Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 709 free, full-text research articles on human participants. First 3 results:

Successful Etanercept Treatment for Primary Biliary Cirrhosis Associated with Rheumatoid Arthritis.
 

Author(s): Attila Kovács, Adelina G Siminischi, Beáta Baksay, András Gáll, Mária Takács, Zoltán Szekanecz

Journal: Isr. Med. Assoc. J.. 2015 Feb;17(2):114-6.

 

Last Updated: 30 Jul 2015

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Anti-neutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis Associated with Primary Biliary Cirrhosis: A Case Report and Literature Review.
 

Author(s): Hiroyuki Yamashita, Akitake Suzuki, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori

Journal: Intern. Med.. 2015 ;54(10):1303-8.

 

We herein report a rare case of microscopic polyangiitis with primary biliary cirrhosis (PBC) and a literature review of six previously reported cases of PBC complicated by anti-neutrophil cytoplasmic antibody-associated vasculitis. Due to the scarcity of similar reports, it was not ...

Last Updated: 19 May 2015

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A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis.
 

Author(s): Lu Wang, Guan-ya Guo, Jing-bo Wang, Xin-min Zhou, Qiong Yang, Zhe-yi Han, Qiang Li, Jing-wen Zhang, Yun Cai, Xiao-li Ren, Xia Zhou, Rui-Rui Chen, Yong-quan Shi, Ying Han, Dai-ming Fan

Journal:

 

Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of lysosome-associated membrane protein 2 (LAMP-2) was correlated with the severity of PBC. This study aimed to determine ...

Last Updated: 21 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 108 free, full-text review articles on human participants. First 3 results:

Primary biliary cirrhosis is a generalized autoimmune epithelitis.
 

Author(s): Jun Gao, Liang Qiao, Bingyuan Wang

Journal:

 

Primary biliary cirrhosis (PBC) is a chronic progressive autoimmune cholestatic liver disease characterized by highly specific antimitochondrial antibodies (AMAs) and the specific immune-mediated injury of small intrahepatic bile ducts. Unique apoptotic feature of biliary epithelial ...

Last Updated: 25 Mar 2015

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Network meta-analysis of randomized controlled trials: efficacy and safety of UDCA-based therapies in primary biliary cirrhosis.
 

Author(s): Gui-Qi Zhu, Ke-Qing Shi, Sha Huang, Gui-Qian Huang, Yi-Qian Lin, Zhi-Rui Zhou, Martin Braddock, Yong-Ping Chen, Ming-Hua Zheng

Journal: Medicine (Baltimore). 2015 Mar;94(11):e609.

 

Major ursodeoxycholic acid (UDCA)-based therapies for primary biliary cirrhosis (PBC) include UDCA only, or combined with either methotrexate (MTX), corticosteroids (COT), colchicine (COC), or bezafibrate (BEF). As the optimum treatment regimen is unclear and warrants exploration, ...

Last Updated: 20 Mar 2015

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Advances in pharmacotherapy for primary biliary cirrhosis.
 

Author(s): Hani S Mousa, Ana Lleo, Pietro Invernizzi, Christopher L Bowlus, Merril Eric Gershwin

Journal: Expert Opin Pharmacother. 2015 Apr;16(5):633-43.

 

Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disease mostly seen in middle-aged women characterized by progressive nonsuppurative destruction of small bile ducts resulting in intrahepatic cholestasis, parenchymal injury and ultimately end-stage liver disease. Despite ...

Last Updated: 9 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 15 Sep 2015

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Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 5 Jan 2016

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Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 30 May 2013

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