Portal hypertension

Common Name(s)

Portal hypertension

Portal hypertension is abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. Portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. It may be caused by a variety of conditions, but cirrhosis is the most common cause in Western countries. Treatment is generally directed toward the cause of the condition, although emergency treatment is sometimes needed for serious complications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal hypertension" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal hypertension" returned 607 free, full-text research articles on human participants. First 3 results:

The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
 

Author(s): Bernhard Scheiner, Mattias Mandorfer, Philipp Schwabl, Berit Anna Payer, Theresa Bucsics, Simona Bota, Maximilian C Aichelburg, Katharina Grabmeier-Pfistershammer, Albert Stättermayer, Peter Ferenci, Michael Trauner, Markus Peck-Radosavljevic, Thomas Reiberger

Journal:

 

Faster fibrosis progression and hepatic steatosis are hallmarks of HIV/HCV coinfection. A single nucleotide polymorphism (SNP) of the PNPLA3-gene is associated with development of non-alcoholic steatohepatitis and a worse outcome in alcoholic liver disease. However, the role of PNPLA3 ...

Last Updated: 25 Nov 2015

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Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1.
 

Author(s): Barbara Renga, Sabrina Cipriani, Adriana Carino, Michele Simonetti, Angela Zampella, Stefano Fiorucci

Journal:

 

GPBAR1 is a bile acids activated receptor expressed in entero-hepatic tissues. In the liver expression of GPBAR1 is restricted to sinusoidal and Kuppfer cells. In the systemic circulation vasodilation caused by GPBAR1 agonists is abrogated by inhibition of cystathione-γ-liase (CSE), ...

Last Updated: 6 Nov 2015

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Key factors of therapeutic effects for surgery in patients with cirrhotic portal hypertension.
 

Author(s): Y-F Lv, X-Y Han, X-G Gong, N Liu, J Yue, Y-J Li, S-J Zhang, Y-B Pang

Journal: Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3492-9.

 

In the clinical management of cirrhotic portal hypertension, surgery is often necessary; however, the operative mortality rate is high.

Last Updated: 7 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal hypertension" returned 115 free, full-text review articles on human participants. First 3 results:

Contemporary concepts of the medical therapy of portal hypertension under liver cirrhosis.
 

Author(s): Dmitry Victorovich Garbuzenko

Journal: World J. Gastroenterol.. 2015 May;21(20):6117-26.

 

Severe complications of liver cirrhosis are mostly related to portal hypertension. At the base of the pathogenesis of portal hypertension is the increase in hepatic vascular resistance to portal blood flow with subsequent development of hyperdynamic circulation, which, despite of ...

Last Updated: 2 Jun 2015

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Idiopathic non-cirrhotic portal hypertension: a review.
 

Author(s): Jeoffrey N L Schouten, Joanne Verheij, Susana Seijo

Journal:

 

Idiopathic non-cirrhotic portal hypertension (INCPH) is a rare disease characterized of intrahepatic portal hypertension in the absence of cirrhosis or other causes of liver disease and splanchnic venous thrombosis. The etiology of INCPH can be classified in five categories: 1) immunological ...

Last Updated: 6 Jun 2015

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Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments.
 

Author(s): Jaume Bosch, Roberto J Groszmann, Vijay H Shah

Journal: J. Hepatol.. 2015 Apr;62(1 Suppl):S121-30.

 

Among the common complication of cirrhosis portal hypertension witnessed a major improvement of prognosis during the past decades. Principally due to the introduction of rational treatments based on new pathophysiological paradigms (concepts of thought) developed in the 1980s. The ...

Last Updated: 29 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MRI in Portal Hypertension
 

Status: Recruiting

Condition Summary: Portal Hypertension

 

Last Updated: 14 Jan 2014

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Transient Elastography to Assess Liver Fibrosis and Portal Hypertension in HCV Cirrhotic Patients Treated With New Antiviral Drugs (SPLEEN-C)
 

Status: Recruiting

Condition Summary: Chronic Hepatitis C; Cirrhosis; Portal Hypertension

 

Last Updated: 6 May 2015

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Value of Von Willebrand Factor in Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Hypertension

 

Last Updated: 24 Sep 2015

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