Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 69 free, full-text research articles on human participants. First 3 results:

Localized pigmented villonodular synovitis in a child knee.
 

Author(s): O Şahap Atik, Hasan Hüseyin Bozkurt, Efkan Özcan, Batuhan Bahadır, Murat Uçar, Betül Öğüt, Leyla Memiş

Journal: Eklem Hastalik Cerrahisi. 2017 Apr;28(1):46-9.

 

Pigmented villonodular synovitis is a benign proliferative tumor of the synovium. It is very rare, and most cases occur in the knee joint. In this article, we report a case of localized pigmented villonodular synovitis in the knee joint of a 14-year-old boy. This condition is rare ...

Last Updated: 31 Dec 1969

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Multifocal pigmented villonodular synovitis in a child: A case report.
 

Author(s): Liang Zhao, Kaiyu Zhou, Yimin Hua, Yifei Li, Dezhi Mu

Journal: Medicine (Baltimore). 2016 Aug;95(33):e4572.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. Multifocal PVNS is very rare, particularly in childhood. We reported a rare case of multifocal PVNS affecting over ...

Last Updated: 31 Dec 1969

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Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis.
 

Author(s): Tahsin Beyzadeoğlu, Esra Çirci

Journal: Acta Orthop Traumatol Turc. 2016 ;50(3):379-81.

 

We report a 24-year-old male who was admitted to the emergency department with an unusual complaint of locked hip joint. Magnetic resonance imaging (MRI) showed a 3-cm intra-articular synovial nodular mass and a 3.0x2.4x1.6-cm yellow-brownish colored pediculed synovial nodular mass ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 6 free, full-text review articles on human participants. First 3 results:

MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review.
 

Author(s): Samuel J Lynskey, Marcus J Pianta

Journal: Br J Radiol. 2015 ;88(1056):20150528.

 

The purpose of this study was to characterize the MRI and thallium-201 ((201)TI) scintigraphy attributes of pigmented villonodular synovitis (PVNS) and giant cell tumours of tendon sheaths (GCTTS). The epidemiology of these uncommon lesions was also assessed and less commonly encountered ...

Last Updated: 31 Dec 1969

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Posterior interosseous nerve palsy secondary to pigmented villonodular synovitis of the elbow: case report and review of literature.
 

Author(s): K Kohyama, H Sugiura, K Yamada, I Hyodo, H Kato, Y Kamei

Journal: Orthop Traumatol Surg Res. 2013 Apr;99(2):247-51.

 

Local tumor compression is the main mechanical cause of posterior interosseous nerve (PIN) palsy. The reported cases of these tumors do not include that of pigmented villonodular synovitis (PVNS). Here, we report a case of a 53-year-old male with a 9-year history of painless swelling ...

Last Updated: 31 Dec 1969

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Adult multifocal pigmented villonodular synovitis--clinical review.
 

Author(s): Paul Botez, Paul Dan Sirbu, Carmen Grierosu, Dan Mihailescu, Liliana Savin, Marius M Scarlat

Journal: Int Orthop. 2013 Apr;37(4):729-33.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disease of the synovial tissue that affects a single joint or a tendon sheath. Data from the literature present only a few cases of multifocal PVNS. This paper presents multifocal PVNS in the adult. This disease ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Tumor

 

Last Updated: 24 Oct 2017

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Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project
 

Status: Recruiting

Condition Summary: Giant Cell Tumors

 

Last Updated: 28 Nov 2017

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Pexidartinib Effects on How the Body Processes Midazolam and S-warfarin (Pharmacokinetics)
 

Status: Not yet recruiting

Condition Summary: Drug Interaction Potential

 

Last Updated: 6 Dec 2017

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