Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 323 free, full-text research articles on human participants. First 3 results:

Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice.
 

Author(s): Silvia Monticone, Jacopo Burrello, Davide Tizzani, Chiara Bertello, Andrea Viola, Fabrizio Buffolo, Luisa Gabetti, Giulio Mengozzi, Tracy A Williams, Franco Rabbia, Franco Veglio, Paolo Mulatero

Journal: J. Am. Coll. Cardiol.. 2017 Apr;69(14):1811-1820.

 

Despite being widely recognized as the most common form of secondary hypertension, among the general hypertensive population the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), remains ...

Last Updated: 7 Apr 2017

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A single-centre experience of the implementation of adrenal vein sampling procedure: the impact on the diagnostic work-up in primary aldosteronism.
 

Author(s): Jacek Kądziela, Aleksander Prejbisz, Ilona Michałowska, Sylwia Kołodziejczyk-Kruk, Leo Schultze Kool, Marek Kabat, Hanna Janaszek-Sitkowska, Sadegh Toutounchi, Zbigniew Gałązka, Urszula Ambroziak, Tomasz Bednarczuk, Dorota Ptasińska-Wnuk, Michał Hoffmann, Magdalena Januszewicz, Andrzej Januszewicz, Adam Witkowski

Journal: Kardiol Pol. 2017 ;75(1):28-34.

 

Primary aldosteronism is one of the most common causes of secondary hypertension. Adrenal vein sampling (AVS) remains a "gold standard" procedure in differentiation between unilateral (adenoma) and bilateral (hyperplasia) disease.

Last Updated: 23 Nov 2016

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CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
 

Author(s): Georgios Daniil, Fabio L Fernandes-Rosa, Jean Chemin, Iulia Blesneac, Jacques Beltrand, Michel Polak, Xavier Jeunemaitre, Sheerazed Boulkroun, Laurence Amar, Tim M Strom, Philippe Lory, Maria-Christina Zennaro

Journal: EBioMedicine. 2016 Nov;13():225-236.

 

Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH). A recurrent mutation in CACNA1H (coding for Cav3.2) was identified in ...

Last Updated: 12 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 48 free, full-text review articles on human participants. First 3 results:

Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary?
 

Author(s): Fabrizio Buffolo, Silvia Monticone, Tracy A Williams, Denis Rossato, Jacopo Burrello, Martina Tetti, Franco Veglio, Paolo Mulatero

Journal:

 

Aldosterone producing adenoma and bilateral adrenal hyperplasia are the two most common subtypes of primary aldosteronism (PA) that require targeted and distinct therapeutic approaches: unilateral adrenalectomy or lifelong medical therapy with mineralocorticoid receptor antagonists. ...

Last Updated: 19 Apr 2017

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[Primary aldosteronism is an underdiagnosed cause of hypertension. Important to find undiagnosed patients--effective treatment available].
 

Author(s): Oskar Ragnarsson, Andreas Muth, Gudmundur Johannsson, Bo Wängberg

Journal:

 

Primary aldosteronism is the most common cause of secondary hypertension with an estimated prevalence of 5-13 % among patients with hypertension. The most common causes are aldosterone producing adrenal adenoma and idiopathic adrenal hyperplasia. Patients with primary aldosteronism ...

Last Updated: 2 Dec 2015

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Adrenal histopathology in primary aldosteronism: is it time for a change?
 

Author(s): Francesca Gioco, Teresa Maria Seccia, Elise P Gomez-Sanchez, Gian Paolo Rossi, Celso E Gomez-Sanchez

Journal: Hypertension. 2015 Oct;66(4):724-30.

 

Last Updated: 10 Sep 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chongqing Primary Aldosteronism Study
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 19 Jul 2017

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Open-label Study on Treatment of Primary Aldosteronism With Everolimus
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 30 May 2017

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Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism; Primary Aldosteronism Due to Aldosterone Producing Adenoma; Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)

 

Last Updated: 31 May 2017

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