Premature aging

Common Name(s)

Premature aging

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature aging" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature aging" returned 65 free, full-text research articles on human participants. First 3 results:

Nucleolar expansion and elevated protein translation in premature aging.
 

Author(s): Abigail Buchwalter, Martin W Hetzer

Journal:

 

Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis ...

Last Updated: 31 Dec 1969

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Dysfunction of the MDM2/p53 axis is linked to premature aging.
 

Author(s): Davor Lessel, Danyi Wu, Carlos Trujillo, Thomas Ramezani, Ivana Lessel, Mohammad K Alwasiyah, Bidisha Saha, Fuki M Hisama, Katrin Rading, Ingrid Goebel, Petra Schütz, Günter Speit, Josef Högel, Holger Thiele, Gudrun Nürnberg, Peter Nürnberg, Matthias Hammerschmidt, Yan Zhu, David R Tong, Chen Katz, George M Martin, Junko Oshima, Carol Prives, Christian Kubisch

Journal: J. Clin. Invest.. 2017 Oct;127(10):3598-3608.

 

The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated with aging in mice. Several ...

Last Updated: 31 Dec 1969

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Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence.
 

Author(s): Kamil C Kural, Neetu Tandon, Mikhail Skoblov, Olga V Kel-Margoulis, Ancha V Baranova

Journal:

 

In culturing normal diploid cells, senescence may either happen naturally, in the form of replicative senescence, or it may be a consequence of external challenges such as oxidative stress. Here we present a comparative analysis aimed at reconstruction of molecular cascades specific ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature aging" returned 17 free, full-text review articles on human participants. First 3 results:

Molecular insights into the premature aging disease progeria.
 

Author(s): Sandra Vidak, Roland Foisner

Journal: Histochem. Cell Biol.. 2016 Apr;145(4):401-17.

 

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare premature aging disease presenting many features resembling the normal aging process. HGPS patients die before the age of 20 years due to cardiovascular problems and heart failure. HGPS is linked to mutations in the ...

Last Updated: 31 Dec 1969

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Skin Disease in Laminopathy-Associated Premature Aging.
 

Author(s): Tomás McKenna, Agustín Sola Carvajal, Maria Eriksson

Journal: J. Invest. Dermatol.. 2015 Nov;135(11):2577-2583.

 

The nuclear lamina, a protein network located under the nuclear membrane, has during the past decade found increasing interest due to its significant involvement in a range of genetic diseases, including the segmental premature aging syndromes Hutchinson-Gilford progeria syndrome, ...

Last Updated: 31 Dec 1969

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SIRTain regulators of premature senescence and accelerated aging.
 

Author(s): Shrestha Ghosh, Zhongjun Zhou

Journal: Protein Cell. 2015 May;6(5):322-33.

 

The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mental Ability Challenge Study in Adults With and Without HIV
 

Status: Recruiting

Condition Summary: HIV-1-infection; Aging, Premature; Cognitive Impairment; Memory Impairment; HIV-Associated Cognitive Motor Complex

 

Last Updated: 4 Aug 2017

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Inovium Ovarian Rejuvenation Trials
 

Status: Recruiting

Condition Summary: Perimenopausal Disorder; Menopause; Menopause, Premature; Menopause Related Conditions; Menopause Premature Symptomatic; Menopause Premature Asymptomatic; Premature Ovarian Failure; Premature Ovarian Failure, Familial; Premature Ovarian Failure 2A; Premature Ovarian Failure 3; Premature Ovarian Failure 4; Premature Ovarian Failure 1; Premature Ovarian Failure 5; Premature Ovarian Failure 6; Premature Ovarian Failure 7; Premature Ovarian Failure 9; Premature Ovarian Failure 8; Infertility; Infertility, Female; Infertility Unexplained

 

Last Updated: 3 Oct 2017

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