Preeclampsia

Common Name(s)

Preeclampsia

Preeclampsia is a disorder that only affects pregnant women. The condition is characterized by high blood pressure and protein in the urine after 20 weeks of pregnancy. Preeclampsia and related hypertensive disorders in pregnancy are seen in 5-8% of pregnancies. Symptoms of preeclampsia include swelling, sudden weight gain, problems with vision and severe headaches, though symptoms will differ depending on the patient and some women will exhibit no symptoms. Preeclampsia is a serious condition. The high blood pressure, if untreated, may damage the pregnant woman's kidneys, and potentially other organs such as the liver and brain. When preeclampsia damage causes seizures the condition is called "eclampsia." In addition to harming the pregnant woman, preeclampsia-eclampsia can harm the developing baby. With proper prenatal care, preeclampsia can be diagnosed early and treated. Preeclampsia is detected by measuring protein in the mother's urine, a sign of kidney damage. If the pregnancy is to term, or almost to term, labor is often induced or a cesarean section performed. If the pregnancy is still in its early or middle stages, medication, bed rest, and other treatments will often be prescribed to help control the mother's blood pressure and treat symptoms until the baby can be safely delivered. Once the baby is delivered, preeclampsia usually goes away very quickly. Risk factors for developing preeclampsia include women with chronic hypertension, who are obese, who are under 20 or over 40 years of age, who are pregnant with more than one baby, and who have preexisting health problems, such as diabetes. The cause of preeclampsia is unknown, but researchers have produced a number of theories about the condition. (See also Eclampsia and Gestational hypertension.)

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

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Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia" for support, advocacy or research.

H.E.L.L.P. Syndrome International Foundation, S.a, UK, USA

HELLP Syndrome is a life-threatening condition to both mother and unborn baby during gestation. Our goal: To enhance and extend life.

Last Updated: 19 Aug 2013

View Details
Preeclampsia Foundation

The Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices. We envision a world where preeclampsia no longer threatens the lives of mothers and babies.

http://www.preeclampsia.org

Last Updated: 23 Oct 2014

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Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

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General Support Organizations

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General Resources

The Preeclampsia Registry

The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders

Updated 23 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Preeclampsia" returned 1129 free, full-text research articles on human participants. First 3 results:

Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes.
 

Author(s): Alfredo Leaños-Miranda, Francisco Méndez-Aguilar, Karla Leticia Ramírez-Valenzuela, Marilyn Serrano-Rodríguez, Guadalupe Berumen-Lechuga, Carlos José Molina-Pérez, Irma Isordia-Salas, Inova Campos-Galicia

Journal: Medicine (Baltimore). 2017 Jan;96(4):e6005.

 

Gestational hypertension (GH) and preeclampsia (PE) are characterized by an imbalance in angiogenic factors. However, the relationship among these factors with the severity of hypertensive disorders of pregnancy (HDP) and adverse outcomes are not fully elucidated. We examined whether ...

Last Updated: 25 Jan 2017

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The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia.
 

Author(s): Yun Ji Jung, Hee Young Cho, Sihyun Cho, Young Han Kim, Jin Dong Jeon, Young Jin Kim, Sanghoo Lee, Jimyeong Park, Ha Yan Kim, Yong Won Park, Ja Young Kwon

Journal: Yonsei Med. J.. 2017 Mar;58(2):401-406.

 

The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE).

Last Updated: 25 Jan 2017

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Association between higher expression of interleukin-8 (IL-8) and haplotype -353A/-251A/+678T of IL-8 gene with preeclampsia: A case-control study.
 

Author(s): Lei Sun, Dongwei Mao, Yan Cai, Wenhua Tan, Yanlan Hao, Lin Li, Wei Liu

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5537.

 

Preeclampsia (PE) is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide.The present study was performed to investigate the role of a CXC chemokine interleukin-8 (IL-8), in the pathogenesis of PE. IL-8 expression levels ...

Last Updated: 29 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Preeclampsia" returned 173 free, full-text review articles on human participants. First 3 results:

Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis.
 

Author(s): Tracey L Weissgerber, Natasa M Milic, Jelena S Milin-Lazovic, Vesna D Garovic

Journal: Hypertension. 2016 Feb;67(2):415-23.

 

Endothelial dysfunction is believed to play a critical role in preeclampsia; however, it is unclear whether this dysfunction precedes the pregnancy or is caused by pathophysiological events in early pregnancy. It is also unclear for how long vascular dysfunction may persist postpartum ...

Last Updated: 14 Jan 2016

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Prevalence of Preeclampsia and Eclampsia in Iran.
 

Author(s): Roghieh Kharaghani, Zahra Cheraghi, Batool Okhovat Esfahani, Zahra Mohammadian, Reyhaneh Sadat Nooreldinc

Journal: Arch Iran Med. 2016 Jan;19(1):64-71.

 

Several studies have been conducted to investigate the prevalence of preeclampsia and eclampsia in Iran. These studies have yielded different results. This meta-analysis was aimed to estimate the prevalence of preeclampsia and eclampsia in Iran.

Last Updated: 25 Dec 2015

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Preeclampsia and Pregnancy-Related Hypertensive Disorders.
 

Author(s): S Ananth Karumanchi, Joey P Granger

Journal: Hypertension. 2016 Feb;67(2):238-42.

 

Our understanding of hypertension during pregnancy and, in particular, preeclampsia has changed dramatically over the last decade. During the last year (2014–2015), several articles published in Hypertension have provided important insights into the pathogenesis of preeclampsia ...

Last Updated: 14 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 18 Nov 2016

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Low Dose Aspirin in the Prevention of Preeclampsia in China
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 6 Dec 2016

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Standard 24-hour Urine Protein vs Shorter Period for Diagnosis of Pre-eclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 15 Aug 2016

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