Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 231 free, full-text research articles on human participants. First 3 results:

Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage.
 

Author(s): Naoka Murakami, Naohiro Yoshida, Kunihisa Hamano, Hisanori Suzuki, Megumi Miyakawa, Akira Takeshita, Yasuhiro Takeuchi

Journal: Intern. Med.. 2015 ;54(4):415-20.

 

The aldosterone-renin ratio (ARR) is considered to be the most reliable and sensitive screening parameter for primary aldosteronism (PA). However, little is known regarding how stroke influences the ARR. We herein present a case of a 35-year-old man who was ultimately found to have ...

Last Updated: 9 Mar 2015

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A clinical prediction score for diagnosing unilateral primary aldosteronism may not be generalizable.
 

Author(s): Erik S Venos, Benny So, Valerian C Dias, Adrian Harvey, Janice L Pasieka, Gregory A Kline

Journal:

 

A published clinical prediction score indicated that a unilateral adrenal adenoma and either hypokalemia or an estimated glomerular filtration rate of 100 ml/min/1.73 m2 was 100% specific for unilateral primary aldosteronism. This study aimed to validate this score in a separate cohort ...

Last Updated: 7 Jan 2015

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An adverse pregnancy-associated outcome due to overlooked primary aldosteronism.
 

Author(s): Kazuo Eguchi, Satoshi Hoshide, Shuichi Nagashima, Takashi Maekawa, Hironobu Sasano, Kazuomi Kario

Journal: Intern. Med.. 2014 ;53(21):2499-504.

 

A 31-year-old woman with treatment-resistant pregnancy-induced hypertension during her first pregnancy delivered a small-for-gestational-age infant (weight: 1,070 g). After delivery, she was diagnosed with primary aldosteronism (PA) associated with a left adrenal adenoma. Following ...

Last Updated: 4 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 27 free, full-text review articles on human participants. First 3 results:

Progress in aldosteronism: a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension.
 

Author(s): George Piaditis, Athina Markou, Labrini Papanastasiou, Ioannis I Androulakis, Gregory Kaltsas

Journal: Eur. J. Endocrinol.. 2015 May;172(5):R191-203.

 

Primary aldosteronism (PA) secondary to excessive and/or autonomous aldosterone secretion from the renin-angiotensin system accounts for ∼10% of cases of hypertension and is primarily caused by bilateral adrenal hyperplasia (BAH) or aldosterone-producing adenomas (APAs). Although ...

Last Updated: 25 Mar 2015

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An update on novel mechanisms of primary aldosteronism.
 

Author(s): Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa

Journal: J. Endocrinol.. 2015 Feb;224(2):R63-77.

 

Primary aldosteronism (PA) is the most common and curable form of secondary hypertension. It is caused in the majority of cases by either unilateral aldosterone overproduction due to an aldosterone-producing adenoma (APA) or by bilateral adrenal hyperplasia. Recent advances in genome ...

Last Updated: 13 Jan 2015

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Progress in primary aldosteronism. Mineralocorticoid antagonist treatment for aldosterone-producing adenoma.
 

Author(s): Laurence Amar, Aurélien Lorthioir, Michel Azizi, Pierre-Francois Plouin

Journal: Eur. J. Endocrinol.. 2015 Mar;172(3):R125-9.

 

Mineralocorticoid receptor antagonists have been used in patients with aldosterone-producing adenomas (APAs) as a test designed to predict the blood pressure (BP) outcome of surgery. They are commonly used in patients undergoing adrenalectomy to reduce BP and increase plasma potassium ...

Last Updated: 9 Feb 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Primary Hyperaldosteronism

 

Last Updated: 23 Jul 2013

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Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

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Last Updated: 28 Apr 2014

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