Premature aging

Common Name(s)

Premature aging

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature aging" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature aging" returned 57 free, full-text research articles on human participants. First 3 results:

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.
 

Author(s): Amelie Boquoi, Sanjeevani Arora, Tina Chen, Sam Litwin, James Koh, Greg H Enders

Journal: Aging Cell. 2015 Feb;14(1):139-47.

 

The cyclin-dependent kinase (Cdk) inhibitor p16(Ink4a) (p16) is a canonical mediator of cellular senescence and accumulates in aging tissues, where it constrains proliferation of some progenitor cells. However, whether p16 induction in tissues is sufficient to inhibit cell proliferation, ...

Last Updated: 28 Jan 2015

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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
 

Author(s): Morten Scheibye-Knudsen, Sarah J Mitchell, Evandro F Fang, Teruaki Iyama, Theresa Ward, James Wang, Christopher A Dunn, Nagendra Singh, Sebastian Veith, Md Mahdi Hasan-Olive, Aswin Mangerich, Mark A Wilson, Mark P Mattson, Linda H Bergersen, Victoria C Cogger, Alessandra Warren, David G Le Couteur, Ruin Moaddel, David M Wilson, Deborah L Croteau, Rafael de Cabo, Vilhelm A Bohr

Journal: Cell Metab.. 2014 Nov;20(5):840-55.

 

Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csb(m/m) mice were ...

Last Updated: 2 Dec 2014

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Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice.
 

Author(s): Mohsen Hosseini, Walid Mahfouf, Martin Serrano-Sanchez, Houssam Raad, Ghida Harfouche, Marc Bonneu, Stephane Claverol, Frederic Mazurier, Rodrigue Rossignol, Alain Taieb, Hamid Reza Rezvani

Journal: J. Invest. Dermatol.. 2015 Apr;135(4):1108-18.

 

Xeroderma pigmentosum type C (XP-C) is characterized mostly by a predisposition to skin cancers and accelerated photoaging, but little is known about premature skin aging in this disease. By comparing young and old mice, we found that the level of progerin and p16(INK4a) expression, ...

Last Updated: 19 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature aging" returned 14 free, full-text review articles on human participants. First 3 results:

SIRTain regulators of premature senescence and accelerated aging.
 

Author(s): Shrestha Ghosh, Zhongjun Zhou

Journal: Protein Cell. 2015 May;6(5):322-33.

 

The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic ...

Last Updated: 4 May 2015

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Loss of renal function causes premature aging of the immune system.
 

Author(s): Michiel G H Betjes, Ruud W J Meijers, Nicolle H R Litjens

Journal: Blood Purif.. 2013 ;36(3-4):173-8.

 

Uremia-associated immune deficiency is a well-known complication of loss of renal function and contributes significantly to the overall mortality and morbidity of patients with end-stage renal disease. Chronic inflammation and increased oxidative stress are underlying the uremia-associated ...

Last Updated: 5 Feb 2014

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The epidemiology of premature aging and associated comorbidities.
 

Author(s): Fabio Coppedè

Journal: Clin Interv Aging. 2013 ;8():1023-32.

 

Hutchinson-Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. The discovery of their genetic ...

Last Updated: 10 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.