Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Patent ductus arteriosus (PDA) is a common heart defect that occurs when the ductus arteriosis does not close shortly after birth. The ductus arteriosis is a fetal artery connecting the aorta and the pulmonary artery. When the artery is not closed properly, it acts as a detour by not sending all the blood to the lungs (fetal blood obtains oxygen from the placenta). After birth, oxygen poor blood needs to go to the lungs to obtain oxygen. If the ductus arteriosis does not close, it can cause both the lungs and the heart to work too hard. PDA is sometimes found with other heart defects or in certain genetic conditions such as Down syndrome. PDA appears to be more common in girls.

Usually PDA is diagnosed in infancy but if it is small, symptoms may only appear in childhood. Severity of symptoms depends on the size and whether other heart defects are also present. Symptoms may include poor feeding or sweating while feeding, shortness of breath, tiring easily, fast pulse and poor growth. The causes of PDA are likely a combination of genetics and environment. Risk factors include premature birth, being born at a high altitude, a rubella infection during pregnancy, or a family history of certain genetic conditions.

A heart murmur is usually heard in infancy, but may be missed in a premature baby. The diagnosis will be confirmed using X-rays and an electrocardiogram (EKG). Other tests may check for other possible heart defects. In premature babies, the opening may close on its own even after the first few days, so the PDA may just be watched. Treatment options include medication and surgery, and may not be necessary. Outlook is excellent if PDA occurs without any associated birth defects. Talk to your baby’s cardiologist about treatment and management options. If the PDA is part of a syndrome or runs in your family, talk to a genetic counselor. Support groups are a good source of information and can connect you to other families affected by PDA.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 484 free, full-text research articles on human participants. First 3 results:

Familial clustering of congenital deafness, patent ductus arteriosus, Eisenmenger complex, and differential cyanosis: A case report.
 

Author(s): Ting-Wei Lin, Chih-Wei Tseng, Chi-Yao Huang, Kuo-Yang Wang, Kae-Woei Liang

Journal: Medicine (Baltimore). 2017 Jun;96(24):e7105.

 

Few studies had reported syndromes that include patent ductus arteriosus (PDA) with Eisenmenger syndrome and congenital deafness clustered in male siblings without facial, skeletal, or mental abnormalities.

Last Updated: 14 Jun 2017

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Transcatheter Closure of Patent Ductus Arteriosus in Adolescents and Adults: A Case Series.
 

Author(s): Sukman Tulus Putra, Mulyadi M Djer, Nikmah S Idris, Sudigdo Sastroasmoro

Journal: Acta Med Indones. 2016 Oct;48(4):314-319.

 

During 11 years period from January 2005 to December 2015 there were 18 adolescent and adult patients  who underwent transcatheter closure of PDA using PDA Amplatzer Duct Occluder (ADO). There were 9 cases with age of 14 to 18 years and 9 cases with age of more than 18 years where ...

Last Updated: 1 Feb 2017

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Comparison of the Mortality and In-Hospital Outcomes of Preterm Infants Treated with Ibuprofen for Patent Ductus Arteriosus with or without Clinical Symptoms Attributable to the Patent Ductus Arteriosus at the Time of Ibuprofen Treatment.
 

Author(s): Hani Yoo, Jin A Lee, Sohee Oh, Young Hwa Jung, Jin A Sohn, Seung Han Shin, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim

Journal: J. Korean Med. Sci.. 2017 Jan;32(1):115-123.

 

The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory ...

Last Updated: 3 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 34 free, full-text review articles on human participants. First 3 results:

Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
 

Author(s): Hye Won Park, Yong-Sung Choi, Kyo Sun Kim, Soo-Nyung Kim

Journal:

 

Chorioamnionitis has recently been reported as a risk factor for various neonatal diseases, including cerebral palsy, bronchopulmonary dysplasia, and necrotizing enterocolitis, but its effect on patent ductus arteriosus (PDA) is unclear. We performed a systematic review and meta-analysis ...

Last Updated: 17 Sep 2015

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Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.
 

Author(s): Sorina R Simon, Lieke van Zogchel, Maria Pilar Bas-Suárez, Giacomo Cavallaro, Ronald I Clyman, Eduardo Villamor

Journal: Neonatology. 2015 ;108(2):143-51.

 

Several cohort studies have shown an association between low platelet counts in the first day(s) of life and patent ductus arteriosus (PDA) in preterm infants. However, these results have not been confirmed by other studies.

Last Updated: 17 Aug 2015

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Treatment Options for Pediatric Patent Ductus Arteriosus: Systematic Review and Meta-analysis.
 

Author(s): Jennifer Y Lam, Steven R Lopushinsky, Irene W Y Ma, Frank Dicke, Mary E Brindle

Journal: Chest. 2015 Sep;148(3):784-793.

 

Patent ductus arteriosus (PDA) in the nonpremature pediatric patient is currently treated by surgical ligation or catheter occlusion. There is no clear superiority of one technique over the other. This meta-analysis compares the clinical outcomes of the two treatment options for PDA.

Last Updated: 1 Sep 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

IV Acetaminophen and Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 28 Jun 2017

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International Experience in Timing And Choices for Ductal Closure in Patent Ductus Arteriosus:INTERPDA Trial
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 20 Sep 2016

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Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 18 Jan 2017

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