POEMS syndrome

Common Name(s)

POEMS syndrome

POEMS syndrome is a rare blood disorder. It is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma proliferative disorder, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy, enlarged liver and spleen, swollen lymph nodes, and darkening of the skin. Further testing and evaluation may show plasma cell disorder and sclerotic bone lesions. Many people with POEMS syndrome have diabetes (20-50%) and primary gonadal failure (55-70%). Other general signs and symptoms may include increased body hair, thickening of the skin, whitening of the nails, fatigue, weakness, swelling of the ankles and legs, enlarged breast tissue, generalized aches and pains, fluid in the lungs, and vision changes. Sign and symptoms tend to begin in a person's 40's to 50's. POEMS syndrome is a rapidly progressive disorder that can become life threatening. Currently the exact cause of POEMS syndrome is unknown.  Researchers believe the syndrome involves an overgrowth of bone marrow cells (plasma cells), which produce chemicals that damage other parts of the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "POEMS syndrome" returned 134 free, full-text research articles on human participants. First 3 results:

[Chronic kidney disease associated with Poems syndrome: Report of one case].
 

Author(s): Jorge Vega

Journal: Rev Med Chil. 2016 Apr;144(4):516-20.

 

POEMS syndrome is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes. We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, ...

Last Updated: 12 Jul 2016

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Multiple glomeruloid hemangiomas without POEMS syndrome.
 

Author(s): Vishal Gupta, Ajay Rai, Asit Ranjan Mridha, Vinod Kumar Sharma

Journal: Indian J Dermatol Venereol Leprol. ;82(4):442-4.

 

Last Updated: 9 Jun 2016

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Longitudinal bioimpedance assessments to evaluate hydration in POEMS syndrome.
 

Author(s): Amara Callistus Nwosu, Lauren Morris, Catriona Mayland, Stephen Mason, Andrew Pettitt, John Ellershaw

Journal: BMJ Support Palliat Care. 2016 Sep;6(3):369-72.

 

Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia and multiorgan failure. POEMS syndrome is potentially fatal and adversely affects quality of life. Oedema ...

Last Updated: 19 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "POEMS syndrome" returned 18 free, full-text review articles on human participants. First 3 results:

POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification.
 

Author(s): Nobuyuki Araki, Sonoko Misawa, Kazumoto Shibuya, Satoshi Ota, Takashi Oide, Asuka Kawano, Minako Beppu, Yukio Nakatani, Satoshi Kuwabara

Journal:

 

Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, ...

Last Updated: 12 Apr 2016

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POEMS syndrome: update on diagnosis, risk-stratification, and management.
 

Author(s): Angela Dispenzieri

Journal: Am. J. Hematol.. 2015 Oct;90(10):951-62.

 

POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman ...

Last Updated: 21 Sep 2015

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POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) treated with autologous hematopoietic stem cell transplantation: a case report and literature review.
 

Author(s): Carlos Arana, José Antonio Pérez de León, Gerardo Gómez-Moreno, Ramón Pérez-Cano, Tomás Martín Hernández

Journal:

 

POEMS syndrome is a rare systemic pathology of paraneoplastic origin that is associated with plasma cell dyscrasia. It is characterized by the presence of sensorimotor polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes, and other systemic manifestations. ...

Last Updated: 2 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

POEMS Syndrome Treatment With Lenalidomide
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 8 Mar 2015

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Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome
 

Status: Recruiting

Condition Summary: Plasmacytoma; POEMS Syndrome

 

Last Updated: 13 Jan 2017

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