POEMS syndrome

Common Name(s)

POEMS syndrome

POEMS syndrome is a rare blood disorder. It is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma proliferative disorder, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy, enlarged liver and spleen, swollen lymph nodes, and darkening of the skin. Further testing and evaluation may show plasma cell disorder and sclerotic bone lesions. Many people with POEMS syndrome have diabetes (20-50%) and primary gonadal failure (55-70%). Other general signs and symptoms may include increased body hair, thickening of the skin, whitening of the nails, fatigue, weakness, swelling of the ankles and legs, enlarged breast tissue, generalized aches and pains, fluid in the lungs, and vision changes. Sign and symptoms tend to begin in a person's 40's to 50's. POEMS syndrome is a rapidly progressive disorder that can become life threatening. Currently the exact cause of POEMS syndrome is unknown.  Researchers believe the syndrome involves an overgrowth of bone marrow cells (plasma cells), which produce chemicals that damage other parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "POEMS syndrome" returned 103 free, full-text research articles on human participants. First 3 results:

Pathological Fracture Caused by Vascular Endothelial Cell Hemangioma-like Hyperplasia in POEMS Syndrome.
 

Author(s): Jie Fang, LiXia Sun, JinQiao Zhang

Journal: Am. J. Med. Sci.. 2015 Jun;349(6):546-7.

 

Last Updated: 29 May 2015

Go To URL
POEMS syndrome in a 20-year-old patient diagnosed following a complaint of reduced visual acuity.
 

Author(s): Shinichiro Doi, Shuhei Kimura, Yuki Morizane, Mika Hosogi, Mio Hosokawa, Yusuke Shiode, Tetsuhiro Kawata, Eisei Kondo, Fumio Shiraga

Journal: Acta Med. Okayama. 2014 Dec;68(6):379-83.

 

We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted ...

Last Updated: 18 Dec 2014

Go To URL
Clinicopathologic analysis of POEMS syndrome and related diseases.
 

Author(s): Xiaofeng Shi, Shudong Hu, Xianqiu Yu, Qin Zhuang, Min Luo, Qian Jiang, Lixia Wang, Yilong Lu, Xiaoming Fei, Xiaodong Xi, Yan Zhu

Journal: Clin Lymphoma Myeloma Leuk. 2015 Jan;15(1):e15-21.

 

POEMS syndrome, a rare paraneoplastic disease, is related to multiple organs, multiple systems, and multiple disciplines and can be mistaken for other disorders. Consequently, the diagnoses are often delayed. In this work we studied the clinicopathologic characteristics of the POEMS ...

Last Updated: 22 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "POEMS syndrome" returned 12 free, full-text review articles on human participants. First 3 results:

A review of POEMS syndrome.
 

Author(s): Angela Dispenzieri, Francis K Buadi

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27(12):1242-50.

 

POEMS syndrome is a rare paraneoplastic syndrome that is caused by an underlying plasma cell disorder. Its main features include polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Other important characteristics of POEMS include ...

Last Updated: 14 Mar 2014

Go To URL
[Treatment for POEMS syndrome with subcutaneous administration of bortezomib followed by autologous peripheral blood stem cell transplantation: a case report and literatures review].
 

Author(s): Ke Zeng, Zhi-gang Liu, Jin-rong Yang, Li Hou, Yu-ming Yang, Ting Liu, Ting Niu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):550-2.

 

Last Updated: 5 Jul 2013

Go To URL
[Advance in diagnosis and treatment of POEMS syndrome].
 

Author(s): Jian Li, Dao-bin Zhou

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Oct;33(10):881-3.

 

Last Updated: 6 Feb 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

POEMS Syndrome Treatment With Lenalidomide
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 8 Mar 2015

Go to URL
The Treatment of Lenalidomide in Patients With POEMS Syndrome
 

Status: Recruiting

Condition Summary: POEMS Syndrome

 

Last Updated: 1 Sep 2010

Go to URL

Last Updated: 27 Jul 2015

Go to URL