Preeclampsia

Common Name(s)

Preeclampsia

Preeclampsia is a disorder that only affects pregnant women. The condition is characterized by high blood pressure and protein in the urine after 20 weeks of pregnancy. Preeclampsia and related hypertensive disorders in pregnancy are seen in 5-8% of pregnancies. Symptoms of preeclampsia include swelling, sudden weight gain, problems with vision and severe headaches, though symptoms will differ depending on the patient and some women will exhibit no symptoms. Preeclampsia is a serious condition. The high blood pressure, if untreated, may damage the pregnant woman's kidneys, and potentially other organs such as the liver and brain. When preeclampsia damage causes seizures the condition is called "eclampsia." In addition to harming the pregnant woman, preeclampsia-eclampsia can harm the developing baby. With proper prenatal care, preeclampsia can be diagnosed early and treated. Preeclampsia is detected by measuring protein in the mother's urine, a sign of kidney damage. If the pregnancy is to term, or almost to term, labor is often induced or a cesarean section performed. If the pregnancy is still in its early or middle stages, medication, bed rest, and other treatments will often be prescribed to help control the mother's blood pressure and treat symptoms until the baby can be safely delivered. Once the baby is delivered, preeclampsia usually goes away very quickly. Risk factors for developing preeclampsia include women with chronic hypertension, who are obese, who are under 20 or over 40 years of age, who are pregnant with more than one baby, and who have preexisting health problems, such as diabetes. The cause of preeclampsia is unknown, but researchers have produced a number of theories about the condition. (See also Eclampsia and Gestational hypertension.)

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

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General Support Organizations

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General Resources

The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Preeclampsia" returned 1232 free, full-text research articles on human participants. First 3 results:

AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia.
 

Author(s): Xiaotao Yang, Ping Xu, Fumei Zhang, Li Zhang, Yangxi Zheng, Mingyu Hu, Lulu Wang, Ting-Li Han, Chuan Peng, Lianlian Wang, Li Wen, Yiwen Zeng, Rufei Gao, Yong Xia, Chao Tong, Zhu Yang, Hongbo Qi, Philip N Baker

Journal: Cell. Physiol. Biochem.. 2018 ;49(2):578-594.

 

Preeclampsia (PE) has long been assumed to be an ischemic disease of the placenta, although there is limited evidence as to how the ischemia impacts on the placenta. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy metabolism and plays an important role in ...

Last Updated: 31 Dec 1969

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Proteinuria in preeclampsia: is it important?
 

Author(s): Attila Özkara, Aşkı Ellibeş Kaya, Alper Başbuğ, Sabri Berkem Ökten, Ozan Doğan, Mete Çağlar, Selahattin Kumru

Journal: Ginekol. Pol.. 2018 ;89(5):256-261.

 

Our aim is to evaluate the laboratory results and proteinuria levels of preeclamptic women and their relation-ships to maternal and fetal outcomes.

Last Updated: 31 Dec 1969

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Placental expression of AChE, α7nAChR and NF-κB in patients with preeclampsia.
 

Author(s): Linmei Zheng, Lei Shi, Zhongyi Zhou, Xiaoju Chen, Li Wang, Zhicheng Lu, Rong Tang

Journal: Ginekol. Pol.. 2018 ;89(5):249-255.

 

This study aimed to investigate placental expression of AChE, α7nAChR and NF-κB in patients with preeclampsia and discuss about its clinical significance.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Preeclampsia" returned 201 free, full-text review articles on human participants. First 3 results:

The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis.
 

Author(s): Ling Yan, Yu Jin, Hongdong Hang, Bin Yan

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12192.

 

The association between urinary tract infection (UTI) during pregnancy and preeclampsia (PE) continues to be the subject of debate. This meta-analysis aimed to examine the relationship between UTI during pregnancy and PE.

Last Updated: 31 Dec 1969

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Vitamin B Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth.
 

Author(s): Nobuyuki Takahashi, Feng Li, Tomofumi Fushima, Gen Oyanagi, Emiko Sato, Yuji Oe, Akiyo Sekimoto, Daisuke Saigusa, Hiroshi Sato, Sadayoshi Ito

Journal: Tohoku J. Exp. Med.. 2018 03;244(3):243-248.

 

Up to 8% of pregnant women suffer from preeclampsia (PE), a deadly disease characterized by high blood pressure (BP), blood vessel damage, called endotheliosis (vascular endothelial swelling with narrowing of capillary lumen), and high levels of protein in the urine. PE is often associated ...

Last Updated: 31 Dec 1969

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[New perspectives on preeclampsia].
 

Author(s): Céline Méhats, Francisco Miralles, Daniel Vaiman

Journal: Med Sci (Paris). 2017 Dec;33(12):1079-1088.

 

Preeclampsia is a major, frequent and potentially severe condition of pregnancy, characterized by severe hypertension and proteinuria. In this review, we describe recent advances in understanding the pathology, and discuss the long-term impacts on maternal vascular health. Next, we ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 8 May 2017

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Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 27 Aug 2018

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Novel Biomarkers of Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 12 Jun 2018

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