Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 285 free, full-text research articles on human participants. First 3 results:

Living Donor Liver Transplantation for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis after Concurrent Chemoradiation Therapy.
 

Author(s): Dai Hoon Han, Dong Jin Joo, Myoung Soo Kim, Gi Hong Choi, Jin Sub Choi, Young Nyun Park, Jinsil Seong, Kwang Hyub Han, Soon Il Kim

Journal: Yonsei Med. J.. 2016 Sep;57(5):1276-81.

 

Locally advanced hepatocellular carcinoma (HCC) with portal vein thrombosis carries a 1-year survival rate <10%. Localized concurrent chemoradiotherapy (CCRT), followed by hepatic arterial infusion chemotherapy (HAIC), was recently introduced in this setting. Here, we report our early ...

Last Updated: 12 Jul 2016

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Survival outcomes of hepatic resection compared with transarterial chemoembolization or sorafenib for hepatocellular carcinoma with portal vein tumor thrombosis.
 

Author(s): Jung Min Lee, Byoung Kuk Jang, Yoo Jin Lee, Wang Yong Choi, Sei Myong Choi, Woo Jin Chung, Jae Seok Hwang, Koo Jeong Kang, Young Hwan Kim, Anil Kumar Chauhan, Soo Young Park, Won Young Tak, Young Oh Kweon, Byung Seok Kim, Chang Hyeong Lee

Journal: Clin Mol Hepatol. 2016 Mar;22(1):160-7.

 

Treating hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains controversial. We compared the outcomes of hepatic resection (HR), transarterial chemoembolization (TACE), and sorafenib therapy as treatments for HCC with PVTT.

Last Updated: 5 Apr 2016

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Pre-transplant portal vein thrombosis is an independent risk factor for graft loss due to hepatic artery thrombosis in liver transplant recipients.
 

Author(s): Jonathan G Stine, Shawn J Pelletier, Timothy M Schmitt, Robert J Porte, Patrick G Northup

Journal: HPB (Oxford). 2016 Mar;18(3):279-86.

 

Hepatic artery thrombosis is an uncommon but catastrophic complication following liver transplantation. We hypothesize that recipients with portal vein thrombosis are at increased risk.

Last Updated: 28 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 30 free, full-text review articles on human participants. First 3 results:

Acute Cholecystitis Complicated with Portal Vein Thrombosis: A Case Report and Literature Review.
 

Author(s): Mohammed Muneer, Husham Abdelrahman, Ayman El-Menyar, Ahmad Zarour, Ahmed Awad, Hassan Al-Thani

Journal:

 

Portal vein thrombosis (PVT) is an infrequent clinical condition usually associated with multiple etiological factors and diseases. In some cases, PVT remains undiagnosed and is incidentally detected during routine examination for a known etiology.

Last Updated: 18 Sep 2015

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Contrast-enhanced ultrasound in differentiating malignant from benign portal vein thrombosis in hepatocellular carcinoma.
 

Author(s): Luciano Tarantino, Pasquale Ambrosino, Matteo Nicola Dario Di Minno

Journal: World J. Gastroenterol.. 2015 Aug;21(32):9457-60.

 

Portal vein thrombosis (PVT) may occur in liver cirrhosis patients. Malignant PVT is a common complication in cirrhotic patients with concomitant hepatocellular carcinoma (HCC) and, in some cases, it may be even the initial sign of an undetected HCC. Detection of malignant PVT in ...

Last Updated: 2 Sep 2015

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New perspectives on the management of hepatocellular carcinoma with portal vein thrombosis.
 

Author(s): Hyun Young Woo, Jeong Heo

Journal: Clin Mol Hepatol. 2015 Jun;21(2):115-21.

 

Despite advances in the treatment of hepatocellular carcinoma (HCC), managing HCC with portal vein thrombosis (PVT) remains challenging. PVT is present in 10-40% of HCC cases at the time of diagnosis and its therapeutic options are very limited. Current guidelines mainly recommend ...

Last Updated: 9 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Vein Thrombosis

 

Last Updated: 8 Mar 2016

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The Effect of Anticoagulation in Cirrhotic Patients With Portal Vein Thrombosis:A Multicenter RCT
 

Status: Not yet recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 14 Dec 2015

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The Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 8 Dec 2015

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