Primary biliary cirrhosis

Common Name(s)

Primary biliary cirrhosis

Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary biliary cirrhosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary biliary cirrhosis" returned 650 free, full-text research articles on human participants. First 3 results:

Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis.
 

Author(s): I Ben Ghorbel, N Bel Feki, T Ben Salem, A Hamzaoui, M Khanfir, M Lamloum, M Miled, M H Houman

Journal: Saudi J Kidney Dis Transpl. 2015 Mar;26(2):359-62.

 

The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe here a patient who presented with sensorimotor neuropathy along with hypothyroidism, renal failure and liver dysfunction. Detection of antinuclear antibodies ...

Last Updated: 12 Mar 2015

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Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.
 

Author(s): Gideon M Hirschfield, Andrew Mason, Velimir Luketic, Keith Lindor, Stuart C Gordon, Marlyn Mayo, Kris V Kowdley, Catherine Vincent, Henry C Bodhenheimer, Albert Parés, Michael Trauner, Hanns-Ulrich Marschall, Luciano Adorini, Cathi Sciacca, Tessa Beecher-Jones, Erin Castelloe, Olaf Böhm, David Shapiro

Journal: Gastroenterology. 2015 Apr;148(4):751-61.e8.

 

We evaluated the efficacy and safety of obeticholic acid (OCA, α-ethylchenodeoxycholic acid) in a randomized controlled trial of patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid therapy.

Last Updated: 25 Mar 2015

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The association between bile salt export pump single-nucleotide polymorphisms and primary biliary cirrhosis susceptibility and ursodeoxycholic acid response.
 

Author(s): Rui-rui Chen, Yuan-jun Li, Xin-min Zhou, Lu Wang, Juan Xing, Shuang Han, Li-na Cui, Lin-hua Zheng, Kai-chun Wu, Yong-quan Shi, Zhe-yi Han, Ying Han, Dai-ming Fan

Journal: Dis. Markers. 2014 ;2014():350690.

 

Primary biliary cirrhosis (PBC) is a chronic and progressive cholestasis liver disease. Bile salt export pump (BSEP) is the predominant bile salt efflux system of hepatocytes. BSEP gene has been attached great importance in the susceptibility of PBC and the response rate of ursodeoxycholic ...

Last Updated: 13 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary biliary cirrhosis" returned 97 free, full-text review articles on human participants. First 3 results:

Primary biliary cirrhosis in the era of liver transplantation.
 

Author(s): Joanna Raczyńska, Andrzej Habior, Leszek Pączek, Bartosz Foroncewicz, Andrzej Pawełas, Krzysztof Mucha

Journal:

 

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by the presence of antimitochondrial antibodies (AMA) and progressive immune-mediated destruction of biliary ductules, which lead to cirrhosis. Theories of the PBC etiopathogenesis assume that the ...

Last Updated: 29 Sep 2014

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Role of cholangiocytes in primary biliary cirrhosis.
 

Author(s): Ana Lleo, Luca Maroni, Shannon Glaser, Gianfranco Alpini, Marco Marzioni

Journal: Semin. Liver Dis.. 2014 Aug;34(3):273-84.

 

Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by selective destruction of intrahepatic cholangiocytes. Mechanisms underlying the development and progression of the disease are still controversial and largely undefined. Evidence suggests that PBC results ...

Last Updated: 25 Jul 2014

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Environmental factors in primary biliary cirrhosis.
 

Author(s): Brian D Juran, Konstantinos N Lazaridis

Journal: Semin. Liver Dis.. 2014 Aug;34(3):265-72.

 

The etiology of the autoimmune liver disease primary biliary cirrhosis (PBC) remains largely unresolved, owing in large part to the complexity of interaction between environmental and genetic contributors underlying disease development. Observations of disease clustering, differences ...

Last Updated: 25 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 21 Jan 2015

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Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Primary Biliary Cirrhosis

 

Last Updated: 8 Dec 2014

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B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis
 

Status: Recruiting

Condition Summary: Fatigue; Primary Biliary Cirrhosis

 

Last Updated: 11 Mar 2015

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