Parkes Weber syndrome

Common Name(s)

Parkes Weber syndrome

Parkes Weber syndrome (PWS) is a rare congenital condition causing an individual to have a large number of abnormal blood vessels. The main characteristics of PWS typically include a capillary malformation on the skin; hypertrophy (excessive growth) of the bone and soft tissue of the affected limb; and multiple arteriovenous fistulas (abnormal connections between arteries and veins) which can potentially lead to heart failure. Individuals may also have pain in the affected limb and a difference in size between the limbs. There has been evidence that some cases of PWS are caused by mutations in the RASA1 gene and are inherited in an autosomal dominant manner.  Management typically depends on the presence and severity of symptoms and may include embolization or surgery in the affected limb.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkes Weber syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Parkes Weber syndrome" returned 6 free, full-text research articles on human participants. First 3 results:

Rat Model of Parkes Weber Syndrome.
 

Author(s): Krzysztof Bojakowski, Gabriela Janusz, Iwona Grabowska, Oliwia Zegrocka-Stendel, Agnieszka Surowiecka-Pastewka, Magdalena Kowalewska, Dorota Maciejko, Katarzyna Koziak

Journal:

 

The Parkes Weber syndrome is a congenital vascular malformation, characterized by varicose veins, arterio-venous fistulas and overgrown limbs. No broadly accepted animal model of Parkes Weber syndrome has been described. We created side-to-side arterio-venous fistula between common ...

Last Updated: 29 Jul 2015

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Images in clinical medicine. Parkes Weber syndrome.
 

Author(s): Stefan Stefanov-Kiuri, Alvaro Fernandez-Heredero

Journal: N. Engl. J. Med.. 2014 Nov;371(22):2114.

 

Last Updated: 27 Nov 2014

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Giant arteriovenous fistula in Parkes Weber syndrome.
 

Author(s): Andres R Plasencia, Alejandro Santillan

Journal: J. Vasc. Surg.. 2014 Jul;60(1):233.

 

Last Updated: 27 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Parkes Weber syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome
 

Status: Recruiting

Condition Summary: Sturge-Weber Syndrome

 

Last Updated: 12 Oct 2015

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Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
 

Status: Recruiting

Condition Summary: Sturge Weber Syndrome; Port-wine Mark

 

Last Updated: 18 Dec 2015

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Lymphatic Anomalies Registry
 

Status: Recruiting

Condition Summary: Lymphatic Malformation; Generalized Lymphatic Anomaly (GLA); Central Conducting Lymphatic Anomaly; CLOVES Syndrome; Gorham-Stout Disease ("Disappearing Bone Disease"); Blue Rubber Bleb Nevus Syndrome; Kaposiform Lymphangiomatosis; Kaposiform Hemangioendothelioma/Tufted Angioma; Klippel-Trenaunay Syndrome; Lymphangiomatosis

 

Last Updated: 4 Nov 2015

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