POEMS syndrome

Common Name(s)

POEMS syndrome

POEMS syndrome is a rare blood disorder. It is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma proliferative disorder, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy, enlarged liver and spleen, swollen lymph nodes, and darkening of the skin. Further testing and evaluation may show plasma cell disorder and sclerotic bone lesions. Many people with POEMS syndrome have diabetes (20-50%) and primary gonadal failure (55-70%). Other general signs and symptoms may include increased body hair, thickening of the skin, whitening of the nails, fatigue, weakness, swelling of the ankles and legs, enlarged breast tissue, generalized aches and pains, fluid in the lungs, and vision changes. Sign and symptoms tend to begin in a person's 40's to 50's. POEMS syndrome is a rapidly progressive disorder that can become life threatening. Currently the exact cause of POEMS syndrome is unknown.  Researchers believe the syndrome involves an overgrowth of bone marrow cells (plasma cells), which produce chemicals that damage other parts of the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "POEMS syndrome" returned 93 free, full-text research articles on human participants. First 3 results:

A patient with POEMS syndrome: the pathology of glomerular microangiopathy.
 

Author(s): Yasuhiro Nakamura, Motonobu Nishimura, Takashi Terano, Keely M McNamara, Hironobu Sasano, Akira Kurosu, Kensuke Joh

Journal: Tohoku J. Exp. Med.. 2013 ;231(3):229-34.

 

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is potentially fatal multisystem disorder but its renal complication has often been overlooked because renal involvement is not necessarily included in the diagnostic criteria of ...

Last Updated: 18 Nov 2013

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POEMS syndrome and Castleman disease.
 

Author(s): Swati Andhavarapu, Liuyan Jiang

Journal: Blood. 2013 Jul;122(2):159.

 

Last Updated: 4 Sep 2013

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[Poems syndrome].
 

Author(s): Fatma Derbali, Fatma Ben Fredj Ismail, Aymen Laatiri Mohamed, Monia Karmani, Amel Rezgui, Samira Azzebi, Chedia Laouani Kechrid

Journal: Tunis Med. 2013 Jun;91(6):421-2.

 

Last Updated: 22 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "POEMS syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

[Treatment for POEMS syndrome with subcutaneous administration of bortezomib followed by autologous peripheral blood stem cell transplantation: a case report and literatures review].
 

Author(s): Ke Zeng, Zhi-gang Liu, Jin-rong Yang, Li Hou, Yu-ming Yang, Ting Liu, Ting Niu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):550-2.

 

Last Updated: 5 Jul 2013

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[Advance in diagnosis and treatment of POEMS syndrome].
 

Author(s): Jian Li, Dao-bin Zhou

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Oct;33(10):881-3.

 

Last Updated: 6 Feb 2013

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How I treat POEMS syndrome.
 

Author(s): Angela Dispenzieri

Journal: Blood. 2012 Jun;119(24):5650-8.

 

POEMS syndrome is a paraneoplastic syndrome whose acronym stands for less than half of the defining features of the disease, that is, polyradiculoneuropathy, organomegaly, potentially including coexisting Castleman disease, endocrinopathy, monoclonal plasma cell neoplasm, and skin ...

Last Updated: 15 Jun 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 8 Jul 2014

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The Treatment of Lenalidomide in Patients With POEMS Syndrome
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 1 Sep 2010

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POEMS Syndrome Treatment With Lenalidomide
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 9 May 2014

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