Pick's Disease

Common Name(s)

Pick's Disease, Pick disease of the brain

Pick disease refers to the neuropathologic finding of 'Pick bodies,' which are argyrophilic, intraneuronal inclusions, and 'Pick cells,' which are enlarged neurons. The clinical correlates of Pick disease of brain include those of frontotemporal dementia, which encompass the behavioral variant of FTD, semantic dementia, and progressive nonfluent aphasia (summary by {19:Piguet et al., 2011}). {11:Kertesz (2003)} suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy ({601104}), and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pick's Disease" for support, advocacy or research.

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pick's Disease" for support, advocacy or research.

Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pick's Disease" returned 30 free, full-text research articles on human participants. First 3 results:

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.
 

Author(s): Edward Rockenstein, Cassia R Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquert, Margarita Trejo-Morales, Brian Spencer, Eliezer Masliah

Journal:

 

Tauopathies are a group of disorders leading to cognitive and behavioral impairment in the aging population. While four-repeat (4R) Tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and Alzheimer's disease, three-repeat (3R) Tau is the most abundant ...

Last Updated: 25 Mar 2015

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Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain.
 

Author(s): Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poon

Journal:

 

Although the risk factor for apolipoprotein E (apoE) polymorphism in Alzheimer's disease (AD) has been well described, the role that apoE plays in other neurodegenerative diseases, including Pick's disease, is not well established. To examine a possible role of apoE in Pick's disease, ...

Last Updated: 6 Dec 2013

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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
 

Author(s): Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L Miller, Gil D Rabinovici, Eric J Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W Seeley, Maria Luisa Gorno-Tempini

Journal: Behav Neurol. 2013 ;26(1-2):95-106.

 

The role of biomarkers in predicting pathological findings in the frontotemporal dementia (FTD) clinical spectrum disorders is still being explored. We present comprehensive, prospective longitudinal data for a 66 year old, right-handed female who met current criteria for the nonfluent/agrammatic ...

Last Updated: 28 Nov 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pick's Disease" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1
 

Status: Recruiting

Condition Summary: Neimann-Pick Disease

 

Last Updated: 15 Jan 2016

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Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
 

Status: Recruiting

Condition Summary: Neimann-Pick Disease, Type C

 

Last Updated: 12 Sep 2015

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A Prospective Non-therapeutic Study in Patients Diagnosed With Niemann-Pick Disease Type C
 

Status: Recruiting

Condition Summary: Niemann-Pick Disease, Type C

 

Last Updated: 15 Feb 2016

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