Paraplegia

Common Name(s)

Paraplegia

Description for this condition is not yet available.
 

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Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Paraplegia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Paraplegia" returned 711 free, full-text research articles on human participants. First 3 results:

Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study.
 

Author(s): Cecilia Smith Simonsen, Elisabeth Gulowsen Celius, Cathrine Brunborg, Chantal Tallaksen, Erik Fink Eriksen, Trygve Holmøy, Stine Marit Moen

Journal:

 

Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this study was to assess whether patients with MS are more likely to develop ...

Last Updated: 6 Dec 2016

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Sports practice, resilience, body and sexual esteem, and higher educational level are associated with better sexual adjustment in men with acquired paraplegia.
 

Author(s): Isabela Dos Passos Porto, Fernando Luiz Cardoso, Cinara Sacomori

Journal: J Rehabil Med. 2016 Oct;48(9):787-792.

 

To analyse the association of team sports practice and physical and psychological factors with sexual adjustment in men with paraplegia. More specifically, we aimed to compare athletes and non-athletes regarding sexual adjustment, resilience, body and sexual self-esteem, and functional independence.

Last Updated: 12 Oct 2016

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CYP2U1 mutations in two Iranian patients with activity induced dystonia, motor regression and spastic paraplegia.
 

Author(s): A Kariminejad, L Schöls, R Schüle, S H Tonekaboni, A Abolhassani, M Fadaee, R O Rosti, J G Gleeson

Journal: Eur. J. Paediatr. Neurol.. 2016 Sep;20(5):782-7.

 

Hereditary spastic paraplegia (HSP) is a heterogeneous condition characterized by progressive spasticity and weakness in the lower limbs. It is divided into two major groups, complicated and uncomplicated, based on the presence of additional features such as intellectual disability, ...

Last Updated: 9 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Paraplegia" returned 38 free, full-text review articles on human participants. First 3 results:

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
 

Author(s): Hans Zempel, Eva-Maria Mandelkow

Journal:

 

In Alzheimer Disease (AD), the mechanistic connection of the two major pathological hallmarks, namely deposition of Amyloid-beta (Aβ) in the form of extracellular plaques, and the pathological changes of the intracellular protein Tau (such as phosphorylation, missorting, aggregation), ...

Last Updated: 22 Dec 2015

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Hereditary spastic paraplegia SPG4: what is known and not known about the disease.
 

Author(s): Joanna M Solowska, Peter W Baas

Journal: Brain. 2015 Sep;138(Pt 9):2471-84.

 

Mutations in more than 70 distinct loci and more than 50 mutated gene products have been identified in patients with hereditary spastic paraplegias, a diverse group of neurological disorders characterized predominantly, but not exclusively, by progressive lower limb spasticity and ...

Last Updated: 25 Aug 2015

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Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms.
 

Author(s): Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai, Antonio Orlacchio

Journal: Exp. Neurol.. 2014 Nov;261():518-39.

 

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition ...

Last Updated: 11 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The ReWalk Exoskeletal Walking System for Persons With Paraplegia
 

Status: Recruiting

Condition Summary: Paraplegia

 

Last Updated: 8 Apr 2015

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Safety and Tolerance of Local Heat Application in the Paralyzed Area of Patients With Complete Paraplegia
 

Status: Recruiting

Condition Summary: Perfusion; Complications

 

Last Updated: 25 Jan 2017

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Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31
 

Status: Recruiting

Condition Summary: Hereditary Spastic Paraplegia

 

Last Updated: 24 Jan 2017

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