POEMS syndrome

Common Name(s)

POEMS syndrome

POEMS syndrome is a rare blood disorder. It is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma proliferative disorder, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy, enlarged liver and spleen, swollen lymph nodes, and darkening of the skin. Further testing and evaluation may show plasma cell disorder and sclerotic bone lesions. Many people with POEMS syndrome have diabetes (20-50%) and primary gonadal failure (55-70%). Other general signs and symptoms may include increased body hair, thickening of the skin, whitening of the nails, fatigue, weakness, swelling of the ankles and legs, enlarged breast tissue, generalized aches and pains, fluid in the lungs, and vision changes. Sign and symptoms tend to begin in a person's 40's to 50's. POEMS syndrome is a rapidly progressive disorder that can become life threatening. Currently the exact cause of POEMS syndrome is unknown.  Researchers believe the syndrome involves an overgrowth of bone marrow cells (plasma cells), which produce chemicals that damage other parts of the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "POEMS syndrome" returned 133 free, full-text research articles on human participants. First 3 results:

[POEMS syndrome. A report of four cases].
 

Author(s): Diego Andresik, M Paula Russo

Journal: Medicina (B Aires). 2015 ;75(5):324-7.

 

Four cases of a rare paraneoplastic syndrome associated to a plasmatic cell disorder with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin lesions (POEMS) are here reported. The purpose of the communication is to warn of different forms of presentation ...

Last Updated: 27 Oct 2015

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Cardiac Involvement in a Patient With POEMS Syndrome Detected Using Cardiac Magnetic Resonance Imaging.
 

Author(s): Guoyuan Pei, Dan Yang, Jiayu Sun, Yong Luo, Jiaqi Yan, Yucheng Chen

Journal: Int Heart J. 2015 ;56(5):571-3.

 

We present a case of POEMS syndrome in which cardiac MRI (CMR) revealed cardiac involvement. POEMS syndrome is a very rare disease and cardiac involvement in POEMS syndrome is rarely reported. In the present case, echocardiography revealed left ventricular hypertrophy with moderately ...

Last Updated: 1 Oct 2015

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[POEMS syndrome: a diagnosis to not to ignore].
 

Author(s): Madiha Mahfoudhi, Sami Turki, Adel Kheder

Journal:

 

Last Updated: 28 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "POEMS syndrome" returned 16 free, full-text review articles on human participants. First 3 results:

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) treated with autologous hematopoietic stem cell transplantation: a case report and literature review.
 

Author(s): Carlos Arana, José Antonio Pérez de León, Gerardo Gómez-Moreno, Ramón Pérez-Cano, Tomás Martín Hernández

Journal:

 

POEMS syndrome is a rare systemic pathology of paraneoplastic origin that is associated with plasma cell dyscrasia. It is characterized by the presence of sensorimotor polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes, and other systemic manifestations. ...

Last Updated: 2 Mar 2015

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A review of POEMS syndrome.
 

Author(s): Angela Dispenzieri, Francis K Buadi

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27(12):1242-50.

 

POEMS syndrome is a rare paraneoplastic syndrome that is caused by an underlying plasma cell disorder. Its main features include polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Other important characteristics of POEMS include ...

Last Updated: 14 Mar 2014

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POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management.
 

Author(s): Angela Dispenzieri

Journal: Am. J. Hematol.. 2014 Feb;89(2):214-23.

 

POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman ...

Last Updated: 17 Feb 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

POEMS Syndrome Treatment With Lenalidomide
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 8 Mar 2015

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The Treatment of Lenalidomide in Patients With POEMS Syndrome
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 1 Sep 2010

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