Premature aging

Common Name(s)

Premature aging

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature aging" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature aging" returned 48 free, full-text research articles on human participants. First 3 results:

Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.
 

Author(s): Patricia Fernandez, Paola Scaffidi, Elke Markert, Ji-Hyeon Lee, Sushil Rane, Tom Misteli

Journal: Cell Rep. 2014 Oct;9(1):248-60.

 

Advanced age and DNA damage accumulation are prominent risk factors for cancer. The premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) provides a unique opportunity for studying the interplay between DNA damage and aging-associated tumor mechanisms, given that HGPS ...

Last Updated: 11 Oct 2014

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Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression.
 

Author(s): Donna Lowe, Kenneth Raj

Journal: Aging Cell. 2014 Oct;13(5):900-10.

 

Age is undoubtedly a major risk factor for heart disease. However, the reason for this is not entirely clear. In the course of our investigation into the mechanism of radiation-induced cardiovascular disease, we made several unexpected findings that inform us on this question. We ...

Last Updated: 23 Sep 2014

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Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities.
 

Author(s): Hong Zhao, Zbigniew Darzynkiewicz

Journal:

 

Described is an in vitro model of premature senescence in pulmonary adenocarcinoma A549 cells induced by persistent DNA replication stress in response to treatment with the DNA damaging drug mitoxantrone (Mxt). The degree of cellular senescence, based on characteristic changes in ...

Last Updated: 2 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature aging" returned 12 free, full-text review articles on human participants. First 3 results:

Loss of renal function causes premature aging of the immune system.
 

Author(s): Michiel G H Betjes, Ruud W J Meijers, Nicolle H R Litjens

Journal: Blood Purif.. 2013 ;36(3-4):173-8.

 

Uremia-associated immune deficiency is a well-known complication of loss of renal function and contributes significantly to the overall mortality and morbidity of patients with end-stage renal disease. Chronic inflammation and increased oxidative stress are underlying the uremia-associated ...

Last Updated: 5 Feb 2014

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The epidemiology of premature aging and associated comorbidities.
 

Author(s): Fabio Coppedè

Journal: Clin Interv Aging. 2013 ;8():1023-32.

 

Hutchinson-Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. The discovery of their genetic ...

Last Updated: 10 Sep 2013

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The endothelium abridges insulin resistance to premature aging.
 

Author(s): Angelo Avogaro, Saula Vigili de Kreutzenberg, Massimo Federici, Gian Paolo Fadini

Journal:

 

Last Updated: 6 Aug 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.