventually liver cirrhosis. ...

Last Updated: 11 Nov 2016

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Primary Sclerosing Cholangitis: Multiple Phenotypes, Multiple Approaches.
 

Author(s): Souvik Sarkar, Christopher L Bowlus

Journal: Clin Liver Dis. 2016 Feb;20(1):67-77.

 

Primary sclerosing cholangitis (PSC) is a heterogeneous, idiopathic, inflammatory disorder frequently associated with inflammatory bowel diseases. PSC patients may be classified into several subphenotypes. Investigations of pediatric, nonwhite, and female PSC patients have revealed ...

Last Updated: 23 Nov 2015

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Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management.
 

Author(s): Sumera Rizvi, John E Eaton, Gregory J Gores

Journal: Clin. Gastroenterol. Hepatol.. 2015 Nov;13(12):2152-65.

 

Primary sclerosing cholangitis (PSC) is a premalignant biliary tract disease that confers a significant risk for the development of cholangiocarcinoma (CCA). The chronic biliary tract inflammation of PSC promotes pro-oncogenic processes such as cellular proliferation, induction of ...

Last Updated: 20 Oct 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 24 Feb 2017

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A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 12 Jun 2017

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A Study of Oral Hymecromone to Treat Adults With Primary Sclerosing Cholangitis
 

Status: Not yet recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 20 May 2016

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