Pemphigus vulgaris

Common Name(s)

Pemphigus vulgaris

Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. In most cases, the exact cause of pemphigus vulgaris is unknown.  It has rarely been observed in multiple members of the same family. Treatment is aimed at reducing symptoms and preventing complications. Severe cases are treated similarly to severe burns.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus vulgaris" returned 173 free, full-text research articles on human participants. First 3 results:

Human amnion membrane as a substrate for the detection of autoantibodies in pemphigus vulgaris and bullous pemphigoid.
 

Author(s): Tanya Sezin, Emily Avitan-Hersh, Margarita Indelman, Roni Moscona, Edmond Sabo, Rina Katz, Shimon Pollack, Reuven Bergman

Journal: Isr. Med. Assoc. J.. 2014 Apr;16(4):217-23.

 

Human amnion membrane (HAM) was suggested to be a superior antigenic substrate for immunoblotting in detecting autoantibodies of autoimmune bullous skin diseases.

Last Updated: 19 May 2014

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[Proposal for recognition of the comfort pattern in clients with pemphigus vulgaris using Fuzzy Logic].
 

Author(s): Euzeli da Silva Brandão, Iraci dos Santos, Regina Serrão Lanzillotti, Augusto Júnior Moreira

Journal: Rev Esc Enferm USP. 2013 Aug;47(4):958-64.

 

The objective was to propose the use of Fuzzy Logic for recognition of comfort patterns in people undergoing a technology of nursing care because of pemphigus vulgaris, a rare mucocutaneous disease that affects mainly adults. The proposal applied experimental methods, with subjects ...

Last Updated: 6 Dec 2013

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Severe multi-resistant pemphigus vulgaris: prolonged remission with a single cycle of rituximab.
 

Author(s): Isabela Soubhia Corral, Thais Helena Proença de Freitas, Renata Telles Rudge de Aquino, Daniella Abbruzzini S Koller, Maria Elisa Ruffolo Magliari, Helena Muller

Journal: An Bras Dermatol. ;88(4):639-42.

 

Pemphigus vulgaris is an autoimmune bullous disease whose therapy is based on systemic corticosteroids, with or without immunosuppressants. Rituximab is a chimeric monoclonal antibody of the IgG class, directed at a specific CD20 B cell surface antigen, used in pemphigus vulgaris ...

Last Updated: 26 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus vulgaris" returned 15 free, full-text review articles on human participants. First 3 results:

[Cutaneous pemphigus vulgaris. A case report].
 

Author(s): Cristina Bello, Luis Mondaca-Cornejo, Cristian Navarrete-Dechent, Sergio González

Journal: Rev Med Chil. 2013 Apr;141(4):525-30.

 

Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old mole presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, ...

Last Updated: 31 Jul 2013

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Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review.
 

Author(s): Sanjay Singh

Journal: Indian J Dermatol Venereol Leprol. ;77(4):456-69.

 

Pemphigus, bullous pemphigoid, and epidermolysis bullosa acquisita are autoimmune diseases of skin associated with considerable morbidity and sometimes mortality. There is no cure for these diseases. Aims: To summarize evidence-based treatments for these diseases by performing a systematic review.

Last Updated: 5 Jul 2011

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Refractory pemphigus vulgaris associated with herpes infection: case report and review.
 

Author(s): Maria Luiza Figueiredo Braga Brandão, Nurimar C Fernandes, Danielle Pereira de Oliveira Batista, Norma Santos

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;53(2):113-7.

 

Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering of the skin and mucosa, which develops due to the interaction between predisposing genetic and environmental factors. Infections caused by members of the Herpesviridae family have been suggested as a possible ...

Last Updated: 3 May 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 27 May 2014

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Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus

 

Last Updated: 10 Jul 2014

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