Polycystic liver disease

Common Name(s)

Polycystic liver disease

Polycystic liver disease is an inherited condition characterized by many cysts of various sizes scattered throughout the liver. Abdominal discomfort from swelling of the liver may occur; however, most affected individuals do not have any symptoms. In some cases, polycystic liver disease appears to occur randomly, with no apparent cause. Most cases are inherited in an autosomal dominant fashion. Sometimes, cysts are found in the liver in association with the presence of autosomal dominant polycystic kidney disease (AD-PKD). In fact, about half of the people who have AD-PKD experience liver cysts. However, kidney cysts are uncommon in those affected by polycystic liver disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polycystic liver disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polycystic liver disease" returned 81 free, full-text research articles on human participants. First 3 results:

Cyst infection in hospital-admitted autosomal dominant polycystic kidney disease patients is predominantly multifocal and associated with kidney and liver volume.
 

Author(s): B E P Balbo, M T Sapienza, C R Ono, S K Jayanthi, J B Dettoni, I Castro, L F Onuchic

Journal: Braz. J. Med. Biol. Res.. 2014 Jul;47(7):584-93.

 

Positron-emission tomography/computed tomography (PET/CT) has improved cyst infection (CI) management in autosomal dominant polycystic kidney disease (ADPKD). The determinants of kidney and/or liver involvement, however, remain uncertain. In this study, we evaluated clinical and imaging ...

Last Updated: 9 Jul 2014

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Symptomatic polycystic liver disease treated with transcatheter hepatic arterial embolization and inferior vena cava stenting: a case report.
 

Author(s): Takeshi Fujita, Masahiro Tanabe, Koichi Uchiyama, Hideyasu Matsuyama, Naofumi Matsunaga

Journal: Exp Clin Transplant. 2014 Aug;12(4):377-80.

 

Autosomal-dominant polycystic kidney disease is frequently complicated by polycystic liver disease. Some patients with polycystic liver disease have a full-stomach sensation and intractable ascites. We report a 56-year-old woman with polycystic liver disease waiting to receive a liver ...

Last Updated: 6 Aug 2014

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Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.
 

Author(s): Daisuke Yoshihara, Masanori Kugita, Mai Sasaki, Shigeo Horie, Koichi Nakanishi, Takaaki Abe, Harold M Aukema, Tamio Yamaguchi, Shizuko Nagao

Journal:

 

Human autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital hepatic fibrosis characterized by dilated bile ducts and portal hypertension. The PCK rat is an orthologous model of human ...

Last Updated: 10 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polycystic liver disease" returned 10 free, full-text review articles on human participants. First 3 results:

Nonalcoholic fatty liver disease and polycystic ovary syndrome.
 

Author(s): Evangeline Vassilatou

Journal: World J. Gastroenterol.. 2014 Jul;20(26):8351-63.

 

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world comprising a spectrum of liver damage from fatty liver infiltration to end-stage liver disease, in patients without significant alcohol consumption. Increased prevalence ...

Last Updated: 15 Jul 2014

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Polycystic liver disease: an overview of pathogenesis, clinical manifestations and management.
 

Author(s): Wybrich R Cnossen, Joost P H Drenth

Journal:

 

Polycystic liver disease (PLD) is the result of embryonic ductal plate malformation of the intrahepatic biliary tree. The phenotype consists of numerous cysts spread throughout the liver parenchyma. Cystic bile duct malformations originating from the peripheral biliary tree are called ...

Last Updated: 4 Jun 2014

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New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications.
 

Author(s): Grzegorz Telega, David Cronin, Ellis D Avner

Journal: Pediatr Transplant. 2013 Jun;17(4):328-35.

 

Improved neonatal medical care and renal replacement technology have improved the long-term survival of patients with ARPKD. Ten-yr survival of those surviving the first year of life is reported to be 82% and is continuing to improve further. However, despite increases in overall ...

Last Updated: 22 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pasireotide LAR in Severe Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Somatostatin Analogs; Polycystic Liver Disease; Autosomal Dominant Polycystic Kidney Disease; Autosomal Dominant Polycystic Liver Disease

 

Last Updated: 6 Apr 2015

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Ursodeoxycholic Acid as Treatment for Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Polycystic Liver Disease (PLD):; Polycystic Kidney, Autosomal Dominant; Polycystic Liver Disease

 

Last Updated: 5 Nov 2014

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Development and Assessment of The Polycystic Liver Disease Questionnaire (PLD-Q).
 

Status: Recruiting

Condition Summary: Polycystic Liver Disease

 

Last Updated: 6 Apr 2015

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