Periventricular leukomalacia

Common Name(s)

Periventricular leukomalacia, Periventricular Leukomylasia

Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periventricular leukomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periventricular leukomalacia" returned 52 free, full-text research articles on human participants. First 3 results:

Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis.
 

Author(s): María Luisa García-Gomar, Efraín Santiago-Rodríguez, Mario Rodríguez-Camacho, Thalía Harmony

Journal:

 

Periventricular Leukomalacia (PVL) affects white matter, but grey matter injuries have also been reported, particularly in the dorsomedial nucleus and the cortex. Both structures have been related to working memory (WM) processes. The aim of this study was to compare behavioral performances ...

Last Updated: 7 Aug 2013

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Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related.
 

Author(s): Donna A Goff, David M Shera, Stephen Tang, Natasha A Lavin, Susan M Durning, Susan C Nicolson, Lisa M Montenegro, Jonathan J Rome, J William Gaynor, Thomas L Spray, Arastoo Vossough, Daniel J Licht

Journal: J. Thorac. Cardiovasc. Surg.. 2014 Apr;147(4):1312-8.

 

Preoperative brain injury is common in neonates with complex congenital heart disease. Increasing evidence suggests a complex interaction of prenatal and postnatal risk factors for development of brain white matter injury, called periventricular leukomalacia (PVL), in neonates with ...

Last Updated: 17 Mar 2014

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12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
 

Author(s): Robin L Haynes, Klaus van Leyen

Journal: Dev. Neurosci.. 2013 ;35(2-3):140-54.

 

Oxidative stress involving premyelinating oligodendrocytes (OLs) is a major factor in the pathogenesis of preterm white matter injury. In animal and cell culture studies, activation of the lipid-oxidizing enzyme 12/15-lipoxygenase (12/15-LOX) plays a central role as an inflammatory ...

Last Updated: 10 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periventricular leukomalacia" returned 2 free, full-text review articles on human participants. First 3 results:

Periventricular leukomalacia - fungal mimicker in newborn brain: a case report with review of literature.
 

Author(s): Kirti Gupta, Nidhi Sharma, Venkataseshan Sundaram, Rakesh Kumar Vasishta, Nandita Kakkar

Journal: Neurol India. ;58(6):951-3.

 

Last Updated: 14 Dec 2010

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Progress in periventricular leukomalacia.
 

Author(s): Wenbin Deng, Jeanette Pleasure, David Pleasure

Journal: Arch. Neurol.. 2008 Oct;65(10):1291-5.

 

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants who survive to demonstrate these neurologic deficts is increasing. Magnetic ...

Last Updated: 14 Oct 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy
 

Status: Recruiting

Condition Summary: Periventricular Leukomalacia

 

Last Updated: 20 Jan 2015

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Randomized Trial of Maternal Progesterone Therapy
 

Status: Recruiting

Condition Summary: Congenital Heart Disease; Periventricular Leucomalacia; Brain Development; Cardiac Surgery; Neurodevelopmental Disability; Fetal Neuroprotection

 

Last Updated: 2 Feb 2015

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Inhaled Nitric Oxide and Neuroprotection in Premature Infants
 

Status: Recruiting

Condition Summary: Prematurity; Bronchopulmonary Dysplasia; Intraventricular Hemorrhage; Periventricular Leukomalacia

 

Last Updated: 10 Nov 2014

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