Premature ovarian failure

Common Name(s)

Premature ovarian failure

Premature ovarian failure (POF) is when a woman stops menstruating, or having her period, before the age of 40. In POF, the ovaries may stop functioning completely and menstruation will be absent, or the ovaries will remain partially functional and menstruation will occur less frequently.

POF can be caused by follicular depletion or follicle dysfunction. A follicle is a small fluid-filled sac located in the ovaries that contains an egg. One egg is released from its follicle each month during ovulation. Follicle depletion occurs when there are no more follicles left in one or both of the ovaries, and thus ovulation does not occur. This can be the result of a genetic condition or damage to the eggs caused by chemotherapy or radiation therapy. Follicle dysfunction can be caused by damage to the ovaries such as from the immune system as well as other causes.

Ovarian failure can occur as slowly as over the course of several years, or as quickly as over the course of a few months. An affected woman will typically begin skipping periods, with widening gaps of time between periods until they stop altogether. Symptoms of menopause, such as vaginal dryness, hot flashes, and mood swings, are often experienced. POF is also associated with infertility and increased risk of osteoporosis and heart disease.

While there is currently no way to reverse POF, there are several treatment options including estrogen therapy that can help with the symptoms. If you have been diagnosed with POF, talk to your doctor about the most current treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a great source of information and can connect you with other women living with POF.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

Last Updated: 20 Jul 2010

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Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

http://www.ipofa.org

Last Updated: 20 Jul 2010

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Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

http://www.rachelswell.org/

Last Updated: 5 May 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature ovarian failure" returned 159 free, full-text research articles on human participants. First 3 results:

CSB-PGBD3 Mutations Cause Premature Ovarian Failure.
 

Author(s): Yingying Qin, Ting Guo, Guangyu Li, Tie-Shan Tang, Shidou Zhao, Xue Jiao, Juanjuan Gong, Fei Gao, Caixia Guo, Joe Leigh Simpson, Zi-Jiang Chen

Journal:

 

Premature ovarian failure (POF) is a rare, heterogeneous disorder characterized by cessation of menstruation occurring before the age of 40 years. Genetic etiology is responsible for perhaps 25% of cases, but most cases are sporadic and unexplained. In this study, through whole exome ...

Last Updated: 29 Jul 2015

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Comparison of Specificity and Sensitivity of AMH and FSH in Diagnosis of Premature Ovarian Failure.
 

Author(s): Farzaneh Alipour, Athar Rasekhjahromi, Mehrnoosh Maalhagh, Saeid Sobhanian, Masoumeh Hosseinpoor

Journal: Dis. Markers. 2015 ;2015():585604.

 

Anti-Müllerian hormone represents the primitive follicular number and ovarian age. Low level of AMH is in relation to early menopausal state and decreased ovarian reserve. AMH level changes occur prior to FSH level in representing ovarian failure. The aim of this study is to compare ...

Last Updated: 26 Jun 2015

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Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure.
 

Author(s): Dongmei Lai, Fangyuan Wang, Xiaofen Yao, Qiuwan Zhang, Xiaoxing Wu, Charlie Xiang

Journal:

 

Human endometrial mesenchymal stem cells (EnSCs) derived from menstrual blood have mesenchymal stem/stromal cells (MSCs) characteristics and can differentiate into cell types that arise from all three germ layers. We hypothesized that EnSCs may offer promise for restoration of ovarian ...

Last Updated: 24 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature ovarian failure" returned 20 free, full-text review articles on human participants. First 3 results:

Aetiological coding sequence variants in non-syndromic premature ovarian failure: From genetic linkage analysis to next generation sequencing.
 

Author(s): Paul Laissue

Journal: Mol. Cell. Endocrinol.. 2015 Aug;411():243-57.

 

Premature ovarian failure (POF) is a frequent pathology affecting 1-1.5% of women under 40 years old. Despite advances in diagnosing and treating human infertility, POF is still classified as being idiopathic in 50-80% of cases, strongly suggesting a genetic origin for the disease. ...

Last Updated: 6 Jun 2015

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Oocyte cryopreservation for fertility preservation in postpubertal female children at risk for premature ovarian failure due to accelerated follicle loss in Turner syndrome or cancer treatments.
 

Author(s): K Oktay, G Bedoschi

Journal: J Pediatr Adolesc Gynecol. 2014 Dec;27(6):342-6.

 

To preliminarily study the feasibility of oocyte cryopreservation in postpubertal girls aged between 13 and 15 years who were at risk for premature ovarian failure due to the accelerated follicle loss associated with Turner syndrome or cancer treatments.

Last Updated: 2 Dec 2014

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[Premature ovarian failure].
 

Author(s): Carmen Regina Leal de Assumpção

Journal: Arq Bras Endocrinol Metabol. 2014 Mar;58(2):132-43.

 

This article is a review on different aspects of premature ovarian failure (POF) defined as the development of hypogonadism in women before 40 years of age. The review will discuss the etiopathogeny, autoimmune and iatrogenic causes, abnormalities of chromosome X, as well as clinical ...

Last Updated: 16 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Premature Ovarian Failure (Genetic and Physiopathologic Analysis)
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 27 Oct 2008

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Rejuvenation of Premature Ovarian Failure With Stem Cells
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 4 Mar 2016

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Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 12 May 2014

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