Plasma cell leukemia

Common Name(s)

Plasma cell leukemia

Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. Different types of treatments are available for patients with PCL. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Plasma cell leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Plasma cell leukemia" returned 68 free, full-text research articles on human participants. First 3 results:

Biclonal light chain gammopathy with aberrant CD33 expression in secondary plasma cell leukemia.
 

Author(s): Michael Gentry, Mark Pettenati, Changlee S Pang

Journal:

 

Plasma cell leukemia is a rare neoplastic proliferation of circulating plasma cells. Clonal proliferations of plasma cells, such as in plasma cell leukemia or plasma cell myeloma, are typically characterized by production of a monoclonal heavy and/or light chain immunoglobulin. We ...

Last Updated: 17 Oct 2013

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Biological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia.
 

Author(s): Marta Lionetti, Pellegrino Musto, Maria Teresa Di Martino, Sonia Fabris, Luca Agnelli, Katia Todoerti, Giacomo Tuana, Laura Mosca, Maria E Gallo Cantafio, Vitina Grieco, Gabriella Bianchino, Fiorella D'Auria, Teodora Statuto, Carmela Mazzoccoli, Luciana De Luca, Maria Teresa Petrucci, Massimo Offidani, Francesco Di Raimondo, Antonietta Falcone, Tommaso Caravita, Paola Omede', Fortunato Morabito, Pierfrancesco Tassone, Mario Boccadoro, Antonio Palumbo, Antonino Neri

Journal: Clin. Cancer Res.. 2013 Jun;19(12):3130-42.

 

Primary plasma cell leukemia (pPCL) is a rare and very aggressive form of plasma cell dyscrasia. To date, no information on microRNA (miRNA) expression in pPCL has been reported. This study aimed at investigating the involvement of miRNAs in pPCL and their possible relationship with ...

Last Updated: 17 Jun 2013

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Transcriptional characterization of a prospective series of primary plasma cell leukemia revealed signatures associated with tumor progression and poorer outcome.
 

Author(s): Katia Todoerti, Luca Agnelli, Sonia Fabris, Marta Lionetti, Giacomo Tuana, Laura Mosca, Luigia Lombardi, Vitina Grieco, Gabriella Bianchino, Fiorella D'Auria, Teodora Statuto, Carmela Mazzoccoli, Luciana De Luca, Maria Teresa Petrucci, Fortunato Morabito, Massimo Offidani, Francesco Di Raimondo, Antonietta Falcone, Paola Omede', Pierfrancesco Tassone, Mario Boccadoro, Antonio Palumbo, Antonino Neri, Pellegrino Musto

Journal: Clin. Cancer Res.. 2013 Jun;19(12):3247-58.

 

Plasma cell leukemia (PCL) is a rare form of plasma cell dyscrasia that presents either as a progression of previously diagnosed multiple myeloma, namely secondary PCL, or as initial manifestation of disease, namely primary PCL (pPCL). Although the presenting signs and symptoms include ...

Last Updated: 17 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Plasma cell leukemia" returned 7 free, full-text review articles on human participants. First 3 results:

Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature.
 

Author(s): Shuji Ueda, Masahiko Kubo, Noriko Matsuura, Hitomi Matsunaga, Seiko Kataoka, Tetsuo Maeda, Yoshiaki Inui, Sumio Kawata, Yuzuru Kanakura

Journal: Intern. Med.. 2013 ;52(11):1235-8.

 

Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib ...

Last Updated: 3 Jun 2013

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How I treat plasma cell leukemia.
 

Author(s): Niels W C J van de Donk, Henk M Lokhorst, Kenneth C Anderson, Paul G Richardson

Journal: Blood. 2012 Sep;120(12):2376-89.

 

Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell proliferative disorder with a very poor prognosis and with distinct biologic, clinical, and laboratory features. Compared with multiple myeloma, pPCL presents more often with extramedullary involvement, anemia, ...

Last Updated: 21 Sep 2012

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Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review of the literature.
 

Author(s): Yasunobu Sekiguchi, Syuichi Shirane, Hidenori Imai, Keiji Sugimoto, Mutsumi Wakabayashi, Tomonori Sawada, Noriko Chigira, Kunimoto Ichikawa, Norio Komatsu, Masaaki Noguchi

Journal: Intern. Med.. 2012 ;51(11):1393-8.

 

Pleural effusion or ascites complicating plasmacytoma is rare and has a poor prognosis. A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained a very good partial ...

Last Updated: 12 Jun 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bortezomib in Combination With Liposomal Doxorubicin and Dexamethasone to Treat Plasma Cell Leukemia
 

Status: Recruiting

Condition Summary: Plasma Cell Leukemia; Multiple Myeloma

 

Last Updated: 21 Sep 2011

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Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL)
 

Status: Recruiting

Condition Summary: Multiple Myeloma; Multiple Myeloma in Relapse; Mantle Cell Lymphoma in Relapse; Diffuse Large B Cell Lymphoma in Relapse; Other B Cell Lymphoma in Relapse; Plasma Cell Leukemia

 

Last Updated: 5 Jun 2014

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Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
 

Status: Not yet recruiting

Condition Summary: Acute Myeloid Leukemia (AML); Acute Lymphocytic Leukemia (ALL); Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelofibrosis; Myelodysplasia; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Marginal Zone B-Cell Lymphoma; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle-Cell Lymphoma; Prolymphocytic Leukemia; Diffuse Large B Cell Lymphoma; Lymphoblastic Lymphoma; Burkitt's Lymphoma; Non-Hodgkin Lymphoma; Multiple Myeloma

 

Last Updated: 15 May 2014

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