Pemphigus

Common Name(s)

Pemphigus

Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).  This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.  Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections.

There are three main types of pemphigus:

Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus" returned 679 free, full-text research articles on human participants. First 3 results:

Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: A case report.
 

Author(s): Qu Jiang, Bin Hong Zhang

Journal: Medicine (Baltimore). 2017 Feb;96(8):e6184.

 

Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.

Last Updated: 22 Feb 2017

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Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman's disease.
 

Author(s): Haijun Gong, Shiyou Zhou, Yuxin Hu, Yuqin Lan, Hong Zeng, Liangchun Wang, Qingyu Liu, Mei Wang

Journal:

 

The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis.

Last Updated: 13 Jul 2016

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A Case Report on Paraneoplastic Pemphigus Associated Colonic Carcinoma.
 

Author(s): Yan-Zhao Wang, Zhao-Ya Gao, Fu-Ming Lei, Jin-Xia Zhang, Jin Gu

Journal: Chin. Med. J.. 2016 Jun;129(12):1501-2.

 

Last Updated: 9 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus" returned 50 free, full-text review articles on human participants. First 3 results:

Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: report of a case and review of literature.
 

Author(s): Zheng Su, Gaojie Liu, Jianping Liu, Tingfeng Fang, Yunjie Zeng, Huayao Zhang, Shanglin Yang, Yang Wang, Junmin Zhang, Jinxing Wei, Yingru Li, Youfeng Guo

Journal:

 

Follicular dendritic cell sarcoma (FDCS) is a rare tumor associated with paraneoplastic pemphigus. It is Blame drenchs auxiliary cell tumor which is derived from the peripheral lymphoid tissues. Throughout the world, several patients of paraneoplastic pemphigus associated follicular ...

Last Updated: 1 Jan 2016

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Pemphigus and pregnancy. Analysis and summary of case reports over 49 years.
 

Author(s): Lin Lin, Xin Zeng, Qianming Chen

Journal: Saudi Med J. 2015 Sep;36(9):1033-8.

 

Pemphigus is a group of immune-mediated bullous disorders, which often cause fragile blisters and extensive lesions of the skin or mucous membranes, such as in the mouth. This disease could be life-threatening in some cases. During pregnancy, its condition will become more complicated ...

Last Updated: 31 Aug 2015

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Efficacy of rituximab for pemphigus: a systematic review and meta-analysis of different regimens.
 

Author(s): Hsiao-Han Wang, Che-Wei Liu, Yu-Chuan Li, Yu-Chen Huang

Journal: Acta Derm. Venereol.. 2015 Nov;95(8):928-32.

 

This meta-analysis examined the efficacy of different dosing regimens containing rituximab (RTX) in treating pemphigus. The analysis included 578 patients with pemphigus from 30 studies. Seventy-six percent of patients achieved complete remission (CR) after 1 cycle of RTX. Mean time ...

Last Updated: 4 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 28 Feb 2017

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A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus)
 

Status: Not yet recruiting

Condition Summary: Pemphigus; Pemphigus Vulgaris; Pemphigus Foliaceus

 

Last Updated: 8 Mar 2017

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