Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 289 free, full-text research articles on human participants. First 3 results:

Hypokalemic rhabdomyolysis: a rare manifestation of primary aldosteronism.
 

Author(s): A Zavatto, A Concistrè, C Marinelli, V Zingaretti, I Umbro, F Fiacco, F Tinti, L Petramala, A P Mitterhofer, C Letizia

Journal: Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3910-6.

 

Rhabdomyolysis is a rare presentation of hypokalemia, although muscle weakness is a well-known manifestation of hypokalemia. Primary aldosteronism is characterized by hypertension, suppressed plasma renin activity, increased aldosterone excretion and hypokalemia with metabolic alkalosis. ...

Last Updated: 4 Nov 2015

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Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
 

Author(s): Ada E D Teo, Sumedha Garg, Lalarukh Haris Shaikh, Junhua Zhou, Fiona E Karet Frankl, Mark Gurnell, Lisa Happerfield, Alison Marker, Mariann Bienz, Elena A B Azizan, Morris J Brown

Journal: N. Engl. J. Med.. 2015 Oct;373(15):1429-36.

 

Recent discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas with distinct clinical presentations and pathological features. Here we describe three women with hyperaldosteronism, two who presented in pregnancy and one who presented after ...

Last Updated: 8 Oct 2015

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Reversible heart rhythm complexity impairment in patients with primary aldosteronism.
 

Author(s): Yen-Hung Lin, Vin-Cent Wu, Men-Tzung Lo, Xue-Ming Wu, Chi-Sheng Hung, Kwan-Dun Wu, Chen Lin, Yi-Lwun Ho, Michael Stowasser, Chung-Kang Peng

Journal:

 

Excess aldosterone secretion in patients with primary aldosteronism (PA) impairs their cardiovascular system. Heart rhythm complexity analysis, derived from heart rate variability (HRV), is a powerful tool to quantify the complex regulatory dynamics of human physiology. We prospectively ...

Last Updated: 18 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 40 free, full-text review articles on human participants. First 3 results:

Genetic and potential autoimmune triggers of primary aldosteronism.
 

Author(s): Tracy Ann Williams, Paolo Mulatero, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke

Journal: Hypertension. 2015 Aug;66(2):248-53.

 

Last Updated: 9 Jul 2015

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[Genetic alterations in primary aldosteronism].
 

Author(s): Maria-Christina Zennaro, Fabio Fernandes-Rosa, Sheerazed Boulkroun

Journal: Med Sci (Paris). 2015 Apr;31(4):389-96.

 

Primary aldostéronism (PA) is the most frequent form of arterial hypertension. It is caused in the majority of cases by an aldosterone producing adenoma (APA) of the adrenal cortex or by bilateral adrenal hyperplasia. Recent advances have allowed to identify a certain number of genetic ...

Last Updated: 11 May 2015

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Nuclear imaging in the diagnosis of primary aldosteronism.
 

Author(s): Andrew S Powlson, Mark Gurnell, Morris J Brown

Journal: Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):150-6.

 

Primary aldosteronism is increasingly recognized as a common secondary cause of hypertension. Successful demonstration of a unilateral cause (e.g. a classical 'Conn's adenoma') offers the potential for curative adrenalectomy. Adrenal vein sampling (AVS), in conjunction with cross-sectional ...

Last Updated: 22 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Optimizing Diagnosis Of Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 26 Jul 2016

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Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

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Last Updated: 28 Apr 2014

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