Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 287 free, full-text research articles on human participants. First 3 results:

Hypokalemic rhabdomyolysis: a rare manifestation of primary aldosteronism.
 

Author(s): A Zavatto, A Concistrè, C Marinelli, V Zingaretti, I Umbro, F Fiacco, F Tinti, L Petramala, A P Mitterhofer, C Letizia

Journal: Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3910-6.

 

Rhabdomyolysis is a rare presentation of hypokalemia, although muscle weakness is a well-known manifestation of hypokalemia. Primary aldosteronism is characterized by hypertension, suppressed plasma renin activity, increased aldosterone excretion and hypokalemia with metabolic alkalosis. ...

Last Updated: 4 Nov 2015

Go To URL
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
 

Author(s): Ada E D Teo, Sumedha Garg, Lalarukh Haris Shaikh, Junhua Zhou, Fiona E Karet Frankl, Mark Gurnell, Lisa Happerfield, Alison Marker, Mariann Bienz, Elena A B Azizan, Morris J Brown

Journal: N. Engl. J. Med.. 2015 Oct;373(15):1429-36.

 

Recent discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas with distinct clinical presentations and pathological features. Here we describe three women with hyperaldosteronism, two who presented in pregnancy and one who presented after ...

Last Updated: 8 Oct 2015

Go To URL
Aldosterone-to-renin ratio acts as the predictor distinguishing the primary aldosteronism from chronic kidney disease.
 

Author(s): Wei-Guo Chen, Ting-Ting Zhou, Peng Zhou, Xiao-Wei Li, Zhun Wu, Kai-Yan Zhang, Jin-Chun Xing

Journal:

 

Aldosterone-to-renin ratio (ARR) is a screening test for primary aldosteronism, but it was impacted by a bunch of clinical covariates. The ARR is associated with chronic kidney disease (CKD), renal artery stenosis, renin adenoma. This study aims to investigate relationship between ...

Last Updated: 11 Aug 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 38 free, full-text review articles on human participants. First 3 results:

[Genetic alterations in primary aldosteronism].
 

Author(s): Maria-Christina Zennaro, Fabio Fernandes-Rosa, Sheerazed Boulkroun

Journal: Med Sci (Paris). 2015 Apr;31(4):389-96.

 

Primary aldostéronism (PA) is the most frequent form of arterial hypertension. It is caused in the majority of cases by an aldosterone producing adenoma (APA) of the adrenal cortex or by bilateral adrenal hyperplasia. Recent advances have allowed to identify a certain number of genetic ...

Last Updated: 11 May 2015

Go To URL
Nuclear imaging in the diagnosis of primary aldosteronism.
 

Author(s): Andrew S Powlson, Mark Gurnell, Morris J Brown

Journal: Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):150-6.

 

Primary aldosteronism is increasingly recognized as a common secondary cause of hypertension. Successful demonstration of a unilateral cause (e.g. a classical 'Conn's adenoma') offers the potential for curative adrenalectomy. Adrenal vein sampling (AVS), in conjunction with cross-sectional ...

Last Updated: 22 Apr 2015

Go To URL
[Hypertension in the course of primary aldosteronism during pregnancy].
 

Author(s): Magdalena Wyskida, Katarzyna Wyskida, Magdalena Olszanecka-Glinianowicz, Iwona Maruniak-Chudek, Jerzy Sikora, Jerzy Chudek

Journal:

 

Hypertension is one of the most common cardiovascular diseases during pregnancy. Primary hyperaldosteronism (PHA) is the most frequent endocrinological, secondary cause of hypertension, rarely diagnosed in pregnant women. In the available literature about 50 cases of PHA in pregnant ...

Last Updated: 27 Feb 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Optimizing Diagnosis Of Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 26 Jul 2016

Go to URL
Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

Go to URL

Last Updated: 28 Apr 2014

Go to URL