Polyarteritis nodosa

Common Name(s)

Polyarteritis nodosa, PAN

Polyarteritis nodosa (PAN) is a rare disease that causes redness and swelling (inflammation) of the medium sized tubes that carry blood around the body (blood vessels). This inflammation causes poor blood flow and leads to damage of affected organs. PAN most commonly affects the arteries in the skin, nerves, gut (intestinal tract), and kidneys. If only the skin is affected, it is called cutaneous PAN. If only one organ is affected, it is called localized PAN. Symptoms of PAN depend on the organ system involved. Symptoms may include general tiredness (fatigue), fever, loss of appetite, weight loss, pain in muscles or joints, skin sores, abdominal pain, blood in the stool, shortness of breath, chest pain, high blood pressure, and numbness. PAN can sometimes cause an increase in the size of part of a blood vessel (aneurysm), which can cause the vessel to break open (rupture).

The exact cause of PAN is unknown. Researchers believe it can be triggered by a reaction to a medication or a reaction to an infection (either bacterial or viral). These reactions are usually due to an issue with the body’s immune system. Men usually have PAN more often than women and people typically develop the condition between the ages of 40 and 60. Your doctor will use a combination of your symptoms, physical exam, blood tests and imaging tests (x-rays, MRIs and CTs) to diagnose PAN. In some cases, removal and examination of an affected area (biopsy) may be needed to confirm the diagnosis. Treatment of PAN varies, depending on the underlying cause and affected area. If you have been diagnosed with PAN, speak with your doctor to discuss the most current treatment options. Support groups are also a good source of additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polyarteritis nodosa" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polyarteritis nodosa" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polyarteritis nodosa" returned 177 free, full-text research articles on human participants. First 3 results:

Cholangitis as an initial manifestation of polyarteritis nodosa.
 

Author(s): Risa Kanai, Masamoto Nakamura, Kota Tomisato, Tomofumi Fukuhara, Akiyuki Kondo, Shoko Nakamura, Shinobu Matsukawa, Akira Yabutani, Kasen Kobashikawa, Tomokuni Nakayoshi, Nobufumi Uchima, Noritake Kosuge, Naoki Yoshimi

Journal: Intern. Med.. 2014 ;53(20):2307-12.

 

A previously healthy 89-year-old man was admitted to our hospital with right upper quadrant pain and mild fever. A diagnosis of cholangitis was suspected based on the patient's physical findings and imaging features. Although he received treatment typical for cholangitis, he suddenly ...

Last Updated: 16 Oct 2014

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Cutaneous polyarteritis nodosa presenting as a solitary blue toe.
 

Author(s): Amanda Joy Tschetter, Vincent Liu, Karolyn A Wanat

Journal: J. Am. Acad. Dermatol.. 2014 Sep;71(3):e95-7.

 

Last Updated: 16 Aug 2014

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Polyarteritis nodosa mimicking giant cell (temporal) arteritis.
 

Author(s): Kenichiro Yaita, Kazuhiko Nakaharai, Yukihiro Yoshimura, Motoharu Hirano

Journal: Intern. Med.. 2014 ;53(14):1591-2.

 

Last Updated: 17 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polyarteritis nodosa" returned 16 free, full-text review articles on human participants. First 3 results:

Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature.
 

Author(s): Ruby Haviv, Maya Capua, Jacob Amir, Liora Harel

Journal:

 

Cutaneous Polyarteritis Nodosa (cPAN) was first described in 1931. cPAN is considered a rare disease, its true incidence is unknown. The age of onset is diverse. Most studies have shown no significant gender predominance. cPAN presents with distinct skin findings, such as a maculopapular ...

Last Updated: 20 Oct 2014

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Acute kidney injury in a patient with polyarteritis nodosa and multiple myeloma.
 

Author(s): Kazuhiro Yokota, Tsutomu Inoue, Yuji Akiyama, Hiroshi Kajiyama, Yu Funakubo Asanuma, Eiichi Arai, Hiromichi Suzuki, Toshihide Mimura

Journal: Intern. Med.. 2014 ;53(3):263-7.

 

We herein report the case of a Japanese man with polyarteritis nodosa (PAN) accompanied by multiple myeloma (MM). The patient was diagnosed with PAN. Concurrently, IgG kappa paraprotein was detected, and bone marrow changes indicative of MM were observed. Prednisolone (PSL) administered ...

Last Updated: 4 Feb 2014

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Coil embolization of intracranial aneurysm in polyarteritis nodosa. A case report and review of the literature.
 

Author(s): V Gupta, S D Chinchure, G Goe, A N Jha, S Malviya, R Gupta

Journal: Interv Neuroradiol. 2013 Jun;19(2):203-8.

 

Polyarteritis nodosa (PAN) is a rare multisystem disease characterized by systemic necrotizing arteritis of small and medium size arteries. The skin, joints, kidneys, gastrointestinal tract and peripheral nerves are most commonly involved. Although aneurysms are commonly seen in the ...

Last Updated: 22 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determining Disease Activity Biomarkers in Individuals With Polyarteritis Nodosa
 

Status: Recruiting

Condition Summary: Polyarteritis Nodosa

 

Last Updated: 13 Feb 2015

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Pediatric Vasculitis Initiative
 

Status: Recruiting

Condition Summary: Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

 

Last Updated: 2 Dec 2014

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One-Time DNA Study for Vasculitis
 

Status: Recruiting

Condition Summary: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss); Giant Cell Arteritis; Granulomatosis With Polyangiitis (Wegener's); Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu's Arteritis

 

Last Updated: 13 Feb 2015

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