Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Persistent patency of the ductus arteriosus, or patent ductus arteriosus (PDA), is the second most common congenital heart disease, affecting approximately 1 in 1,600 to 5,000 live births in the U.S. ({3:Mitchell et al., 1971}). In fetal life, the ductus arteriosus, a muscular artery, shunts blood from the pulmonary artery to the aorta, bypassing the lungs. Its abrupt closure at birth establishes the mature circulatory pattern and represents a dramatic example of vascular remodeling. Failure of this normal process results in persistent PDA, which left untreated can result in pulmonary hypertension and heart failure. Closure of the ductus is a complex process. Aspects of this process are regulated by oxygen tension and a decrease in levels of hormones such as prostaglandin E2. PDA occurring in preterm infants often closes spontaneously or in response to inhibitors of prostaglandin biosynthesis ({6:Ramsay et al., 1987}). Term PDA typically has not been regarded as a genetic disorder, because it most often occurs sporadically. Nonetheless, term PDA recurs among 5% of sibs of PDA cases ({5:Polani and Campbell, 1960}; {1:Lamy et al., 1957}), suggesting a genetic component to disease pathogenesis that has typically been presumed to be multifactorial. That single genes can influence this trait has been demonstrated by a mouse model of PDA resulting from disruption of the prostaglandin E2 receptor ({4:Nguyen et al., 1997}) and by rare syndromic forms of PDA such as Char syndrome ({169100}), an autosomal dominant disorder caused by mutations in the transcription factor TFAP2B ({601601}) ({2:Mani et al., 2002}).
 

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Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 311 free, full-text research articles on human participants. First 3 results:

Noninvasive technique for the diagnosis of patent ductus arteriosus in premature infants by analyzing pulse wave phases on photoplethysmography signals measured in the right hand and the left foot.
 

Author(s): Sabrina Goudjil, Fatiha Imestouren, Aurelie Armougon, Lucie Razafimanantsoa, Mahdi Mahmoudzadeh, Fabrice Wallois, André Leke, Guy Kongolo

Journal:

 

To evaluate the impact of patent ductus arteriosus (PDA) on the pulse phase difference (PPD) between the left foot (postductal region) and the right hand (preductal region).

Last Updated: 4 Jun 2014

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Last Updated: 8 May 2014

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The timing of surgical ligation for patent ductus arteriosus is associated with neonatal morbidity in extremely preterm infants born at 23-25 weeks of gestation.
 

Author(s): Se In Sung, Soo Young Choi, Jae Hyun Park, Myung Sook Lee, Hye Soo Yoo, So Yoon Ahn, Yun Sil Chang, Won Soon Park

Journal: J. Korean Med. Sci.. 2014 Apr;29(4):581-6.

 

The purpose of this study was to evaluate prognostic factors associated with surgical ligation for patent ductus arteriosus (PDA) in extremely preterm infants born at the limits of viability. Ninety infants who were born at 23-25 weeks of gestation and who received surgical ligation ...

Last Updated: 22 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 29 free, full-text review articles on human participants. First 3 results:

Transcatheter closure of patent ductus arteriosus: past, present and future.
 

Author(s): Alban-Elouen Baruteau, Sébastien Hascoët, Julien Baruteau, Younes Boudjemline, Virginie Lambert, Claude-Yves Angel, Emre Belli, Jérôme Petit, Robert Pass

Journal: Arch Cardiovasc Dis. 2014 Feb;107(2):122-32.

 

This review aims to describe the past history, present techniques and future directions in transcatheter treatment of patent ductus arteriosus (PDA). Transcatheter PDA closure is the standard of care in most cases and PDA closure is indicated in any patient with signs of left ventricular ...

Last Updated: 17 Mar 2014

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Patent ductus arteriosus in preterm infants: do we have the right answers?
 

Author(s): Hesham Abdel-Hady, Nehad Nasef, Abd Elazeez Shabaan, Islam Nour

Journal: Biomed Res Int. 2013 ;2013():676192.

 

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality. Therefore, cyclooxygenase ...

Last Updated: 23 Jan 2014

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The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia.
 

Author(s): Ronald I Clyman

Journal: Semin. Perinatol.. 2013 Apr;37(2):102-7.

 

A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and prolongs the need for mechanical ventilation. In preclinical trials, pharmacologic PDA closure ...

Last Updated: 15 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus; Surgery; Necrotizing Enterocolitis; Intestinal Perforation

 

Last Updated: 13 Jan 2015

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Treating the Resistant Patent Ductus Arteriosus (PDA)
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 14 Feb 2008

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Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 18 Sep 2013

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