Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Persistent patency of the ductus arteriosus, or patent ductus arteriosus (PDA), is the second most common congenital heart disease, affecting approximately 1 in 1,600 to 5,000 live births in the U.S. ({3:Mitchell et al., 1971}). In fetal life, the ductus arteriosus, a muscular artery, shunts blood from the pulmonary artery to the aorta, bypassing the lungs. Its abrupt closure at birth establishes the mature circulatory pattern and represents a dramatic example of vascular remodeling. Failure of this normal process results in persistent PDA, which left untreated can result in pulmonary hypertension and heart failure. Closure of the ductus is a complex process. Aspects of this process are regulated by oxygen tension and a decrease in levels of hormones such as prostaglandin E2. PDA occurring in preterm infants often closes spontaneously or in response to inhibitors of prostaglandin biosynthesis ({6:Ramsay et al., 1987}). Term PDA typically has not been regarded as a genetic disorder, because it most often occurs sporadically. Nonetheless, term PDA recurs among 5% of sibs of PDA cases ({5:Polani and Campbell, 1960}; {1:Lamy et al., 1957}), suggesting a genetic component to disease pathogenesis that has typically been presumed to be multifactorial. That single genes can influence this trait has been demonstrated by a mouse model of PDA resulting from disruption of the prostaglandin E2 receptor ({4:Nguyen et al., 1997}) and by rare syndromic forms of PDA such as Char syndrome ({169100}), an autosomal dominant disorder caused by mutations in the transcription factor TFAP2B ({601601}) ({2:Mani et al., 2002}).
 

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Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 315 free, full-text research articles on human participants. First 3 results:

Indicators of surgical treatment of patent ductus arteriosus in preterm neonates in the first week of life.
 

Author(s): Renato Braulio, Cláudio Léo Gelape, Fátima Derlene da Rocha Araújo, Kelly Nascimento Brandão, Luciana Drummond Guimarães Abreu, Paulo Henrique Nogueira Costa, Flávio Diniz Capanema

Journal: Rev Bras Cir Cardiovasc. ;28(4):504-8.

 

To identify clinical and echocardiographic indicators of the necessity for early surgical closure of patent ductus arteriosus in preterm neonates.

Last Updated: 6 Mar 2014

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Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates.
 

Author(s): Gianluca Terrin, Francesca Conte, Antonella Scipione, Erica Bacchio, Maria Giulia Conti, Rosalia Ferro, Flavia Ventriglia, Mario De Curtis

Journal:

 

Inhibitors of the cyclo-oxygenase component of prostaglandin-H2 synthetase, namely indomethacin and ibuprofen, are commonly used in the treatment of hemodynamically significant patent ductus arteriosus. These drugs are associated with serious adverse events, including gastrointestinal ...

Last Updated: 4 Mar 2014

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Predictors of bronchopulmonary dysplasia or death in premature infants with a patent ductus arteriosus.
 

Author(s): Valerie Y Chock, Rajesh Punn, Anushri Oza, William E Benitz, Krisa P Van Meurs, Alice S Whittemore, Fariborz Behzadian, Norman H Silverman

Journal: Pediatr. Res.. 2014 Apr;75(4):570-5.

 

Preterm infants with a patent ductus arteriosus (PDA) are at risk for death or development of bronchopulmonary dysplasia (BPD). However, PDA treatment remains controversial. We investigated if PDA treatment and other clinical or echocardiographic (ECHO) factors were associated with ...

Last Updated: 19 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 29 free, full-text review articles on human participants. First 3 results:

Patent ductus arteriosus in preterm infants: do we have the right answers?
 

Author(s): Hesham Abdel-Hady, Nehad Nasef, Abd Elazeez Shabaan, Islam Nour

Journal: Biomed Res Int. 2013 ;2013():676192.

 

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality. Therefore, cyclooxygenase ...

Last Updated: 23 Jan 2014

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The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia.
 

Author(s): Ronald I Clyman

Journal: Semin. Perinatol.. 2013 Apr;37(2):102-7.

 

A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and prolongs the need for mechanical ventilation. In preclinical trials, pharmacologic PDA closure ...

Last Updated: 15 Apr 2013

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Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
 

Author(s): Ronald I Clyman, James Couto, Gail M Murphy

Journal: Semin. Perinatol.. 2012 Apr;36(2):123-9.

 

Although a moderate-sized patent ductus arteriosus (PDA) needs to be closed by the time a child is 1-2 years old, there is great uncertainty about whether it needs to be closed during the neonatal period. Although 95% of neonatologists believe that a moderate-sized PDA should be closed ...

Last Updated: 14 Mar 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus; Surgery; Necrotizing Enterocolitis; Intestinal Perforation

 

Last Updated: 8 Jul 2014

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Treating the Resistant Patent Ductus Arteriosus (PDA)
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 14 Feb 2008

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Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 18 Sep 2013

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