Premature ovarian failure

Common Name(s)

Premature ovarian failure

Premature ovarian failure (POF) is when a woman stops menstruating, or having her period, before the age of 40. In POF, the ovaries may stop functioning completely and menstruation will be absent, or the ovaries will remain partially functional and menstruation will occur less frequently.

POF can be caused by follicular depletion or follicle dysfunction. A follicle is a small fluid-filled sac located in the ovaries that contains an egg. One egg is released from its follicle each month during ovulation. Follicle depletion occurs when there are no more follicles left in one or both of the ovaries, and thus ovulation does not occur. This can be the result of a genetic condition or damage to the eggs caused by chemotherapy or radiation therapy. Follicle dysfunction can be caused by damage to the ovaries such as from the immune system as well as other causes.

Ovarian failure can occur as slowly as over the course of several years, or as quickly as over the course of a few months. An affected woman will typically begin skipping periods, with widening gaps of time between periods until they stop altogether. Symptoms of menopause, such as vaginal dryness, hot flashes, and mood swings, are often experienced. POF is also associated with infertility and increased risk of osteoporosis and heart disease.

While there is currently no way to reverse POF, there are several treatment options including estrogen therapy that can help with the symptoms. If you have been diagnosed with POF, talk to your doctor about the most current treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a great source of information and can connect you with other women living with POF.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

Last Updated: 20 Jul 2010

View Details
Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

http://www.ipofa.org

Last Updated: 20 Jul 2010

View Details
Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

http://www.rachelswell.org/

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature ovarian failure" returned 161 free, full-text research articles on human participants. First 3 results:

DTC chemotherapy regimen is associated with higher incidence of premature ovarian failure in women of reproductive age with breast cancer.
 

Author(s): J-P Long, F Wan, F Zhang, J Zhou, L-F Don

Journal: Eur Rev Med Pharmacol Sci. 2016 ;20(6):1087-92.

 

Different chemotherapy regimens may contribute differently to the development of Premature Ovarian Failure (POF) in women of reproductive age with breast cancer. Here we evaluated how two different chemotherapy regimens, CAF (tegafur + pirarubicin + ifosfamide) and DTC (docetaxel ...

Last Updated: 7 Apr 2016

Go To URL
Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model.
 

Author(s): Dan Song, Yun Zhong, Chunfeng Qian, Qinyan Zou, Jian Ou, Yichao Shi, Liang Gao, Gaigai Wang, Zhenxing Liu, Haibo Li, Hailei Ding, Huihua Wu, Fuxin Wang, Jing Wang, Hong Li

Journal: Biomed Res Int. 2016 ;2016():2517514.

 

Premature ovarian failure (POF) is one of the most common causes of infertility in women. In our present study, we established cyclophosphamide- (CTX-) induced POF rat model and elucidated its effect on ovarian function. We detected the serum estrogen, follicle stimulating hormone, ...

Last Updated: 6 Apr 2016

Go To URL
Diminished ovarian reserve, premature ovarian failure, poor ovarian responder--a plea for universal definitions.
 

Author(s): J Cohen, N Chabbert-Buffet, E Darai

Journal: J. Assist. Reprod. Genet.. 2015 Dec;32(12):1709-12.

 

Diminished ovarian reserve (DOR) is characterized by poor fertility outcomes, and it represents a major challenge in reproductive medicine. Although consensus exists on the concept of DOR, its definition remains blurry. DOR has to be distinguished from premature ovarian failure (POF) ...

Last Updated: 29 Feb 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature ovarian failure" returned 20 free, full-text review articles on human participants. First 3 results:

Aetiological coding sequence variants in non-syndromic premature ovarian failure: From genetic linkage analysis to next generation sequencing.
 

Author(s): Paul Laissue

Journal: Mol. Cell. Endocrinol.. 2015 Aug;411():243-57.

 

Premature ovarian failure (POF) is a frequent pathology affecting 1-1.5% of women under 40 years old. Despite advances in diagnosing and treating human infertility, POF is still classified as being idiopathic in 50-80% of cases, strongly suggesting a genetic origin for the disease. ...

Last Updated: 6 Jun 2015

Go To URL
Oocyte cryopreservation for fertility preservation in postpubertal female children at risk for premature ovarian failure due to accelerated follicle loss in Turner syndrome or cancer treatments.
 

Author(s): K Oktay, G Bedoschi

Journal: J Pediatr Adolesc Gynecol. 2014 Dec;27(6):342-6.

 

To preliminarily study the feasibility of oocyte cryopreservation in postpubertal girls aged between 13 and 15 years who were at risk for premature ovarian failure due to the accelerated follicle loss associated with Turner syndrome or cancer treatments.

Last Updated: 2 Dec 2014

Go To URL
[Premature ovarian failure].
 

Author(s): Carmen Regina Leal de Assumpção

Journal: Arq Bras Endocrinol Metabol. 2014 Mar;58(2):132-43.

 

This article is a review on different aspects of premature ovarian failure (POF) defined as the development of hypogonadism in women before 40 years of age. The review will discuss the etiopathogeny, autoimmune and iatrogenic causes, abnormalities of chromosome X, as well as clinical ...

Last Updated: 16 May 2014

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Nov 2015

Go to URL
Rejuvenation of Premature Ovarian Failure With Stem Cells
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 1 Jan 2017

Go to URL
Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 9 Apr 2016

Go to URL