Periventricular leukomalacia

Common Name(s)

Periventricular leukomalacia, Periventricular Leukomylasia

Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periventricular leukomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periventricular leukomalacia" returned 77 free, full-text research articles on human participants. First 3 results:

Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia.
 

Author(s): Karina J Kersbergen, Linda S de Vries, Floris Groenendaal, Ingrid C van Haastert, Andrew T M Chew, Antonios Makropoulos, Sarah L Dawson, Frances M Cowan, Manon J N L Benders, Serena J Counsell

Journal: J. Pediatr.. 2015 Aug;167(2):260-8.e3.

 

To measure both fractional anisotropy (FA) values in the corticospinal tracts (CSTs) and volume of the thalami in preterm infants with cystic periventricular leukomalacia (c-PVL) and to compare these measurements with control infants.

Last Updated: 27 Jul 2015

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Scoring system for periventricular leukomalacia in infants with congenital heart disease.
 

Author(s): Ann L McCarthy, Madeline E Winters, David R Busch, Ernesto Gonzalez-Giraldo, Tiffany S Ko, Jennifer M Lynch, Peter J Schwab, Rui Xiao, Erin M Buckley, Arastoo Vossough, Daniel J Licht

Journal: Pediatr. Res.. 2015 Sep;78(3):304-9.

 

Currently two magnetic resonance imaging (MRI) methods have been used to assess periventricular leukomalacia (PVL) severity in infants with congenital heart disease: manual volumetric lesion segmentation and an observational categorical scale. Volumetric classification is labor intensive ...

Last Updated: 18 Aug 2015

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Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia.
 

Author(s): R Z Huang, Y J Zhang, J F Zhang, Y M Su, L Q Peng, N Ya

Journal:

 

This study aims to explore the relation between changes in myelin basic protein (MBP) and S100 protein (S100B) serum levels and prognosis in premature infants with periventricular leukomalacia (PVL). In our hospital, 78 premature infants with PVL and 43 normal premature infants were ...

Last Updated: 13 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periventricular leukomalacia" returned 3 free, full-text review articles on human participants. First 3 results:

Periventricular leukomalacia - fungal mimicker in newborn brain: a case report with review of literature.
 

Author(s): Kirti Gupta, Nidhi Sharma, Venkataseshan Sundaram, Rakesh Kumar Vasishta, Nandita Kakkar

Journal: Neurol India. ;58(6):951-3.

 

Last Updated: 14 Dec 2010

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Progress in periventricular leukomalacia.
 

Author(s): Wenbin Deng, Jeanette Pleasure, David Pleasure

Journal: Arch. Neurol.. 2008 Oct;65(10):1291-5.

 

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants who survive to demonstrate these neurologic deficts is increasing. Magnetic ...

Last Updated: 14 Oct 2008

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White-matter disease of prematurity, periventricular leukomalacia, and ischemic lesions.
 

Author(s): K C Kuban

Journal: Dev Med Child Neurol. 1998 Aug;40(8):571-3.

 

Last Updated: 8 Oct 1998

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Randomized Trial of Maternal Progesterone Therapy
 

Status: Recruiting

Condition Summary: Congenital Heart Disease; Periventricular Leucomalacia; Brain Development; Cardiac Surgery; Neurodevelopmental Disability; Fetal Neuroprotection

 

Last Updated: 7 Sep 2016

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Prediction of Brain Injury in Premature Infants
 

Status: Recruiting

Condition Summary: Intraventricular Hemorrhage; Periventricular Leukomalacia; Brain Injury; Extreme Prematurity

 

Last Updated: 23 Jun 2016

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Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
 

Status: Recruiting

Condition Summary: Intraventricular Hemorrhage; Periventricular Leukomalacia; Brain Injury; Renal Injury

 

Last Updated: 19 Aug 2014

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