Pigmented villonodular synovitis

Common Name(s)

Pigmented villonodular synovitis

Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pigmented villonodular synovitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pigmented villonodular synovitis" returned 71 free, full-text research articles on human participants. First 3 results:

Localized pigmented villonodular synovitis in a child knee.
 

Author(s): O Şahap Atik, Hasan Hüseyin Bozkurt, Efkan Özcan, Batuhan Bahadır, Murat Uçar, Betül Öğüt, Leyla Memiş

Journal: Eklem Hastalik Cerrahisi. 2017 Apr;28(1):46-9.

 

Pigmented villonodular synovitis is a benign proliferative tumor of the synovium. It is very rare, and most cases occur in the knee joint. In this article, we report a case of localized pigmented villonodular synovitis in the knee joint of a 14-year-old boy. This condition is rare ...

Last Updated: 14 Mar 2017

Go To URL
Multifocal pigmented villonodular synovitis in a child: A case report.
 

Author(s): Liang Zhao, Kaiyu Zhou, Yimin Hua, Yifei Li, Dezhi Mu

Journal: Medicine (Baltimore). 2016 Aug;95(33):e4572.

 

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. Multifocal PVNS is very rare, particularly in childhood. We reported a rare case of multifocal PVNS affecting over ...

Last Updated: 19 Aug 2016

Go To URL
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis.
 

Author(s): Tahsin Beyzadeoğlu, Esra Çirci

Journal: Acta Orthop Traumatol Turc. 2016 ;50(3):379-81.

 

We report a 24-year-old male who was admitted to the emergency department with an unusual complaint of locked hip joint. Magnetic resonance imaging (MRI) showed a 3-cm intra-articular synovial nodular mass and a 3.0x2.4x1.6-cm yellow-brownish colored pediculed synovial nodular mass ...

Last Updated: 30 Apr 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pigmented villonodular synovitis" returned 8 free, full-text review articles on human participants. First 3 results:

[Pigmented villonodular synovitis. A rare differential diagnosis of synovial joint swelling].
 

Author(s): K A Jendrissek, T Hotfiel, B Swoboda, S Söder, R Janka

Journal: Z Rheumatol. 2016 Mar;75(2):157-65.

 

Pigmented villonodular synovitis (PVNS) describes a rare disease caused by an abnormal proliferation of the synovial membrane in large and small joints. In order to achieve an optimal result of treatment it is necessary to carry out specific diagnostics and a targeted therapy approach.

Last Updated: 14 Mar 2016

Go To URL
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review.
 

Author(s): Samuel J Lynskey, Marcus J Pianta

Journal: Br J Radiol. 2015 ;88(1056):20150528.

 

The purpose of this study was to characterize the MRI and thallium-201 ((201)TI) scintigraphy attributes of pigmented villonodular synovitis (PVNS) and giant cell tumours of tendon sheaths (GCTTS). The epidemiology of these uncommon lesions was also assessed and less commonly encountered ...

Last Updated: 20 Nov 2015

Go To URL
Review article: Open versus arthroscopic synovectomy for pigmented villonodular synovitis of the knee.
 

Author(s): E Carlos Rodriguez-Merchan

Journal: J Orthop Surg (Hong Kong). 2014 Dec;22(3):406-8.

 

Studies published in MEDLINE between January 2010 and October 2013 were reviewed to compare open with arthroscopic synovectomy for pigmented villonodular synovitis of the knee in terms of rates of recurrence, complication, and osteoarthritis. 10 studies specifically on this topic ...

Last Updated: 31 Dec 2014

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Tumor

 

Last Updated: 13 Sep 2016

Go to URL
MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)
 

Status: Recruiting

Condition Summary: Pigmented Villonodular Synovitis; PVNS; Giant Cell Tumor of the Tendon Sheath; GCCTS; Tenosynovial Giant Cell Tumor Localized or Diffused Type; GCTS

 

Last Updated: 3 May 2017

Go to URL
A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor
 

Status: Recruiting

Condition Summary: Solid Tumors; Tenosynovial Giant Cell Tumor; Synovitis, Pigmented Villonodular

 

Last Updated: 25 Apr 2017

Go to URL