Porphyria cutanea tarda

Common Name(s)

Porphyria cutanea tarda

Porphyria cutanea tarda (PCT) is the most common type of porphyria with a prevalence of approximately 1 in 10,000. It is characterized by cutaneous blisters that develop on sun-exposed areas of the skin such as the hands and face. The skin in these areas may blister or peel after minor trauma. Increased hair growth, as well as darkening and thickening, of the skin may also occur. Neurological and abdominal symptoms are not characteristic of PCT. Liver function abnormalities are common, but are usually mild. Progression to cirrhosis and even liver cancer occurs in some patients. PCT is caused by a deficiency of the enzyme uroporphyrinogen decarboxylase. Excess iron and multiple other susceptibility factors, including alcohol, estrogens, smoking, chronic hepatitis C, HIV and mutations in the HFE gene which is associated with the disease hemochromatosis, contribute to the development of PCT. PCT is managed with regular phlebotomies or a low dose regimen of hydroxychloroquine as well as removal of factors that activated the disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Porphyria cutanea tarda" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Porphyria cutanea tarda" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Porphyria cutanea tarda" returned 129 free, full-text research articles on human participants. First 3 results:

Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil).
 

Author(s): Isabella Brasil Succi, Luís Cristóvão Pôrto, Patricia Mariana Gonçalves da Rocha Porto Domingues, João Carlos Macedo Fonseca

Journal: An Bras Dermatol. ;93(1):148-150.

 

Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria ...

Last Updated: 31 Dec 1969

Go To URL
Hepatitis C Treatment in Patients With Porphyria Cutanea Tarda.
 

Author(s): Ashwani K Singal, Krishna V R Venkata, Sarat Jampana, Fakhar-Ul Islam, Karl E Anderson

Journal: Am. J. Med. Sci.. 2017 06;353(6):523-528.

 

Hepatitis C virus (HCV) infection is a common susceptibility factor for porphyria cutanea tarda (PCT). Experience on HCV treatment in patients with PCT is limited. Recently, HCV treatment has improved with direct-acting antivirals (DAA). We review our experience on HCV treatment in ...

Last Updated: 31 Dec 1969

Go To URL
Porphyria cutanea tarda in a HIV- positive patient.
 

Author(s): Valéria Aparecida Zanela Franzon, Emanuella Stella Mikilita, Fernanda Henriques Camelo, Rosana Camargo

Journal: An Bras Dermatol. ;91(4):520-3.

 

This is a case report about Porphyria cutanea tarda (PCT) and its relationship with the infection caused by the human immunodeficiency virus (HIV). Cutaneous porphyria is an illness caused by enzymatic modification that results in partial deficiency of uroporphyrinogen decarboxylase ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Porphyria cutanea tarda" returned 7 free, full-text review articles on human participants. First 3 results:

Increased photosensitivity? Case report of porphyria cutanea tarda associated with systemic lupus erythematosus.
 

Author(s): Scheila Fritsch, Adma Silva de Lima Wojcik, Lilian Schade, Milton Marcio Machota Junior, Fabiane Mulinari Brenner, Eduardo dos Santos Paiva

Journal: Rev Bras Reumatol. 2012 Dec;52(6):968-70.

 

The association of porphyria cutanea tarda (PCT) and systemic lupus erythematosus (SLE) is rare. Systemic lupus erythematosus, of complex pathophysiology and pleomorphic clinical manifestations, is similar to PCT regarding photosensitivity. One finding that can differentiate both ...

Last Updated: 31 Dec 1969

Go To URL
Hepatitis C, porphyria cutanea tarda and liver iron: an update.
 

Author(s): F Ryan Caballes, Hossein Sendi, Herbert L Bonkovsky

Journal: Liver Int.. 2012 Jul;32(6):880-93.

 

Porphyria cutanea tarda (PCT) is the most common form of porphyria across the world. Unlike other forms of porphyria, which are inborn errors of metabolism, PCT is usually an acquired liver disease caused by exogenous factors, chief among which are excess alcohol intake, iron overload, ...

Last Updated: 31 Dec 1969

Go To URL
[Porphyria cutanea tarda, hemosiderosis and hepatocellular carcinoma: report of one case].
 

Author(s): Carolina Whittle, Juan Hepp, Rodolfo Armas, Marcela Schultz

Journal: Rev Med Chil. 2010 May;138(5):581-5.

 

Porphyria cutanea tarda (PCT) is a hereditary or acquired disease. It can be unleashed by iron overload, alcohol, estrogens and other conditions. In these patients, hepatic involvement can be associated to cirrhosis, iron overload or C and B viral infections, that are predisposing ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda
 

Status: Recruiting

Condition Summary: Porphyria Cutanea Tarda

 

Last Updated: 26 Feb 2018

Go to URL
Harvoni Treatment Porphyria Cutanea Tarda
 

Status: Recruiting

Condition Summary: Porphyria Cutanea Tarda; Hepatitis C

 

Last Updated: 22 Jun 2018

Go to URL
EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)
 

Status: Recruiting

Condition Summary: Acute Hepatic Porphyria

 

Last Updated: 18 Dec 2017

Go to URL