Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 298 free, full-text research articles on human participants. First 3 results:

CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
 

Author(s): Georgios Daniil, Fabio L Fernandes-Rosa, Jean Chemin, Iulia Blesneac, Jacques Beltrand, Michel Polak, Xavier Jeunemaitre, Sheerazed Boulkroun, Laurence Amar, Tim M Strom, Philippe Lory, Maria-Christina Zennaro

Journal: EBioMedicine. 2016 Nov;13():225-236.

 

Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH). A recurrent mutation in CACNA1H (coding for Cav3.2) was identified in ...

Last Updated: 12 Oct 2016

Go To URL
Risk factors for renal impairment revealed after unilateral adrenalectomy in patients with primary aldosteronism.
 

Author(s): Do Hee Kim, Hee Jin Kwon, Sang A Ji, Hye Ryoun Jang, Sin-Ho Jung, Jung-Han Kim, Jae Hyeon Kim, Jung Eun Lee, Wooseong Huh, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh

Journal: Medicine (Baltimore). 2016 Jul;95(27):e3930.

 

Primary aldosteronism (PA) may induce significant decline of renal function and structural damage of kidney. However, it is difficult to evaluate accurate renal function in patients with PA, because glomerular hyperfiltration and aldosterone escape can conceal renal impairment. In ...

Last Updated: 18 Oct 2016

Go To URL
Comparison between adrenal venous sampling and computed tomography in the diagnosis of primary aldosteronism and in the guidance of adrenalectomy.
 

Author(s): Limin Zhu, Ying Zhang, Hua Zhang, Wenlong Zhou, Zhoujun Shen, Fangfang Zheng, Xiaofeng Tang, Bo Tao, Jin Zhang, Xiaohong Lu, Jianzhong Xu, Shaoli Chu, Dingliang Zhu, Pingjin Gao, Ji-Guang Wang

Journal: Medicine (Baltimore). 2016 Sep;95(39):e4986.

 

In our series of patients with primary aldosteronism, we compared diagnostic concordance and clinical outcomes after adrenalectomy between adrenal venous sampling (AVS) and computed tomography (CT) imaging.Our retrospective analysis included 886 patients with primary aldosteronism ...

Last Updated: 30 Sep 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 40 free, full-text review articles on human participants. First 3 results:

Adrenal histopathology in primary aldosteronism: is it time for a change?
 

Author(s): Francesca Gioco, Teresa Maria Seccia, Elise P Gomez-Sanchez, Gian Paolo Rossi, Celso E Gomez-Sanchez

Journal: Hypertension. 2015 Oct;66(4):724-30.

 

Last Updated: 10 Sep 2015

Go To URL
Genetic and potential autoimmune triggers of primary aldosteronism.
 

Author(s): Tracy Ann Williams, Paolo Mulatero, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke

Journal: Hypertension. 2015 Aug;66(2):248-53.

 

Last Updated: 9 Jul 2015

Go To URL
[Genetic alterations in primary aldosteronism].
 

Author(s): Maria-Christina Zennaro, Fabio Fernandes-Rosa, Sheerazed Boulkroun

Journal: Med Sci (Paris). 2015 Apr;31(4):389-96.

 

Primary aldostéronism (PA) is the most frequent form of arterial hypertension. It is caused in the majority of cases by an aldosterone producing adenoma (APA) of the adrenal cortex or by bilateral adrenal hyperplasia. Recent advances have allowed to identify a certain number of genetic ...

Last Updated: 11 May 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of CS-3150 in Patients With Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 13 Dec 2016

Go to URL
Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Adrenal Adenoma

 

Last Updated: 16 Aug 2016

Go to URL
Renal Sympathetic Denervation From The Adventitia on Hypertension
 

Status: Recruiting

Condition Summary: Primary Aldosteronism Due to Aldosterone Producing Adenoma

 

Last Updated: 9 Jan 2017

Go to URL