Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 328 free, full-text research articles on human participants. First 3 results:

Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice.
 

Author(s): Silvia Monticone, Jacopo Burrello, Davide Tizzani, Chiara Bertello, Andrea Viola, Fabrizio Buffolo, Luisa Gabetti, Giulio Mengozzi, Tracy A Williams, Franco Rabbia, Franco Veglio, Paolo Mulatero

Journal: J. Am. Coll. Cardiol.. 2017 Apr;69(14):1811-1820.

 

Despite being widely recognized as the most common form of secondary hypertension, among the general hypertensive population the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), remains ...

Last Updated: 7 Apr 2017

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Optimization of left adrenal vein sampling in primary aldosteronism: Coping with asymmetrical cortisol secretion.
 

Author(s): Mitsuhiro Kishino, Takanobu Yoshimoto, Masashi Nakadate, Yoshiaki Katada, Eiichiro Kanda, Shuichiro Nakaminato, Yukihisa Saida, Yoshihiro Ogawa, Ukihide Tateishi

Journal: Endocr. J.. 2017 Mar;64(3):347-355.

 

We evaluated the influence of catheter sampling position and size on left adrenal venous sampling (AVS) in patients with primary aldosteronism (PA) and analyzed their relationship to cortisol secretion. This retrospective study included 111 patients with a diagnosis of primary aldosteronism ...

Last Updated: 30 Jan 2017

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Aldosterone excess may inhibit insulin secretion: A comparative study on glucose metabolism pre- and post-adrenalectomy in patients with primary aldosteronism.
 

Author(s): Yuya Tsurutani, Chiho Sugisawa, Akiko Ishida, Kosuke Inoue, Jun Saito, Masao Omura, Shoichiro Nagasaka, Tetsuo Nishikawa

Journal: Endocr. J.. 2017 Mar;64(3):339-346.

 

Conflicting data have been published on the effects of aldosterone excess on glucose metabolism. Specifically, there are limited data on whether adrenalectomy in patients with aldosterone-producing adenomas (APA) can improve glucose metabolism. In this study we evaluated changes in ...

Last Updated: 23 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 51 free, full-text review articles on human participants. First 3 results:

Diagnosis and management of primary aldosteronism.
 

Author(s): Leticia A P Vilela, Madson Q Almeida

Journal: Arch Endocrinol Metab. ;61(3):305-312.

 

Primary aldosteronism (PA) is the most common form of secondary hypertension (HTN), with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Patients with PA have higher cardiovascular morbidity and mortality than age- and sex-matched ...

Last Updated: 12 Jul 2017

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Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary?
 

Author(s): Fabrizio Buffolo, Silvia Monticone, Tracy A Williams, Denis Rossato, Jacopo Burrello, Martina Tetti, Franco Veglio, Paolo Mulatero

Journal:

 

Aldosterone producing adenoma and bilateral adrenal hyperplasia are the two most common subtypes of primary aldosteronism (PA) that require targeted and distinct therapeutic approaches: unilateral adrenalectomy or lifelong medical therapy with mineralocorticoid receptor antagonists. ...

Last Updated: 19 Apr 2017

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Proportion of Patients With Hypertension Resolution Following Adrenalectomy for Primary Aldosteronism: A Systematic Review and Meta-Analysis.
 

Author(s): Jamie L Benham, Maysoon Eldoma, Bushra Khokhar, Derek J Roberts, Doreen M Rabi, Gregory A Kline

Journal: J Clin Hypertens (Greenwich). 2016 Dec;18(12):1205-1212.

 

Unilateral primary aldosteronism (PA) is often treated with adrenalectomy, but hypertension resolution rates are variable. A valid estimate of the postoperative normotension rate is necessary to inform the utility of PA testing and treatment. The authors searched MEDLINE In-Process ...

Last Updated: 19 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chongqing Primary Aldosteronism Study
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 19 Jul 2017

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Open-label Study on Treatment of Primary Aldosteronism With Everolimus
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 30 May 2017

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Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism; Primary Aldosteronism Due to Aldosterone Producing Adenoma; Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)

 

Last Updated: 31 May 2017

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