Arthritis

Common Name(s)

Arthritis

Arthritis is the inflammation of a joint (the point where two bones fit together). There are many types of arthritis and each one has its own cause and symptoms. Typically, all forms of arthritis are associated with symptoms that include pain, stiffness, swelling, redness, and decreased range of motion in the joint that usually gets worse with age. Severe arthritis that affects the hands and arms may make it difficult to do daily tasks while arthritis that affects the knees or ankles may make it difficult to walk or stand. The most common types of arthritis are osteoarthritis and rheumatoid arthritis (RA). Osteoarthritis is caused by the breakdown of the hard tissue that covers and protects the ends of bones (cartilage). Rheumatoid arthritis (RA) is an autoimmune disease that causes the body’s immune system to attack the lining of joints (synovium).

Risk factors for arthritis include a family history of arthritis, increasing age, previous joint injury, obesity and gender, as women are more likely than men to develop RA. Causes of other forms of arthritis include a build up of uric acid crystals in the joint, infections, or underlying disease, such as psoriasis or lupus. Your doctor may use a physical exam, imaging, lab tests and video assessment of your joints to diagnosis arthritis. Imaging can include an X-ray and an MRI to get a detailed look at the joint and cartilage. Doctors may also perform arthroscopy, which uses a small video camera inserted into a small cut near the affected joint to obtain images of the affected area. Although there is no cure for arthritis, there are treatments that help reduce symptoms. These include pain medications, therapy and surgery. If you or someone in your family has been diagnosed with arthritis, talk with a doctor to determine the best treatment plan.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Arthritis" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Arthritis" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Arthritis" returned 14186 free, full-text research articles on human participants. First 3 results:

Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey.
 

Author(s): Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha

Journal:

 

This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South ...

Last Updated: 19 Apr 2017

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Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis.
 

Author(s): Hasan Al Faruque, Jin Hee Kang, Seung Rim Hwang, Shijin Sung, Md Mahmudul Alam, Keum Hee Sa, Eon Jeong Nam, Young Ro Byun, Young Mo Kang

Journal:

 

Identification of the structure-function relationship of heparin, particularly between 2-O-, 6-O-, and N-sulfation and its anticoagulant or anti-inflammatory activities, is critical in order to evaluate the biological effects of heparin, especially in conjunction with modifications ...

Last Updated: 18 Apr 2017

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Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients.
 

Author(s): Anis Barati, Ahmad Reza Jamshidi, Hossein Ahmadi, Zahra Aghazadeh, Abbas Mirshafiey

Journal:

 

Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis characterized by pain, swelling and destruction of joints, with a resultant disability. Disease-modifying anti-rheumatic drugs (DMARDs) and biological drugs can interfere with the disease process. ...

Last Updated: 14 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Arthritis" returned 1709 free, full-text review articles on human participants. First 3 results:

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.
 

Author(s): Qi Qiu, Jing Huang, Yang Lin, Xiaoming Shu, Huizheng Fan, Zhihua Tu, Youwen Zhou, Cheng Xiao

Journal: Medicine (Baltimore). 2017 Mar;96(11):e6337.

 

Methotrexate (MTX) is widely used and considered a first-line disease modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). However, 10% to 30% of patients discontinue therapy within a year of starting the treatment, usually because of undesirable side ...

Last Updated: 15 Mar 2017

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Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis.
 

Author(s): Charles J Malemud

Journal:

 

Elevated levels of pro-inflammatory cytokines are generally thought to be responsible for driving the progression of synovial joint inflammation in rheumatoid arthritis (RA) and osteoarthritis (OA). These cytokines activate several signal transduction pathways, including the Janus ...

Last Updated: 1 Mar 2017

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Assessment and therapeutic choice in septic arthritis of the hip in an intravenous drug abuser: case report at 14 years follow-up and review of literature.
 

Author(s): P Persiani, F M Ranaldi, O Mazza, A Calistri, M Bove, M Crostelli, C Villani

Journal: Clin Ter. ;168(1):e8-e13.

 

Osteoarticular infections are found frequently in drug addicted individuals, representing one of the main reasons for their hospitalization. Through inoculation, the pathogenic agents can enter the individual's system directly through the skin or parenterally, transmitted, that is, ...

Last Updated: 27 Feb 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CPMC Early Undifferentiated Arthritis Registry
 

Status: Recruiting

Condition Summary: Arthritis

 

Last Updated: 31 Jan 2017

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Discovering the Antecedents of Rheumatoid Arthritis Flare
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 6 Oct 2016

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Pro-calcitonin for Early Detection of Septic Arthritis
 

Status: Recruiting

Condition Summary: Arthritis, Infectious

 

Last Updated: 17 Nov 2015

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