Portal hypertension

Common Name(s)

Portal hypertension

Portal hypertension is abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. Portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. It may be caused by a variety of conditions, but cirrhosis is the most common cause in Western countries. Treatment is generally directed toward the cause of the condition, although emergency treatment is sometimes needed for serious complications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal hypertension" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal hypertension" returned 599 free, full-text research articles on human participants. First 3 results:

Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites.
 

Author(s): Keisuke Kakisaka, Kei Endo, Akiko Suzuki, Sadanari Hayashi, Tamami Abe, Yuichi Yoshida, Takayoshi Oikawa, Yasuhiro Miyamoto, Kei Sawara, Kinji Ishida, Hidekatsu Kuroda, Yasuhiro Takikawa

Journal: Intern. Med.. 2015 ;54(18):2327-31.

 

A man diagnosed with alcoholic liver cirrhosis complained of abdominal distention due to massive ascites. The ascites did not resolve with diuretic agents. The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites ...

Last Updated: 15 Sep 2015

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Fast-track protocols in devascularization for cirrhotic portal hypertension.
 

Author(s): Yang Fei, Guang-quan Zong, Jian Chen, Ren-min Liu

Journal: Rev Assoc Med Bras. ;61(3):250-7.

 

fast-tract surgery (FTS) has been rapidly embraced by surgeons as a mechanism for improving patient care and driving down complications and costs. The aim of this study was to determine if any improvement in outcomes occurred after FTS protocol for selective double portazygous disconnection ...

Last Updated: 7 Aug 2015

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Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
 

Author(s): Thiago A Pereira, Wing-Kin Syn, Mariana V Machado, Paula V Vidigal, Vivian Resende, Izabela Voieta, Guanhua Xie, Alba Otoni, Márcia M Souza, Elisângela T Santos, Isaac S Chan, Guilherme V M Trindade, Steve S Choi, Rafal P Witek, Fausto E Pereira, William E Secor, Zilton A Andrade, José Roberto Lambertucci, Anna Mae Diehl

Journal: Clin. Sci.. 2015 Nov;129(10):875-83.

 

Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. We evaluated the hypothesis that schistosome eggs release ...

Last Updated: 2 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal hypertension" returned 114 free, full-text review articles on human participants. First 3 results:

Contemporary concepts of the medical therapy of portal hypertension under liver cirrhosis.
 

Author(s): Dmitry Victorovich Garbuzenko

Journal: World J. Gastroenterol.. 2015 May;21(20):6117-26.

 

Severe complications of liver cirrhosis are mostly related to portal hypertension. At the base of the pathogenesis of portal hypertension is the increase in hepatic vascular resistance to portal blood flow with subsequent development of hyperdynamic circulation, which, despite of ...

Last Updated: 2 Jun 2015

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Idiopathic non-cirrhotic portal hypertension: a review.
 

Author(s): Jeoffrey N L Schouten, Joanne Verheij, Susana Seijo

Journal:

 

Idiopathic non-cirrhotic portal hypertension (INCPH) is a rare disease characterized of intrahepatic portal hypertension in the absence of cirrhosis or other causes of liver disease and splanchnic venous thrombosis. The etiology of INCPH can be classified in five categories: 1) immunological ...

Last Updated: 6 Jun 2015

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Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments.
 

Author(s): Jaume Bosch, Roberto J Groszmann, Vijay H Shah

Journal: J. Hepatol.. 2015 Apr;62(1 Suppl):S121-30.

 

Among the common complication of cirrhosis portal hypertension witnessed a major improvement of prognosis during the past decades. Principally due to the introduction of rational treatments based on new pathophysiological paradigms (concepts of thought) developed in the 1980s. The ...

Last Updated: 29 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MRI in Portal Hypertension
 

Status: Recruiting

Condition Summary: Portal Hypertension

 

Last Updated: 14 Jan 2014

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Transient Elastography to Assess Liver Fibrosis and Portal Hypertension in HCV Cirrhotic Patients Treated With New Antiviral Drugs (SPLEEN-C)
 

Status: Recruiting

Condition Summary: Chronic Hepatitis C; Cirrhosis; Portal Hypertension

 

Last Updated: 6 May 2015

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Value of Von Willebrand Factor in Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Hypertension

 

Last Updated: 24 Sep 2015

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