Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 276 free, full-text research articles on human participants. First 3 results:

Peritoneal tuberculosis presenting with portal vein thrombosis and transudative Ascites - a diagnostic dilemma: case report.
 

Author(s): Ushani Mayurika Wariyapperuma, Champa Indrani Welikala Jayasundera

Journal:

 

Peritoneal tuberculosis is an important problem in regions of the world where tuberculosis is still prevalent (Chest 1991; 99:1134). Atypical presentations such as portal vein thrombosis can delay diagnosis or result in misdiagnosis (Gut 1990; 31:1130, Acta ClinBelg 2012; 67(2):137-9, ...

Last Updated: 1 Oct 2015

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The incidence and risk factors of portal vein system thrombosis after splenectomy and pericardial devascularization.
 

Author(s): Shengli Wu, Zheng Wu, Xiaogang Zhang, Ruitao Wang, Jigang Bai

Journal: Turk J Gastroenterol. 2015 Sep;26(5):423-8.

 

This study aimed to investigate the incidence and risk factors of portal vein system thrombosis (PVST) in patients with liver cirrhosis after splenectomy and pericardial devascularization.

Last Updated: 9 Sep 2015

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Surgical Strategy for Hepatocellular Carcinoma Patients with Portal/Hepatic Vein Tumor Thrombosis.
 

Author(s): Li Shaohua, Wang Qiaoxuan, Sun Peng, Li Qing, Yang Zhongyuan, Shi Ming, Wei Wei, Guo Rongping

Journal:

 

Portal/hepatic vein tumor thrombosis (PVTT/HVTT) in hepatocellular carcinoma (HCC) is a sign of advanced stage disease and is associated with poor prognosis. This study investigated the surgical outcomes of patients with HCC and PVTT/HVTT to determine the most appropriate surgical ...

Last Updated: 16 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 28 free, full-text review articles on human participants. First 3 results:

Acute Cholecystitis Complicated with Portal Vein Thrombosis: A Case Report and Literature Review.
 

Author(s): Mohammed Muneer, Husham Abdelrahman, Ayman El-Menyar, Ahmad Zarour, Ahmed Awad, Hassan Al-Thani

Journal:

 

Portal vein thrombosis (PVT) is an infrequent clinical condition usually associated with multiple etiological factors and diseases. In some cases, PVT remains undiagnosed and is incidentally detected during routine examination for a known etiology.

Last Updated: 18 Sep 2015

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New perspectives on the management of hepatocellular carcinoma with portal vein thrombosis.
 

Author(s): Hyun Young Woo, Jeong Heo

Journal: Clin Mol Hepatol. 2015 Jun;21(2):115-21.

 

Despite advances in the treatment of hepatocellular carcinoma (HCC), managing HCC with portal vein thrombosis (PVT) remains challenging. PVT is present in 10-40% of HCC cases at the time of diagnosis and its therapeutic options are very limited. Current guidelines mainly recommend ...

Last Updated: 9 Jul 2015

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Portal vein thrombosis in cirrhosis: Controversies and latest developments.
 

Author(s): Damian J Harding, M Thamara P R Perera, Frederick Chen, Simon Olliff, Dhiraj Tripathi

Journal: World J. Gastroenterol.. 2015 Jun;21(22):6769-84.

 

Portal vein thrombosis (PVT) is encountered in liver cirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also ...

Last Updated: 16 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Vein Thrombosis

 

Last Updated: 8 Mar 2016

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Placebo-controlled Study of NPB-06 in Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis

 

Last Updated: 5 Oct 2015

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Anticoagulation for Non-occlusive Portal Vein Thrombosis in Patients With Liver Cirrhosis
 

Status: Not yet recruiting

Condition Summary: Liver Cirrhosis; Portal Vein Thrombosis; Anticoagulation

 

Last Updated: 15 Aug 2015

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