Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 64 free, full-text research articles on human participants. First 3 results:

Localized pigmented villonodular synovitis in a child knee.
 

Author(s): O Şahap Atik, Hasan Hüseyin Bozkurt, Efkan Özcan, Batuhan Bahadır, Murat Uçar, Betül Öğüt, Leyla Memiş

Journal: Eklem Hastalik Cerrahisi. 2017 Apr;28(1):46-9.

 

Pigmented villonodular synovitis is a benign proliferative tumor of the synovium. It is very rare, and most cases occur in the knee joint. In this article, we report a case of localized pigmented villonodular synovitis in the knee joint of a 14-year-old boy. This condition is rare ...

Last Updated: 31 Dec 1969

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Multifocal pigmented villonodular synovitis in a child: A case report.
 

Author(s): Liang Zhao, Kaiyu Zhou, Yimin Hua, Yifei Li, Dezhi Mu

Journal: Medicine (Baltimore). 2016 Aug;95(33):e4572.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. Multifocal PVNS is very rare, particularly in childhood. We reported a rare case of multifocal PVNS affecting over ...

Last Updated: 31 Dec 1969

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Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis.
 

Author(s): Tahsin Beyzadeoğlu, Esra Çirci

Journal: Acta Orthop Traumatol Turc. 2016 ;50(3):379-81.

 

We report a 24-year-old male who was admitted to the emergency department with an unusual complaint of locked hip joint. Magnetic resonance imaging (MRI) showed a 3-cm intra-articular synovial nodular mass and a 3.0x2.4x1.6-cm yellow-brownish colored pediculed synovial nodular mass ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 9 free, full-text review articles on human participants. First 3 results:

Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review.
 

Author(s): Yanfang Duan, Jing Qian, Kun Chen, Zhuo Zhang

Journal: Medicine (Baltimore). 2018 Jan;97(3):e9637.

 

Pigmented villonodular synovitis (PVNS) is an idiopathic, proliferative disorder lesion of synovial tissue, which is regarded as a benign disease, but has a local invasion. Up to now, these are no consensus about the etiology and pathogenesis of PVNS. Because of the lack of typical ...

Last Updated: 31 Dec 1969

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Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review.
 

Author(s): Mingxuan Gao, Hong Li, Xiaoyan Liang, Xiaoyan Fu, Xusheng Li

Journal:

 

Pigmented villonodular synovitis (PVNS) is an uncommon entity of proliferative lesion of the synovium, presenting with different clinical signs and symptoms. PVNS rarely forms an osteolytic lesion in a bone. Here we report a unique case of PVNS with a nodular lesion in the left patella.

Last Updated: 31 Dec 1969

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Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis).
 

Author(s): F Gouin, T Noailles

Journal: Orthop Traumatol Surg Res. 2017 Feb;103(1S):S91-S97.

 

Tenosynovial giant cell tumor (TSGCT) is a rare benign tumor arising from joint synovia, bursae and tendon sheaths. Their variable clinical presentation is related to variations in site and progression. Localized forms are most frequent in the hands, and diffuse forms in the knee. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Tumor

 

Last Updated: 24 Oct 2017

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Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project
 

Status: Recruiting

Condition Summary: Giant Cell Tumors

 

Last Updated: 28 Nov 2017

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Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)
 

Status: Recruiting

Condition Summary: Drug Interaction Potential

 

Last Updated: 29 Mar 2018

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