Preeclampsia

Common Name(s)

Preeclampsia

Preeclampsia is a disorder that only affects pregnant women. The condition is characterized by high blood pressure and protein in the urine after 20 weeks of pregnancy. Preeclampsia and related hypertensive disorders in pregnancy are seen in 5-8% of pregnancies. Symptoms of preeclampsia include swelling, sudden weight gain, problems with vision and severe headaches, though symptoms will differ depending on the patient and some women will exhibit no symptoms. Preeclampsia is a serious condition. The high blood pressure, if untreated, may damage the pregnant woman's kidneys, and potentially other organs such as the liver and brain. When preeclampsia damage causes seizures the condition is called "eclampsia." In addition to harming the pregnant woman, preeclampsia-eclampsia can harm the developing baby. With proper prenatal care, preeclampsia can be diagnosed early and treated. Preeclampsia is detected by measuring protein in the mother's urine, a sign of kidney damage. If the pregnancy is to term, or almost to term, labor is often induced or a cesarean section performed. If the pregnancy is still in its early or middle stages, medication, bed rest, and other treatments will often be prescribed to help control the mother's blood pressure and treat symptoms until the baby can be safely delivered. Once the baby is delivered, preeclampsia usually goes away very quickly. Risk factors for developing preeclampsia include women with chronic hypertension, who are obese, who are under 20 or over 40 years of age, who are pregnant with more than one baby, and who have preexisting health problems, such as diabetes. The cause of preeclampsia is unknown, but researchers have produced a number of theories about the condition. (See also Eclampsia and Gestational hypertension.)

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

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General Support Organizations

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General Resources

The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Preeclampsia" returned 989 free, full-text research articles on human participants. First 3 results:

Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia.
 

Author(s): Cornelius A Turpin, Samuel A Sakyi, William K B A Owiredu, Richard K D Ephraim, Enoch O Anto

Journal:

 

Gestational hypertension (GH) and Preeclampsia, (PE) are the most complicated amongst hypertensive disorders of pregnancy. The mechanism that links hypertension in pregnancy to adverse maternal outcomes is not fully understood though some relate this to endothelial dysfunction originating ...

Last Updated: 25 Aug 2015

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[Early intervention with aspirin for preventing preeclampsia in high-risk women: a meta-analysis].
 

Author(s): Shuo Yao, Huan Wu, Yanhong Yu

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jun;35(6):868-73.

 

To estimate the effect of early intervention with aspirin for prevention of preeclampsia in high-risk women.

Last Updated: 26 Jun 2015

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[Expression of progesterone-induced blocking factor in severe preeclampsia and its association with immune tolerance imbalance].
 

Author(s): Liang Lin, Yunpeng Huang, Yanhong Yu, Yin Yang

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jun;35(6):848-51.

 

To explore progesterone-induced blocking factor (PIBF) expression in the placenta and blood of patients with severe preeclampsia and its relationship with immune tolerance imbalance.

Last Updated: 26 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Preeclampsia" returned 152 free, full-text review articles on human participants. First 3 results:

Biomarker development for presymptomatic molecular diagnosis of preeclampsia: feasible, useful or even unnecessary?
 

Author(s): Sinuhe Hahn, Olav Lapaire, Nandor Gabor Than

Journal: Expert Rev. Mol. Diagn.. 2015 May;15(5):617-29.

 

The past decade saw the advent of a number of promising biomarkers to detect pregnancies at risk for preeclampsia (PE), the foremost being those associated with an imbalance of angiogenic factors. In late pregnancy, these are useful for the detection of imminent cases of PE, while ...

Last Updated: 21 Apr 2015

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Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia.
 

Author(s): Keiichi Matsubara, Takashi Higaki, Yuko Matsubara, Akihiro Nawa

Journal:

 

Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward uterine spiral arteries leading to increased uteroplacental vascular resistance and by vascular dysfunction resulting in reduced systemic vasodilatory properties. Its pathogenesis is mediated ...

Last Updated: 5 Mar 2015

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Flow-mediated dilation: can new approaches provide greater mechanistic insight into vascular dysfunction in preeclampsia and other diseases?
 

Author(s): Tracey L Weissgerber

Journal: Curr. Hypertens. Rep.. 2014 Nov;16(11):487.

 

Endothelial dysfunction is a key feature of preeclampsia and may contribute to increased cardiovascular disease risk years after pregnancy. Flow-mediated dilation (FMD) is a non-invasive endothelial function test that predicts cardiovascular event risk. New protocols allow researchers ...

Last Updated: 3 Sep 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

First-trimester Prediction of Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia; Severe Preeclampsia; Fetal Growth Restriction; Preterm Birth

 

Last Updated: 16 Feb 2015

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The Preeclampsia Registry
 

Status: Recruiting

Condition Summary: Preeclampsia; Eclampsia; HELLP Syndrome; Toxemia; Hypertensive Disorder of Pregnancy

 

Last Updated: 22 Oct 2015

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Preeclampsia: A Marker for Future Cardiovascular Risk in Women
 

Status: Recruiting

Condition Summary: Preeclampsia; Pregnancy Induced Hypertension

 

Last Updated: 7 Jan 2016

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