Paraplegia

Common Name(s)

Paraplegia

Description for this condition is not yet available.
 

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Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Paraplegia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Paraplegia" returned 724 free, full-text research articles on human participants. First 3 results:

The spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.
 

Author(s): Amir Jahic, Mukhran Khundadze, Nadine Jaenisch, Rebecca Schüle, Sven Klimpe, Stephan Klebe, Christiane Frahm, Jan Kassubek, Giovanni Stevanin, Ludger Schöls, Alexis Brice, Christian A Hübner, Christian Beetz

Journal:

 

The hereditary spastic paraplegias (HSPs) are rare neurodegenerative gait disorders which are genetically highly heterogeneous. For each single form, eventual consideration of therapeutic strategies requires an understanding of the mechanism by which mutations confer pathogenicity. ...

Last Updated: 17 Nov 2015

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Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2.
 

Author(s): Nyamkhishig Sambuughin, Lev G Goldfarb, Tatiana M Sivtseva, Tatiana K Davydova, Vsevolod A Vladimirtsev, Vladimir L Osakovskiy, Al'bina P Danilova, Raisa S Nikitina, Anastasia N Ylakhova, Margarita P Diachkovskaya, Anna C Sundborger, Neil M Renwick, Fyodor A Platonov, Jenny E Hinshaw, Camilo Toro

Journal:

 

Hereditary Spastic Paraplegia (HSP) represents a large group of clinically and genetically heterogeneous disorders linked to over 70 different loci and more than 60 recognized disease-causing genes. A heightened vulnerability to disruption of various cellular processes inherent to ...

Last Updated: 31 Oct 2015

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Abnormal Paraplegin Expression in Swollen Neurites, τ- and α-Synuclein Pathology in a Case of Hereditary Spastic Paraplegia SPG7 with an Ala510Val Mutation.
 

Author(s): Dietmar R Thal, Stephan Züchner, Stephan Gierer, Claudia Schulte, Ludger Schöls, Rebecca Schüle, Matthis Synofzik

Journal:

 

Mutations in the SPG7 gene are the most frequent cause of autosomal recessive hereditary spastic paraplegias and spastic ataxias. Ala510Val is the most common SPG7 mutation, with a frequency of up to 1% in the general population. Here we report the clinical, genetic, and neuropathological ...

Last Updated: 28 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Paraplegia" returned 37 free, full-text review articles on human participants. First 3 results:

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
 

Author(s): Hans Zempel, Eva-Maria Mandelkow

Journal:

 

In Alzheimer Disease (AD), the mechanistic connection of the two major pathological hallmarks, namely deposition of Amyloid-beta (Aβ) in the form of extracellular plaques, and the pathological changes of the intracellular protein Tau (such as phosphorylation, missorting, aggregation), ...

Last Updated: 22 Dec 2015

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Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms.
 

Author(s): Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai, Antonio Orlacchio

Journal: Exp. Neurol.. 2014 Nov;261():518-39.

 

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition ...

Last Updated: 11 Oct 2014

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Spontaneous spinal epidural hematoma: a rare cause of paraplegia in pregnancy.
 

Author(s): Prasad Krishnan, Rajaraman Kartikueyan

Journal: Neurol India. ;62(2):205-7.

 

Last Updated: 14 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The ReWalk Exoskeletal Walking System for Persons With Paraplegia
 

Status: Recruiting

Condition Summary: Paraplegia

 

Last Updated: 8 Apr 2015

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Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia
 

Status: Recruiting

Condition Summary: Hereditary Spastic Paraplegia

 

Last Updated: 6 Jul 2016

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SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
 

Status: Recruiting

Condition Summary: Cerebellar Ataxias; Spastic Paraplegias

 

Last Updated: 26 Mar 2012

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