Pilocytic astrocytoma

Common Name(s)

Pilocytic astrocytoma

Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. The tumor may be in the form of a cyst and usually does not spread to nearby tissues. Symptoms vary depending upon the size and location of the tumor. Most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. The underlying cause of a pilocytic astrocytoma is unknown. It most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome, and tuberous sclerosis. This type of tumor can often be cured with surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pilocytic astrocytoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pilocytic astrocytoma" returned 67 free, full-text research articles on human participants. First 3 results:

Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma.
 

Author(s): Thomas Buder, Andreas Deutsch, Barbara Klink, Anja Voss-Böhme

Journal:

 

Pilocytic astrocytoma (PA) is the most common brain tumor in children. This tumor is usually benign and has a good prognosis. Total resection is the treatment of choice and will cure the majority of patients. However, often only partial resection is possible due to the location of ...

Last Updated: 15 Dec 2015

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IDH1 R132H mutation in a pilocytic astrocytoma: a case report.
 

Author(s): Felix Behling, Julia Steinhilber, Marcos Tatagiba, Sotirios Bisdas, Jens Schittenhelm

Journal:

 

We present the case of a 72-year old female with a right cerebellar pilocytic astrocytoma WHO grade I with an Isocitrate dehydrogenase 1 (IDH1) R132H mutation. The patient is recurrence-free 6 years after the initial diagnosis. Only one single case with strikingly similar clinicopathological ...

Last Updated: 30 Nov 2015

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Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features.
 

Author(s): Krzysztof Zakrzewski, Michał Jarząb, Aleksandra Pfeifer, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Paweł P Liberski, Magdalena Zakrzewska

Journal:

 

Pilocytic astrocytoma is the most common type of brain tumor in the pediatric population, with a generally favorable prognosis, although recurrences or leptomeningeal dissemination are sometimes also observed. For tumors originating in the supra-or infratentorial location, a different ...

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pilocytic astrocytoma" returned 6 free, full-text review articles on human participants. First 3 results:

Adult anaplastic pilocytic astrocytoma - a diagnostic challenge? A case series and literature review.
 

Author(s): Michael Fiechter, Ekkehard Hewer, Urspeter Knecht, Roland Wiest, Jürgen Beck, Andreas Raabe, Markus F Oertel

Journal: Clin Neurol Neurosurg. 2016 Aug;147():98-104.

 

Anaplastic pilocytic astrocytoma (APA) is an exceptionally rare type of high-grade glioma in adults. Establishing histopathological diagnosis is challenging and its clinical and radiological appearance insidious. By this case series and first literature review we investigated the ...

Last Updated: 20 Jul 2016

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Pilocytic astrocytoma: pathology, molecular mechanisms and markers.
 

Author(s): V Peter Collins, David T W Jones, Caterina Giannini

Journal: Acta Neuropathol.. 2015 Jun;129(6):775-88.

 

Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over 90%. Many require merely surgical removal and only very infrequently do they progress to more malignant ...

Last Updated: 19 May 2015

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MAPK pathway activation in pilocytic astrocytoma.
 

Author(s): David T W Jones, Jan Gronych, Peter Lichter, Olaf Witt, Stefan M Pfister

Journal: Cell. Mol. Life Sci.. 2012 Jun;69(11):1799-811.

 

Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS). A body of research over recent years has demonstrated a key role for mitogen-activated protein kinase (MAPK) pathway signaling in the development and behavior of PAs. Several mechanisms ...

Last Updated: 14 May 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Pegylated Interferon
 

Status: Recruiting

Condition Summary: Juvenile Pilocytic Astrocytomas; Optic Pathway Gliomas

 

Last Updated: 21 Nov 2016

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Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
 

Status: Recruiting

Condition Summary: Glioma; Neurofibromatosis Type 1; Recurrent Childhood Pilocytic Astrocytoma; Recurrent Childhood Visual Pathway Glioma

 

Last Updated: 2 Feb 2017

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A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
 

Status: Recruiting

Condition Summary: Pilomyxoid Astrocytoma; Pilocytic Astrocytoma; Glioma, Astrocytic; Optic Nerve Glioma; Pleomorphic Xanthoastrocytoma; Glioblastoma Multiforme; Anaplastic Astrocytoma; Gliosarcoma; Diffuse Intrinsic Pontine Glioma; DIPG; Low-grade Glioma; Brainstem Glioma

 

Last Updated: 30 Jan 2017

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