Polycystic liver disease

Common Name(s)

Polycystic liver disease

Polycystic liver disease is an inherited condition characterized by many cysts of various sizes scattered throughout the liver. Abdominal discomfort from swelling of the liver may occur; however, most affected individuals do not have any symptoms. In some cases, polycystic liver disease appears to occur randomly, with no apparent cause. Most cases are inherited in an autosomal dominant fashion. Sometimes, cysts are found in the liver in association with the presence of autosomal dominant polycystic kidney disease (AD-PKD). In fact, about half of the people who have AD-PKD experience liver cysts. However, kidney cysts are uncommon in those affected by polycystic liver disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polycystic liver disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polycystic liver disease" returned 74 free, full-text research articles on human participants. First 3 results:

Ruptured cerebral aneurysm and acute bilateral carotid artery dissection in a patient with polycystic kidney disease and polycystic liver disease.
 

Author(s): Christian Roth, Jens Kleffmann, Carsten Bergmann, Wolfgang Deinsberger, Andreas Ferbert

Journal: Cerebrovasc. Dis.. 2013 ;35(6):590-1.

 

Last Updated: 31 Jul 2013

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The MELD score exception for polycystic liver disease.
 

Author(s): G Smira, E Matei, L Gheorghe, I Popescu

Journal: Chirurgia (Bucur). ;108(3):418-21.

 

Polycystic Liver Disease (PLD) is a rare progressive disease characterized by increased liver volume due to many cysts, with symptoms related mainly to the size of the liver and the compression on adjacent organs. Most patients who have PLD require no medical or surgical intervention. ...

Last Updated: 24 Jun 2013

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Molecular signature of adipose tissue in patients with both non-alcoholic fatty liver disease (NAFLD) and polycystic ovarian syndrome (PCOS).
 

Author(s): Ancha Baranova, Thuy Phuong Tran, Arian Afendy, Lei Wang, Amirhossein Shamsaddini, Rohini Mehta, Vikas Chandhoke, Aybike Birerdinc, Zobair M Younossi

Journal:

 

Polycystic ovarian syndrome (PCOS) is one of the most common reproductive disorders with strong association with both insulin resistance and non-alcoholic fatty liver disease (NAFLD). To untangle the complex relationship between PCOS and NAFLD, we analyzed serum biomarkers of apoptosis, ...

Last Updated: 14 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polycystic liver disease" returned 7 free, full-text review articles on human participants. First 3 results:

New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications.
 

Author(s): Grzegorz Telega, David Cronin, Ellis D Avner

Journal: Pediatr Transplant. 2013 Jun;17(4):328-35.

 

Improved neonatal medical care and renal replacement technology have improved the long-term survival of patients with ARPKD. Ten-yr survival of those surviving the first year of life is reported to be 82% and is continuing to improve further. However, despite increases in overall ...

Last Updated: 22 May 2013

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Isolated polycystic liver disease.
 

Author(s): Qi Qian

Journal: Adv Chronic Kidney Dis. 2010 Mar;17(2):181-9.

 

Isolated polycystic liver disease (PCLD) is an autosomal dominant disease with genetic and clinical heterogeneity. Apart from liver cysts, it exhibits few extrahepatic manifestations, and the majority of patients with this condition are asymptomatic or subclinical. However, a small ...

Last Updated: 11 Mar 2010

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Congenital disorders of glycosylation in hepatology: the example of polycystic liver disease.
 

Author(s): Manoe J Janssen, Esmé Waanders, Jannes Woudenberg, Dirk J Lefeber, Joost P H Drenth

Journal: J. Hepatol.. 2010 Mar;52(3):432-40.

 

Autosomal dominant polycystic liver disease (PCLD) is a rare progressive disorder characterized by an increased liver volume due to many (>20) fluid-filled cysts of biliary origin. Disease causing mutations in PRKCSH or SEC63 are found in approximately 25% of the PCLD patients. Both ...

Last Updated: 2 Mar 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pasireotide LAR in Severe Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Somatostatin Analogs; Polycystic Liver Disease; Autosomal Dominant Polycystic Kidney Disease; Autosomal Dominant Polycystic Liver Disease

 

Last Updated: 8 May 2014

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Ursodeoxycholic Acid as Treatment for Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Polycystic Liver Disease (PLD):; Polycystic Kidney, Autosomal Dominant; Polycystic Liver Disease

 

Last Updated: 19 Dec 2013

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Development and Assessment of The Polycystic Liver Disease Questionnaire (PLD-Q).
 

Status: Recruiting

Condition Summary: Polycystic Liver Disease

 

Last Updated: 20 Jun 2014

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