Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 735 free, full-text research articles on human participants. First 3 results:

Visfatin and TGF-Β1 in primary biliary cirrhosis and two other common liver diseases.
 

Author(s): Marek Waluga, Michał Kukla, Michał Żorniak, Anna Kochel-Jankowska, Maciej Kajor, Tadeusz Krzemiński, Rafał Kotulski

Journal: Folia Med Cracov. 2015 ;55(4):59-70.

 

The aim of this study is to investigate plasma concentration of visfatin and transforming growth factor Β1 (TGF-Β1) in three groups of patients: primary biliary cirrhosis (PBC), non-alcoholic fatty liver disease (NAFLD) and toxic cirrhosis (TC). We qualified the patients into the ...

Last Updated: 12 Feb 2016

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Increased Risks of Spontaneous Bacterial Peritonitis and Interstitial Lung Disease in Primary Biliary Cirrhosis Patients With Concomitant Sjögren Syndrome.
 

Author(s): Chun-Ting Chen, Yu-Chen Tseng, Chih-Wei Yang, Hsuan-Hwai Lin, Peng-Jen Chen, Tien-Yu Huang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu

Journal: Medicine (Baltimore). 2016 Jan;95(2):e2537.

 

The incidence of Sjögren syndrome (SS) in primary biliary cirrhosis (PBC) patients is high. The influence of SS on the clinical outcomes of PBC patients, however, remains unclear. Our study retrospectively collected data on PBC-only patients and PBC patients with concomitant SS (PBC-SS) ...

Last Updated: 15 Jan 2016

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The Distribution and the Fibrotic Role of Elevated Inflammatory Th17 Cells in Patients With Primary Biliary Cirrhosis.
 

Author(s): TianYan Shi, Ting Zhang, LiNa Zhang, YunJiao Yang, HaoZe Zhang, FengChun Zhang

Journal: Medicine (Baltimore). 2015 Nov;94(44):e1888.

 

T helper (Th) 17 cells were reported to have the property of proinflammation and profibrosis. We first investigate the levels of Th17 cells in primary biliary cirrhosis (PBC) patients, and then explore their distribution and fibrotic role in the disease.We compared the circulating ...

Last Updated: 11 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 113 free, full-text review articles on human participants. First 3 results:

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis.
 

Author(s): Qin Yin, Jingjing Li, Yujing Xia, Rong Zhang, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Yuanyuan Zheng, Huerxidan Abudumijiti, Rongxia Chen, Kan Chen, Sainan Li, Tong Liu, Fan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

Journal:

 

Ursodeoxycholic acid (UDCA) is the standard treatment for primary biliary cirrhosis (PBC), but not all cases respond well. Evidence has shown that combination therapy of UDCA with bezafibrate significantly improved liver function. A meta-analysis was performed to assess the efficacy ...

Last Updated: 22 Oct 2015

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Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis.
 

Author(s): Vasiliy Ivanovich Reshetnyak

Journal: World J. Gastroenterol.. 2015 Jul;21(25):7683-708.

 

Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and ...

Last Updated: 13 Jul 2015

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Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis.
 

Author(s): Gui-Qi Zhu, Sha Huang, Gui-Qian Huang, Li-Ren Wang, Yi-Qian Lin, Yi-Ming Wu, Ke-Qing Shi, Jiang-Tao Wang, Zhi-Rui Zhou, Martin Braddock, Yong-Ping Chen, Meng-Tao Zhou, Ming-Hua Zheng

Journal: Oncotarget. 2015 Sep;6(27):24533-49.

 

Most comprehensive treatments for PBC include UDCA, combination of methotrexate (MTX), corticosteroids (COT), colchicine (COC) or bezafibrate (BEF), cyclosporin A (CYP), D-penicillamine (DPM), methotrexate (MTX), or azathioprine (AZP). Since the optimum treatment regimen remains inconclusive, ...

Last Updated: 25 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 12 Apr 2016

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Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 5 Jan 2016

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Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 30 May 2013

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