Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Persistent patency of the ductus arteriosus, or patent ductus arteriosus (PDA), is the second most common congenital heart disease, affecting approximately 1 in 1,600 to 5,000 live births in the U.S. ({3:Mitchell et al., 1971}). In fetal life, the ductus arteriosus, a muscular artery, shunts blood from the pulmonary artery to the aorta, bypassing the lungs. Its abrupt closure at birth establishes the mature circulatory pattern and represents a dramatic example of vascular remodeling. Failure of this normal process results in persistent PDA, which left untreated can result in pulmonary hypertension and heart failure. Closure of the ductus is a complex process. Aspects of this process are regulated by oxygen tension and a decrease in levels of hormones such as prostaglandin E2. PDA occurring in preterm infants often closes spontaneously or in response to inhibitors of prostaglandin biosynthesis ({6:Ramsay et al., 1987}). Term PDA typically has not been regarded as a genetic disorder, because it most often occurs sporadically. Nonetheless, term PDA recurs among 5% of sibs of PDA cases ({5:Polani and Campbell, 1960}; {1:Lamy et al., 1957}), suggesting a genetic component to disease pathogenesis that has typically been presumed to be multifactorial. That single genes can influence this trait has been demonstrated by a mouse model of PDA resulting from disruption of the prostaglandin E2 receptor ({4:Nguyen et al., 1997}) and by rare syndromic forms of PDA such as Char syndrome ({169100}), an autosomal dominant disorder caused by mutations in the transcription factor TFAP2B ({601601}) ({2:Mani et al., 2002}).
 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 324 free, full-text research articles on human participants. First 3 results:

Transcatheter patent ductus arteriosus closure with echocardiographic guidance: can radiation exposure be reduced?
 

Author(s): Ibrahim Cansaran Tanıdır, Alper Güzeltaş, Yakup Ergül, Erkut Oztürk, Isa Ozyılmaz, Ender Odemiş

Journal: Turk Kardiyol Dern Ars. 2014 Oct;42(7):643-50.

 

The radiation dose from interventional cardiac catheterization is particularly relevant when treating children because of their greater radiosensitivity compared to adults. The transcatheter closure of patent ductus arteriosus (PDA), as well as other more complex pediatric interventions, ...

Last Updated: 10 Dec 2014

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Transcatheter closure of post-operative residual ventricular septal defect using a patent ductus arteriosus closure device in an adult: a case report.
 

Author(s): Mulyadi M Djer, Nikmah S Idris, Idrus Alwi, Ika P Wijaya

Journal: Acta Med Indones. 2014 Jul;46(3):233-7.

 

Transcatheter closure of perimembranous and muscular ventricular septal defect (VSD) has been performed widely and it has more advantages compare to surgery. However, transcatheter closure of residual VSD post operation of complex congenital heart disease is still challenging because ...

Last Updated: 28 Oct 2014

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Anesthetic management of a newborn with trisomy 18 undergoing closure of patent ductus arteriosus and pulmonary artery banding.
 

Author(s): Oguzha Arun, Bahar Oc, Mehmet Oc, Ates Duman

Journal:

 

Peri-operative management of infants with trisomy 18 syndrome is challenging due to various congenital cardiac and facial anomalies.

Last Updated: 6 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 29 free, full-text review articles on human participants. First 3 results:

Current controversies in the management of patent ductus arteriosus in preterm infants.
 

Author(s): Thowfique K Ibrahim, A A Abdul Haium, S Chandran, V S Rajadurai

Journal: Indian Pediatr. 2014 Apr;51(4):289-94.

 

Patent ductus arteriosus is very commonly seen in very low birth weight (VLBW) infants, affecting about one-third. The present review tries to identify the group of VLBW infants who need active intervention in day-to-day practice and to determine the mode of intervention, based on ...

Last Updated: 14 May 2014

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Transcatheter closure of patent ductus arteriosus: past, present and future.
 

Author(s): Alban-Elouen Baruteau, Sébastien Hascoët, Julien Baruteau, Younes Boudjemline, Virginie Lambert, Claude-Yves Angel, Emre Belli, Jérôme Petit, Robert Pass

Journal: Arch Cardiovasc Dis. 2014 Feb;107(2):122-32.

 

This review aims to describe the past history, present techniques and future directions in transcatheter treatment of patent ductus arteriosus (PDA). Transcatheter PDA closure is the standard of care in most cases and PDA closure is indicated in any patient with signs of left ventricular ...

Last Updated: 17 Mar 2014

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Patent ductus arteriosus in preterm infants: do we have the right answers?
 

Author(s): Hesham Abdel-Hady, Nehad Nasef, Abd Elazeez Shabaan, Islam Nour

Journal: Biomed Res Int. 2013 ;2013():676192.

 

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality. Therefore, cyclooxygenase ...

Last Updated: 23 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus; Surgery; Necrotizing Enterocolitis; Intestinal Perforation

 

Last Updated: 13 Jan 2015

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Treating the Resistant Patent Ductus Arteriosus (PDA)
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 14 Feb 2008

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Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 18 Sep 2013

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