Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 267 free, full-text research articles on human participants. First 3 results:

Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
 

Author(s): Ada E D Teo, Sumedha Garg, Lalarukh Haris Shaikh, Junhua Zhou, Fiona E Karet Frankl, Mark Gurnell, Lisa Happerfield, Alison Marker, Mariann Bienz, Elena A B Azizan, Morris J Brown

Journal: N. Engl. J. Med.. 2015 Oct;373(15):1429-36.

 

Recent discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas with distinct clinical presentations and pathological features. Here we describe three women with hyperaldosteronism, two who presented in pregnancy and one who presented after ...

Last Updated: 8 Oct 2015

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Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism.
 

Author(s): Ute I Scholl, Gabriel Stölting, Carol Nelson-Williams, Alfred A Vichot, Murim Choi, Erin Loring, Manju L Prasad, Gerald Goh, Tobias Carling, C Christofer Juhlin, Ivo Quack, Lars C Rump, Anne Thiel, Marc Lande, Britney G Frazier, Majid Rasoulpour, David L Bowlin, Christine B Sethna, Howard Trachtman, Christoph Fahlke, Richard P Lifton

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Many Mendelian traits are likely unrecognized owing to absence of traditional segregation patterns in families due to causation by de novo mutations, incomplete penetrance, and/or variable expressivity. Genome-level sequencing can overcome these complications. Extreme childhood phenotypes ...

Last Updated: 24 Apr 2015

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Primary aldosteronism with concurrent primary hyperparathyroidism: clinical case load in a single centre.
 

Author(s): A Concistré, L Petramala, L Zinnamosca, A Settevendemmie, F Corpaci, C Marinelli, G F Tonnarini, G D'Ermo, G De Toma, C Letizia

Journal: Eur Rev Med Pharmacol Sci. 2015 ;19(6):971-6.

 

Primary aldosteronism (PA) represents the main cause of endocrine secondary arterial hypertension in which aldosterone production is inappropriately elevated. Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by hypercalcemia due to overproduction of parathyroid ...

Last Updated: 10 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 35 free, full-text review articles on human participants. First 3 results:

Nuclear imaging in the diagnosis of primary aldosteronism.
 

Author(s): Andrew S Powlson, Mark Gurnell, Morris J Brown

Journal: Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):150-6.

 

Primary aldosteronism is increasingly recognized as a common secondary cause of hypertension. Successful demonstration of a unilateral cause (e.g. a classical 'Conn's adenoma') offers the potential for curative adrenalectomy. Adrenal vein sampling (AVS), in conjunction with cross-sectional ...

Last Updated: 22 Apr 2015

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Progress in aldosteronism: a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension.
 

Author(s): George Piaditis, Athina Markou, Labrini Papanastasiou, Ioannis I Androulakis, Gregory Kaltsas

Journal: Eur. J. Endocrinol.. 2015 May;172(5):R191-203.

 

Primary aldosteronism (PA) secondary to excessive and/or autonomous aldosterone secretion from the renin-angiotensin system accounts for ∼10% of cases of hypertension and is primarily caused by bilateral adrenal hyperplasia (BAH) or aldosterone-producing adenomas (APAs). Although ...

Last Updated: 25 Mar 2015

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An update on novel mechanisms of primary aldosteronism.
 

Author(s): Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa

Journal: J. Endocrinol.. 2015 Feb;224(2):R63-77.

 

Primary aldosteronism (PA) is the most common and curable form of secondary hypertension. It is caused in the majority of cases by either unilateral aldosterone overproduction due to an aldosterone-producing adenoma (APA) or by bilateral adrenal hyperplasia. Recent advances in genome ...

Last Updated: 13 Jan 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Primary Hyperaldosteronism

 

Last Updated: 23 Jul 2013

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Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

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Last Updated: 28 Apr 2014

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