Pheochromocytoma

Common Name(s)

Pheochromocytoma, Adrenal gland tumor

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

http://www.pheo-para-alliance.org

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 517 free, full-text research articles on human participants. First 3 results:

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.
 

Author(s): Jean-Pierre Bayley, Rogier A Oldenburg, Jennifer Nuk, Attje S Hoekstra, Conny A van der Meer, Esther Korpershoek, Barbara McGillivray, Eleonora P M Corssmit, Winand N M Dinjens, Ronald R de Krijger, Peter Devilee, Jeroen C Jansen, Frederik J Hes

Journal:

 

The SDHD gene encodes a subunit of the mitochondrial tricarboxylic acid cycle enzyme and tumor suppressor, succinate dehydrogenase. Mutations in this gene show a remarkable pattern of parent-of-origin related tumorigenesis, with almost all SDHD-related cases of head and neck paragangliomas ...

Last Updated: 13 Oct 2014

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In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma.
 

Author(s): Martin Ullrich, Ralf Bergmann, Mirko Peitzsch, Marc Cartellieri, Nan Qin, Monika Ehrhart-Bornstein, Norman L Block, Andrew V Schally, Jens Pietzsch, Graeme Eisenhofer, Stefan R Bornstein, Christian G Ziegler

Journal: Endocrinology. 2014 Nov;155(11):4149-56.

 

Pheochromocytoma (PHEO) is a rare but potentially lethal neuroendocrine tumor arising from catecholamine-producing chromaffin cells. Especially for metastatic PHEO, the availability of animal models is essential for developing novel therapies. For evaluating therapeutic outcome in ...

Last Updated: 18 Oct 2014

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Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.
 

Author(s): Stephanie M J Fliedner, Tobias Engel, Nikoletta K Lendvai, Uma Shankavaram, Svenja Nölting, Robert Wesley, Abdel G Elkahloun, Hendrik Ungefroren, Angela Oldoerp, Gary Lampert, Hendrik Lehnert, Henri Timmers, Karel Pacak

Journal:

 

To date, malignant pheochromocytomas and paragangliomas (PHEOs/PGLs) cannot be effectively cured and thus novel treatment strategies are urgently needed. Lovastatin has been shown to effectively induce apoptosis in mouse PHEO cells (MPC) and the more aggressive mouse tumor tissue-derived ...

Last Updated: 21 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 73 free, full-text review articles on human participants. First 3 results:

HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors.
 

Author(s): I Jochmanová, T Zelinka, J Widimský, K Pacak

Journal: Physiol Res. 2014 ;63 Suppl 2():S251-62.

 

Hypoxia-inducible factors (HIFs) are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to tumorigenesis and cancer progression. Recent findings revealed the important role of HIFs in the pathogenesis ...

Last Updated: 9 Jun 2014

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Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment.
 

Author(s): Victoria L Martucci, Karel Pacak

Journal: Curr Probl Cancer. ;38(1):7-41.

 

Last Updated: 18 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 18 Mar 2013

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Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 20 Feb 2015

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RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
 

Status: Recruiting

Condition Summary: Pheochromocytoma; Extra-Adrenal Paraganglioma; Non-functioning Carcinoid

 

Last Updated: 28 Jun 2010

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