Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 732 free, full-text research articles on human participants. First 3 results:

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial.
 

Author(s): Vinod S Hegade, Stuart F W Kendrick, Robert L Dobbins, Sam R Miller, Duncan Richards, James Storey, George Dukes, Kim Gilchrist, Susan Vallow, Graeme J Alexander, Margaret Corrigan, Gideon M Hirschfield, David E J Jones

Journal:

 

Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) have been proposed as potential pruritogens in PBC. The ileal bile acid transporter ...

Last Updated: 19 Jul 2016

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Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population.
 

Author(s): Ping Li, Guanting Lu, Ying Cui, Ziyan Wu, Si Chen, Jing Li, Xiaoting Wen, Haoze Zhang, Shijie Mu, Fengchun Zhang, Yongzhe Li

Journal: Medicine (Baltimore). 2016 May;95(19):e3665.

 

Genome-wide association studies in European individuals have revealed that IL12A is strongly associated with primary biliary cirrhosis (PBC). However, this association was not detected in replicative studies conducted in Chinese Han and Japanese populations.To verify contributions ...

Last Updated: 14 May 2016

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Quantitative fibrosis parameters highly predict esophageal-gastro varices in primary biliary cirrhosis.
 

Author(s): Q-M Wu, X-Y Zhao, H You

Journal: Eur Rev Med Pharmacol Sci. 2016 ;20(6):1037-43.

 

Esophageal-gastro Varices (EGV) may develop in any histological stages of primary biliary cirrhosis (PBC). We aim to establish and validate quantitative fibrosis (qFibrosis) parameters in portal, septal and fibrillar areas as ideal predictors of EGV in PBC patients.

Last Updated: 7 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 113 free, full-text review articles on human participants. First 3 results:

Combination antiretroviral studies for patients with primary biliary cirrhosis.
 

Author(s): Ellina Lytvyak, Aldo J Montano-Loza, Andrew L Mason

Journal: World J. Gastroenterol.. 2016 Jan;22(1):349-60.

 

Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis (PBC), pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct ...

Last Updated: 12 Jan 2016

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Genome-Wide Association Studies in Primary Biliary Cirrhosis.
 

Author(s): Aliya F Gulamhusein, Brian D Juran, Konstantinos N Lazaridis

Journal: Semin. Liver Dis.. 2015 Nov;35(4):392-401.

 

Genome-wide association studies (GWASs) have been a significant technological advance in our ability to evaluate the genetic architecture of complex diseases such as primary biliary cirrhosis (PBC). To date, six large-scale studies have been performed that have identified 27 risk ...

Last Updated: 17 Dec 2015

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Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis.
 

Author(s): Qin Yin, Jingjing Li, Yujing Xia, Rong Zhang, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Yuanyuan Zheng, Huerxidan Abudumijiti, Rongxia Chen, Kan Chen, Sainan Li, Tong Liu, Fan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

Journal:

 

Ursodeoxycholic acid (UDCA) is the standard treatment for primary biliary cirrhosis (PBC), but not all cases respond well. Evidence has shown that combination therapy of UDCA with bezafibrate significantly improved liver function. A meta-analysis was performed to assess the efficacy ...

Last Updated: 22 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 12 Apr 2016

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Last Updated: 14 Oct 2016

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Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 29 Mar 2016

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