Pineoblastoma

Common Name(s)

Pineoblastoma

Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.   Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pineoblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pineoblastoma" returned 8 free, full-text research articles on human participants. First 3 results:

Germ-line and somatic DICER1 mutations in pineoblastoma.
 

Author(s): Leanne de Kock, Nelly Sabbaghian, Harriet Druker, Evan Weber, Nancy Hamel, Suzanne Miller, Catherine S Choong, Nicholas G Gottardo, Ursula R Kees, Surya P Rednam, Liselotte P van Hest, Marjolijn C Jongmans, Shalini Jhangiani, James R Lupski, Margaret Zacharin, Dorothée Bouron-Dal Soglio, Annie Huang, John R Priest, Arie Perry, Sabine Mueller, Steffen Albrecht, David Malkin, Richard G Grundy, William D Foulkes

Journal: Acta Neuropathol.. 2014 Oct;128(4):583-95.

 

Germ-line RB-1 mutations predispose to pineoblastoma (PinB), but other predisposing genetic factors are not well established. We recently identified a germ-line DICER1 mutation in a child with a PinB. This was accompanied by loss of heterozygosity (LOH) of the wild-type allele within ...

Last Updated: 10 Sep 2014

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Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
 

Author(s): Suzanne Miller, Hazel A Rogers, Paul Lyon, Vikki Rand, Martyna Adamowicz-Brice, Steven C Clifford, James T Hayden, Sara Dyer, Stefan Pfister, Andrey Korshunov, Marie-Anne Brundler, James Lowe, Beth Coyle, Richard G Grundy

Journal: Neuro-oncology. 2011 Aug;13(8):866-79.

 

Central nervous system primitive neuroectodermal tumor (CNS PNET) and pineoblastoma are highly malignant embryonal brain tumors with poor prognoses. Current therapies are based on the treatment of pediatric medulloblastoma, even though these tumors are distinct at both the anatomical ...

Last Updated: 29 Jul 2011

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Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma.
 

Author(s): Juliana Paulino Oliveira, Luciana de Paula Lima Gazzola, Stanley de Almeida Araújo

Journal: Rev. Soc. Bras. Med. Trop.. ;42(1):86-7.

 

Last Updated: 16 Mar 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pineoblastoma" returned 3 free, full-text review articles on human participants. First 3 results:

The long-term postsurgical prognosis of patients with pineoblastoma.
 

Author(s): Matthew Tate, Michael E Sughrue, Martin J Rutkowski, Ari J Kane, Derick Aranda, Lashaun McClinton, Lashay McClinton, Igor J Barani, Andrew T Parsa

Journal: Cancer. 2012 Jan;118(1):173-9.

 

For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes.

Last Updated: 6 Jan 2012

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[Spinal dissemination of pineoblastoma five years after irradiation of a pineal tumor. Case report].
 

Author(s): M Hamasaki, K Kuwamura, Y Nishida

Journal: Neurol. Med. Chir. (Tokyo). 1987 Nov;27(11):1109-13.

 

Last Updated: 19 Apr 1988

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The separation of pineocytoma from pineoblastoma.
 

Author(s): A Borit, W Blackwood, W G Mair

Journal: Cancer. 1980 Mar;45(6):1408-18.

 

From our study of eight pineoblastomas and five pineocytomas and a review of the literature, we have described two clinicopathologic syndromes that characterize these neoplasms. Pineoblastomas highly resemble the medulloblastoma-neuroblastoma group of tumors and occur mostly in young ...

Last Updated: 23 May 1980

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
 

Status: Recruiting

Condition Summary: Brain Tumor; Medulloblastoma; Pineoblastoma

 

Last Updated: 25 Feb 2016

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Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Central Nervous System Germ Cell Tumor; Adult Ependymoblastoma; Adult Medulloblastoma; Adult Pineoblastoma; Adult Supratentorial Primitive Neuroectodermal Tumor; Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Ependymoblastoma; Medulloepithelioma; Ototoxicity; Recurrent Adult Brain Neoplasm; Recurrent Childhood Central Nervous System Embryonal Neoplasm; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 28 Apr 2016

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