Portal hypertension

Common Name(s)

Portal hypertension

Portal hypertension is abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. Portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. It may be caused by a variety of conditions, but cirrhosis is the most common cause in Western countries. Treatment is generally directed toward the cause of the condition, although emergency treatment is sometimes needed for serious complications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal hypertension" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal hypertension" returned 464 free, full-text research articles on human participants. First 3 results:

Influence of clinically significant portal hypertension on hepatectomy for hepatocellular carcinoma: a meta-analysis.
 

Author(s): Yun-Hao Tang, Wen-Jiang Zhu, Tian-Fu Wen

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(4):1649-54.

 

Clinically significant portal hypertension (PHT) is considered as a contraindication for hepatectomy according to the guidelines of the European Association for Study of Liver and the American Association for Study of Liver Diseases. However, this issue remains controversial. Here ...

Last Updated: 19 Mar 2014

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Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease.
 

Author(s): Won Ki Hong, Kwang Yong Shim, Soon Koo Baik, Moon Young Kim, Mee Yon Cho, Yoon Ok Jang, Young Shik Park, Jin Han, Gaeun Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Sang Ok Kwon

Journal: J. Korean Med. Sci.. 2014 Mar;29(3):392-9.

 

Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular resistance ...

Last Updated: 11 Mar 2014

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Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease.
 

Author(s): Chao Wang, Juan Han, Liang Xiao, Chang-E Jin, Dong-Jian Li, Zhen Yang

Journal: World J. Gastroenterol.. 2014 Jan;20(4):1079-87.

 

To investigate the association between endogenous hydrogen sulfide (H₂S) and portal hypertension as well as its effect on vascular smooth muscle cells.

Last Updated: 27 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal hypertension" returned 84 free, full-text review articles on human participants. First 3 results:

Non-cirrhotic portal hypertension - diagnosis and management.
 

Author(s): Rajeev Khanna, Shiv K Sarin

Journal: J. Hepatol.. 2014 Feb;60(2):421-41.

 

NCPH is a heterogeneous group of liver disorders of vascular origin, leading to PHT with near normal HVPG. NCPF/IPH is a disorder of young adults or middle aged women, whereas EHPVO is a disorder of childhood. Early age acute or recurrent infections in an individual with thrombotic ...

Last Updated: 20 Jan 2014

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Portal hypertension and gastrointestinal bleeding: diagnosis, prevention and management.
 

Author(s): Erwin Biecker

Journal: World J. Gastroenterol.. 2013 Aug;19(31):5035-50.

 

Bleeding from esophageal varices is a life threatening complication of portal hypertension. Primary prevention of bleeding in patients at risk for a first bleeding episode is therefore a major goal. Medical prophylaxis consists of non-selective beta-blockers like propranolol or carvedilol. ...

Last Updated: 21 Aug 2013

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Current concepts on the role of nitric oxide in portal hypertension.
 

Author(s): Liang Shuo Hu, Jacob George, Jian Hua Wang

Journal: World J. Gastroenterol.. 2013 Mar;19(11):1707-17.

 

Portal hypertension (PHT) is defined as a pathological increase in portal venous pressure and frequently accompanies cirrhosis. Portal pressure can be increased by a rise in portal blood flow, an increase in vascular resistance, or the combination. In cirrhosis, the primary factor ...

Last Updated: 4 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MRI in Portal Hypertension
 

Status: Recruiting

Condition Summary: Portal Hypertension

 

Last Updated: 14 Jan 2014

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Value of Von Willebrand Factor in Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Portal Hypertension

 

Last Updated: 23 Oct 2013

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A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Hepatic Cirrhosis; Portal Hypertension

 

Last Updated: 4 Nov 2014

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