Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 68 free, full-text research articles on human participants. First 3 results:

Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis.
 

Author(s): Takehiro Ota, Hiroshi Urakawa, Eiji Kozawa, Kunihiro Ikuta, Shunsuke Hamada, Satoshi Tsukushi, Yoshie Shimoyama, Naoki Ishiguro, Yoshihiro Nishida

Journal: Tumour Biol.. 2015 Jul;36(7):5361-7.

 

Pigmented villonodular synovitis (PVNS) is a benign, translocation-derived neoplasm. Because of its high local recurrence rate after surgery and occurrence of osteochondral destruction, a novel therapeutic target is required. The present study aimed to evaluate the significance of ...

Last Updated: 28 Jul 2015

Go To URL
Localized form of pigmented villonodular synovitis of the knee: the meniscal mime.
 

Author(s): N Bouguennec, A Meyer, N Graveleau

Journal: Orthop Traumatol Surg Res. 2014 Apr;100(2):251-4.

 

The localized form of pigmented villonodular synovitis of the knee is a rare condition with non-specific symptoms. This makes diagnosis especially difficult when the meniscus is affected. A full assessment with several imaging modalities can help support the preoperative diagnosis. ...

Last Updated: 25 Mar 2014

Go To URL
[Pigmented Villonodular Synovitis: a diagnostic challenge. Review of 28 cases].
 

Author(s): M Coutinho, A Laranjo, J Casanova

Journal: Acta Reumatol Port. ;37(4):335-41.

 

Pigmented Villonodular Synovitis (PVNS) is a benign and uncommon clinical entity, characterized by excessive proliferation of synovial membrane of joints, tendon sheaths and bursas. The objective of this study was to evaluate demographic and clinical parameters, diagnostic and treatment ...

Last Updated: 15 Oct 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 6 free, full-text review articles on human participants. First 3 results:

Review article: Open versus arthroscopic synovectomy for pigmented villonodular synovitis of the knee.
 

Author(s): E Carlos Rodriguez-Merchan

Journal: J Orthop Surg (Hong Kong). 2014 Dec;22(3):406-8.

 

Studies published in MEDLINE between January 2010 and October 2013 were reviewed to compare open with arthroscopic synovectomy for pigmented villonodular synovitis of the knee in terms of rates of recurrence, complication, and osteoarthritis. 10 studies specifically on this topic ...

Last Updated: 31 Dec 2014

Go To URL
Posterior interosseous nerve palsy secondary to pigmented villonodular synovitis of the elbow: case report and review of literature.
 

Author(s): K Kohyama, H Sugiura, K Yamada, I Hyodo, H Kato, Y Kamei

Journal: Orthop Traumatol Surg Res. 2013 Apr;99(2):247-51.

 

Local tumor compression is the main mechanical cause of posterior interosseous nerve (PIN) palsy. The reported cases of these tumors do not include that of pigmented villonodular synovitis (PVNS). Here, we report a case of a 53-year-old male with a 9-year history of painless swelling ...

Last Updated: 2 Apr 2013

Go To URL
Adult multifocal pigmented villonodular synovitis--clinical review.
 

Author(s): Paul Botez, Paul Dan Sirbu, Carmen Grierosu, Dan Mihailescu, Liliana Savin, Marius M Scarlat

Journal: Int Orthop. 2013 Apr;37(4):729-33.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disease of the synovial tissue that affects a single joint or a tendon sheath. Data from the literature present only a few cases of multifocal PVNS. This paper presents multifocal PVNS in the adult. This disease ...

Last Updated: 28 Mar 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Giant Cell Tumors of the Tendon Sheath; Tenosynovial Giant Cell Tumour

 

Last Updated: 18 Jan 2016

Go to URL
MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; PVNS; Giant Cell Tumor of the Tendon Sheath; GCCTS; Tenosynovial Giant Cell Tumor (Localized or Diffused Type)

 

Last Updated: 6 Jan 2016

Go to URL
Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Tumor

 

Last Updated: 1 Feb 2016

Go to URL