Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 222 free, full-text research articles on human participants. First 3 results:

Sleep quality in patients with primary aldosteronism.
 

Author(s): Franziska M Hanusch, Evelyn Fischer, Katharina Lang, Sven Diederich, Stephan Endres, Bruno Allolio, Felix Beuschlein, Martin Reincke, Marcus Quinkler

Journal: Hormones (Athens). ;13(1):57-64.

 

In subjects at high risk for sleep apnea (SA), aldosterone concentrations correlate with severity of SA and primary aldosteronism (PA) is very often diagnosed. Patients with PA show a high prevalence of SA. Treatment of PA either by adrenalectomy (ADX) or mineralocorticoid receptor ...

Last Updated: 11 Apr 2014

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GATA6, SF1, NGFIB and DAX1 in the remodeled subcapsular zones in primary aldosteronism.
 

Author(s): Yasuhiro Nakamura, Yumi Kurotaki, Kazue Ise, Saulo J A Felizola, Keely M McNamara, Hironobu Sasano

Journal: Endocr. J.. 2014 ;61(4):393-401.

 

The majority of the cases diagnosed as primary aldosteronism (PA) are caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). Histopathologically, both IHA and adjacent adrenal glands of APA demonstrate remodeled subcapsular zone (RSZ) but these zones ...

Last Updated: 5 May 2014

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Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.
 

Author(s): Chi-Sheng Hung, Yi-Lwun Ho, Yi-Yao Chang, Vin-Cent Wu, Xue-Ming Wu, Jen-Kuang Lee, Shih-Chieh Chueh, Yen-Hung Lin, Yuan-Shian Changh, Shao-Yu Yang, Ya-Hui Hu, Ming-Jai Sui, Ming-Fong Chen, Kwan-Dun Wu

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Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour ...

Last Updated: 24 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 23 free, full-text review articles on human participants. First 3 results:

Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.
 

Author(s): Anna Riester, Martin Reincke

Journal: Eur. J. Endocrinol.. 2015 Jan;172(1):R23-30.

 

Primary aldosteronism (PA) is the most common cause of secondary hypertension. In this review, we discuss the diagnosis and management of PA during pregnancy based on the literature. As aldosterone and renin are physiologically increased during pregnancy and confirmation tests are ...

Last Updated: 25 Nov 2014

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An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism.
 

Author(s): Gian Paolo Rossi, Richard J Auchus, Morris Brown, Jacques W M Lenders, Mitsuhide Naruse, Pierre Francois Plouin, Fumitoshi Satoh, William F Young

Journal: Hypertension. 2014 Jan;63(1):151-60.

 

Adrenal venous sampling is recommended by current guidelines to identify surgically curable causes of hyperaldosteronism but remains markedly underused. Key factors contributing to the poor use of adrenal venous sampling include the prevailing perceptions that it is a technically ...

Last Updated: 16 Dec 2013

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Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism.
 

Author(s): I David Weiner

Journal: Semin. Nephrol.. 2013 May;33(3):265-76.

 

The identification of primary aldosteronism as a common cause of resistant hypertension is a significant advance in our ability to care for patients with hypertension. Primary aldosteronism is common, and when unrecognized is associated with an increased incidence of adverse cardiovascular ...

Last Updated: 19 Aug 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
 

Status: Not yet recruiting

Condition Summary: Primary Aldosteronism; Primary Hyperaldosteronism

 

Last Updated: 23 Jul 2013

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Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 28 Nov 2007

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Last Updated: 28 Apr 2014

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