Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 298 free, full-text research articles on human participants. First 3 results:

Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations.
 

Author(s): Ada E D Teo, Morris J Brown

Journal: N. Engl. J. Med.. 2016 Apr;374(15):1494.

 

Last Updated: 14 Apr 2016

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The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile.
 

Author(s): Mitsuhiro Kometani, Takashi Yoneda, Masashi Demura, Shigehiro Karashima, Shunsuke Mori, Masashi Oe, Toshitaka Sawamura, Rika Okuda, Masakazu Yamagishi, Yoshiyu Takeda

Journal: Intern. Med.. 2016 ;55(7):769-73.

 

Primary aldosteronism (PA) is a major cause of secondary hypertension, divided into two subtypes: unilateral and bilateral. Unilateral PA (u-PA) is surgically-curable. Medical treatment with mineralocorticoid receptors antagonists is recommended as a second-line treatment when the ...

Last Updated: 4 Apr 2016

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Cost-Effectiveness of Screening for Primary Aldosteronism and Subtype Diagnosis in the Resistant Hypertensive Patients.
 

Author(s): Carrie C Lubitz, Konstantinos P Economopoulos, Stephen Sy, Colden Johanson, Heike E Kunzel, Martin Reincke, G Scott Gazelle, Milton C Weinstein, Thomas A Gaziano

Journal: Circ Cardiovasc Qual Outcomes. 2015 Nov;8(6):621-30.

 

Primary aldosteronism (PA) is a common and underdiagnosed disease with significant morbidity potentially cured by surgery. We aim to assess if the long-term cardiovascular benefits of identifying and treating surgically correctable PA outweigh the upfront increased costs in patients ...

Last Updated: 20 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 42 free, full-text review articles on human participants. First 3 results:

Adrenal histopathology in primary aldosteronism: is it time for a change?
 

Author(s): Francesca Gioco, Teresa Maria Seccia, Elise P Gomez-Sanchez, Gian Paolo Rossi, Celso E Gomez-Sanchez

Journal: Hypertension. 2015 Oct;66(4):724-30.

 

Last Updated: 10 Sep 2015

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Genetic and potential autoimmune triggers of primary aldosteronism.
 

Author(s): Tracy Ann Williams, Paolo Mulatero, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke

Journal: Hypertension. 2015 Aug;66(2):248-53.

 

Last Updated: 9 Jul 2015

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[Genetic alterations in primary aldosteronism].
 

Author(s): Maria-Christina Zennaro, Fabio Fernandes-Rosa, Sheerazed Boulkroun

Journal: Med Sci (Paris). 2015 Apr;31(4):389-96.

 

Primary aldostéronism (PA) is the most frequent form of arterial hypertension. It is caused in the majority of cases by an aldosterone producing adenoma (APA) of the adrenal cortex or by bilateral adrenal hyperplasia. Recent advances have allowed to identify a certain number of genetic ...

Last Updated: 11 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of CS-3150 in Patients With Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 7 Oct 2016

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Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Adrenal Adenoma

 

Last Updated: 16 Aug 2016

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Renal Sympathetic Denervation From The Adventitia on Hypertension
 

Status: Recruiting

Condition Summary: Primary Aldosteronism Due to Aldosterone Producing Adenoma

 

Last Updated: 31 Dec 2015

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