Porphyria cutanea tarda

Common Name(s)

Porphyria cutanea tarda

Porphyria cutanea tarda (PCT) is the most common type of porphyria with a prevalence of approximately 1 in 10,000. It is characterized by cutaneous blisters that develop on sun-exposed areas of the skin such as the hands and face. The skin in these areas may blister or peel after minor trauma. Increased hair growth, as well as darkening and thickening, of the skin may also occur. Neurological and abdominal symptoms are not characteristic of PCT. Liver function abnormalities are common, but are usually mild. Progression to cirrhosis and even liver cancer occurs in some patients. PCT is caused by a deficiency of the enzyme uroporphyrinogen decarboxylase. Excess iron and multiple other susceptibility factors, including alcohol, estrogens, smoking, chronic hepatitis C, HIV and mutations in the HFE gene which is associated with the disease hemochromatosis, contribute to the development of PCT. PCT is managed with regular phlebotomies or a low dose regimen of hydroxychloroquine as well as removal of factors that activated the disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Porphyria cutanea tarda" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Porphyria cutanea tarda" returned 128 free, full-text research articles on human participants. First 3 results:

Porphyria cutanea tarda and Sjogren's syndrome.
 

Author(s): Su Fang, XiaoJie Sun, ZanFeng Wang, DanYang Song, TieNan Li

Journal: An Bras Dermatol. ;89(4):689-91.

 

Porphyria cutanea tarda is prevalent in connective tissue disease, common in systemic lupus erythematosus. However, the co-existence of primary sjogren's syndrome and porphyria cutanea tarda is rare and poses diagnostic and therapeutic challenges. We report a case of porphyria cutanea ...

Last Updated: 24 Jul 2014

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A skin disease, a blood disease or something in between? An exploratory focus group study of patients' experiences with porphyria cutanea tarda.
 

Author(s): J Andersen, E Gjengedal, S Sandberg, M RÃ¥heim

Journal: Br. J. Dermatol.. 2015 Jan;172(1):223-9.

 

Porphyria cutanea tarda (PCT) is characterized by fragile skin with blistering on sun-exposed areas. Symptoms typically develop in late adulthood and can be triggered by iron overload, alcohol intake, oestrogens and various liver diseases. Treatment consists of phlebotomy to reduce ...

Last Updated: 13 Jan 2015

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Ocular manifestations in porphyria cutanea tarda.
 

Author(s): Pratik Yeshwant Gogri, Neeta Somen Misra, Somen Misra

Journal:

 

A 24-year-old man presented with pain, sticky discharge and loss of vision in the right eye. He has had typical skin manifestations of porphyria cutanea tarda (PCT) since 6 years and ophthalmological symptom for 6 weeks. On ophthalmological examination, visual acuity was light perception ...

Last Updated: 9 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Porphyria cutanea tarda" returned 7 free, full-text review articles on human participants. First 3 results:

Increased photosensitivity? Case report of porphyria cutanea tarda associated with systemic lupus erythematosus.
 

Author(s): Scheila Fritsch, Adma Silva de Lima Wojcik, Lilian Schade, Milton Marcio Machota Junior, Fabiane Mulinari Brenner, Eduardo dos Santos Paiva

Journal: Rev Bras Reumatol. 2012 Dec;52(6):968-70.

 

The association of porphyria cutanea tarda (PCT) and systemic lupus erythematosus (SLE) is rare. Systemic lupus erythematosus, of complex pathophysiology and pleomorphic clinical manifestations, is similar to PCT regarding photosensitivity. One finding that can differentiate both ...

Last Updated: 11 Dec 2012

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Hepatitis C, porphyria cutanea tarda and liver iron: an update.
 

Author(s): F Ryan Caballes, Hossein Sendi, Herbert L Bonkovsky

Journal: Liver Int.. 2012 Jul;32(6):880-93.

 

Porphyria cutanea tarda (PCT) is the most common form of porphyria across the world. Unlike other forms of porphyria, which are inborn errors of metabolism, PCT is usually an acquired liver disease caused by exogenous factors, chief among which are excess alcohol intake, iron overload, ...

Last Updated: 7 Jun 2012

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[Porphyria cutanea tarda, hemosiderosis and hepatocellular carcinoma: report of one case].
 

Author(s): Carolina Whittle, Juan Hepp, Rodolfo Armas, Marcela Schultz

Journal: Rev Med Chil. 2010 May;138(5):581-5.

 

Porphyria cutanea tarda (PCT) is a hereditary or acquired disease. It can be unleashed by iron overload, alcohol, estrogens and other conditions. In these patients, hepatic involvement can be associated to cirrhosis, iron overload or C and B viral infections, that are predisposing ...

Last Updated: 29 Jul 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda
 

Status: Recruiting

Condition Summary: Porphyria Cutanea Tarda

 

Last Updated: 5 Feb 2016

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Safety and Efficacy of Oral Deferasirox in Patients With Porphyria Cutanea Tarda
 

Status: Recruiting

Condition Summary: Porphyria Cutanea Tarda

 

Last Updated: 26 Jan 2011

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Longitudinal Study of the Porphyrias
 

Status: Recruiting

Condition Summary: Acute Porphyrias; Cutaneous Porphyrias

 

Last Updated: 6 Jun 2016

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