Periodic Paralysis

Common Name(s)

Periodic Paralysis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

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Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

Last Updated: 14 Nov 2012

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

Last Updated: 12 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

Logo
Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

http://www.periodicparalysis.org

Last Updated: 14 Nov 2012

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

http://hkpp.org

Last Updated: 12 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periodic Paralysis" returned 153 free, full-text research articles on human participants. First 3 results:

Possible brugada phenocopy induced by hypokalemia in a patient with congenital hypokalemic periodic paralysis.
 

Author(s): Daniel D Anselm, Natalia Rodriguez Genaro, Adrian Baranchuk

Journal: Arq. Bras. Cardiol.. 2014 Jan;102(1):104.

 

Last Updated: 21 Mar 2014

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NaV1.4 mutations cause hypokalaemic periodic paralysis by disrupting IIIS4 movement during recovery.
 

Author(s): James R Groome, Frank Lehmann-Horn, Chunxiang Fan, Markus Wolf, Vern Winston, Luciano Merlini, Karin Jurkat-Rott

Journal: Brain. 2014 Apr;137(Pt 4):998-1008.

 

Hypokalaemic periodic paralysis is typically associated with mutations of voltage sensor residues in calcium or sodium channels of skeletal muscle. To date, causative sodium channel mutations have been studied only for the two outermost arginine residues in S4 voltage sensor segments ...

Last Updated: 20 Mar 2014

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A case of family periodic paralysis with a critical digest of the literature.
 

Author(s): Alastair Campston

Journal: Brain. 2013 Dec;136(Pt 12):3520-4.

 

Last Updated: 28 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periodic Paralysis" returned 7 free, full-text review articles on human participants. First 3 results:

Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis.
 

Author(s): Chih-Jen Cheng, Elizabeth Kuo, Chou-Long Huang

Journal: Semin. Nephrol.. 2013 May;33(3):237-47.

 

Extracellular potassium makes up only about 2% of the total body's potassium store. The majority of the body potassium is distributed in the intracellular space, of which about 80% is in skeletal muscle. Movement of potassium in and out of skeletal muscle thus plays a pivotal role ...

Last Updated: 19 Aug 2013

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Mechanism of thyrotoxic periodic paralysis.
 

Author(s): Shih-Hua Lin, Chou-Long Huang

Journal: J. Am. Soc. Nephrol.. 2012 Jun;23(6):985-8.

 

The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increased Na(+)-K(+) ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs ...

Last Updated: 1 Jun 2012

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Muscle channelopathies: does the predicted channel gating pore offer new treatment insights for hypokalaemic periodic paralysis?
 

Author(s): E Matthews, M G Hanna

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1879-86.

 

Hypokalaemic periodic paralysis (hypoPP) is the archetypal skeletal muscle channelopathy caused by dysfunction of one of two sarcolemmal ion channels, either the sodium channel Nav1.4 or the calcium channel Cav1.1. Clinically, hypoPP is characterised by episodes of often severe flaccid ...

Last Updated: 2 Jun 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lamotrigine as Treatment of Myotonia
 

Status: Recruiting

Condition Summary: Dystrophia Myotonica Type 1; Myotonia Congenita; Paramyotonia Congenita; Hyperkalemic Periodic Paralysis; Potassium-Aggravated Myotonia

 

Last Updated: 4 Jun 2014

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