Periodic Paralysis

Common Name(s)

Periodic Paralysis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

Last Updated: 12 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

http://www.periodicparalysis.org

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

http://hkpp.org

Last Updated: 12 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periodic Paralysis" returned 184 free, full-text research articles on human participants. First 3 results:

A case of thyrotoxic periodic paralysis with respiratory failure in an African American woman.
 

Author(s): Denise L Shields

Journal: Am. J. Crit. Care. 2015 May;24(3):264-7.

 

Thyrotoxic periodic paralysis is an acute endocrine emergency characterized by hyperthyroidism, profound muscle weakness and/or paralysis, and hypokalemia that is not due to potassium deficiency. Typically described in young males of Asian descent, it is becoming increasingly recognized ...

Last Updated: 2 May 2015

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The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis.
 

Author(s): Xiaobing Li, Sheng Yao, Yining Xiang, Xiaolei Zhang, Xiangbing Wu, Laimin Luo, Haihua Huang, Min Zhu, Hui Wan, Daojun Hong

Journal:

 

Thyrotoxic periodic paralysis (TPP) is a life-threatening channelopathy manifesting as recurrent episodes of hypokalemia and muscle weakness in the presence of hyperthyroidism. Recent findings indicate defects of inward rectifying K+ (Kir) channels are associated with some TPP patients. ...

Last Updated: 18 Apr 2015

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Rare KCNJ18 variants do not explain hypokalaemic periodic paralysis in 263 unrelated patients.
 

Author(s): Marius Kuhn, Karin Jurkat-Rott, Frank Lehmann-Horn

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 Jan;87(1):49-52.

 

To examine rare KCNJ18 variations recently reported to cause sporadic and thyrotoxic hypokalaemic periodic paralysis (TPP).

Last Updated: 18 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periodic Paralysis" returned 8 free, full-text review articles on human participants. First 3 results:

Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis.
 

Author(s): Chih-Jen Cheng, Elizabeth Kuo, Chou-Long Huang

Journal: Semin. Nephrol.. 2013 May;33(3):237-47.

 

Extracellular potassium makes up only about 2% of the total body's potassium store. The majority of the body potassium is distributed in the intracellular space, of which about 80% is in skeletal muscle. Movement of potassium in and out of skeletal muscle thus plays a pivotal role ...

Last Updated: 19 Aug 2013

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Mechanism of thyrotoxic periodic paralysis.
 

Author(s): Shih-Hua Lin, Chou-Long Huang

Journal: J. Am. Soc. Nephrol.. 2012 Jun;23(6):985-8.

 

The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increased Na(+)-K(+) ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs ...

Last Updated: 1 Jun 2012

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Muscle channelopathies: does the predicted channel gating pore offer new treatment insights for hypokalaemic periodic paralysis?
 

Author(s): E Matthews, M G Hanna

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1879-86.

 

Hypokalaemic periodic paralysis (hypoPP) is the archetypal skeletal muscle channelopathy caused by dysfunction of one of two sarcolemmal ion channels, either the sodium channel Nav1.4 or the calcium channel Cav1.1. Clinically, hypoPP is characterised by episodes of often severe flaccid ...

Last Updated: 2 Jun 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bumetanide in Hypokalaemic Periodic Paralysis
 

Status: Recruiting

Condition Summary: Hypokalemic Periodic Paralysis

 

Last Updated: 21 Oct 2015

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