Portal hypertension

Common Name(s)

Portal hypertension

Portal hypertension is abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. Portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. It may be caused by a variety of conditions, but cirrhosis is the most common cause in Western countries. Treatment is generally directed toward the cause of the condition, although emergency treatment is sometimes needed for serious complications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal hypertension" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal hypertension" returned 446 free, full-text research articles on human participants. First 3 results:

Intrapulmonary vascular dilatation evaluated by 99mTc-MAA scintigraphy and its association with portal hypertension in schistosomiasis.
 

Author(s): Andréa Simone Siqueira de Queirós, Simone Cristina Soares Brandão, Ana Lúcia Coutinho Domingues, Liana Gonçalves Macedo, Maira Souto Ourem, Edmundo Pessoa Almeida Lopes

Journal:

 

Portal hypertension is responsible for various complications in patients with schistosomiasis, among them intrapulmonary vascular dilations (IPVD). In cirrhotic patients the presence of IPVD is a sign of poor prognosis, but in patients with hepatosplenic schistosomiasis (HSS) there ...

Last Updated: 27 Jun 2014

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Clinical outcomes of transjugular intrahepatic portosystemic shunt for portal hypertension: Korean multicenter real-practice data.
 

Author(s): Hyung Ki Kim, Yoon Jun Kim, Woo Jin Chung, Soon Sun Kim, Jae Jun Shim, Moon Seok Choi, Do Young Kim, Dae Won Jun, Soon Ho Um, Sung Jae Park, Hyun Young Woo, Young Kul Jung, Soon Koo Baik, Moon Young Kim, Soo Young Park, Jae Myeong Lee, Young Seok Kim

Journal: Clin Mol Hepatol. 2014 Mar;20(1):18-27.

 

This retrospective study assessed the clinical outcome of a transjugular intrahepatic portosystemic shunt (TIPS) procedure for managing portal hypertension in Koreans with liver cirrhosis.

Last Updated: 23 Apr 2014

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Idiopathic non cirrhotic portal hypertension and spleno-portal axis abnormalities in patients with severe primary antibody deficiencies.
 

Author(s): Federica Pulvirenti, Ilaria Pentassuglio, Cinzia Milito, Michele Valente, Adriano De Santis, Valentina Conti, Giulia d'Amati, Oliviero Riggio, Isabella Quinti

Journal: J Immunol Res. 2014 ;2014():672458.

 

Portal hypertension has been reported in association with acquired and primary immune deficiencies without a comprehensive description of associated spleno-portal axis abnormalities. Pathological mechanisms are poorly defined.

Last Updated: 17 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal hypertension" returned 87 free, full-text review articles on human participants. First 3 results:

Therapeutic potential of microRNA: a new target to treat intrahepatic portal hypertension?
 

Author(s): Can-Jie Guo, Qin Pan, Hua Xiong, Yu-Qi Qiao, Zhao-Lian Bian, Wei Zhong, Li Sheng, Hai Li, Lei Shen, Jing Hua, Xiong Ma

Journal: Biomed Res Int. 2014 ;2014():797898.

 

Intrahepatic portal hypertension accounts for most of the morbidity and mortality encountered in patients with liver cirrhosis, due to increased portal inflow and intrahepatic vascular resistance. Most treatments have focused only on portal inflow or vascular resistance. However, ...

Last Updated: 9 May 2014

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[Therapeutic effect of sorafenib on portal hypertension: research progress and mechanisms].
 

Author(s): Yun Zhu, Yang Cheng, Aimin Li, Rongcheng Luo

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jan;34(1):133-6.

 

Portal hypertension, as one of the major complications of liver cirrhosis, is a common clinical syndrome characterized by an increased portal pressure and the formation of portal-systemic collaterals. Currently no ideal therapeutic agent has been available for portal hypertension. ...

Last Updated: 27 Jan 2014

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Non-cirrhotic portal hypertension - diagnosis and management.
 

Author(s): Rajeev Khanna, Shiv K Sarin

Journal: J. Hepatol.. 2014 Feb;60(2):421-41.

 

NCPH is a heterogeneous group of liver disorders of vascular origin, leading to PHT with near normal HVPG. NCPF/IPH is a disorder of young adults or middle aged women, whereas EHPVO is a disorder of childhood. Early age acute or recurrent infections in an individual with thrombotic ...

Last Updated: 20 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MRI in Portal Hypertension
 

Status: Recruiting

Condition Summary: Portal Hypertension

 

Last Updated: 14 Jan 2014

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Value of Von Willebrand Factor in Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Hypertension

 

Last Updated: 12 Jan 2015

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A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Hepatic Cirrhosis; Portal Hypertension

 

Last Updated: 14 Jan 2015

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