Periventricular leukomalacia

Common Name(s)

Periventricular leukomalacia, Periventricular Leukomylasia

Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periventricular leukomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periventricular leukomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periventricular leukomalacia" returned 54 free, full-text research articles on human participants. First 3 results:

Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis.
 

Author(s): María Luisa García-Gomar, Efraín Santiago-Rodríguez, Mario Rodríguez-Camacho, Thalía Harmony

Journal:

 

Periventricular Leukomalacia (PVL) affects white matter, but grey matter injuries have also been reported, particularly in the dorsomedial nucleus and the cortex. Both structures have been related to working memory (WM) processes. The aim of this study was to compare behavioral performances ...

Last Updated: 7 Aug 2013

Go To URL
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
 

Author(s): Robin L Haynes, Klaus van Leyen

Journal: Dev. Neurosci.. 2013 ;35(2-3):140-54.

 

Oxidative stress involving premyelinating oligodendrocytes (OLs) is a major factor in the pathogenesis of preterm white matter injury. In animal and cell culture studies, activation of the lipid-oxidizing enzyme 12/15-lipoxygenase (12/15-LOX) plays a central role as an inflammatory ...

Last Updated: 10 Jul 2013

Go To URL
Application of decision tree in the prediction of periventricular leukomalacia (PVL) occurrence in neonates after heart surgery.
 

Author(s): Ali Jalali, Daniel J Licht, C Nataraj

Journal: Conf Proc IEEE Eng Med Biol Soc. 2012 ;2012():5931-4.

 

This paper is concerned with the prediction of the occurrence of periventricular leukomalacia (PVL) that occurs in neonates after heart surgery. The data which is collected over a period of 12 hours after cardiac surgery contains vital measurements as well as blood gas measurements ...

Last Updated: 31 Jan 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periventricular leukomalacia" returned 2 free, full-text review articles on human participants. First 3 results:

Periventricular leukomalacia - fungal mimicker in newborn brain: a case report with review of literature.
 

Author(s): Kirti Gupta, Nidhi Sharma, Venkataseshan Sundaram, Rakesh Kumar Vasishta, Nandita Kakkar

Journal: Neurol India. ;58(6):951-3.

 

Last Updated: 14 Dec 2010

Go To URL
Progress in periventricular leukomalacia.
 

Author(s): Wenbin Deng, Jeanette Pleasure, David Pleasure

Journal: Arch. Neurol.. 2008 Oct;65(10):1291-5.

 

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants who survive to demonstrate these neurologic deficts is increasing. Magnetic ...

Last Updated: 14 Oct 2008

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Inhaled Nitric Oxide and Neuroprotection in Premature Infants
 

Status: Recruiting

Condition Summary: Prematurity; Bronchopulmonary Dysplasia; Intraventricular Hemorrhage; Periventricular Leukomalacia

 

Last Updated: 27 Mar 2014

Go to URL
Randomized Trial of Maternal Progesterone Therapy
 

Status: Recruiting

Condition Summary: Congenital Heart Disease; Periventricular Leucomalacia; Brain Development; Cardiac Surgery; Neurodevelopmental Disability; Fetal Neuroprotection

 

Last Updated: 21 Jul 2014

Go to URL
Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
 

Status: Recruiting

Condition Summary: Intraventricular Hemorrhage; Periventricular Leukomalacia; Brain Injury; Renal Injury

 

Last Updated: 19 Aug 2014

Go to URL