Pineoblastoma

Common Name(s)

Pineoblastoma

Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.   Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pineoblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pineoblastoma" returned 6 free, full-text research articles on human participants. First 3 results:

Germ-line and somatic DICER1 mutations in pineoblastoma.
 

Author(s): Leanne de Kock, Nelly Sabbaghian, Harriet Druker, Evan Weber, Nancy Hamel, Suzanne Miller, Catherine S Choong, Nicholas G Gottardo, Ursula R Kees, Surya P Rednam, Liselotte P van Hest, Marjolijn C Jongmans, Shalini Jhangiani, James R Lupski, Margaret Zacharin, Dorothée Bouron-Dal Soglio, Annie Huang, John R Priest, Arie Perry, Sabine Mueller, Steffen Albrecht, David Malkin, Richard G Grundy, William D Foulkes

Journal: Acta Neuropathol.. 2014 Oct;128(4):583-95.

 

Germ-line RB-1 mutations predispose to pineoblastoma (PinB), but other predisposing genetic factors are not well established. We recently identified a germ-line DICER1 mutation in a child with a PinB. This was accompanied by loss of heterozygosity (LOH) of the wild-type allele within ...

Last Updated: 10 Sep 2014

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Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
 

Author(s): Suzanne Miller, Hazel A Rogers, Paul Lyon, Vikki Rand, Martyna Adamowicz-Brice, Steven C Clifford, James T Hayden, Sara Dyer, Stefan Pfister, Andrey Korshunov, Marie-Anne Brundler, James Lowe, Beth Coyle, Richard G Grundy

Journal: Neuro-oncology. 2011 Aug;13(8):866-79.

 

Central nervous system primitive neuroectodermal tumor (CNS PNET) and pineoblastoma are highly malignant embryonal brain tumors with poor prognoses. Current therapies are based on the treatment of pediatric medulloblastoma, even though these tumors are distinct at both the anatomical ...

Last Updated: 29 Jul 2011

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Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma.
 

Author(s): Juliana Paulino Oliveira, Luciana de Paula Lima Gazzola, Stanley de Almeida Araújo

Journal: Rev. Soc. Bras. Med. Trop.. ;42(1):86-7.

 

Last Updated: 16 Mar 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pineoblastoma" returned 2 free, full-text review articles on human participants. First 3 results:

The long-term postsurgical prognosis of patients with pineoblastoma.
 

Author(s): Matthew Tate, Michael E Sughrue, Martin J Rutkowski, Ari J Kane, Derick Aranda, Lashaun McClinton, Lashay McClinton, Igor J Barani, Andrew T Parsa

Journal: Cancer. 2012 Jan;118(1):173-9.

 

For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes.

Last Updated: 6 Jan 2012

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[Spinal dissemination of pineoblastoma five years after irradiation of a pineal tumor. Case report].
 

Author(s): M Hamasaki, K Kuwamura, Y Nishida

Journal: Neurol. Med. Chir. (Tokyo). 1987 Nov;27(11):1109-13.

 

Last Updated: 19 Apr 1988

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
 

Status: Recruiting

Condition Summary: Brain Tumor; Medulloblastoma; Pineoblastoma

 

Last Updated: 2 Apr 2015

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18F-DOPA-PET in Planning Surgery in Patients With Gliomas
 

Status: Recruiting

Condition Summary: Acoustic Schwannoma; Adult Anaplastic (Malignant) Meningioma; Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Choroid Plexus Neoplasm; Adult Craniopharyngioma; Adult Diffuse Astrocytoma; Adult Ependymoblastoma; Adult Ependymoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Medulloblastoma; Adult Mixed Glioma; Adult Myxopapillary Ependymoma; Adult Oligodendroglioma; Adult Papillary Meningioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Pineoblastoma; Adult Pineocytoma; Adult Primary Melanocytic Lesion of Meninges; Adult Subependymal Giant Cell Astrocytoma; Adult Subependymoma; Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebellar Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Cerebral Astrocytoma; Childhood Choroid Plexus Neoplasm; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood Infratentorial Ependymoma; Childhood Mixed Glioma; Childhood Supratentorial Ependymoma; Malignant Adult Intracranial Hemangiopericytoma; Medulloepithelioma; Newly Diagnosed Childhood Ependymoma; Recurrent Adult Brain Neoplasm; Recurrent Childhood Anaplastic Astrocytoma; Recurrent Childhood Anaplastic Oligoastrocytoma; Recurrent Childhood Anaplastic Oligodendroglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Diffuse Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Fibrillary Astrocytoma; Recurrent Childhood Gemistocytic Astrocytoma; Recurrent Childhood Giant Cell Glioblastoma; Recurrent Childhood Glioblastoma; Recurrent Childhood Gliomatosis Cerebri; Recurrent Childhood Gliosarcoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Oligoastrocytoma; Recurrent Childhood Oligodendroglioma; Recurrent Childhood Pilocytic Astrocytoma; Recurrent Childhood Pilomyxoid Astrocytoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Pleomorphic Xanthoastrocytoma; Recurrent Childhood Protoplasmic Astrocytoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway Glioma; Untreated Childhood Anaplastic Astrocytoma; Untreated Childhood Anaplastic Oligoastrocytoma; Untreated Childhood Anaplastic Oligodendroglioma; Untreated Childhood Brain Stem Glioma; Untreated Childhood Diffuse Astrocytoma; Untreated Childhood Fibrillary Astrocytoma; Untreated Childhood Gemistocytic Astrocytoma; Untreated Childhood Giant Cell Glioblastoma; Untreated Childhood Glioblastoma; Untreated Childhood Gliomatosis Cerebri; Untreated Childhood Gliosarcoma; Untreated Childhood Medulloblastoma; Untreated Childhood Oligoastrocytoma; Untreated Childhood Oligodendroglioma; Untreated Childhood Pilocytic Astrocytoma; Untreated Childhood Pilomyxoid Astrocytoma; Untreated Childhood Pineoblastoma; Untreated Childhood Pleomorphic Xanthoastrocytoma; Untreated Childhood Protoplasmic Astrocytoma; Untreated Childhood Subependymal Giant Cell Astrocytoma; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor; Untreated Childhood Visual Pathway Glioma

 

Last Updated: 23 Jun 2015

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18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy
 

Status: Recruiting

Condition Summary: Adult Anaplastic (Malignant) Meningioma; Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Brain Stem Glioma; Adult Choroid Plexus Neoplasm; Adult Ependymoblastoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Medulloblastoma; Adult Mixed Glioma; Adult Papillary Meningioma; Adult Pineal Gland Astrocytoma; Adult Pineoblastoma; Adult Primary Melanocytic Lesion of Meninges; Adult Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 23 Jun 2015

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