Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 746 free, full-text research articles on human participants. First 3 results:

Red Blood Cell Distribution Width to Platelet Ratio is Related to Histologic Severity of Primary Biliary Cirrhosis.
 

Author(s): Huan Wang, Hongqin Xu, Xiaomei Wang, Ruihong Wu, Xiuzhu Gao, Qinglong Jin, Junqi Niu

Journal: Medicine (Baltimore). 2016 Mar;95(11):e3114.

 

We aimed to investigate whether red blood cell distribution width (RDW) and RDW to platelet ratio (RPR) were related to the histologic severity of primary biliary cirrhosis (PBC). Seventy-three treatment-naïve PBC patients who had undergone a liver biopsy between January 2010 and ...

Last Updated: 18 Mar 2016

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Visfatin and TGF-Β1 in primary biliary cirrhosis and two other common liver diseases.
 

Author(s): Marek Waluga, Michał Kukla, Michał Żorniak, Anna Kochel-Jankowska, Maciej Kajor, Tadeusz Krzemiński, Rafał Kotulski

Journal: Folia Med Cracov. 2015 ;55(4):59-70.

 

The aim of this study is to investigate plasma concentration of visfatin and transforming growth factor Β1 (TGF-Β1) in three groups of patients: primary biliary cirrhosis (PBC), non-alcoholic fatty liver disease (NAFLD) and toxic cirrhosis (TC). We qualified the patients into the ...

Last Updated: 12 Feb 2016

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Increased Risks of Spontaneous Bacterial Peritonitis and Interstitial Lung Disease in Primary Biliary Cirrhosis Patients With Concomitant Sjögren Syndrome.
 

Author(s): Chun-Ting Chen, Yu-Chen Tseng, Chih-Wei Yang, Hsuan-Hwai Lin, Peng-Jen Chen, Tien-Yu Huang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu

Journal: Medicine (Baltimore). 2016 Jan;95(2):e2537.

 

The incidence of Sjögren syndrome (SS) in primary biliary cirrhosis (PBC) patients is high. The influence of SS on the clinical outcomes of PBC patients, however, remains unclear. Our study retrospectively collected data on PBC-only patients and PBC patients with concomitant SS (PBC-SS) ...

Last Updated: 15 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 115 free, full-text review articles on human participants. First 3 results:

Genome-Wide Association Studies in Primary Biliary Cirrhosis.
 

Author(s): Aliya F Gulamhusein, Brian D Juran, Konstantinos N Lazaridis

Journal: Semin. Liver Dis.. 2015 Nov;35(4):392-401.

 

Genome-wide association studies (GWASs) have been a significant technological advance in our ability to evaluate the genetic architecture of complex diseases such as primary biliary cirrhosis (PBC). To date, six large-scale studies have been performed that have identified 27 risk ...

Last Updated: 17 Dec 2015

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Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis.
 

Author(s): Qin Yin, Jingjing Li, Yujing Xia, Rong Zhang, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Yuanyuan Zheng, Huerxidan Abudumijiti, Rongxia Chen, Kan Chen, Sainan Li, Tong Liu, Fan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

Journal:

 

Ursodeoxycholic acid (UDCA) is the standard treatment for primary biliary cirrhosis (PBC), but not all cases respond well. Evidence has shown that combination therapy of UDCA with bezafibrate significantly improved liver function. A meta-analysis was performed to assess the efficacy ...

Last Updated: 22 Oct 2015

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The immunogenetics of primary biliary cirrhosis: A comprehensive review.
 

Author(s): G J Webb, K A Siminovitch, G M Hirschfield

Journal: J. Autoimmun.. 2015 Nov;64():42-52.

 

Primary biliary cirrhosis (PBC), a classic autoimmune liver disease, is characterised by a progressive T cell predominant lymphocytic cholangitis, and a serologic pattern of reactivity in the form of specific anti-mitochondrial antibodies (AMA). CD4+ T cells are particularly implicated ...

Last Updated: 31 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 12 Apr 2016

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Last Updated: 14 Oct 2016

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The Health Burden of Primary Biliary Cirrhosis (PBC) in Switzerland
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 26 Jul 2016

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