Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 281 free, full-text research articles on human participants. First 3 results:

Efficacy of External Beam Radiation-Based Treatment plus Locoregional Therapy for Hepatocellular Carcinoma Associated with Portal Vein Tumor Thrombosis.
 

Author(s): Ming-Yang Chen, Yu-Chao Wang, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Ngan-Ming Tsang, Kun-Ming Chan, Wei-Chen Lee

Journal: Biomed Res Int. 2016 ;2016():6017406.

 

Background. Portal vein tumor thrombosis (PVTT) is a common event in advanced hepatocellular carcinoma (HCC). The optimal treatment for these patients remains controversial. Methods. A retrospective review of 149 patients who had unresectable HCC associated with PVTT between January ...

Last Updated: 21 Dec 2016

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Left branch of portal vein thrombosis in a liver transplant recipient with donation after cardiac death donor: A case report.
 

Author(s): Maogen Chen, Weiqiang Ju, Xiaohong Lin, Qiang Zhao, Dongping Wang, Xiaoshun He

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5520.

 

Portal vein thrombosis (PVT) is one of the most severe complications after liver transplantation, which usually causes graft loss and recipient mortality. The founding of the embolic branch of portal system and its result are not well described in the literature.

Last Updated: 8 Dec 2016

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Living Donor Liver Transplantation for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis after Concurrent Chemoradiation Therapy.
 

Author(s): Dai Hoon Han, Dong Jin Joo, Myoung Soo Kim, Gi Hong Choi, Jin Sub Choi, Young Nyun Park, Jinsil Seong, Kwang Hyub Han, Soon Il Kim

Journal: Yonsei Med. J.. 2016 Sep;57(5):1276-81.

 

Locally advanced hepatocellular carcinoma (HCC) with portal vein thrombosis carries a 1-year survival rate <10%. Localized concurrent chemoradiotherapy (CCRT), followed by hepatic arterial infusion chemotherapy (HAIC), was recently introduced in this setting. Here, we report our early ...

Last Updated: 12 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 29 free, full-text review articles on human participants. First 3 results:

Acute Cholecystitis Complicated with Portal Vein Thrombosis: A Case Report and Literature Review.
 

Author(s): Mohammed Muneer, Husham Abdelrahman, Ayman El-Menyar, Ahmad Zarour, Ahmed Awad, Hassan Al-Thani

Journal:

 

Portal vein thrombosis (PVT) is an infrequent clinical condition usually associated with multiple etiological factors and diseases. In some cases, PVT remains undiagnosed and is incidentally detected during routine examination for a known etiology.

Last Updated: 18 Sep 2015

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Portal Vein Thrombosis of a Newborn with Corrected Total Anomalous Pulmonary Venous Return.
 

Author(s): Ufuk Çakır, Dilek Kahvecioğlu, Serdar Alan, Ömer Erdeve, Begüm Atasay, Tayfun Uçar, Saadet Arsan, Hasan Çakmaklı, Mehmet Ertem, Semra Atalay

Journal: Turk J Haematol. 2015 Sep;32(3):267-70.

 

Total anomalous pulmonary venous return (TAPVR) is a rare and frequently isolated defect identified in 1% to 3% of all congenital heart diseases. To the best of our knowledge, portal vein thrombosis (PVT) associated with TAPVR has not been reported in the literature. We report a successfully ...

Last Updated: 17 Sep 2015

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Contrast-enhanced ultrasound in differentiating malignant from benign portal vein thrombosis in hepatocellular carcinoma.
 

Author(s): Luciano Tarantino, Pasquale Ambrosino, Matteo Nicola Dario Di Minno

Journal: World J. Gastroenterol.. 2015 Aug;21(32):9457-60.

 

Portal vein thrombosis (PVT) may occur in liver cirrhosis patients. Malignant PVT is a common complication in cirrhotic patients with concomitant hepatocellular carcinoma (HCC) and, in some cases, it may be even the initial sign of an undetected HCC. Detection of malignant PVT in ...

Last Updated: 2 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Vein Thrombosis

 

Last Updated: 8 Mar 2016

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The Effect of Anticoagulation in Cirrhotic Patients With Portal Vein Thrombosis:A Multicenter RCT
 

Status: Not yet recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 14 Dec 2015

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The Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 8 Dec 2015

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