Paraplegia

Common Name(s)

Paraplegia

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Paraplegia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Paraplegia" returned 564 free, full-text research articles on human participants. First 3 results:

Novel SPAST deletion and reduced DPY30 expression in a Spastic Paraplegia type 4 kindred.
 

Author(s): Loretta Racis, Eugenia Storti, Maura Pugliatti, Virgilio Agnetti, Alessandra Tessa, Filippo M Santorelli

Journal:

 

The hereditary spastic paraplegias (HSPs) are pleiomorphic disorders of motor pathway and a large number of affected genes have been discovered. Yet, mutations in SPG4/SPAST represent the most frequent molecular etiology in autosomal dominant (AD) patients and sporadic cases. We describe ...

Last Updated: 8 Apr 2014

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Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia.
 

Author(s): Typhaine Esteves, Alexandra Durr, Emeline Mundwiller, José L Loureiro, Maxime Boutry, Michael A Gonzalez, Julie Gauthier, Khalid H El-Hachimi, Christel Depienne, Marie-Paule Muriel, Rafael F Acosta Lebrigio, Marion Gaussen, Anne Noreau, Fiorella Speziani, Alexandre Dionne-Laporte, Jean-François Deleuze, Patrick Dion, Paula Coutinho, Guy A Rouleau, Stephan Zuchner, Alexis Brice, Giovanni Stevanin, Frédéric Darios

Journal: Am. J. Hum. Genet.. 2014 Feb;94(2):268-77.

 

Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous neurological conditions. Their main pathogenic mechanisms are thought to involve alterations in endomembrane trafficking, mitochondrial function, and lipid metabolism. With a combination of whole-genome ...

Last Updated: 10 Feb 2014

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A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system.
 

Author(s): Mukhran Khundadze, Katrin Kollmann, Nicole Koch, Christoph Biskup, Sandor Nietzsche, Geraldine Zimmer, J Christopher Hennings, Antje K Huebner, Judit Symmank, Amir Jahic, Elena I Ilina, Kathrin Karle, Ludger Schöls, Michael Kessels, Thomas Braulke, Britta Qualmann, Ingo Kurth, Christian Beetz, Christian A Hübner

Journal: PLoS Genet.. 2013 ;9(12):e1003988.

 

Hereditary spastic paraplegias (HSPs) are characterized by progressive weakness and spasticity of the legs because of the degeneration of cortical motoneuron axons. SPG15 is a recessively inherited HSP variant caused by mutations in the ZFYVE26 gene and is additionally characterized ...

Last Updated: 24 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Paraplegia" returned 22 free, full-text review articles on human participants. First 3 results:

Spontaneous spinal epidural hematoma: a rare cause of paraplegia in pregnancy.
 

Author(s): Prasad Krishnan, Rajaraman Kartikueyan

Journal: Neurol India. ;62(2):205-7.

 

Last Updated: 14 May 2014

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Ophthalmoplegia and flaccid paraplegia in a patient with anti-NMDA receptor encephalitis: a case report and literature review.
 

Author(s): Yuichi Ishikawa, Ken Ikeda, Kiyoko Murata, Takehisa Hirayama, Takanori Takazawa, Masaru Yanagihashi, Osamu Kano, Kiyokazu Kawabe, Yukitoshi Takahashi, Yasuo Iwasaki

Journal: Intern. Med.. 2013 ;52(24):2811-5.

 

We herein report the case of a 26-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis presenting with ophthalmoplegia and flaccid paraplegia. She developed disorientation and hallucination after fever and vomiting. Hypothermia, hypoventilation, hypertension, ...

Last Updated: 16 Dec 2013

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Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.
 

Author(s): John K Fink

Journal: Acta Neuropathol.. 2013 Sep;126(3):307-28.

 

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals of diverse ethnic groups with prevalence ...

Last Updated: 27 Aug 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The ReWalk Exoskeletal Walking System for Persons With Paraplegia
 

Status: Recruiting

Condition Summary: Paraplegia

 

Last Updated: 27 Mar 2014

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SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
 

Status: Recruiting

Condition Summary: Cerebellar Ataxias; Spastic Paraplegias

 

Last Updated: 26 Mar 2012

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