Primary sclerosing cholangitis

Common Name(s)

Primary sclerosing cholangitis

Primary Sclerosing Cholangitis (PSC) is a rare liver and bile duct disease which may have an autoimmune component. It's not curable, but some of the symptoms are treatable - and there's hope. PSC is often associated with ulcerative colitis, Crohn’s disease, and related gastrointestinal and autoimmune diseases. Some PSC patients eventually require a liver transplant. Many PSCers, despite daily limitations and medications, are able to live full lives.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

Last Updated: 4 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary sclerosing cholangitis" for support, advocacy or research.

PSC Partners Seeking a Cure

PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation whose mission is to provide education and support to PSC patients and their families, raise funds with which to research PSC, find treatments and promote awareness of PSC. The organization holds an annual three-day conference at various PSC centers in the US. Attendees come from all over the world. PSC Partners provides online support to patients, and has an important PSC and related diseases literature site. PSC Partners has a competitive research grant program and quarterly newsletters. Our website is a hub for PSCers.

http://www.pscpartners.org

Last Updated: 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary sclerosing cholangitis" returned 323 free, full-text research articles on human participants. First 3 results:

A novel learning algorithm to predict individual survival after liver transplantation for primary sclerosing cholangitis.
 

Author(s): Axel Andres, Aldo Montano-Loza, Russell Greiner, Max Uhlich, Ping Jin, Bret Hoehn, David Bigam, James Andrew Mark Shapiro, Norman Mark Kneteman

Journal:

 

Deciding who should receive a liver transplant (LT) depends on both urgency and utility. Most survival scores are validated through discriminative tests, which compare predicted outcomes between patients. Assessing post-transplant survival utility is not discriminate, but should be ...

Last Updated: 31 Dec 1969

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Association of gadolinium-enhanced magnetic resonance imaging with hepatic fibrosis and inflammation in primary sclerosing cholangitis.
 

Author(s): Sarah Keller, Annette Aigner, Roman Zenouzi, Anne C Kim, Arnoud Meijer, Sören A Weidemann, Till Krech, Ansgar W Lohse, Gerhard Adam, Christoph Schramm, Jin Yamamura

Journal:

 

To evaluate magnetic resonance imaging (MRI) parameters T2 signal, contrast enhancement (CE), and relative liver enhancement (RLE) of extracellular gadolinium-based contrast agent (GBCA)-enhanced MRI as a marker for hepatic fibrosis and inflammation in patients with primary sclerosing ...

Last Updated: 31 Dec 1969

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Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis.
 

Author(s): Kentaro Yamao, Mamoru Takenaka, Hajime Imai, Atsushi Nakai, Shunske Omoto, Ken Kamata, Kosuke Minaga, Takeshi Miyata, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Ippei Matsumoto, Yosihumi Takeyama, Takaaki Chikugo, Masatoshi Kudo

Journal: Oncology. 2017 ;93 Suppl 1():76-80.

 

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by multiple fibrotic strictures of the bile duct. More than 40% of deaths in PSC patients are related to malignant tumors, including cholangiocarcinoma. Primary hepatic adenosquamous carcinoma ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary sclerosing cholangitis" returned 69 free, full-text review articles on human participants. First 3 results:

Endoscopic Management of Primary Sclerosing Cholangitis.
 

Author(s): Jodie A Barkin, Cynthia Levy, Enrico O Souto

Journal: Ann Hepatol. ;16(6):842-850.

 

Primary sclerosing cholangitis (PSC) remains a rare but potentially devastating chronic, cholestatic liver disease. PSC causes obstruction of intra- and/or extra-hepatic bile ducts by inflammation and fibrosis, leading to biliary obstruction, cirrhosis and portal hypertension with ...

Last Updated: 31 Dec 1969

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Pathogenesis and clinical spectrum of primary sclerosing cholangitis.
 

Author(s): Neelam G Gidwaney, Swati Pawa, Kiron M Das

Journal: World J. Gastroenterol.. 2017 Apr;23(14):2459-2469.

 

Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory ...

Last Updated: 31 Dec 1969

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Emerging pharmacologic therapies for primary sclerosing cholangitis.
 

Author(s): Angela C Cheung, Konstantinos N Lazaridis, Nicholas F LaRusso, Gregory J Gores

Journal: Curr. Opin. Gastroenterol.. 2017 May;33(3):149-157.

 

The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Quality of Life in Patients With Primary Sclerosing Cholangitis
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 1 Mar 2018

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Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis
 

Status: Not yet recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 7 Jun 2018

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A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC)
 

Status: Recruiting

Condition Summary: Primary Sclerosing Cholangitis

 

Last Updated: 6 Jun 2018

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