Juvenile idiopathic arthritis

Common Name(s)

Juvenile idiopathic arthritis, JIA, Juvenile rheumatoid arthritis, JRA, Pediatric arthritis

Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most common form of arthritis in children ages 6 months to 17 years. JIA causes inflammation (redness, swelling, heat, pain) in one, or many, joints (areas of the body where two bones fit together). JIA is not the same as the adult type of arthritis. There are seven different types of JIA (see related conditions below).

JIA causes pain, stiffness, swelling, and redness most commonly in the knees and joints of hands and feet. The joint may not move fully (decreased range of motion). Symptoms are usually worse in the morning or after a nap. The symptoms may go away after a few months or be lifelong. Some types of JIA can affect other parts of the body, causing swollen lymph nodes, rashes and fever, eye inflammation and growth problems.

The cause of JIA is unknown (idiopathic). However, it is believed that both environmental and genetic factors play a role. JIA may be an autoimmune or autoinflammatory disease. Usually, our immune system protects us from illness and infection by attacking viruses, bacteria and other foreign bodies. Sometimes our immune system attacks its own healthy cells. Different parts of our immune system can go wrong causing either an autoimmune or an autoinflammatory response.

Girls are more likely to have JIA. Certain viruses may also increase a child’s risk. To diagnose this condition, your child’s doctor or specialist may perform a physical exam, blood tests and special imaging tests of your child’s joints (using X-ray, MRI and video imaging). Although there is no cure for JIA, there are treatments that help reduce pain and swelling. These treatments include medications, therapy, and possibly surgery. If your child has been diagnosed with JIA, talk with their doctor about the most current treatment options. Support groups are also a good source of information and will help connect you with other families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile idiopathic arthritis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

Last Updated: 2 Aug 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile idiopathic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

http://www.isabellasaviary.com

Last Updated: 2 Aug 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile idiopathic arthritis" returned 696 free, full-text research articles on human participants. First 3 results:

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
 

Author(s): Terri H Finkel, Jin Li, Zhi Wei, Wei Wang, Haitao Zhang, Edward M Behrens, Emma L Reuschel, Sophie Limou, Carol Wise, Marilynn Punaro, Mara L Becker, Jane E Munro, Berit Flatø, Øystein Førre, Susan D Thompson, Carl D Langefeld, David N Glass, Joseph T Glessner, Cecilia E Kim, Edward Frackelton, Debra K Shivers, Kelly A Thomas, Rosetta M Chiavacci, Cuiping Hou, Kexiang Xu, James Snyder, Haijun Qiu, Frank Mentch, Kai Wang, Cheryl A Winkler, Benedicte A Lie, Justine A Ellis, Hakon Hakonarson

Journal:

 

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease among children, the etiology of which involves a strong genetic component, but much of the underlying genetic determinants still remain unknown. Our aim was to identify novel genetic variants that predispose to JIA.

Last Updated: 23 Mar 2016

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Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt.
 

Author(s): Ana Filipa Mourão, Maria José Santos, Sílvia Mendonça, Filipa Oliveira-Ramos, Manuel Salgado, Paula Estanqueiro, José Melo-Gomes, Fernando Martins, Ana Lopes, Bruno Filipe Bettencourt, Jácome Bruges-Armas, José Costa, Carolina Furtado, Ricardo Figueira, Iva Brito, Jaime Branco, João Eurico Fonseca, Helena Canhão

Journal: J Immunol Res. 2015 ;2015():706515.

 

This study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA).

Last Updated: 27 Oct 2015

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Is Antibiotic Exposure Associated With Newly Diagnosed Juvenile Idiopathic Arthritis?
 

Author(s): Joseph L Mathew, Surjit Singh, Janani Sankar

Journal: Indian Pediatr. 2015 Oct;52(10):883-8.

 

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile idiopathic arthritis" returned 91 free, full-text review articles on human participants. First 3 results:

Uveitis in juvenile idiopathic arthritis: recent therapeutic advances.
 

Author(s): Jane M Wells, Justine R Smith

Journal: Ophthalmic Res.. 2015 ;54(3):124-7.

 

Uveitis is a common association of juvenile idiopathic arthritis (JIA) that has previously been characterized by poor visual prognosis with limited options for effective treatment. Since corticosteroid treatment is not a preferred long-term option for most patients with this condition, ...

Last Updated: 7 Oct 2015

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EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice.
 

Author(s): A N Colebatch-Bourn, C J Edwards, P Collado, M-A D'Agostino, R Hemke, S Jousse-Joulin, M Maas, A Martini, E Naredo, M Østergaard, M Rooney, N Tzaribachev, M A van Rossum, J Vojinovic, P G Conaghan, C Malattia

Journal: Ann. Rheum. Dis.. 2015 Nov;74(11):1946-57.

 

To develop evidence based points to consider the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice. The task force comprised a group of paediatric rheumatologists, rheumatologists experienced in imaging, radiologists, methodologists ...

Last Updated: 10 Oct 2015

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Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody for juvenile idiopathic arthritis.
 

Author(s): Yan Wang, Fengyan Pei, Xingjuan Wang, Zhiyu Sun, Chengjin Hu, Hengli Dou

Journal: J Immunol Res. 2015 ;2015():915276.

 

To estimate the diagnostic accuracy of the anti-CCP test in JIA and to evaluate factors associated with higher accuracy.

Last Updated: 19 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cost of Care for Juvenile Idiopathic Arthritis
 

Status: Not yet recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 17 Nov 2011

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Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or Methotrexate
 

Status: Recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 29 Feb 2016

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Effective Dose of Etanercept in Patients Treated for Juvenile Idiopathic Arthritis
 

Status: Recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 8 Oct 2015

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