Polyarteritis nodosa

Common Name(s)

Polyarteritis nodosa, PAN

Polyarteritis nodosa (PAN) is a rare disease that causes redness and swelling (inflammation) of the medium sized tubes that carry blood around the body (blood vessels). This inflammation causes poor blood flow and leads to damage of affected organs. PAN most commonly affects the arteries in the skin, nerves, gut (intestinal tract), and kidneys. If only the skin is affected, it is called cutaneous PAN. If only one organ is affected, it is called localized PAN. Symptoms of PAN depend on the organ system involved. Symptoms may include general tiredness (fatigue), fever, loss of appetite, weight loss, pain in muscles or joints, skin sores, abdominal pain, blood in the stool, shortness of breath, chest pain, high blood pressure, and numbness. PAN can sometimes cause an increase in the size of part of a blood vessel (aneurysm), which can cause the vessel to break open (rupture).

The exact cause of PAN is unknown. Researchers believe it can be triggered by a reaction to a medication or a reaction to an infection (either bacterial or viral). These reactions are usually due to an issue with the body’s immune system. Men usually have PAN more often than women and people typically develop the condition between the ages of 40 and 60. Your doctor will use a combination of your symptoms, physical exam, blood tests and imaging tests (x-rays, MRIs and CTs) to diagnose PAN. In some cases, removal and examination of an affected area (biopsy) may be needed to confirm the diagnosis. Treatment of PAN varies, depending on the underlying cause and affected area. If you have been diagnosed with PAN, speak with your doctor to discuss the most current treatment options. Support groups are also a good source of additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polyarteritis nodosa" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polyarteritis nodosa" returned 232 free, full-text research articles on human participants. First 3 results:

Cutaneous Polyarteritis Nodosa Associated with Destructive Arthritis.
 

Author(s): Lihi Atzmony, Hana Feuerman, Yair Molad, Yelena Didkovsky, Emmilia Hodak

Journal: Isr. Med. Assoc. J.. 2015 Sep;17(9):587-8.

 

Last Updated: 2 Dec 2015

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Recurrent Unilateral Orchitis as a Presenting Symptom of Polyarteritis Nodosa.
 

Author(s): Gabriel S Breuer, Konstantin Reinus, Gideon Nesher, Gabriel Munter

Journal: Isr. Med. Assoc. J.. 2015 Sep;17(9):585-6.

 

Last Updated: 2 Dec 2015

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Cutaneous polyarteritis nodosa.
 

Author(s): María Alejandra Matteoda, Paola Cecilia Stefano, Marcela Bocián, María Marta Katsicas, Josefina Sala, Andrea Bettina Cervini

Journal: An Bras Dermatol. ;90(3 Suppl 1):188-90.

 

Polyarteritis nodosa is a rare vasculitis in children characterized by necrotizing inflammation in small and medium size arteries. It is classified into systemic and cutaneous PAN according to the presence of systemic symptoms or visceral involvement. We describe the case of a 14-year-old ...

Last Updated: 28 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polyarteritis nodosa" returned 19 free, full-text review articles on human participants. First 3 results:

Polyarteritis nodosa.
 

Author(s): Travis Howard, Kinza Ahmad, Jerome Allen A Swanson, Sanjay Misra

Journal: Tech Vasc Interv Radiol. 2014 Dec;17(4):247-51.

 

The first description of polyarteritis nodosa (PAN) was in 1852 by Karl Rokitansky, a pathologist at the University of Vienna. The initial report describes a 23-year-old man who had a 5-day history of fever and diarrhea. Since then, the definition of PAN has evolved. The currently ...

Last Updated: 16 Mar 2015

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Pancreatic mass as an initial manifestation of polyarteritis nodosa: a case report and review of the literature.
 

Author(s): Yoshihiro Yokoi, Ippei Nakamura, Takeshi Kaneko, Tomoki Sawayanagi, Youichi Watahiki, Makoto Kuroda

Journal: World J. Gastroenterol.. 2015 Jan;21(3):1014-9.

 

Classic polyarteritis nodosa (PAN) that targets medium-sized muscular arteries and microscopic polyangiitis (MPA), characterized by inflammation of small-caliber vessels and the presence of circulating myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA), are distinct ...

Last Updated: 27 Jan 2015

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Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature.
 

Author(s): Ruby Haviv, Maya Capua, Jacob Amir, Liora Harel

Journal:

 

Cutaneous Polyarteritis Nodosa (cPAN) was first described in 1931. cPAN is considered a rare disease, its true incidence is unknown. The age of onset is diverse. Most studies have shown no significant gender predominance. cPAN presents with distinct skin findings, such as a maculopapular ...

Last Updated: 20 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determining Disease Activity Biomarkers in Individuals With Polyarteritis Nodosa
 

Status: Recruiting

Condition Summary: Polyarteritis Nodosa

 

Last Updated: 10 May 2016

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Pediatric Vasculitis Initiative
 

Status: Recruiting

Condition Summary: Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

 

Last Updated: 19 Aug 2016

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One-Time DNA Study for Vasculitis
 

Status: Recruiting

Condition Summary: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss); Giant Cell Arteritis; Granulomatosis With Polyangiitis (Wegener's); Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu's Arteritis

 

Last Updated: 10 May 2016

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