Pheochromocytoma

Common Name(s)

Pheochromocytoma, Adrenal gland tumor

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

http://www.pheo-para-alliance.org

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 693 free, full-text research articles on human participants. First 3 results:

Pheochromocytoma crisis with severe cyclic blood pressure fluctuations in a cardiac pheochromocytoma patient successfully resuscitated by extracorporeal membrane oxygenation: a case report.
 

Author(s): Xiang Zhou, Dawei Liu, Longxiang Su, Yun Long, Wei Du, Qi Miao, Fang Li, Zhengyu Jin, Zhengpei Zeng, Ailun Luo, Yuguang Huang

Journal: Medicine (Baltimore). 2015 May;94(17):e790.

 

Cardiac pheochromocytoma is relatively rare. Few reports describe the intraoperative and postoperative progression of patients experiencing a life-threatening pheochromocytoma crisis treated with extracorporeal membrane oxygenation (ECMO).A 35-year-old man was referred to our facility ...

Last Updated: 1 May 2015

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Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.
 

Author(s): Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu, Shirley ShiDu Yan

Journal:

 

17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting conditions leads to recovery of a homeostatic state. Across disease states, increased HSD10 levels can have a profound ...

Last Updated: 17 Apr 2015

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Expression of the pituitary tumor transforming gene (PTTG1) in pheochromocytoma as a potential marker for distinguishing benign versus malignant tumors.
 

Author(s): Mohamad Reza Haji Amousha, Nastaran Sabetkish, Nastaran Sabet Kish, Ramin Heshmat, Afsaneh Rajabiani, Hiva Saffar, Vahid Haghpanah, Seyed Mohammad Tavangar

Journal: Acta Med Iran. 2015 ;53(4):236-41.

 

The Distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. To date, the only reliable criterion is metastasis. The aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene ...

Last Updated: 15 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 89 free, full-text review articles on human participants. First 3 results:

A probabilistic assessment of the diagnosis of paraganglioma/pheochromocytoma based on clinical criteria and biochemical/imaging findings.
 

Author(s): Ioannis Ilias, Georgios Meristoudis, Athanasios Notopoulos

Journal: Hell J Nucl Med. ;18(1):63-5.

 

Paragangliomas (PGL) and pheochromocytomas (P) are rare neural-crest-derived neoplasms. Very recently guidelines on diagnosis and treatment of PGL/P have been presented by the US Endocrine Society. In the following overview we assessed the implementation of these guidelines with probabilistic ...

Last Updated: 4 Apr 2015

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Pheochromocytoma-induced atrial tachycardia leading to cardiogenic shock and cardiac arrest: resolution with atrioventricular node ablation and pacemaker placement.
 

Author(s): Hassan Shawa, Mandeep Bajaj, Glenn R Cunningham

Journal:

 

Pheochromocytoma should be considered in young patients who have acute cardiac decompensation, even if they have no history of hypertension. Atrioventricular node ablation and pacemaker placement should be considered for stabilizing pheochromocytoma patients with cardiogenic shock ...

Last Updated: 16 Jan 2015

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Laboratory evaluation of pheochromocytoma and paraganglioma.
 

Author(s): Graeme Eisenhofer, Mirko Peitzsch

Journal: Clin. Chem.. 2014 Dec;60(12):1486-99.

 

Pheochromocytomas and paragangliomas (PPGLs) are potentially lethal yet usually surgically curable causes of endocrine hypertension; therefore, once clinical suspicion is aroused it is imperative that clinicians choose the most appropriate laboratory tests to identify the tumors.

Last Updated: 29 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 14 Jul 2015

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Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 23 Jan 2016

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Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 23 Dec 2014

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