Pemphigus

Common Name(s)

Pemphigus

Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).  This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.  Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections.

There are three main types of pemphigus:

Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus" returned 426 free, full-text research articles on human participants. First 3 results:

The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus.
 

Author(s): Marta Sar-Pomian, Marta Kurzeja, Lidia Rudnicka, Malgorzata Olszewska

Journal: An Bras Dermatol. ;89(6):1007-12.

 

Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease.

Last Updated: 12 Nov 2014

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Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil.
 

Author(s): Stephanie Del Rio Navarrete Biot, Joanna Pimenta de Araujo Franco, Ricardo Barbosa Lima, Henrique Novo Costa Pereira, Luiz Paulo José Marques, Carlos José Martins

Journal: An Bras Dermatol. ;89(6):980-4.

 

The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus ...

Last Updated: 12 Nov 2014

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Prevalence of Metabolic Syndrome and its components in a Brazilian sample of pemphigus patients.
 

Author(s): Marcela Vendruscolo Ambiel, Ana Maria Roselino

Journal: An Bras Dermatol. ;89(5):752-6.

 

Pemphigus foliaceus and pemphigus vulgaris are endemic in the northeastern region of São Paulo State, Brazil. They are treated mainly with systemic corticosteroids, which may provoke osteoporosis; atherosclerosis, higher blood pressure, insulin resistance, glucose intolerance, hyperlipidemia ...

Last Updated: 4 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus" returned 36 free, full-text review articles on human participants. First 3 results:

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus.
 

Author(s): Adriana Maria Porro, Livia de Vasconcelos Nasser Caetano, Laura de Sena Nogueira Maehara, Milvia Maria dos Santos Enokihara

Journal: An Bras Dermatol. ;89(1):96-106.

 

The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present ...

Last Updated: 14 Mar 2014

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Pemphigus.
 

Author(s): Frank A Santoro, Eric T Stoopler, Victoria P Werth

Journal: Dent. Clin. North Am.. 2013 Oct;57(4):597-610.

 

Pemphigus vulgaris and paraneoplastic pemphigus are 2 subtypes of pemphigus that involve the oral mucosa. These autoimmune blistering disorders have antibodies targeted against proteins of keratinocyte adhesion, thereby causing acantholysis. Clinical findings include oral erosions ...

Last Updated: 16 Sep 2013

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[Cutaneous pemphigus vulgaris. A case report].
 

Author(s): Cristina Bello, Luis Mondaca-Cornejo, Cristian Navarrete-Dechent, Sergio González

Journal: Rev Med Chil. 2013 Apr;141(4):525-30.

 

Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old mole presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, ...

Last Updated: 31 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Wound Dressings for Pemphigus and Pemphigoid
 

Status: Recruiting

Condition Summary: Pemphigus; Pemphigoid

 

Last Updated: 18 Feb 2015

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Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 13 Apr 2015

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Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus
 

Status: Recruiting

Condition Summary: Pemphigus

 

Last Updated: 14 Jan 2014

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