Plasma cell leukemia

Common Name(s)

Plasma cell leukemia

Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers. Different types of treatments are available for patients with PCL. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Plasma cell leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Plasma cell leukemia" returned 81 free, full-text research articles on human participants. First 3 results:

A case of secondary plasma cell leukemia resistant to novel agents, in which stringent complete remission was achieved and maintained for a long period of time after VAD therapy and tandem autologous transplantation.
 

Author(s): Yasunobu Sekiguchi, Asami Shimada, Mutsumi Wakabayashi, Keiji Sugimoto, Shigeki Tomita, Hiroshi Izumi, Noriko Nakamura, Tomohiro Sawada, Yasunori Ohta, Norio Komatsu, Masaaki Noguchi

Journal:

 

A 61-year-old woman was diagnosed in June 2011 as having immunoglobulin G (IgG) ĸ-type multiple myeloma (MM), stage II, according to the International Staging System (ISS). Chromosome analysis showed a complex karyotype, including t(11;14) and del 13q. Analysis of the cell surface ...

Last Updated: 22 Oct 2014

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Two cases of nonsecretory multiple myeloma presenting as primary plasma cell leukemia.
 

Author(s): Tohru Takahashi, Shin-ichi Kanno, Hideto Itoh, Mitsuru Yoshimoto, Masayuki Tsujisaki, Michihiro Fujino

Journal: Intern. Med.. 2014 ;53(18):2121-5.

 

Plasma cell leukemia (PCL) is a rare variant of multiple myeloma (MM) with a poor prognosis. Nonsecretory myeloma is also a rare form of MM characterized by the absence of detectable M-protein in the serum and urine. This report describes two cases of nonsecretory PCL. The first patient ...

Last Updated: 16 Sep 2014

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Chance identification of synchronous hairy cell leukemia and plasma cell myeloma in a potential HSC donor.
 

Author(s): Xiangrong Zhao, Irina Maric

Journal: Blood. 2014 Jun;123(24):3694.

 

Last Updated: 22 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Plasma cell leukemia" returned 9 free, full-text review articles on human participants. First 3 results:

Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature.
 

Author(s): Shuji Ueda, Masahiko Kubo, Noriko Matsuura, Hitomi Matsunaga, Seiko Kataoka, Tetsuo Maeda, Yoshiaki Inui, Sumio Kawata, Yuzuru Kanakura

Journal: Intern. Med.. 2013 ;52(11):1235-8.

 

Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib ...

Last Updated: 3 Jun 2013

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Therapeutic advances in the treatment of primary plasma cell leukemia: a focus on hematopoietic cell transplantation.
 

Author(s): Taiga Nishihori, Sarah M Abu Kar, Rachid Baz, Melissa Alsina, Jean-Luc Harousseau, Mohamed A Kharfan-Dabaja

Journal: Biol. Blood Marrow Transplant.. 2013 Aug;19(8):1144-51.

 

Primary plasma cell leukemia (pPCL) is an uncommon but aggressive plasma cell malignancy associated with frequent extramedullary involvement, high-risk cytogenetic abnormalities, and frequent organ dysfunction, ultimately resulting in poor prognosis. Here we review recent advances ...

Last Updated: 22 Jul 2013

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Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.
 

Author(s): C Fernández de Larrea, R A Kyle, B G M Durie, H Ludwig, S Usmani, D H Vesole, R Hajek, J F San Miguel, O Sezer, P Sonneveld, S K Kumar, A Mahindra, R Comenzo, A Palumbo, A Mazumber, K C Anderson, P G Richardson, A Z Badros, J Caers, M Cavo, X LeLeu, M A Dimopoulos, C S Chim, R Schots, A Noeul, D Fantl, U-H Mellqvist, O Landgren, A Chanan-Khan, P Moreau, R Fonseca, G Merlini, J J Lahuerta, J Bladé, R Z Orlowski, J J Shah,

Journal: Leukemia. 2013 Apr;27(4):780-91.

 

Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct ...

Last Updated: 11 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bortezomib in Combination With Liposomal Doxorubicin and Dexamethasone to Treat Plasma Cell Leukemia
 

Status: Recruiting

Condition Summary: Plasma Cell Leukemia; Multiple Myeloma

 

Last Updated: 21 Sep 2011

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Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
 

Status: Not yet recruiting

Condition Summary: Acute Myeloid Leukemia (AML); Acute Lymphocytic Leukemia (ALL); Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelofibrosis; Myelodysplasia; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Marginal Zone B-Cell Lymphoma; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle-Cell Lymphoma; Prolymphocytic Leukemia; Diffuse Large B Cell Lymphoma; Lymphoblastic Lymphoma; Burkitt's Lymphoma; Non-Hodgkin Lymphoma; Multiple Myeloma

 

Last Updated: 22 Apr 2015

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Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
 

Status: Recruiting

Condition Summary: B-Cell Prolymphocytic Leukemia; Plasma Cell Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Childhood Hodgkin Lymphoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Chronic Lymphocytic Leukemia; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Small Lymphocytic Lymphoma; T-Cell Prolymphocytic Leukemia; Waldenstrom Macroglobulinemia

 

Last Updated: 17 Mar 2015

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