Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 225 free, full-text research articles on human participants. First 3 results:

Sleep quality in patients with primary aldosteronism.
 

Author(s): Franziska M Hanusch, Evelyn Fischer, Katharina Lang, Sven Diederich, Stephan Endres, Bruno Allolio, Felix Beuschlein, Martin Reincke, Marcus Quinkler

Journal: Hormones (Athens). ;13(1):57-64.

 

In subjects at high risk for sleep apnea (SA), aldosterone concentrations correlate with severity of SA and primary aldosteronism (PA) is very often diagnosed. Patients with PA show a high prevalence of SA. Treatment of PA either by adrenalectomy (ADX) or mineralocorticoid receptor ...

Last Updated: 11 Apr 2014

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Changes in the clinical manifestations of primary aldosteronism.
 

Author(s): Sun Hwa Kim, Jae Hee Ahn, Ho Cheol Hong, Hae Yoon Choi, Yoon Jung Kim, Nam Hoon Kim, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Nan Hee Kim, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi

Journal: Korean J. Intern. Med.. 2014 Mar;29(2):217-25.

 

Primary aldosteronism (PA) is now widely recognized to have a higher prevalence than was once thought. In view of its increasing prevalence, we compared chronological changes in clinical manifestations of PA according to different times of diagnosis.

Last Updated: 20 Mar 2014

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GATA6, SF1, NGFIB and DAX1 in the remodeled subcapsular zones in primary aldosteronism.
 

Author(s): Yasuhiro Nakamura, Yumi Kurotaki, Kazue Ise, Saulo J A Felizola, Keely M McNamara, Hironobu Sasano

Journal: Endocr. J.. 2014 ;61(4):393-401.

 

The majority of the cases diagnosed as primary aldosteronism (PA) are caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). Histopathologically, both IHA and adjacent adrenal glands of APA demonstrate remodeled subcapsular zone (RSZ) but these zones ...

Last Updated: 5 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 25 free, full-text review articles on human participants. First 3 results:

An update on novel mechanisms of primary aldosteronism.
 

Author(s): Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa

Journal: J. Endocrinol.. 2015 Feb;224(2):R63-77.

 

Primary aldosteronism (PA) is the most common and curable form of secondary hypertension. It is caused in the majority of cases by either unilateral aldosterone overproduction due to an aldosterone-producing adenoma (APA) or by bilateral adrenal hyperplasia. Recent advances in genome ...

Last Updated: 13 Jan 2015

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Progress in primary aldosteronism. Mineralocorticoid antagonist treatment for aldosterone-producing adenoma.
 

Author(s): Laurence Amar, Aurélien Lorthioir, Michel Azizi, Pierre-Francois Plouin

Journal: Eur. J. Endocrinol.. 2015 Mar;172(3):R125-9.

 

Mineralocorticoid receptor antagonists have been used in patients with aldosterone-producing adenomas (APAs) as a test designed to predict the blood pressure (BP) outcome of surgery. They are commonly used in patients undergoing adrenalectomy to reduce BP and increase plasma potassium ...

Last Updated: 9 Feb 2015

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Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.
 

Author(s): Anna Riester, Martin Reincke

Journal: Eur. J. Endocrinol.. 2015 Jan;172(1):R23-30.

 

Primary aldosteronism (PA) is the most common cause of secondary hypertension. In this review, we discuss the diagnosis and management of PA during pregnancy based on the literature. As aldosterone and renin are physiologically increased during pregnancy and confirmation tests are ...

Last Updated: 25 Nov 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Primary Hyperaldosteronism

 

Last Updated: 23 Jul 2013

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Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

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Last Updated: 28 Apr 2014

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