Plasma cell leukemia

Common Name(s)

Plasma cell leukemia

Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. Different types of treatments are available for patients with PCL. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Plasma cell leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Plasma cell leukemia" returned 118 free, full-text research articles on human participants. First 3 results:

Pleomorphic plasma cell leukemia.
 

Author(s): Huifei Liu, Xiaoping Sun

Journal: Blood. 2015 Nov;126(21):2436.

 

Last Updated: 22 Feb 2016

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Atypical plasma cell leukemia mistaken for lymphocytosis on blood count.
 

Author(s): Marion Eveillard, Philippe Moreau

Journal: Blood. 2015 Oct;126(16):1965.

 

Last Updated: 11 Jan 2016

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Plasma Soluble CD30 as a Possible Marker of Adult T-cell Leukemia in HTLV-1 Carriers: a Nested Case-Control Study.
 

Author(s): Shigeki Takemoto, Masako Iwanaga, Yasuko Sagara, Toshiki Watanabe

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(18):8253-8.

 

Elevated levels of soluble CD30 (sCD30) are linked with various T-cell neoplasms. However, the relationship between sCD30 levels and the development of adult T-cell leukemia (ATL) in human T-cell leukemia virus type 1 (HTLV-1) carriers remains to be clarified. We here investigated ...

Last Updated: 9 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Plasma cell leukemia" returned 12 free, full-text review articles on human participants. First 3 results:

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.
 

Author(s): Vittorio Simeon, Katia Todoerti, Francesco La Rocca, Antonella Caivano, Stefania Trino, Marta Lionetti, Luca Agnelli, Luciana De Luca, Ilaria Laurenzana, Antonino Neri, Pellegrino Musto

Journal:

 

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. ...

Last Updated: 12 Aug 2015

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[Plasma cell leukemia: three case-reports and review of literature].
 

Author(s): Hicham Eddou, El Mehdi Mahtat, Hamid Zahid, Hicham El Maaroufi, Selim Jennane, Nezha Messaoudi, Kamal Doghmi, Mohamed Mikdame

Journal: Ann. Biol. Clin. (Paris). ;71(6):698-702.

 

Plasma cell leukemia (LP) is a rare hematologic malignancy. Its prognosis is very derogatory. It is defined by the presence in circulating blood of more than 2 G/L plasmocytes or greater than 20% of the total leukocytes. It comes in two forms: secondary plasma cell leukemia complicating ...

Last Updated: 17 Dec 2013

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Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature.
 

Author(s): Shuji Ueda, Masahiko Kubo, Noriko Matsuura, Hitomi Matsunaga, Seiko Kataoka, Tetsuo Maeda, Yoshiaki Inui, Sumio Kawata, Yuzuru Kanakura

Journal: Intern. Med.. 2013 ;52(11):1235-8.

 

Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib ...

Last Updated: 3 Jun 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 4 Aug 2016

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Last Updated: 17 Feb 2016

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SVN53-67/M57-KLH Peptide Vaccine in Treating Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide Maintenance Therapy
 

Status: Recruiting

Condition Summary: Partial Response of Multiple Myeloma or Plasma Cell Leukemia; Plasma Cell Myeloma

 

Last Updated: 22 Nov 2016

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