Pheochromocytoma

Common Name(s)

Pheochromocytoma, Adrenal gland tumor

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

http://www.pheo-para-alliance.org

Last Updated: 10 Feb 2015

View Details
VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 536 free, full-text research articles on human participants. First 3 results:

[Pheochromocytoma during pregnancy: a diagnosis not to be missed].
 

Author(s): Chaouki Mrazguia, Sana Ghades, Mahira Regaieg, Nahed Khelifa, Sawssem Armi, Abedlaziz Falfoul

Journal: Tunis Med. 2014 Jun;92(6):422.

 

Last Updated: 6 Mar 2015

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Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort.
 

Author(s): Judit Dénes, Francesca Swords, Eleanor Rattenberry, Karen Stals, Martina Owens, Treena Cranston, Paraskevi Xekouki, Linda Moran, Ajith Kumar, Christopher Wassif, Naomi Fersht, Stephanie E Baldeweg, Damian Morris, Stafford Lightman, Amar Agha, Aled Rees, Joan Grieve, Michael Powell, Cesar Luiz Boguszewski, Pinaki Dutta, Rajesh V Thakker, Umasuthan Srirangalingam, Chris J Thompson, Maralyn Druce, Claire Higham, Julian Davis, Rosalind Eeles, Mark Stevenson, Brendan O'Sullivan, Phillipe Taniere, Kassiani Skordilis, Plamena Gabrovska, Anne Barlier, Susan M Webb, Anna Aulinas, William M Drake, John S Bevan, Cristina Preda, Nadezhda Dalantaeva, Antônio Ribeiro-Oliveira, Isabel Tena Garcia, Galina Yordanova, Violeta Iotova, Jane Evanson, Ashley B Grossman, Jacqueline Trouillas, Sian Ellard, Constantine A Stratakis, Eamonn R Maher, Federico Roncaroli, Márta Korbonits

Journal: J. Clin. Endocrinol. Metab.. 2015 Mar;100(3):E531-41.

 

Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or in the same family. Coexistence of the two diseases could be due to either a common pathogenic mechanism or a coincidence.

Last Updated: 21 Feb 2015

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Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.
 

Author(s): Jean-Pierre Bayley, Rogier A Oldenburg, Jennifer Nuk, Attje S Hoekstra, Conny A van der Meer, Esther Korpershoek, Barbara McGillivray, Eleonora P M Corssmit, Winand N M Dinjens, Ronald R de Krijger, Peter Devilee, Jeroen C Jansen, Frederik J Hes

Journal:

 

The SDHD gene encodes a subunit of the mitochondrial tricarboxylic acid cycle enzyme and tumor suppressor, succinate dehydrogenase. Mutations in this gene show a remarkable pattern of parent-of-origin related tumorigenesis, with almost all SDHD-related cases of head and neck paragangliomas ...

Last Updated: 13 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 72 free, full-text review articles on human participants. First 3 results:

A case of (123)I-MIBG scintigram-negative functioning pheochromocytoma: immunohistochemical and molecular analysis with review of literature.
 

Author(s): Aiko Kurisaki-Arakawa, Tsuyoshi Saito, Michiko Takahashi, Keiko Mitani, Takashi Yao

Journal:

 

A 70-year-old Japanese woman was referred to our hospital due to hyperhidrosis and rapid weight loss of 10 kg in a month. A lump measuring 26 mm in diameter was detected in the left adrenal gland by computed tomography. Biochemical tests showed high levels of serum and urinary norepinephrine ...

Last Updated: 14 Aug 2014

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HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors.
 

Author(s): I Jochmanová, T Zelinka, J Widimský, K Pacak

Journal: Physiol Res. 2014 ;63 Suppl 2():S251-62.

 

Hypoxia-inducible factors (HIFs) are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to tumorigenesis and cancer progression. Recent findings revealed the important role of HIFs in the pathogenesis ...

Last Updated: 9 Jun 2014

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Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 18 Mar 2013

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Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 26 Feb 2015

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Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 23 Dec 2014

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