Pemphigus

Common Name(s)

Pemphigus

Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).  This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.  Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections.

There are three main types of pemphigus:

Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus" returned 640 free, full-text research articles on human participants. First 3 results:

Long-Term Remissions in Recalcitrant Pemphigus Vulgaris.
 

Author(s): A Razzaque Ahmed, Srini Kaveri, Zachary Spigelman

Journal: N. Engl. J. Med.. 2015 Dec;373(27):2693-4.

 

Last Updated: 31 Dec 2015

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Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.
 

Author(s): Justyna Gornowicz-Porowska, Marian Dmochowski, Pawel Pietkiewicz, Monika Bowszyc-Dmochowska

Journal: An Bras Dermatol. ;90(5):748-51.

 

We describe a 39-year-old woman with an apparent captopril-induced, contact mucosal-dominant pemphigus vulgaris and angioedema, who took captopril during a bout of arterial hypertension. This exposure suggests that captopril and pathophysiology of angioedema stimulated the development ...

Last Updated: 12 Nov 2015

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Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.
 

Author(s): Maria Victória Quaresma, Fred Bernardes Filho, Janaína Hezel, Murilo Calvo Peretti, Bernard Kawa Kac, Luna Azulay-Abulafia

Journal: An Bras Dermatol. ;90(3 Suppl 1):51-4.

 

Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids ...

Last Updated: 28 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus" returned 45 free, full-text review articles on human participants. First 3 results:

The dual nature of interleukin-10 in pemphigus vulgaris.
 

Author(s): Michael Jeffrey Cho, Christoph T Ellebrecht, Aimee S Payne

Journal: Cytokine. 2015 Jun;73(2):335-41.

 

The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. ...

Last Updated: 18 May 2015

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Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus.
 

Author(s): Adriana Maria Porro, Livia de Vasconcelos Nasser Caetano, Laura de Sena Nogueira Maehara, Milvia Maria dos Santos Enokihara

Journal: An Bras Dermatol. ;89(1):96-106.

 

The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present ...

Last Updated: 14 Mar 2014

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Oral pemphigus as first sign of an inflammatory myofibroblastic tumour in an 18-year-old male patient.
 

Author(s): Rutger M Schols, Geerard L Beets, Robert G Riedl, Robert J Schipper

Journal:

 

Last Updated: 29 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Wound Dressings for Pemphigus and Pemphigoid
 

Status: Recruiting

Condition Summary: Pemphigus; Pemphigoid

 

Last Updated: 18 Feb 2015

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Last Updated: 29 Apr 2011

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Identification of Vulnerability Factors in the Course of Pemphigus Patients
 

Status: Recruiting

Condition Summary: Pemphigus; Dermatological Disease

 

Last Updated: 22 Jan 2016

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