Polymyositis

Common Name(s)

Polymyositis

Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  Polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  It is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. The cause of polymyositis is not fully understood.  Although there's no cure for polymyositis, treatment can improve muscle strength and function.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polymyositis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

Last Updated: 14 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polymyositis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

http://www.myositis.org

Last Updated: 14 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polymyositis" returned 400 free, full-text research articles on human participants. First 3 results:

Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis.
 

Author(s): Jayesh M Pandya, Ingela Loell, Mohammad Shahadat Hossain, Mei Zong, Helene Alexanderson, Sukanya Raghavan, Ingrid E Lundberg, Vivianne Malmström

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T-cell infiltrates may persist in muscle tissue of polymyositis (PM) and dermatomyositis (DM) patients despite aggressive immunosuppressive treatment. Here, we investigated to what extent persistent T cells in affected muscle were FOXP3+, a marker for regulatory T cells (Tregs), or ...

Last Updated: 4 Apr 2016

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Risk of myocardial infarction and ischaemic stroke in adults with polymyositis and dermatomyositis: a general population-based study.
 

Author(s): Sharan K Rai, Hyon K Choi, Eric C Sayre, J Antonio Aviña-Zubieta

Journal: Rheumatology (Oxford). 2016 Mar;55(3):461-9.

 

Limited data are available on the risk of cardiovascular disease in DM and PM. The purpose of this study was to estimate the risk of incident myocardial infarction (MI) and ischaemic stroke in adults with incident PM/DM at the general population level.

Last Updated: 10 Feb 2016

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[Muscle paralysis secondary to polymyositis].
 

Author(s): Meryem Ennafiri, Wafae Elotmani, Almahdi Awab, Rachid El Moussaoui, Ahmed El Hijri, Mustapha Alilou, Abderrahim Azzouzi

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Last Updated: 18 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polymyositis" returned 38 free, full-text review articles on human participants. First 3 results:

Polymyositis and dermatomyositis: novel insights into the pathogenesis and potential therapeutic targets.
 

Author(s): Arash H Lahouti, Lisa Christopher-Stine

Journal: Discov Med. 2015 Jun;19(107):463-70.

 

Polymyositis (PM) and dermatomyositis (DM) are the two major forms of inflammatory muscle diseases. They are characterized clinically primarily by proximal muscle weakness. The disease mechanisms that cause muscle damage and dysfunction are not fully understood. However, because of ...

Last Updated: 16 Jul 2015

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Dermatomyositis, polymyositis and immune-mediated necrotising myopathies.
 

Author(s): Yue-Bei Luo, Frank L Mastaglia

Journal: Biochim. Biophys. Acta. 2015 Apr;1852(4):622-32.

 

Dermatomyositis, polymyositis and immune-mediated necrotising myopathy are major forms of idiopathic inflammatory myopathy. We review here recent developments in understanding the pathology and pathogenesis of these diseases, and characterisation of autoantibody biomarkers. Dermatomyositis ...

Last Updated: 9 Feb 2015

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Factors predicting malignancy in patients with polymyositis and dermatomyostis: a systematic review and meta-analysis.
 

Author(s): Xin Lu, Hanbo Yang, Xiaoming Shu, Fang Chen, Yinli Zhang, Sigong Zhang, Qinglin Peng, Xiaolan Tian, Guochun Wang

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To define potential factors that could predict concomitant neoplastic diseases in patients diagnosed with PM/DM, which could inform screening decisions.

Last Updated: 9 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis
 

Status: Recruiting

Condition Summary: Dermatomyositis; Polymyositis

 

Last Updated: 26 Oct 2016

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A Survey for Long-term Use of Prograf Capsules in Patient With Interstitial Pneumonia
 

Status: Recruiting

Condition Summary: Interstitial Pneumonia Associated With Polymyositis/Dermatomyositis

 

Last Updated: 27 Sep 2016

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A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases
 

Status: Recruiting

Condition Summary: Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc

 

Last Updated: 21 Nov 2016

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