Pediatric ulcerative colitis

Common Name(s)

Pediatric ulcerative colitis

Pediatric ulcerative colitis (UC) is a form of inflammatory bowel disease that occurs in children. UC causes redness and swelling (inflammation) inside the large intestine (colon). This inflammation is what causes the major symptoms of UC, which are stomach pain or cramping, rectal bleeding, and diarrhea. Other symptoms may include low energy (fatigue), decreased appetite, joint pain, low blood count (anemia), or liver problems. Children with UC often lose weight or have trouble gaining weight. The exact cause of UC is unknown, but researchers believe it is due to a combination of genetic and environmental reasons. Some cases of UC may be due to the body’s immune system attacking normal cells in the colon (autoimmune disease). UC can occur at any age, but approximately 20% of UC cases occur under the age of 20 in the United States.

Your child’s doctor can diagnose UC by gathering your child’s medical history and performing a physical exam. They may also order blood tests to look for signs of inflammation, x-rays to look at the intestines, and perform stool sample analysis. In addition, your child’s doctor may use a viewing tube to examine the intestines and even collect a small piece of the colon (biopsy). The tube can be inserted through the mouth (called an endoscopy) or inserted through the anus (called a colonoscopy). Although there is no cure for UC, there are options to help manage the symptoms of the condition. There are medications that can reduce the inflammation in the colon and also medications that can reduce the immune response in the body. If the UC is severe, surgery may be needed. Talk to your child's doctor or specialist about the most current treatment options. Support groups are also good source of information and will help connect you with other families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pediatric ulcerative colitis" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pediatric ulcerative colitis" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details
Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pediatric ulcerative colitis" returned 12 free, full-text research articles on human participants. First 3 results:

MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.
 

Author(s): Georgios Koukos, Christos Polytarchou, Jess L Kaplan, Alessio Morley-Fletcher, Beatriz Gras-Miralles, Efi Kokkotou, Mariah Baril-Dore, Charalabos Pothoulakis, Harland S Winter, Dimitrios Iliopoulos

Journal: Gastroenterology. 2013 Oct;145(4):842-52.e2.

 

Altered levels and functions of microRNAs (miRs) have been associated with inflammatory bowel diseases (IBDs), although little is known about their roles in pediatric IBD. We investigated whether colonic mucosal miRs are altered in children with ulcerative colitis (UC).

Last Updated: 23 Sep 2013

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Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery.
 

Author(s): Maija Piekkala, Jaana Hagström, Maarit Tanskanen, Risto Rintala, Caj Haglund, Kaija-Leena Kolho

Journal: World J. Gastroenterol.. 2013 Jun;19(21):3272-80.

 

To investigate whether matrix metalloproteinases-9 (MMP-9) or trypsinogens could serve as histological markers for an aggressive disease course in pediatric ulcerative colitis (UC).

Last Updated: 7 Jun 2013

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Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis.
 

Author(s): Laura Mäkitalo, Maija Piekkala, Merja Ashorn, Mikko Pakarinen, Antti Koivusalo, Riitta Karikoski, Johanna Natunen, Ulpu Saarialho-Kere, Risto Rintala, Kaija-Leena Kolho

Journal: World J. Gastroenterol.. 2012 Aug;18(30):4028-36.

 

To investigate matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pouch mucosa of pediatric onset ulcerative colitis (UC).

Last Updated: 22 Aug 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pediatric ulcerative colitis" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Curcumin in Pediatric Ulcerative Colitis
 

Status: Not yet recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 18 May 2015

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Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis
 

Status: Not yet recruiting

Condition Summary: Ulcerative Colitis (UC)

 

Last Updated: 14 May 2015

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Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Mild to Moderate Ulcerative Colitis

 

Last Updated: 10 Dec 2014

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