Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Patent ductus arteriosus (PDA) is a common heart defect that occurs when the ductus arteriosis does not close shortly after birth. The ductus arteriosis is a fetal artery connecting the aorta and the pulmonary artery. When the artery is not closed properly, it acts as a detour by not sending all the blood to the lungs (fetal blood obtains oxygen from the placenta). After birth, oxygen poor blood needs to go to the lungs to obtain oxygen. If the ductus arteriosis does not close, it can cause both the lungs and the heart to work too hard. PDA is sometimes found with other heart defects or in certain genetic conditions such as Down syndrome. PDA appears to be more common in girls.

Usually PDA is diagnosed in infancy but if it is small, symptoms may only appear in childhood. Severity of symptoms depends on the size and whether other heart defects are also present. Symptoms may include poor feeding or sweating while feeding, shortness of breath, tiring easily, fast pulse and poor growth. The causes of PDA are likely a combination of genetics and environment. Risk factors include premature birth, being born at a high altitude, a rubella infection during pregnancy, or a family history of certain genetic conditions.

A heart murmur is usually heard in infancy, but may be missed in a premature baby. The diagnosis will be confirmed using X-rays and an electrocardiogram (EKG). Other tests may check for other possible heart defects. In premature babies, the opening may close on its own even after the first few days, so the PDA may just be watched. Treatment options include medication and surgery, and may not be necessary. Outlook is excellent if PDA occurs without any associated birth defects. Talk to your baby’s cardiologist about treatment and management options. If the PDA is part of a syndrome or runs in your family, talk to a genetic counselor. Support groups are a good source of information and can connect you to other families affected by PDA.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 440 free, full-text research articles on human participants. First 3 results:

[Risk factors for patent ductus arteriosus in early preterm infants: a case-control study].
 

Author(s): Jin-Feng Du, Tian-Tian Liu, Hui Wu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jan;18(1):15-9.

 

To investigate the risk factors for the occurrence of patent ductus arteriosus (PDA) and to provide a clinical basis for reducing the occurrence of PDA in early preterm infants.

Last Updated: 19 Jan 2016

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[Value of amino-terminal pro-brain natriuretic peptide as a predictive marker of symptomatic patent ductus arteriosus in preterm infants].
 

Author(s): Kai-Shan Lu, Xiao-Ling Guo, Jun-Feng Lv, Shao-Li Huang, Chun-Hui Yang, Zhi-Hui Zou, Zhi-Jun Chen, Chun-Hua Lai, Bing-Yan Yang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Nov;17(11):1160-4.

 

To study the value of amino-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting symptomatic patent ductus arteriosus (sPDA) in preterm infants.

Last Updated: 20 Nov 2015

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Lung function in very preterm infants with patent ductus arteriosus under conservative management: an observational study.
 

Author(s): Hsiu-Lin Chen, Rei-Cheng Yang, Wei-Te Lee, Pei-Lun Lee, Jong-Hau Hsu, Jiunn-Ren Wu, Zen-Kong Dai

Journal:

 

Persistent patent ductus arteriosus (PDA) during hospitalization is thought to be associated with adverse pulmonary outcomes in very preterm infants. This observational study aimed to compare the lung function in very preterm infants with and without PDA at discharge.

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 33 free, full-text review articles on human participants. First 3 results:

Treatment Options for Pediatric Patent Ductus Arteriosus: Systematic Review and Meta-analysis.
 

Author(s): Jennifer Y Lam, Steven R Lopushinsky, Irene W Y Ma, Frank Dicke, Mary E Brindle

Journal: Chest. 2015 Sep;148(3):784-93.

 

Patent ductus arteriosus (PDA) in the nonpremature pediatric patient is currently treated by surgical ligation or catheter occlusion. There is no clear superiority of one technique over the other. This meta-analysis compares the clinical outcomes of the two treatment options for PDA.

Last Updated: 1 Sep 2015

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Current controversies in the management of patent ductus arteriosus in preterm infants.
 

Author(s): Thowfique K Ibrahim, A A Abdul Haium, S Chandran, V S Rajadurai

Journal: Indian Pediatr. 2014 Apr;51(4):289-94.

 

Patent ductus arteriosus is very commonly seen in very low birth weight (VLBW) infants, affecting about one-third. The present review tries to identify the group of VLBW infants who need active intervention in day-to-day practice and to determine the mode of intervention, based on ...

Last Updated: 14 May 2014

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Transcatheter closure of patent ductus arteriosus: past, present and future.
 

Author(s): Alban-Elouen Baruteau, Sébastien Hascoët, Julien Baruteau, Younes Boudjemline, Virginie Lambert, Claude-Yves Angel, Emre Belli, Jérôme Petit, Robert Pass

Journal: Arch Cardiovasc Dis. 2014 Feb;107(2):122-32.

 

This review aims to describe the past history, present techniques and future directions in transcatheter treatment of patent ductus arteriosus (PDA). Transcatheter PDA closure is the standard of care in most cases and PDA closure is indicated in any patient with signs of left ventricular ...

Last Updated: 17 Mar 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus; Surgery; Necrotizing Enterocolitis; Intestinal Perforation

 

Last Updated: 1 Dec 2015

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Treating the Resistant Patent Ductus Arteriosus (PDA)
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 14 Feb 2008

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Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 7 Mar 2016

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