Pick's Disease

Common Name(s)

Pick's Disease, Pick disease of the brain

Pick disease refers to the neuropathologic finding of 'Pick bodies,' which are argyrophilic, intraneuronal inclusions, and 'Pick cells,' which are enlarged neurons. The clinical correlates of Pick disease of brain include those of frontotemporal dementia, which encompass the behavioral variant of FTD, semantic dementia, and progressive nonfluent aphasia (summary by {19:Piguet et al., 2011}). {11:Kertesz (2003)} suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy ({601104}), and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pick's Disease" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Dementias (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 25 Oct 2012

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pick's Disease" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Dementias (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.ftd-picks.org

Last Updated: 25 Oct 2012

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pick's Disease" returned 21 free, full-text research articles on human participants. First 3 results:

Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain.
 

Author(s): Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poon

Journal:

 

Although the risk factor for apolipoprotein E (apoE) polymorphism in Alzheimer's disease (AD) has been well described, the role that apoE plays in other neurodegenerative diseases, including Pick's disease, is not well established. To examine a possible role of apoE in Pick's disease, ...

Last Updated: 6 Dec 2013

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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
 

Author(s): Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L Miller, Gil D Rabinovici, Eric J Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W Seeley, Maria Luisa Gorno-Tempini

Journal: Behav Neurol. 2013 ;26(1-2):95-106.

 

The role of biomarkers in predicting pathological findings in the frontotemporal dementia (FTD) clinical spectrum disorders is still being explored. We present comprehensive, prospective longitudinal data for a 66 year old, right-handed female who met current criteria for the nonfluent/agrammatic ...

Last Updated: 28 Nov 2012

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Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease.
 

Author(s): Yazi D Ke, Yazi Ke, Joe Dramiga, Ulrich Schütz, Jillian J Kril, Lars M Ittner, Hannsjörg Schröder, Jürgen Götz

Journal: PLoS ONE. 2012 ;7(4):e35678.

 

Tau dysfunction characterizes neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Here, we performed an unbiased SAGE (serial analysis of gene expression) of differentially expressed mRNAs in the amygdala of transgenic pR5 mice ...

Last Updated: 4 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pick's Disease" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1
 

Status: Recruiting

Condition Summary: Neimann-Pick Disease

 

Last Updated: 15 Aug 2014

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Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
 

Status: Recruiting

Condition Summary: Neimann-Pick Disease, Type C

 

Last Updated: 17 Sep 2014

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Language in Primary Progressive Aphasia
 

Status: Recruiting

Condition Summary: Primary Progressive Aphasia

 

Last Updated: 22 Jul 2014

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