Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 288 free, full-text research articles on human participants. First 3 results:

Mechanical thrombolysis as an adjunct therapy to management of portal vein thrombosis following Radio Frequency Ablation.
 

Author(s): A O Hairol, C A Affirul, A Azlanudin, Z Zamri, J Razman, S Y Choi

Journal: Clin Ter. ;168(1):e5-e7.

 

Radiofrequency ablation (RFA) has evolved to become the treatment of choice for non-resectable recurrent colorectal liver metastasis. It is however, not without complications. Portal vein thrombosis following RFA is rare but can be fatal to the outcome of the patient. Here, we present ...

Last Updated: 27 Feb 2017

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Clinical Impact of Portal Vein Thrombosis Prior to Liver Transplantation: A Retrospective Cohort Study.
 

Author(s): Constantine J Karvellas, Filipe S Cardoso, Marco Senzolo, Malcolm Wells, Mansour G Alghanem, Fayaz Handou, Lukasz Kwapisz, Norman M Kneteman, Paul J Marotta, Bandar Al-Judaibi

Journal: Ann Hepatol. ;16(2):236-436.

 

To identify the impact of portal vein thrombosis (PVT) and associated medical and surgical factors on outcomes post liver transplant (LT).

Last Updated: 24 Feb 2017

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Efficacy of External Beam Radiation-Based Treatment plus Locoregional Therapy for Hepatocellular Carcinoma Associated with Portal Vein Tumor Thrombosis.
 

Author(s): Ming-Yang Chen, Yu-Chao Wang, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Ngan-Ming Tsang, Kun-Ming Chan, Wei-Chen Lee

Journal: Biomed Res Int. 2016 ;2016():6017406.

 

Background. Portal vein tumor thrombosis (PVTT) is a common event in advanced hepatocellular carcinoma (HCC). The optimal treatment for these patients remains controversial. Methods. A retrospective review of 149 patients who had unresectable HCC associated with PVTT between January ...

Last Updated: 21 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 34 free, full-text review articles on human participants. First 3 results:

A systematic review on the safety and effectiveness of yttrium-90 radioembolization for hepatocellular carcinoma with portal vein tumor thrombosis.
 

Author(s): Zhongzhi Jia, Guomin Jiang, Feng Tian, Chunfu Zhu, Xihu Qin

Journal: Saudi J Gastroenterol. ;22(5):353-359.

 

Over the past two decades, several advances have been made in the management of patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT). Yttrium-90 ( 90 Y) radioembolization has recently been made a treatment option for patients with HCC and PVTT. However, ...

Last Updated: 17 Oct 2016

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Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016.
 

Author(s): Stephen L Chan, Charing C N Chong, Anthony W H Chan, Darren M C Poon, Kenneth S H Chok

Journal: World J. Gastroenterol.. 2016 Aug;22(32):7289-300.

 

Portal vein tumor thrombosis (PVTT) is a common phenomenon in hepatocellular carcinoma (HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer ...

Last Updated: 13 Sep 2016

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Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis.
 

Author(s): Jeong Il Yu, Hee Chul Park

Journal: World J. Gastroenterol.. 2016 Aug;22(30):6851-63.

 

Although the current standard treatment for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration ...

Last Updated: 29 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 18 Jul 2017

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The Effect of Anticoagulation in Cirrhotic Patients With Portal Vein Thrombosis:A Multicenter RCT
 

Status: Not yet recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 14 Dec 2015

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The Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 8 Dec 2015

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