Pemphigus

Common Name(s)

Pemphigus

Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).  This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.  Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections.

There are three main types of pemphigus:

Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus" returned 672 free, full-text research articles on human participants. First 3 results:

[A case of retroperitoneal Castleman's disease with paraneoplastic pemphigus].
 

Author(s): Zhipeng Zhang, Maosong Zhou, Jin Guo, Tiecheng Feng, Xinying Li, Huan Chen, Jindong Li

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 May;41(5):548-52.

 

Paraneoplastic pemphigus is a rare autoimmune bullous dermatosis, which is caused by potential neoplasm, especially the Castleman's disease. Castleman's disease associated with paraneoplastic pemphigus is misdiagnosed frequently and easily in clinical practices. Furthermore, it is ...

Last Updated: 9 Jun 2016

Go To URL
Oral Pemphigus Vulgaris: Case Report.
 

Author(s): Rai Arpita, Arora Monica, Naikmasur Venkatesh, Sattur Atul, Malhotra Varun

Journal: Ethiop J Health Sci. 2015 Oct;25(4):367-72.

 

Pemphigus is a potentially life threatening autoimmune disease that causes blisters and erosions of the skin and the mucous membrane. The epithelial lesions are a result of auto-antibodies that react with desmosomal glycoproteins that are present on the cell surface of the keratinocyte. ...

Last Updated: 7 Mar 2016

Go To URL
Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus.
 

Author(s): Tina Hennerici, Robert Pollmann, Thomas Schmidt, Maria Seipelt, Björn Tackenberg, Christian Möbs, Kamran Ghoreschi, Michael Hertl, Rüdiger Eming

Journal:

 

Pemphigus is an autoimmune disease in which IgG auto-antibodies (auto-ab) against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 cause loss of epidermal keratinocyte adhesion. Aim of this study was to investigate cytokines derived from antigen-presenting cells (APC) and their ...

Last Updated: 13 Feb 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus" returned 52 free, full-text review articles on human participants. First 3 results:

Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: report of a case and review of literature.
 

Author(s): Zheng Su, Gaojie Liu, Jianping Liu, Tingfeng Fang, Yunjie Zeng, Huayao Zhang, Shanglin Yang, Yang Wang, Junmin Zhang, Jinxing Wei, Yingru Li, Youfeng Guo

Journal:

 

Follicular dendritic cell sarcoma (FDCS) is a rare tumor associated with paraneoplastic pemphigus. It is Blame drenchs auxiliary cell tumor which is derived from the peripheral lymphoid tissues. Throughout the world, several patients of paraneoplastic pemphigus associated follicular ...

Last Updated: 1 Jan 2016

Go To URL
Pemphigus and pregnancy. Analysis and summary of case reports over 49 years.
 

Author(s): Lin Lin, Xin Zeng, Qianming Chen

Journal: Saudi Med J. 2015 Sep;36(9):1033-8.

 

Pemphigus is a group of immune-mediated bullous disorders, which often cause fragile blisters and extensive lesions of the skin or mucous membranes, such as in the mouth. This disease could be life-threatening in some cases. During pregnancy, its condition will become more complicated ...

Last Updated: 31 Aug 2015

Go To URL
Efficacy of rituximab for pemphigus: a systematic review and meta-analysis of different regimens.
 

Author(s): Hsiao-Han Wang, Che-Wei Liu, Yu-Chuan Li, Yu-Chen Huang

Journal: Acta Derm. Venereol.. 2015 Nov;95(8):928-32.

 

This meta-analysis examined the efficacy of different dosing regimens containing rituximab (RTX) in treating pemphigus. The analysis included 578 patients with pemphigus from 30 studies. Seventy-six percent of patients achieved complete remission (CR) after 1 cycle of RTX. Mean time ...

Last Updated: 4 Nov 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 11 Apr 2016

Go to URL

Last Updated: 6 Jul 2016

Go to URL

Last Updated: 3 Oct 2016

Go to URL