Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 57 free, full-text research articles on human participants. First 3 results:

Pigmented villonodular synovitis of the ankle.
 

Author(s): Wei-Ting Lin, Shun-Chien Cheng, Chung-Da Wu, Shin-Sung Chiang, Chia-Yang Hong, Chien-Ming Chao

Journal: Intern. Med.. 2013 ;52(10):1149-50.

 

Last Updated: 16 May 2013

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Pigmented villonodular synovitis: a retrospective study of seventy five cases (eighty one joints).
 

Author(s): Xiaomei Ma, Guodong Shi, Chunyan Xia, Huimin Liu, Jin He, Wentao Jin

Journal: Int Orthop. 2013 Jun;37(6):1165-70.

 

Pigmented villonodular synovitis (PVNS) is a relatively rare, benign proliferation lesion of the synovium of large joints, but there is not much information available about the disease's aetiology, clinical history, differential diagnosis, treatment, and long-term effects. We conducted ...

Last Updated: 27 May 2013

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Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years.
 

Author(s): Geumju Park, Young Seok Kim, Jong Hoon Kim, Sang-wook Lee, Si Yeol Song, Eun Kyung Choi, Seong Yoon Yi, Seung Do Ahn

Journal: Acta Orthop. 2012 Jun;83(3):256-60.

 

Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder involving synovial membranes, and patients with PVNS have a variable prognosis. We retrospectively analyzed clinical outcomes after synovectomy plus low-dose external beam radiotherapy for diffuse PVNS of the knee.

Last Updated: 4 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 5 free, full-text review articles on human participants. First 3 results:

Posterior interosseous nerve palsy secondary to pigmented villonodular synovitis of the elbow: case report and review of literature.
 

Author(s): K Kohyama, H Sugiura, K Yamada, I Hyodo, H Kato, Y Kamei

Journal: Orthop Traumatol Surg Res. 2013 Apr;99(2):247-51.

 

Local tumor compression is the main mechanical cause of posterior interosseous nerve (PIN) palsy. The reported cases of these tumors do not include that of pigmented villonodular synovitis (PVNS). Here, we report a case of a 53-year-old male with a 9-year history of painless swelling ...

Last Updated: 2 Apr 2013

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Adult multifocal pigmented villonodular synovitis--clinical review.
 

Author(s): Paul Botez, Paul Dan Sirbu, Carmen Grierosu, Dan Mihailescu, Liliana Savin, Marius M Scarlat

Journal: Int Orthop. 2013 Apr;37(4):729-33.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disease of the synovial tissue that affects a single joint or a tendon sheath. Data from the literature present only a few cases of multifocal PVNS. This paper presents multifocal PVNS in the adult. This disease ...

Last Updated: 28 Mar 2013

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Pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature.
 

Author(s): Mário José Romañach, Bernardo Ferreira Brasileiro, Jorge Esquiche León, Daniel Berreta Alves, Oslei Paes de Almeida, Pablo Agustin Vargas

Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Mar;111(3):e17-28.

 

Pigmented villonodular synovitis (PVNS) is an aggressive proliferative lesion that usually involves the synovial tissues of big joints. To date, there are ∼52 cases of PVNS affecting the temporomandibular joint reported in the English-language literature, about one-third of them ...

Last Updated: 11 Feb 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Diffuse-type Giant Cell Tumor; Tenosynovial Giant Cell Tumor

 

Last Updated: 23 Jan 2014

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MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS)
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; PVNS

 

Last Updated: 27 May 2014

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Safety Study of PLX108-01 in Patients With Solid Tumors
 

Status: Recruiting

Condition Summary: At This Time, All Cohorts Are Closed to Enrollment With the Exception of the Pigmented Villo-nodular Synovitis (PVNS) Cohort.

 

Last Updated: 9 Sep 2013

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