Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 278 free, full-text research articles on human participants. First 3 results:

Primary Sclerosing Cholangitis.
 

Author(s): Konstantinos N Lazaridis, Nicholas F LaRusso

Journal: N. Engl. J. Med.. 2016 12;375(25):2501-2502.

 

Last Updated: 21 Dec 2016

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The importance of IgG4 screening in patients diagnosed with primary sclerosing cholangitis in the past: A case rediagnosed as IgG4-SC after 10 years.
 

Author(s): Yanni Li, Lu Zhou, Xin Zhao, Wenjing Song, Nathasha Karunaratna, Bangmao Wang

Journal: Medicine (Baltimore). 2016 Dec;95(50):e5628.

 

While primary sclerosing cholangitis (PSC) has been recognized for decades, immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) has been correctly diagnosed only in recent years. PSC and IgG4-SC show similar clinical symptoms, serologic markers, and imaging results, but the ...

Last Updated: 15 Dec 2016

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Evaluation of Biliary Calprotectin as a Biomarker in Primary Sclerosing Cholangitis.
 

Author(s): Annika Gauss, Peter Sauer, Adolf Stiehl, Christian Rupp, Johannes Krisam, Yvonne Leopold, Petra Kloeters-Plachky, Wolfgang Stremmel, Daniel Gotthardt

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3510.

 

Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the bile ducts with limited therapeutic options except liver transplantation. Reliable biomarkers to predict the disease course are unavailable, and currently employed disease activity scores such as the Mayo ...

Last Updated: 29 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 59 free, full-text review articles on human participants. First 3 results:

Primary Sclerosing Cholangitis: Multiple Phenotypes, Multiple Approaches.
 

Author(s): Souvik Sarkar, Christopher L Bowlus

Journal: Clin Liver Dis. 2016 Feb;20(1):67-77.

 

Primary sclerosing cholangitis (PSC) is a heterogeneous, idiopathic, inflammatory disorder frequently associated with inflammatory bowel diseases. PSC patients may be classified into several subphenotypes. Investigations of pediatric, nonwhite, and female PSC patients have revealed ...

Last Updated: 23 Nov 2015

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Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management.
 

Author(s): Sumera Rizvi, John E Eaton, Gregory J Gores

Journal: Clin. Gastroenterol. Hepatol.. 2015 Nov;13(12):2152-65.

 

Primary sclerosing cholangitis (PSC) is a premalignant biliary tract disease that confers a significant risk for the development of cholangiocarcinoma (CCA). The chronic biliary tract inflammation of PSC promotes pro-oncogenic processes such as cellular proliferation, induction of ...

Last Updated: 20 Oct 2015

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Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis.
 

Author(s): A Boudewijn de Vries, Marcel Janse, Hans Blokzijl, Rinse K Weersma

Journal: World J. Gastroenterol.. 2015 Feb;21(6):1956-71.

 

To review the current literature for the specific clinical characteristics of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC).

Last Updated: 16 Feb 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 24 Feb 2017

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PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Subjects With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 18 Apr 2016

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Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 20 Jul 2016

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