Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 273 free, full-text research articles on human participants. First 3 results:

Clinical course of primary sclerosing cholangitis and concomitant ulcerative colitis - a preliminary report of retrospective study among patients from Southern Poland.
 

Author(s): Mikołaj K Głowacki, Małgorzata Zwolińska-Wcisło, Paulina Frączek, Martyna Gomulska, Danuta Owczarek, Dorota Cibor, Andrzej Cieśla, Tomasz Mach

Journal: Folia Med Cracov. 2015 ;55(2):61-8.

 

Both ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) are chronic and progressive diseases of uncertain etiology, that may affect one patient. Approximately 70% of PSC cases are also diagnosed with UC, whereas in the group of UC the prevalence of PSC is about 2-5%. ...

Last Updated: 3 Feb 2016

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Malignancies in Primary Sclerosing Cholangitis--A Continuing Threat.
 

Author(s): Giulia Bonato, Laura Cristoferi, Mario Strazzabosco, Luca Fabris

Journal: Dig Dis. 2015 ;33 Suppl 2():140-8.

 

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease of unknown etiology, primarily targeting cholangiocytes at any portion of the biliary tree. No effective medical treatments are currently available. A unique feature of PSC is its close association (about ...

Last Updated: 9 Dec 2015

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Contrasting Pattern of Chronic Inflammatory Bowel Disease in Primary and Autoimmune Sclerosing Cholangitis.
 

Author(s): Ingvar Bjarnason, Bu Hayee, Polychronis Pavlidis, Charlotte Kvasnovsky, Astrid Scalori, Guy Sisson, Annika Charlesworth, Hizbullah Shaikh, Einar Bjornsson, Michael A Heneghan

Journal:

 

Primary sclerosing cholangitis (PSC) and autoimmune sclerosing cholangitis (AISC) are related, but distinct chronic liver diseases. PSC is associated with a high prevalence of ulcerative colitis while the intestinal inflammation associated with AISC is less well characterised.

Last Updated: 2 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 58 free, full-text review articles on human participants. First 3 results:

Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management.
 

Author(s): Sumera Rizvi, John E Eaton, Gregory J Gores

Journal: Clin. Gastroenterol. Hepatol.. 2015 Nov;13(12):2152-65.

 

Primary sclerosing cholangitis (PSC) is a premalignant biliary tract disease that confers a significant risk for the development of cholangiocarcinoma (CCA). The chronic biliary tract inflammation of PSC promotes pro-oncogenic processes such as cellular proliferation, induction of ...

Last Updated: 20 Oct 2015

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Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis.
 

Author(s): A Boudewijn de Vries, Marcel Janse, Hans Blokzijl, Rinse K Weersma

Journal: World J. Gastroenterol.. 2015 Feb;21(6):1956-71.

 

To review the current literature for the specific clinical characteristics of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC).

Last Updated: 16 Feb 2015

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Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: a review of the literature.
 

Author(s): Rosy Wang, Rupert W Leong

Journal: World J. Gastroenterol.. 2014 Jul;20(27):8783-9.

 

To examine and evaluate recent evidence regarding the epidemiology, pathogenesis and management of colorectal cancer (CRC) development in inflammatory bowel disease (IBD)-primary sclerosing cholangitis (PSC) patients. Using the PubMed database, a literature search was conducted for ...

Last Updated: 1 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Not yet recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 30 Mar 2016

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PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Subjects With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 18 Apr 2016

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Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 20 Jul 2016

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