Pemphigus vulgaris

Common Name(s)

Pemphigus vulgaris

Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. In most cases, the exact cause of pemphigus vulgaris is unknown.  It has rarely been observed in multiple members of the same family. Treatment is aimed at reducing symptoms and preventing complications. Severe cases are treated similarly to severe burns.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus vulgaris" returned 269 free, full-text research articles on human participants. First 3 results:

Oral Pemphigus Vulgaris: Case Report.
 

Author(s): Rai Arpita, Arora Monica, Naikmasur Venkatesh, Sattur Atul, Malhotra Varun

Journal: Ethiop J Health Sci. 2015 Oct;25(4):367-72.

 

Pemphigus is a potentially life threatening autoimmune disease that causes blisters and erosions of the skin and the mucous membrane. The epithelial lesions are a result of auto-antibodies that react with desmosomal glycoproteins that are present on the cell surface of the keratinocyte. ...

Last Updated: 7 Mar 2016

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Pregnancy-Associated "Cutaneous Type" Pemphigus Vulgaris.
 

Author(s): Javier Rangel

Journal: Perm J. 2016 ;20(1):e101-2.

 

The development of pemphigus, including pemphigus vulgaris (PV) and pemphigus foliaceus, during pregnancy is rare. PV manifests with mucosal and/or cutaneous erosions with flaccid bullae that are histologically characterized by suprabasilar acantholysis. In contrast, pemphigus foliaceus ...

Last Updated: 30 Jan 2016

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Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris.
 

Author(s): Sara N Stahley, Maxine F Warren, Ron J Feldman, Robert A Swerlick, Alexa L Mattheyses, Andrew P Kowalczyk

Journal: J. Invest. Dermatol.. 2016 Jan;136(1):59-66.

 

Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease in which autoantibodies (IgG) are directed against the desmosomal cadherin desmoglein 3. To better understand how PV IgG alters desmosome morphology and function in vivo, biopsies from patients with PV were analyzed ...

Last Updated: 14 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus vulgaris" returned 17 free, full-text review articles on human participants. First 3 results:

The dual nature of interleukin-10 in pemphigus vulgaris.
 

Author(s): Michael Jeffrey Cho, Christoph T Ellebrecht, Aimee S Payne

Journal: Cytokine. 2015 Jun;73(2):335-41.

 

The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. ...

Last Updated: 18 May 2015

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[Cutaneous pemphigus vulgaris. A case report].
 

Author(s): Cristina Bello, Luis Mondaca-Cornejo, Cristian Navarrete-Dechent, Sergio González

Journal: Rev Med Chil. 2013 Apr;141(4):525-30.

 

Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old mole presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, ...

Last Updated: 31 Jul 2013

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Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review.
 

Author(s): Sanjay Singh

Journal: Indian J Dermatol Venereol Leprol. ;77(4):456-69.

 

Pemphigus, bullous pemphigoid, and epidermolysis bullosa acquisita are autoimmune diseases of skin associated with considerable morbidity and sometimes mortality. There is no cure for these diseases.

Last Updated: 5 Jul 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 11 Apr 2016

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Last Updated: 6 Jul 2016

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Last Updated: 3 Oct 2016

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