Plasma cell leukemia

Common Name(s)

Plasma cell leukemia

Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. Different types of treatments are available for patients with PCL. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Plasma cell leukemia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Plasma cell leukemia" returned 113 free, full-text research articles on human participants. First 3 results:

Abrupt Development of Plasma Cell Leukemia in a Patient with Chronic Anemia under Follow-up.
 

Author(s): Mohamad Reza Farzaneh, Ali Moradi, Mohammad Reza Ravanbod, Mohammad Daghbashi

Journal: Arch Iran Med. 2016 Jan;19(1):75-7.

 

Plasma cell leukemia (PCL) is a very rare and progressive hematologic malignancy with unpleasant prognosis, which present with monoclonal proliferation of plasma cells in peripheral blood. Here we report a 52-year-old female case of PCL which diagnosed by morphology and immunohistochemistery ...

Last Updated: 25 Dec 2015

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Circulating reactive plasma cells in the setting of peripheral T-cell lymphoma mimicking plasma cell leukemia.
 

Author(s): Joo Y Song, Leslie Popplewell

Journal: Blood. 2015 Aug;126(9):1150.

 

Last Updated: 4 Nov 2015

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Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns.
 

Author(s): Ingrid Cifola, Marta Lionetti, Eva Pinatel, Katia Todoerti, Eleonora Mangano, Alessandro Pietrelli, Sonia Fabris, Laura Mosca, Vittorio Simeon, Maria Teresa Petrucci, Fortunato Morabito, Massimo Offidani, Francesco Di Raimondo, Antonietta Falcone, Tommaso Caravita, Cristina Battaglia, Gianluca De Bellis, Antonio Palumbo, Pellegrino Musto, Antonino Neri

Journal: Oncotarget. 2015 Jul;6(19):17543-58.

 

Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell dyscrasia and may represent a valid model for high-risk multiple myeloma (MM). To provide novel information concerning the mutational profile of this disease, we performed the whole-exome sequencing of ...

Last Updated: 29 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Plasma cell leukemia" returned 11 free, full-text review articles on human participants. First 3 results:

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.
 

Author(s): Vittorio Simeon, Katia Todoerti, Francesco La Rocca, Antonella Caivano, Stefania Trino, Marta Lionetti, Luca Agnelli, Luciana De Luca, Ilaria Laurenzana, Antonino Neri, Pellegrino Musto

Journal:

 

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. ...

Last Updated: 12 Aug 2015

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Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature.
 

Author(s): Shuji Ueda, Masahiko Kubo, Noriko Matsuura, Hitomi Matsunaga, Seiko Kataoka, Tetsuo Maeda, Yoshiaki Inui, Sumio Kawata, Yuzuru Kanakura

Journal: Intern. Med.. 2013 ;52(11):1235-8.

 

Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib ...

Last Updated: 3 Jun 2013

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Therapeutic advances in the treatment of primary plasma cell leukemia: a focus on hematopoietic cell transplantation.
 

Author(s): Taiga Nishihori, Sarah M Abu Kar, Rachid Baz, Melissa Alsina, Jean-Luc Harousseau, Mohamed A Kharfan-Dabaja

Journal: Biol. Blood Marrow Transplant.. 2013 Aug;19(8):1144-51.

 

Primary plasma cell leukemia (pPCL) is an uncommon but aggressive plasma cell malignancy associated with frequent extramedullary involvement, high-risk cytogenetic abnormalities, and frequent organ dysfunction, ultimately resulting in poor prognosis. Here we review recent advances ...

Last Updated: 22 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bortezomib in Combination With Liposomal Doxorubicin and Dexamethasone to Treat Plasma Cell Leukemia
 

Status: Recruiting

Condition Summary: Plasma Cell Leukemia; Multiple Myeloma

 

Last Updated: 21 Sep 2011

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Last Updated: 4 Aug 2016

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Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
 

Status: Recruiting

Condition Summary: B-Cell Prolymphocytic Leukemia; Plasma Cell Leukemia; Progression of Multiple Myeloma or Plasma Cell Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Childhood Hodgkin Lymphoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Chronic Lymphocytic Leukemia; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Small Lymphocytic Lymphoma; T-Cell Prolymphocytic Leukemia; Waldenstrom Macroglobulinemia

 

Last Updated: 17 Jun 2016

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