Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 626 free, full-text research articles on human participants. First 3 results:

[Primary biliary cirrhosis: a retrospective study of 36 cases].
 

Author(s): Mehdi Ksiaa, Mohamed Ajili, Aida Ben Slama, Ahlem Souguir, Mohamed Ben Rjeb, Badreddine Sriha, Ahlem Brahem, Ali Jmaa, Salem Ajmi

Journal: Tunis Med. 2014 Feb;92(2):123-7.

 

Primary biliary cirrhosis is a rare cholestasis liver disease affecting the women of mature age,it association with Autoimmune hepatitis defined the overlap syndrome.

Last Updated: 18 Jun 2014

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No rise in incidence but geographical heterogeneity in the occurrence of primary biliary cirrhosis in North East England.
 

Author(s): Richard J Q McNally, Peter W James, Samantha Ducker, Paul D Norman, Oliver F W James

Journal: Am. J. Epidemiol.. 2014 Feb;179(4):492-8.

 

In this study, we examined temporal changes in the incidence of primary biliary cirrhosis (PBC) and investigated associations between PBC incidence and sociodemographic factors and spatial clustering. We included 982 patients aged ≥40 years from North East England with incident ...

Last Updated: 3 Feb 2014

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Primary biliary cirrhosis-specific antimitochondrial antibodies in neonatal haemochromatosis.
 

Author(s): Daniel S Smyk, Maria G Mytilinaiou, Tassos Grammatikopoulos, A S Knisely, Giorgina Mieli-Vergani, Dimitrios P Bogdanos, Diego Vergani

Journal: Clin. Dev. Immunol.. 2013 ;2013():642643.

 

Neonatal hemochromatosis (NH) is characterised by severe liver injury and extrahepatic siderosis sparing the reticuloendothelial system. Its aetiology is obscure, although it has been proposed as an alloimmune disease, resulting from immunological reaction to self-antigens (alloantigens) ...

Last Updated: 30 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 85 free, full-text review articles on human participants. First 3 results:

Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis.
 

Author(s): Yasuyuki Tomiyama, Kazuyuki Takenaka, Takahiro Kodama, Miwa Kawanaka, Kyo Sasaki, Sohji Nishina, Naoko Yoshioka, Yuichi Hara, Keisuke Hino

Journal: Intern. Med.. 2013 ;52(14):1553-9.

 

Early diagnosis of hepatocellular carcinoma (HCC) is critical in the management of patients with primary biliary cirrhosis (PBC), since the prognosis of PBC has improved. The aim of this study was to investigate whether HCC development affects the prognosis of PBC and to identify ...

Last Updated: 16 Jul 2013

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Is there a role for cyclophilin inhibitors in the management of primary biliary cirrhosis?
 

Author(s): Shawn T Wasilenko, Aldo J Montano-Loza, Andrew L Mason

Journal:

 

Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly understood autoimmune liver diseases. Immunosuppression is used to treat AIH and ursodeoxycholic acid is used to slow the progression of PBC. Nevertheless, a proportion of patients with both disorders progress ...

Last Updated: 25 Jan 2013

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Role of autoimmunity in primary biliary cirrhosis.
 

Author(s): Tian-Yan Shi, Feng-Chun Zhang

Journal: World J. Gastroenterol.. 2012 Dec;18(48):7141-8.

 

Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of serum autoantibodies and chronic nonsuppurative destructive cholangitis. The pathogenesis of PBC involves environmental factors, genetic predisposition and loss of immune tolerance. In ...

Last Updated: 17 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 30 May 2013

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Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
 

Status: Not yet recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 3 Mar 2014

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Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 19 Feb 2014

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