Pheochromocytoma

Common Name(s)

Pheochromocytoma

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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VHL Family Alliance

Dedicated to improving diagnosis, treatment, and life quality for individuals and families affected by von Hippel-Lindau disease and funding research to uncover a cure.

Last Updated: 15 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
VHL Family Alliance

Dedicated to improving diagnosis, treatment, and life quality for individuals and families affected by von Hippel-Lindau disease and funding research to uncover a cure.

http://www.vhl.org

Last Updated: 15 Oct 2012

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 542 free, full-text research articles on human participants. First 3 results:

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.
 

Author(s): Jean-Pierre Bayley, Rogier A Oldenburg, Jennifer Nuk, Attje S Hoekstra, Conny A van der Meer, Esther Korpershoek, Barbara McGillivray, Eleonora P M Corssmit, Winand N M Dinjens, Ronald R de Krijger, Peter Devilee, Jeroen C Jansen, Frederik J Hes

Journal:

 

The SDHD gene encodes a subunit of the mitochondrial tricarboxylic acid cycle enzyme and tumor suppressor, succinate dehydrogenase. Mutations in this gene show a remarkable pattern of parent-of-origin related tumorigenesis, with almost all SDHD-related cases of head and neck paragangliomas ...

Last Updated: 13 Oct 2014

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Lack of correlations among histopathological parameters, Ki-67 proliferation index and prognosis in pheochromocytoma patients.
 

Author(s): Irfan Ocal, Arzu Avci, Fulya Cakalagaoglu, Huseyin Can

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(4):1751-5.

 

In this study prognostic correlations of histopathologic parameters and the Ki-67 proliferation index and as well as the diagnostic value of immunohistochemical markers in pheochromocytomas were evaluated.

Last Updated: 19 Mar 2014

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Characterization and plasma measurement of the WE-14 peptide in patients with pheochromocytoma.
 

Author(s): Johann Guillemot, Marlène Guérin, Erwan Thouënnon, Maité Montéro-Hadjadje, Jérôme Leprince, Hervé Lefebvre, Marc Klein, Mihaela Muresan, Youssef Anouar, Laurent Yon

Journal:

 

Granins and their derived peptides are valuable circulating biological markers of neuroendocrine tumors. The aim of the present study was to investigate the tumoral chromogranin A (CgA)-derived peptide WE-14 and the potential advantage to combine plasma WE-14 detection with the EM66 ...

Last Updated: 13 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 71 free, full-text review articles on human participants. First 3 results:

Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.
 

Author(s): Ivana Jochmanová, Chunzhang Yang, Zhengping Zhuang, Karel Pacak

Journal: J. Natl. Cancer Inst.. 2013 Sep;105(17):1270-83.

 

Many solid tumors, including pheochromocytoma (PHEO) and paraganglioma (PGL), are characterized by a (pseudo)hypoxic signature. (Pseudo)hypoxia has been shown to promote both tumor progression and resistance to therapy. The major mediators of the transcriptional hypoxic response are ...

Last Updated: 4 Sep 2013

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Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review.
 

Author(s): V Rufini, G Treglia, P Castaldi, G Perotti, A Giordano

Journal: Q J Nucl Med Mol Imaging. 2013 Jun;57(2):122-33.

 

The aim of this paper was to systematically review published data about the comparison of radiolabelled metaiodobenzylguanidine (MIBG) scintigraphy and positron emission tomography (PET) with different radiopharmaceuticals in patients with pheochromocytoma and paraganglioma (Pheo/PGL).

Last Updated: 4 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 4 Nov 2014

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Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 18 Mar 2013

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RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
 

Status: Recruiting

Condition Summary: Pheochromocytoma; Extra-Adrenal Paraganglioma; Non-functioning Carcinoid

 

Last Updated: 28 Jun 2010

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