Premature ovarian failure

Common Name(s)

Premature ovarian failure

Premature ovarian failure is clearly a heterogeneous disorder. The terms 'hypergonadotropic ovarian failure' and 'hypergonadotropic ovarian dysgenesis' (see ODG1, {233300}) have been used to indicate a group of disorders in which amenorrhea associated with elevated levels of serum gonadotropins occurs long before the age of 40 years ({3:Coulam, 1982}). Cytogenetic studies of X-chromosome aberrations have suggested that it is mainly the long arm of the X chromosome that is involved in defects of ovulation ({2:Bione et al., 1998}). Genetic Heterogeneity of Premature Ovarian Failure Mutations in genes identified within a region defined as POF2 (Xq13.3-q21.1) have been found to cause other forms of POF: POF2A ({300511}) by mutation in the DIAPH2 gene ({300108}) and POF2B ({300604}) by mutation in the POF1B gene ({300603}). See also POF3 ({608996}), caused by mutation in the FOXL2 gene ({605597}) on chromosome 3q22; POF4 (see {300510}), caused by mutation in the BMP15 gene ({300247}) on chromosome Xp11; POF5 ({611548}), caused by mutation in the NOBOX gene ({610934}) on chromosome 7q35; POF6 ({612310}), caused by mutation in the FIGLA gene ({608697}) on chromosome 2p13; POF7 ({612964}), caused by mutation in the NR5A1 gene ({184757}) on chromosome 9q33; POF8 ({615723}), caused by mutation in the STAG3 gene ({608489}) on chromosome 7q22; POF9 ({615724}), caused by mutation in the HFM1 gene ({615684}) on chromosome 1p22; and POF10 ({612885}), caused by mutation in the MCM8 gene ({608187}) on chromosome 20p12.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

Last Updated: 20 Jul 2010

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Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

Last Updated: 5 May 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature ovarian failure" for support, advocacy or research.

International Premature Ovarian Failure Association, Inc.

Our mission is to provide community, support, and information to women with POF and their loved ones, to increase public awareness and understanding of POF, and to work with HCP to better understand this condition.

http://www.ipofa.org

Last Updated: 20 Jul 2010

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Rachel's Well

Rachel's Well in an innovative, multi-disciplinary non-profit organization committed to increaseing women's health research and education, particularly around the issues of menstrual health and primary ovarian insufficiency (POI).

http://www.rachelswell.org/

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature ovarian failure" returned 151 free, full-text research articles on human participants. First 3 results:

American ginseng regulates gene expression to protect against premature ovarian failure in rats.
 

Author(s): Lei Zhu, Ji Li, Nannan Xing, Dongwei Han, Haixue Kuang, Pengling Ge

Journal: Biomed Res Int. 2015 ;2015():767124.

 

Premature ovarian failure (POF) is defined as lost ovarian functions before the age of 40. Three possible molecular markers (PLA2G4A, miR-29a, and miR-144) have been identified in our previous study by integrated analysis of mRNA and miRNA expression profiles. The present study aimed ...

Last Updated: 23 Feb 2015

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Leukodystrophy with premature ovarian failure: think on vanishing white matter disease (VWMD).
 

Author(s): Fernando Freua, Jacy Bezerra Parmera, Denise de Oliveira Doria, Anderson Rodrigues Brandão de Paiva, Lucia Ines Macedo-Souza, Fernando Kok

Journal: Arq Neuropsiquiatr. 2015 Jan;73(1):65.

 

Last Updated: 22 Jan 2015

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Association study of TGFBR2 and miR-518 gene polymorphisms with age at natural menopause, premature ovarian failure, and early menopause among Chinese Han women.
 

Author(s): Xiangyu Ma, Yanchun Chen, Xianghai Zhao, Jinfeng Chen, Chong Shen, Song Yang

Journal: Medicine (Baltimore). 2014 Oct;93(20):e93.

 

Age at natural menopause (ANM), a highly heritable phenotype, has been identified to be closely associated with major hormone-related diseases, including breast cancer and gynecological cancers. We previously identified an important role for the transforming growth factor, β receptor ...

Last Updated: 4 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature ovarian failure" returned 18 free, full-text review articles on human participants. First 3 results:

[Premature ovarian failure].
 

Author(s): Carmen Regina Leal de Assumpção

Journal: Arq Bras Endocrinol Metabol. 2014 Mar;58(2):132-43.

 

This article is a review on different aspects of premature ovarian failure (POF) defined as the development of hypogonadism in women before 40 years of age. The review will discuss the etiopathogeny, autoimmune and iatrogenic causes, abnormalities of chromosome X, as well as clinical ...

Last Updated: 16 May 2014

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Premature ovarian failure.
 

Author(s): Svetlana Vujović, Miomira Ivović, Milina Tancić-Gajić, Ljiljana Marina, Marija Barać, Zorana Arizanović, Ana Nenezić, Maja Ivanisević, Jelena Micić, Silvija Sajić, Dragan Micić

Journal: Srp Arh Celok Lek. ;140(11-12):806-11.

 

Premature ovarian failure (POF) is the occurrence of hypergonadotropic hypoestrogenic amenorrhea in women under the age of forty years. It is idiopathic in 74-90% patients. Known cases can be divided into primary and secondary POF. In primary POF genetic aberrations can involve the ...

Last Updated: 28 Jan 2013

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ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure.
 

Author(s): Yingying Qin, Mei Sun, Li You, Deying Wei, Jielin Sun, Xiaoyan Liang, Bo Zhang, Hong Jiang, Jianfeng Xu, Zi-Jiang Chen

Journal:

 

Premature ovarian failure (POF) is a complex and heterogeneous disorder that is influenced by multiple genetic components. Numerous candidate gene studies designed to identify POF susceptibility loci have been published, but most positive findings have not been confirmed in follow ...

Last Updated: 9 Feb 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Premature Ovarian Failure (Genetic and Physiopathologic Analysis)
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 27 Oct 2008

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Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure

 

Last Updated: 12 May 2014

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Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure
 

Status: Recruiting

Condition Summary: Premature Ovarian Failure,

 

Last Updated: 2 Dec 2012

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