Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 746 free, full-text research articles on human participants. First 3 results:

Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis.
 

Author(s): Zhanyi Li, Bingliang Lin, Guoli Lin, Yuankai Wu, Yusheng Jie, Xiangyong Li, Brian Ko, Yutian Chong, Jian Luo

Journal:

 

Bile acid (BA) synthesis in the liver is regulated by Fibroblast Growth Factor 19 (FGF19) secreted from the ileum as an enterohepatic feedback mechanism. Although FGF19 mRNA is absent in normal liver, FGF19 gene expression was reported to increase in response to both extrahepatic ...

Last Updated: 31 Dec 1969

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Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis.
 

Author(s): Qingshui Huang, Shuai Chu, Xiaofeng Yin, Xiaobin Yu, Chunmin Kang, Xin Li, Yurong Qiu

Journal: Tohoku J. Exp. Med.. 2016 12;240(4):269-275.

 

Primary biliary cirrhosis (PBC) is an autoimmune chronic liver disease with worldwide increasing morbidity. However, the etiology of PBC is still unclear. Recently, the epithelial-mesenchymal transition (EMT) and interleukin-17A (IL-17A), a pro-inflammatory cytokine, were proposed ...

Last Updated: 31 Dec 1969

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Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis.
 

Author(s): Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng

Journal: World J. Gastroenterol.. 2016 Sep;22(33):7579-86.

 

To summarize and compare the clinical characteristics of drug-induced liver injury (DILI) and primary biliary cirrhosis (PBC).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 116 free, full-text review articles on human participants. First 3 results:

Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: an Update on MR Imaging Findings with Recent Developments.
 

Author(s): Jelena Djokić Kovač, Marc-André Weber

Journal: J Gastrointestin Liver Dis. 2016 Dec;25(4):517-524.

 

Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are the most common immune-mediated chronic cholestatic liver diseases leading to cirrhosis and liver failure. Although magnetic resonance imaging (MRI) is not a necessary procedure for the diagnosis of PBC, ...

Last Updated: 31 Dec 1969

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Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC).
 

Author(s): Jochen Mattner

Journal:

 

Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) represent the major clinical entities of chronic cholestatic liver diseases. Both disorders are characterized by portal inflammation and slowly progress to obliterative fibrosis and eventually liver cirrhosis. ...

Last Updated: 31 Dec 1969

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Bile Acids and the Potential Role in Primary Biliary Cirrhosis.
 

Author(s): Hang Yang, Zhijun Duan

Journal: Digestion. 2016 ;94(3):145-153.

 

Bile acids (BAs) play a potential role in regulating the whole-body metabolic homeostasis via the interaction with gut microbiome and the signal transduction as messengers, which establish a link between the primary biliary cirrhosis (PBC) and gut microbiome in many aspects, particularly ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 21 Aug 2017

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Last Updated: 14 Oct 2016

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Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 5 Jul 2016

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