Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 635 free, full-text research articles on human participants. First 3 results:

[Primary biliary cirrhosis: a retrospective study of 36 cases].
 

Author(s): Mehdi Ksiaa, Mohamed Ajili, Aida Ben Slama, Ahlem Souguir, Mohamed Ben Rjeb, Badreddine Sriha, Ahlem Brahem, Ali Jmaa, Salem Ajmi

Journal: Tunis Med. 2014 Feb;92(2):123-7.

 

Primary biliary cirrhosis is a rare cholestasis liver disease affecting the women of mature age,it association with Autoimmune hepatitis defined the overlap syndrome.

Last Updated: 18 Jun 2014

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Increased activated natural killer T cells in the liver of patients with advanced stage primary biliary cirrhosis.
 

Author(s): Yuiko Aso-Ishimoto, Satoshi Yamagiwa, Takafumi Ichida, Ryoko Miyakawa, Chikako Tomiyama, Yoshinobu Sato, Hisami Watanabe, Yutaka Aoyagi

Journal: Biomed. Res.. 2014 ;35(2):161-9.

 

Although growing evidence suggests a major role for T cells in the pathogenesis of primary biliary cirrhosis (PBC), the roles of natural killer (NK) and natural killer T (NKT) cells, which predominate in the liver, in the pathogenesis of PBC remain unclear. We investigated the status ...

Last Updated: 24 Apr 2014

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Ursodeoxycholic acid influences the expression of p27kip1 but not FoxO1 in patients with non-cirrhotic primary biliary cirrhosis.
 

Author(s): Malgorzata Milkiewicz, Justyna Kopycińska, Agnieszka Kempińska-Podhorodecka, Tara Haas, Dimitrios P Bogdanos, Elwyn Elias, Piotr Milkiewicz

Journal: J Immunol Res. 2014 ;2014():921285.

 

Enhanced expression of cell cycle inhibitor p27(kip1) suppresses cell proliferation. Ursodeoxycholic acid (UDCA) delays progression of primary biliary cirrhosis (PBC) but its effect on p27(kip1) expression is uncertain.

Last Updated: 17 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 88 free, full-text review articles on human participants. First 3 results:

Concurrent autoimmune pancreatitis and primary biliary cirrhosis: a rare case report and literature review.
 

Author(s): Aiqing Li, Yongjie Wang, Zheng Deng

Journal:

 

Both autoimmune pancreatitis (AIP) and primary biliary cirrhosis (PBC) are related to various diseases. But the concurrence of AIP and PBC is extremely rare, with only 2 cases reported. Here we report the concurrence of AIP and PBC in a Chinese patient for the first time.

Last Updated: 20 Jan 2014

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Association of human leukocyte antigen class II with susceptibility to primary biliary cirrhosis: a systematic review and meta-analysis.
 

Author(s): Baodong Qin, Jiaqi Wang, Jia Chen, Yan Liang, Zaixing Yang, Renqian Zhong

Journal:

 

Several previous studies suggested that HLA-Class II may be associated with susceptibility to primary biliary cirrhosis (PBC), but data from individual studies remain controversial. Therefore, a systematic review and meta-analysis is needed to comprehensively evaluate the association ...

Last Updated: 22 Nov 2013

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Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis.
 

Author(s): Yasuyuki Tomiyama, Kazuyuki Takenaka, Takahiro Kodama, Miwa Kawanaka, Kyo Sasaki, Sohji Nishina, Naoko Yoshioka, Yuichi Hara, Keisuke Hino

Journal: Intern. Med.. 2013 ;52(14):1553-9.

 

Early diagnosis of hepatocellular carcinoma (HCC) is critical in the management of patients with primary biliary cirrhosis (PBC), since the prognosis of PBC has improved. The aim of this study was to investigate whether HCC development affects the prognosis of PBC and to identify ...

Last Updated: 16 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 19 Feb 2014

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Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 8 Dec 2014

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Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 30 May 2013

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