Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Patent ductus arteriosus (PDA) is a common heart defect that occurs when the ductus arteriosis does not close shortly after birth. The ductus arteriosis is a fetal artery connecting the aorta and the pulmonary artery. When the artery is not closed properly, it acts as a detour by not sending all the blood to the lungs (fetal blood obtains oxygen from the placenta). After birth, oxygen poor blood needs to go to the lungs to obtain oxygen. If the ductus arteriosis does not close, it can cause both the lungs and the heart to work too hard. PDA is sometimes found with other heart defects or in certain genetic conditions such as Down syndrome. PDA appears to be more common in girls.

Usually PDA is diagnosed in infancy but if it is small, symptoms may only appear in childhood. Severity of symptoms depends on the size and whether other heart defects are also present. Symptoms may include poor feeding or sweating while feeding, shortness of breath, tiring easily, fast pulse and poor growth. The causes of PDA are likely a combination of genetics and environment. Risk factors include premature birth, being born at a high altitude, a rubella infection during pregnancy, or a family history of certain genetic conditions.

A heart murmur is usually heard in infancy, but may be missed in a premature baby. The diagnosis will be confirmed using X-rays and an electrocardiogram (EKG). Other tests may check for other possible heart defects. In premature babies, the opening may close on its own even after the first few days, so the PDA may just be watched. Treatment options include medication and surgery, and may not be necessary. Outlook is excellent if PDA occurs without any associated birth defects. Talk to your baby’s cardiologist about treatment and management options. If the PDA is part of a syndrome or runs in your family, talk to a genetic counselor. Support groups are a good source of information and can connect you to other families affected by PDA.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 416 free, full-text research articles on human participants. First 3 results:

[Evaluation of therapeutic effects and safety of different treatment methods for premature patent ductus arteriosus].
 

Author(s): Dan Chen, Jian Mao

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Oct;17(10):1032-8.

 

To explore the clinical treatment methods and their effects in the treatment of premature patent ductus arteriosus (PDA) and to summarize the experience of surgical treatment for PDA.

Last Updated: 20 Oct 2015

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Outcomes of Early Ligation of Patent Ductus Arteriosus in Preterms, Multicenter Experience.
 

Author(s): Mohamed H Ibrahim, Ahmed Azab, Naglaa M Kamal, Mostafa A Salama, Hatem H Elshorbagy, Enas A A Abdallah, Abdulrahman Hammad, Laila M Sherief

Journal: Medicine (Baltimore). 2015 Jun;94(25):e915.

 

Persistent ductal patency may have serious effects in preterm infants. Analysis of the results of different trials were inconclusive in determining whether medical or surgical closure of the ductus is preferable and what is the best timing for surgical intervention.The aim of this ...

Last Updated: 25 Jun 2015

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The effect of professional-led guideline workshops on clinical practice for the management of patent ductus arteriosus in preterm neonates in Japan: a controlled before-and-after study.
 

Author(s): Tetsuya Isayama, Xiang Y Ye, Hironobu Tokumasu, Hiroo Chiba, Hideko Mitsuhashi, Sadequa Shahrook, Satoshi Kusuda, Masanori Fujimura, Katsuaki Toyoshima, Rintaro Mori,

Journal:

 

Clinical guidelines assist physicians to make decisions about suitable healthcare. We conducted a controlled before-and-after study to investigate the impact of professional-led guideline workshops for patent ductus arteriosus (PDA) management on physicians' clinical practices, discharge ...

Last Updated: 20 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 32 free, full-text review articles on human participants. First 3 results:

Current controversies in the management of patent ductus arteriosus in preterm infants.
 

Author(s): Thowfique K Ibrahim, A A Abdul Haium, S Chandran, V S Rajadurai

Journal: Indian Pediatr. 2014 Apr;51(4):289-94.

 

Patent ductus arteriosus is very commonly seen in very low birth weight (VLBW) infants, affecting about one-third. The present review tries to identify the group of VLBW infants who need active intervention in day-to-day practice and to determine the mode of intervention, based on ...

Last Updated: 14 May 2014

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Transcatheter closure of patent ductus arteriosus: past, present and future.
 

Author(s): Alban-Elouen Baruteau, Sébastien Hascoët, Julien Baruteau, Younes Boudjemline, Virginie Lambert, Claude-Yves Angel, Emre Belli, Jérôme Petit, Robert Pass

Journal: Arch Cardiovasc Dis. 2014 Feb;107(2):122-32.

 

This review aims to describe the past history, present techniques and future directions in transcatheter treatment of patent ductus arteriosus (PDA). Transcatheter PDA closure is the standard of care in most cases and PDA closure is indicated in any patient with signs of left ventricular ...

Last Updated: 17 Mar 2014

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Patent ductus arteriosus in preterm infants: do we have the right answers?
 

Author(s): Hesham Abdel-Hady, Nehad Nasef, Abd Elazeez Shabaan, Islam Nour

Journal: Biomed Res Int. 2013 ;2013():676192.

 

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality. Therefore, cyclooxygenase ...

Last Updated: 23 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus; Surgery; Necrotizing Enterocolitis; Intestinal Perforation

 

Last Updated: 1 Dec 2015

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Treating the Resistant Patent Ductus Arteriosus (PDA)
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 14 Feb 2008

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Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 23 Dec 2015

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