Polymyositis

Common Name(s)

Polymyositis

Polymyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.  Polymyositis affects skeletal muscles (those involved with making movement) on both sides of the body.  It is rarely seen in persons under age 18; most cases are seen in adults between the ages of 31 and 60. The cause of polymyositis is not fully understood.  Although there's no cure for polymyositis, treatment can improve muscle strength and function.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polymyositis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

Last Updated: 14 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polymyositis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

http://www.myositis.org

Last Updated: 14 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polymyositis" returned 382 free, full-text research articles on human participants. First 3 results:

Increased Risk of Herpes Zoster Following Dermatomyositis and Polymyositis: A Nationwide Population-Based Cohort Study.
 

Author(s): Shin-Yi Tsai, Cheng-Li Lin, Ying-Chi Wong, Tse-Yen Yang, Chien-Feng Kuo, Jiung-Mou Cheng, Jyh-Seng Wang, Chia-Hung Kao

Journal: Medicine (Baltimore). 2015 Jul;94(28):e1138.

 

This study explored the possible association between dermatomyositis or polymyositis (DM or PM) and the subsequent risk of herpes zoster (HZ). We used data from the Taiwan National Health Insurance (NHI) system to address the research topic. The exposure cohort comprised 2023 patients ...

Last Updated: 18 Jul 2015

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Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population.
 

Author(s): Si Chen, Wei Wu, Jing Li, Qian Wang, Yuan Li, Ziyan Wu, Wenjie Zheng, Qingjun Wu, Chanyuan Wu, Fengchun Zhang, Yongzhe Li

Journal: Immunol. Res.. 2015 Jun;62(2):153-62.

 

Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases influenced by genetic background and environmental factors. Recently, FAM167A-BLK gene has been identified as a potential genetic susceptibility locus for dermatomyositis (DM) in patients of European and Japanese populations. ...

Last Updated: 20 May 2015

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Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.
 

Author(s): Hironao Hozumi, Noriyuki Enomoto, Masato Kono, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Hiromitsu Sumikawa, Takeshi Johkoh, Ran Nakashima, Yoshitaka Imura, Tsuneyo Mimori, Takafumi Suda

Journal:

 

In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established.

Last Updated: 20 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polymyositis" returned 35 free, full-text review articles on human participants. First 3 results:

Factors predicting malignancy in patients with polymyositis and dermatomyostis: a systematic review and meta-analysis.
 

Author(s): Xin Lu, Hanbo Yang, Xiaoming Shu, Fang Chen, Yinli Zhang, Sigong Zhang, Qinglin Peng, Xiaolan Tian, Guochun Wang

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To define potential factors that could predict concomitant neoplastic diseases in patients diagnosed with PM/DM, which could inform screening decisions.

Last Updated: 9 Apr 2014

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New onset of dermatomyositis/polymyositis during anti-TNF-α therapies: a systematic literature review.
 

Author(s): Alexandra Maria Giovanna Brunasso, Werner Aberer, Cesare Massone

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We performed a systematic search of databases from 1990 to 2013 to identify articles concerning the new onset of dermatomyositis/polymyositis (DM/PM) in patients treated with anti-TNF-α therapy. We retrieved 13 publications describing 20 patients where the new onset of DM/PM after ...

Last Updated: 6 Mar 2014

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The concurrent association of inflammatory polymyositis and Crohn's ileo-colitis in a Sri Lankan man: a case report of a rare association and literature review.
 

Author(s): Vipula R Bataduwaarachchi, Nilesh Fenandopulle, Upul Liyanage, Champa Jayasundara

Journal:

 

Crohn's disease is a relapsing, systemic inflammatory disease affecting the gastrointestinal tract with associated extraintestinal manifestations and immune disorders. Among the few cases reported, the association of Crohn's disease with polymyositis varies in its complexity and severity. ...

Last Updated: 3 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis
 

Status: Recruiting

Condition Summary: Dermatomyositis; Polymyositis

 

Last Updated: 17 Jul 2015

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Efficacy and Tolerability of BAF312 in Patients With Polymyositis
 

Status: Recruiting

Condition Summary: Polymyositis

 

Last Updated: 15 Oct 2015

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Abatacept Treatment in Polymyositis and Dermatomyositis
 

Status: Recruiting

Condition Summary: Polymyositis; Dermatomyositis

 

Last Updated: 15 Mar 2011

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