Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 74 free, full-text research articles on human participants. First 3 results:

Pigmented villonodular synovitis of the elbow with rdial, median and ulnar nerve compression.
 

Author(s): Hui Lu, Qiang Chen, Hui Shen

Journal:

 

Pigmented villonodular synovitis (PVNS) is a rare, idiopathic proliferative disorder of the synovium. While, PVNS of elbow is extremely rare. We report an 82-year-old female patient with 20-year-history of gradually increased PVNS in her left elbow. The multiple masses were located ...

Last Updated: 29 Jan 2016

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Surgical treatment of diffuse pigmented villonodular synovitis of the knee.
 

Author(s): Bo Yang, Duan Liu, Jin Lin, Jin Jin, Xi-sheng Weng, Wen-wei Qian, Jun Qian

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Apr;37(2):234-9.

 

To compare the roles of open synovectomy and arthroscopic synovectomy in the treatment of diffuse pigmented villonodular synovitis (D-PVNS).

Last Updated: 4 May 2015

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Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis.
 

Author(s): Takehiro Ota, Hiroshi Urakawa, Eiji Kozawa, Kunihiro Ikuta, Shunsuke Hamada, Satoshi Tsukushi, Yoshie Shimoyama, Naoki Ishiguro, Yoshihiro Nishida

Journal: Tumour Biol.. 2015 Jul;36(7):5361-7.

 

Pigmented villonodular synovitis (PVNS) is a benign, translocation-derived neoplasm. Because of its high local recurrence rate after surgery and occurrence of osteochondral destruction, a novel therapeutic target is required. The present study aimed to evaluate the significance of ...

Last Updated: 28 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 7 free, full-text review articles on human participants. First 3 results:

MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review.
 

Author(s): Samuel J Lynskey, Marcus J Pianta

Journal: Br J Radiol. 2015 ;88(1056):20150528.

 

The purpose of this study was to characterize the MRI and thallium-201 ((201)TI) scintigraphy attributes of pigmented villonodular synovitis (PVNS) and giant cell tumours of tendon sheaths (GCTTS). The epidemiology of these uncommon lesions was also assessed and less commonly encountered ...

Last Updated: 20 Nov 2015

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Review article: Open versus arthroscopic synovectomy for pigmented villonodular synovitis of the knee.
 

Author(s): E Carlos Rodriguez-Merchan

Journal: J Orthop Surg (Hong Kong). 2014 Dec;22(3):406-8.

 

Studies published in MEDLINE between January 2010 and October 2013 were reviewed to compare open with arthroscopic synovectomy for pigmented villonodular synovitis of the knee in terms of rates of recurrence, complication, and osteoarthritis. 10 studies specifically on this topic ...

Last Updated: 31 Dec 2014

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Posterior interosseous nerve palsy secondary to pigmented villonodular synovitis of the elbow: case report and review of literature.
 

Author(s): K Kohyama, H Sugiura, K Yamada, I Hyodo, H Kato, Y Kamei

Journal: Orthop Traumatol Surg Res. 2013 Apr;99(2):247-51.

 

Local tumor compression is the main mechanical cause of posterior interosseous nerve (PIN) palsy. The reported cases of these tumors do not include that of pigmented villonodular synovitis (PVNS). Here, we report a case of a 53-year-old male with a 9-year history of painless swelling ...

Last Updated: 2 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Tumor

 

Last Updated: 13 Sep 2016

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MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; PVNS; Giant Cell Tumor of the Tendon Sheath; GCCTS; Tenosynovial Giant Cell Tumor (Localized or Diffused Type)

 

Last Updated: 6 Jul 2016

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A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Solid Tumors; Tenosynovial Giant Cell Tumor; Synovitis, Pigmented Villonodular

 

Last Updated: 21 Nov 2016

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