Pilocytic astrocytoma

Common Name(s)

Pilocytic astrocytoma

Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. The tumor may be in the form of a cyst and usually does not spread to nearby tissues. Symptoms vary depending upon the size and location of the tumor. Most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. The underlying cause of a pilocytic astrocytoma is unknown. It most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome, and tuberous sclerosis. This type of tumor can often be cured with surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pilocytic astrocytoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pilocytic astrocytoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pilocytic astrocytoma" returned 72 free, full-text research articles on human participants. First 3 results:

A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.
 

Author(s): Tajana Tešan Tomić, Josefin Olausson, Annica Wilzén, Magnus Sabel, Katarina Truvé, Helene Sjögren, Sándor Dósa, Magnus Tisell, Birgitta Lannering, Fredrik Enlund, Tommy Martinsson, Pierre Åman, Frida Abel

Journal:

 

Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). ...

Last Updated: 27 Apr 2017

Go To URL
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.
 

Author(s): Florian Selt, Juliane Hohloch, Thomas Hielscher, Felix Sahm, David Capper, Andrey Korshunov, Diren Usta, Sebastian Brabetz, Johannes Ridinger, Jonas Ecker, Ina Oehme, Jan Gronych, Viktoria Marquardt, David Pauck, Heidi Bächli, Charles D Stiles, Andreas von Deimling, Marc Remke, Martin U Schuhmann, Stefan M Pfister, Tilman Brummer, David T W Jones, Olaf Witt, Till Milde

Journal: Oncotarget. 2017 Feb;8(7):11460-11479.

 

Pilocytic astrocytoma (PA) is the most frequent pediatric brain tumor. Activation of the MAPK pathway is well established as the oncogenic driver of the disease. It is most frequently caused by KIAA1549:BRAF fusions, and leads to oncogene induced senescence (OIS). OIS is thought to ...

Last Updated: 21 Dec 2016

Go To URL
A new NFIA:RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma.
 

Author(s): Christina Westmose Yde, Astrid Sehested, Àngels Mateu-Regué, Olga Østrup, David Scheie, Karsten Nysom, Finn Cilius Nielsen, Maria Rossing

Journal: Cancer Genet. 2016 Oct;209(10):440-444.

 

Pilocytic astrocytoma (PA) is one of the most common brain cancers among children and activation of the Mitogen-Activated Protein Kinase (MAPK) pathway is considered the hallmark. In the majority of cases, oncogenic BRAF fusions or BRAF V600E mutations are observed, while RAF1 or ...

Last Updated: 4 Nov 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pilocytic astrocytoma" returned 7 free, full-text review articles on human participants. First 3 results:

Heterogeneity of histopathological presentation of pilocytic astrocytoma - diagnostic pitfalls. A review.
 

Author(s): E Matyja, W Grajkowska, K Stępień, E Naganska

Journal: Folia Neuropathol. 2016 ;54(3):197-211.

 

Pilocytic astrocytomas (PAs) are the most frequent primary astroglial tumours affecting children and adolescents. They occur sporadically or in association with a genetically determined syndrome - neurofibromatosis type 1. Classic PA usually manifests as a well-circumscribed, often ...

Last Updated: 20 Oct 2016

Go To URL
Adult anaplastic pilocytic astrocytoma - a diagnostic challenge? A case series and literature review.
 

Author(s): Michael Fiechter, Ekkehard Hewer, Urspeter Knecht, Roland Wiest, Jürgen Beck, Andreas Raabe, Markus F Oertel

Journal: Clin Neurol Neurosurg. 2016 Aug;147():98-104.

 

Anaplastic pilocytic astrocytoma (APA) is an exceptionally rare type of high-grade glioma in adults. Establishing histopathological diagnosis is challenging and its clinical and radiological appearance insidious. By this case series and first literature review we investigated the ...

Last Updated: 20 Jul 2016

Go To URL
Pilocytic astrocytoma: pathology, molecular mechanisms and markers.
 

Author(s): V Peter Collins, David T W Jones, Caterina Giannini

Journal: Acta Neuropathol.. 2015 Jun;129(6):775-88.

 

Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over 90%. Many require merely surgical removal and only very infrequently do they progress to more malignant ...

Last Updated: 19 May 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Pegylated Interferon
 

Status: Recruiting

Condition Summary: Juvenile Pilocytic Astrocytomas; Optic Pathway Gliomas

 

Last Updated: 4 Aug 2017

Go to URL
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
 

Status: Recruiting

Condition Summary: BRAF V600E Mutation Analysis; Glioma; Neurofibromatosis Type 1; Recurrent Childhood Pilocytic Astrocytoma; Recurrent Childhood Visual Pathway Glioma

 

Last Updated: 12 Sep 2017

Go to URL
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
 

Status: Recruiting

Condition Summary: Pilomyxoid Astrocytoma; Pilocytic Astrocytoma; Glioma, Astrocytic; Optic Nerve Glioma; Pleomorphic Xanthoastrocytoma; Glioblastoma Multiforme; Anaplastic Astrocytoma; Gliosarcoma; Diffuse Intrinsic Pontine Glioma; DIPG; Low-grade Glioma; Brainstem Glioma

 

Last Updated: 30 Jan 2017

Go to URL